>ref|NP_223648.1| topoisomerase I [Helicobacter pylori J99]
          Length = 686

 Score =  521 bits (1342), Expect = e-149
 Identities = 313/653 (47%), Positives = 413/653 (62%), Gaps = 34/653 (5%)

Query: 1   MKDSVIIIESPNKVEKIKQLTGAEVYATIGHFTNLIGVDIENNFACKFEIKEDKAKKINF 60
           M +SVIIIESPNKV KI+++TGA+V+ATIGHF  L   D  N F   F+  ++K K I  
Sbjct: 1   MNNSVIIIESPNKVAKIREITGAKVFATIGHFMQLKSYDENNGFKPTFDYDQEKKKHIFE 60

Query: 61  LINACRDKKVYIATDPDREGYGIGYQFYEKIKNVASEIYRAEFHEITPSGIESGLKNAVL 120
           +I AC++KKVYIATDPDREGY IGY FY+KIKNVAS IYRAEF EITPSGI  GL+NA+L
Sbjct: 61  MIEACKNKKVYIATDPDREGYAIGYMFYQKIKNVASSIYRAEFFEITPSGINKGLQNALL 120

Query: 121 FSRSNTNLYQSFLGRIASDQVVGFALTSYLRKSLN-LSELSAGRVQTPALALICQRDQEI 179
           F  +N  +YQS L R  +D ++GF L+ YL K+L  +   SAGRVQTP L LI  RD+EI
Sbjct: 121 FENTNRQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREI 180

Query: 180 RDFDKLDAEEKVEYQIQANIVCN-EKEAIIKHVRANEKNELVDFKFKDKNEASQFLKDLK 238
             F  L   EKV YQIQA I  +  +E  IKH   +EK E  + KF DK EA +  + LK
Sbjct: 181 EKFKALPENEKVSYQIQAKINDSANREVTIKH--CDEKGE--EIKFNDKEEALKLFESLK 236

Query: 239 DGLGSMSVLVSLKESLSNKEPKKPFTTSKLLSQASKSLKIPTKEIAQLAQKLFEAGLITY 298
           D    +  L  LK S+   +PKKPF TS LL +AS  L +   E+  LAQ LFEAGLITY
Sbjct: 237 DNKACL--LKDLKNSVVETKPKKPFITSTLLEKASSMLGLSISEVQSLAQNLFEAGLITY 294

Query: 299 HRTDSEFLSPEYLKEHEVFFEPIYPSVYQYREYKAGKNSQAEAHEAIRITHPHALKDLEK 358
            RTD+E LS E+L E E F+ PIY  +Y  REYKAGK SQAEAHEAIRITHPH  +DLE 
Sbjct: 295 IRTDAESLSVEFLDETESFYAPIYKDLYLKREYKAGKQSQAEAHEAIRITHPHTTEDLES 354

Query: 359 VCSDAKISEELALKLYQLIYTNTICSQSRNALYNQYDCIFKIKSESFKLSFKLLKEKGFL 418
           +  +A I+ + ALKLYQLI+  TI SQ +NA+Y++ D +FKIK+E FK S K LK  GFL
Sbjct: 355 IVYNANITNQDALKLYQLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSVKGLKSAGFL 414

Query: 419 ------EIEELIQGKEEINREEQESEIENFSLKENDSVPLKEVFIKKIEKPSPKPYKESA 472
                 E+E      ++ N+E++++    F+LK +D + L ++ +  I++ +P  YKE+ 
Sbjct: 415 AMFSKKELENDESNDDKDNKEKEQN--AQFNLKIDDVLSLNDLVLSTIKRNAPSAYKEAD 472

Query: 473 FIPLLESEGIGRPSTYASFLDLLLKRKYISI-DTKTNAITPTSQGLEVISFFKKDKEVDF 531
           F+ LLE++GIGRPSTYAS+L  L+KR+YISI   K + ITPT +G  V+  F+   +   
Sbjct: 473 FVKLLENKGIGRPSTYASYLPTLVKREYISISQDKKHIITPTHKGKRVVEVFENAYQF-I 531

Query: 532 IALTSKDKSKLGNTTKQFEECLDLIMRGEASYEKFMLEVISKLKSTAKFYQTQSTDNNMP 591
           I LT          TKQ EE LD I+  ++SY  F+  + SK     K    ++ D   P
Sbjct: 532 IDLT---------YTKQMEEVLDEIVENKSSYVDFISNLNSKCPKIEKL--ERNDDEIKP 580

Query: 592 TDK-QLELIDKICKDKKLQKPSQEILQNKEK---CSDWIAEHVKEKPSQKQLN 640
           + + Q+  I+ I +D +L   S+E    KE       ++  ++KE    K+ N
Sbjct: 581 SSEGQITYIENILRDLQLNL-SEEFKNYKEDNRVAKAFLDRYIKEHEFFKKNN 632