>ref|NP_223574.1| putative vacuolating cytotoxin (VacA) paralog [Helicobacter pylori
            J99]
          Length = 2399

 Score = 3959 bits (10267), Expect = 0.0
 Identities = 2077/2537 (81%), Positives = 2189/2537 (85%), Gaps = 146/2537 (5%)

Query: 1    MAFKKARLISKFISKGSFKLNKISKKIFTLNQILKCEKPLKRHKKALKPIKKLSNRNKSF 60
            MAFKKARLIS+FISKGSFKLNKISKK FTLNQILK EKPLKRHKK  K I+K  N+NKSF
Sbjct: 1    MAFKKARLISRFISKGSFKLNKISKKFFTLNQILKREKPLKRHKKT-KSIEKPFNKNKSF 59

Query: 61   LKASVLLIGALGGLSHLRANECRYWSWSSWSYQDNIESGPNSPTHNSYCLFSSTQGSGTY 120
            LKASVLLIGALGGLSHLRANECRYWSWSSWSYQDNIESGPNSPTHNSYCLFSS QGSGTY
Sbjct: 60   LKASVLLIGALGGLSHLRANECRYWSWSSWSYQDNIESGPNSPTHNSYCLFSSAQGSGTY 119

Query: 121  YLNTLTTYSAGGASFTQKFNNGTLNVGENIRFGGTGINGGDVGYITGTYDAQTINFNSSH 180
            YLNTLTTYSAGGASFTQKFN GTL++G NIRFGGTGINGGDVGYITGTY+AQ        
Sbjct: 120  YLNTLTTYSAGGASFTQKFNGGTLDIGGNIRFGGTGINGGDVGYITGTYNAQ-------- 171

Query: 181  LTTGNSYADGGGATLNFNAANNITINQASFDNSHAGTQKSYMNFKGSN-IKVSGSSFTDD 239
                         T+NFN+++  T       NS+A    + +NF  +N I ++ +SF D+
Sbjct: 172  -------------TMNFNSSHITT------GNSYADGGGTTLNFNATNNITINQASF-DN 211

Query: 240  TDGGFSFSGNSNNSTISFNQTSFNQGTYHFSNSATLSFNHSAFNQGTYNFNSTQSAFNNS 299
            +D G                    Q +Y     + +  + S+F   T           N 
Sbjct: 212  SDAG-------------------TQKSYMNFKGSNIKISGSSFTDDT-----------NG 241

Query: 300  AFNQGTYHFNGNASFDNDTFNQGTYSF-NTSKVSFSGINTLNSSSPFASLKGSVSFGSDA 358
             FN    + N   SF+  +FNQGTY+F N++ +SF+  N    +  F S + +       
Sbjct: 242  GFNFSGNNNNSTISFNQTSFNQGTYNFSNSATLSFNNSNFNQGTYHFNSAQSTFE----- 296

Query: 359  IFNLNQTLNNQTYDILTTNGAIQYGVYQSYLWDLINYKGDKAISHVEVGNNTYDVTFDIN 418
                N   N  TY                      N+  + + +     N+T++      
Sbjct: 297  ----NSNFNQGTY----------------------NFNDNTSFN-----NDTFN------ 319

Query: 419  GQDETLQETFNKQSIITQFLGDDLQQQAQKTYQQDLSNSQSALNNAASDNKIANSDTDYT 478
                  Q T+N  S    F G +             S+  ++L  + S N  A  + + T
Sbjct: 320  ------QGTYNFNSSKVSFSGANTLNS---------SSPFASLKGSVSFNSGAIFNLNQT 364

Query: 479  KNKNATIKKDAQGLENTNQQIAQDE-QALQGDLDKLK-QLANSPTGFSEQAFNQAQKQEQ 536
             N N T       +  TN  I     Q+   DL   K   A S    S   ++       
Sbjct: 365  LNNNQTYD-----ILTTNGAIQYGVYQSYLWDLINYKGDKAISHVEVSNNTYDVTFDING 419

Query: 537  QDEQTLQNEEKTFNSEQEGLKQAIQQAQAQQQKQQQKQEQQQAQQTYQEDLTHSQSALND 596
            QDE TLQ   +TF S Q  + Q +               QQQAQQTYQED+ +SQ+ALN 
Sbjct: 420  QDE-TLQ---ETF-SNQSIITQFLGD-----------DLQQQAQQTYQEDVANSQNALNK 463

Query: 597  VASDNTIASNDTNYTNNQNTAIKEDAQGLENTNQQIAQDEQALQGDLDKLKQLANSPTGF 656
            VASDNTIA+NDT+YT + N  I +DAQGLENTNQQI QDE+AL+ DL ++KQLANS TGF
Sbjct: 464  VASDNTIANNDTSYTQSSNPTILKDAQGLENTNQQIQQDEKALEKDLAQIKQLANSTTGF 523

Query: 657  SEQAFNQAQKQEQQDEQTLQNEEKTFNSEQERLKQAIANAK---PT-SPTPSHAPTPTKH 712
            +EQAF QAQKQEQQDEQ LQN+E  FN+EQE L+QAIANAK   PT +PTPS  PTP KH
Sbjct: 524  NEQAFTQAQKQEQQDEQALQNDENAFNTEQEGLEQAIANAKHANPTPNPTPSPTPTPIKH 583

Query: 713  TAPNTPPNKVPPTPPTQNPPAESVWSGVYWLQNKTYSNKGIYYIDPNLSGQSGQSGNTLS 772
            TAPNTPP++VPPTPP+QN P  +VW+GVYWLQNKTYSNKGIYYIDPNLSGQSGQSGNTLS
Sbjct: 584  TAPNTPPSQVPPTPPSQNLPKTNVWNGVYWLQNKTYSNKGIYYIDPNLSGQSGQSGNTLS 643

Query: 773  TYTANLFGRSFSVNIQNGTLIIGNNTESVNSNGLIWIGHGGFGYITGTFSAANIYLTNNF 832
            TYTANL GRSF VN  NGTLIIGNNTESVN NGLIWIGHGGFGYITGTFSAANIYLTNNF
Sbjct: 644  TYTANLLGRSFGVNANNGTLIIGNNTESVNDNGLIWIGHGGFGYITGTFSAANIYLTNNF 703

Query: 833  KTGEGVSNSDGGGANITFKASDNITMDGLNYNDAETVTKMIQTGASQHSYATFDALNNIS 892
            KTGEGVSNSDGGGANITFKASDNITMDGLNYN+AETVTKMIQTGASQHSY TFDA NNIS
Sbjct: 704  KTGEGVSNSDGGGANITFKASDNITMDGLNYNNAETVTKMIQTGASQHSYTTFDATNNIS 763

Query: 893  VTNSSFSDMTWGKFSFSAKNISFSNASFSGFTNPGGSSVISANATNSLSFINSRLNGGAV 952
            VT+S FSDMTWGKFSFSAKNISFSNASFSGFTNPGGSS IS NA+NSLSF +SRLNGGA+
Sbjct: 764  VTDSDFSDMTWGKFSFSAKNISFSNASFSGFTNPGGSSTISTNASNSLSFTDSRLNGGAI 823

Query: 953  YNLQANSLIFNNTQAVFNVLYSRGTSNFNATTQLLGNTNFTLSSQSLLNFNGDTTLQNNA 1012
            YNLQANSLIFNNTQAVFNVLYSRGTSNFNATTQLLGNT+FTLSSQSLLNFNGDTTLQNNA
Sbjct: 824  YNLQANSLIFNNTQAVFNVLYSRGTSNFNATTQLLGNTSFTLSSQSLLNFNGDTTLQNNA 883

Query: 1013 NITLGNKSQAAFKNSLTLDNNSNLSLDNQSVLNANNTSAFNNQASLNIYNGSQATFNSLF 1072
            NITLGNKSQAAFKNSLTLDNNSNLSLDNQSVLNAN TSAFNNQASLNIYNGSQA F+SLF
Sbjct: 884  NITLGNKSQAAFKNSLTLDNNSNLSLDNQSVLNANGTSAFNNQASLNIYNGSQAAFSSLF 943

Query: 1073 FNGGTLSLNASSKLNASNASFSNNTTINLDDSVLSASNTSSLNANINFQGASQADFGGNT 1132
            FNGGTLSLNA+SKLNAS+ASFSNNTTINLDDSVL+A+NTSSLNANINFQGASQADFGGNT
Sbjct: 944  FNGGTLSLNANSKLNASSASFSNNTTINLDDSVLNANNTSSLNANINFQGASQADFGGNT 1003

Query: 1133 IIDTASFNFDSASSLNFNNLTANGALNFNGYTPSLTKALMSVSGQFVLGNNGDINLSDIN 1192
             IDTASFNFDSASSLNFNNLTANGALNFNGY PSLTKALM+VSGQFVLGNNGDINLSDIN
Sbjct: 1004 TIDTASFNFDSASSLNFNNLTANGALNFNGYAPSLTKALMNVSGQFVLGNNGDINLSDIN 1063

Query: 1193 IFDNITKSVTYNILNAQKGITGISGANGYEKILFYGMKIQNATYSDNNNIQTWSFINPLN 1252
            IFDNITKSVTYNILNAQKGITGISGANGYEKILFYGMKIQNATYSDNNNIQTWSFINPLN
Sbjct: 1064 IFDNITKSVTYNILNAQKGITGISGANGYEKILFYGMKIQNATYSDNNNIQTWSFINPLN 1123

Query: 1253 SSQIIQESIKNGDLTIEVLNNPNSASNTIFNIAPELYNYQASKQNPTGYSYDYSDNQAGT 1312
            SSQIIQESIKNGDLTIEVLNNPNSASNTIFNIAPELYNYQ SKQNPTGYSYDYSDNQAGT
Sbjct: 1124 SSQIIQESIKNGDLTIEVLNNPNSASNTIFNIAPELYNYQDSKQNPTGYSYDYSDNQAGT 1183

Query: 1313 YYLTSNIKGLFTPKGSQTPQAPGTYSPFNQPLSSLNIYNKGFSSENLKTLLGILSQNSAT 1372
            YYLTSNIKGLFTPKGSQTPQ PGTYSPFNQPL+SLNIYNKGFSSENLKTLLGILSQNSAT
Sbjct: 1184 YYLTSNIKGLFTPKGSQTPQTPGTYSPFNQPLNSLNIYNKGFSSENLKTLLGILSQNSAT 1243

Query: 1373 LKEMIESNQLDNITNINEVLQLLDKIKITQVQKQALLETINHLTDNINQTFNNGNLIIGA 1432
            LKEMIESNQLDNITNINEVLQLLDKIKITQ QKQALLETINHLTDNINQTFNNGNL+IGA
Sbjct: 1244 LKEMIESNQLDNITNINEVLQLLDKIKITQAQKQALLETINHLTDNINQTFNNGNLVIGA 1303

Query: 1433 TQDNVTNSTSSIWFGGNGYSSPCTLDSATCSSFRNTYLGQLLGSTSPYLGYINADFKAKS 1492
            TQDNVTNSTSSIWFGGNGYSSPC LDSATCSSFRNTYLGQLLGSTSPYLGYINADFKAKS
Sbjct: 1304 TQDNVTNSTSSIWFGGNGYSSPCALDSATCSSFRNTYLGQLLGSTSPYLGYINADFKAKS 1363

Query: 1493 IYITGTIGSGNAFESGGSADVTFQSANNLVLNKANIEAQATDNIFNLLGQKGIEKIFNQG 1552
            IYITGTIGS NAFESGGSADVTFQSANNLVLNKANIEAQATDNIFNLLGQ+GI+KIFNQG
Sbjct: 1364 IYITGTIGSSNAFESGGSADVTFQSANNLVLNKANIEAQATDNIFNLLGQEGIDKIFNQG 1423

Query: 1553 NLANVLSQVAMEKIKQAGGLGNFIENALSPLSKELPASLQNETLGQLIGQNNLDDLLNNS 1612
            NLANVLSQ+AMEKIKQAGGLGNFIENALSPLSKELPASLQ+ETLGQLIGQNNLDDLLNNS
Sbjct: 1424 NLANVLSQMAMEKIKQAGGLGNFIENALSPLSKELPASLQDETLGQLIGQNNLDDLLNNS 1483

Query: 1613 GVMNAIQNIISKKLSIFGNFVTPSIIENYLAKQSLKSMLDDKGLLNFIGGYMNASELSSI 1672
            GVMN IQNIIS+KLSIFGNFVTPSIIENYLAKQSLKSMLDDKGLLNFIGGY++ASELSSI
Sbjct: 1484 GVMNEIQNIISQKLSIFGNFVTPSIIENYLAKQSLKSMLDDKGLLNFIGGYIDASELSSI 1543

Query: 1673 LSVVLKDITNPPTSLQKDIGVVANDLLNEFLGQDVIKKLESQGLVSNIINNIISQGGLSG 1732
            L V+LKDITNPPTSLQKDIGVVANDLLNEFLGQDV+KKLESQGLVSNIINN+ISQGGLSG
Sbjct: 1544 LGVILKDITNPPTSLQKDIGVVANDLLNEFLGQDVVKKLESQGLVSNIINNVISQGGLSG 1603

Query: 1733 VYNQGLGSVLPPSLQNALKENDLGTLLSPRGLHDFWQKGYFNFLSNGYVFVNNSSFSNAT 1792
            VYNQGLGSVLPPSLQNALKENDLGTLLSPRGLHDFWQKGYFNFLSNGYVFVNNSSFSNAT
Sbjct: 1604 VYNQGLGSVLPPSLQNALKENDLGTLLSPRGLHDFWQKGYFNFLSNGYVFVNNSSFSNAT 1663

Query: 1793 GGSLNFVANKSIIFNGDNTIDFSKYQGALIFASNDVSNINITTLNATNGLSLNAGLNNVS 1852
            GGSLNFVANKSIIFNGDNTIDFSKYQGALIFASN VSNINITTLNATNGLSLNAGLNNVS
Sbjct: 1664 GGSLNFVANKSIIFNGDNTIDFSKYQGALIFASNGVSNINITTLNATNGLSLNAGLNNVS 1723

Query: 1853 VQKGEICVNLANCPTTKNSSSTNSSVTPTNESLSVRANNFTFLGAIASNGAIDLSQVKNN 1912
            VQKGEIC+NLANCPTTKNSS  NSSVTPTNESLSV ANNFTFLG I SNGAIDLSQV NN
Sbjct: 1724 VQKGEICINLANCPTTKNSSPANSSVTPTNESLSVHANNFTFLGTIISNGAIDLSQVTNN 1783

Query: 1913 SVIDTLNLNENAALQANNLTITNAFNNASNSTANINGNFTLNQQATLSTNASGLNVMGNF 1972
            SVI TLNLNENA LQANNLTITNAFNNASNSTANI+GNFTLNQQATLSTNASGLNVMGNF
Sbjct: 1784 SVIGTLNLNENATLQANNLTITNAFNNASNSTANIDGNFTLNQQATLSTNASGLNVMGNF 1843

Query: 1973 NSYGDLVFNLSHSVSHAIINAQGSATIMANNNNPLIQFNTSSKEVGTYTLIDSAKAIYYG 2032
            NSYGDLVFNLSHSVSHAIIN QG+ATIMA NNNPLIQFN SSKEVGTYTLIDSAKAIYYG
Sbjct: 1844 NSYGDLVFNLSHSVSHAIINTQGTATIMA-NNNPLIQFNASSKEVGTYTLIDSAKAIYYG 1902

Query: 2033 YNNQITGGSSLDNYLKLYTLIDINGKHMVMTDNGLTYNGQAVSVKDGGLVVGFKDSQNQY 2092
            YNNQITGGSSLDNYLKLY LIDINGKHMVMTDNGLTYNGQAVSVKDGGLVVGFKDSQNQY
Sbjct: 1903 YNNQITGGSSLDNYLKLYALIDINGKHMVMTDNGLTYNGQAVSVKDGGLVVGFKDSQNQY 1962

Query: 2093 IYTSILYNKVKIAVSNDPINNLQAPTLKQYIAQIQGTQGVDSIDQAGGSQAINWLNKIFE 2152
            IYTSILYNKVKIAVSNDPINN QAPTLKQYIAQIQG Q VDSIDQAGG+QAINWLNKIFE
Sbjct: 1963 IYTSILYNKVKIAVSNDPINNPQAPTLKQYIAQIQGVQSVDSIDQAGGNQAINWLNKIFE 2022

Query: 2153 TKGSPLFAPYYLESHSTKDLTTIAGDIANTLEVIANPNFKNDATNILQINTYTQQMSRLA 2212
            TKGSPLFAPYYLESHSTKDLTTIAGDIANTLEVIANPNFKNDATNILQINTYTQQMSRLA
Sbjct: 2023 TKGSPLFAPYYLESHSTKDLTTIAGDIANTLEVIANPNFKNDATNILQINTYTQQMSRLA 2082

Query: 2213 KLSDTSTFASADFHERLEALKNKRFADAIPNAMDVILKYSQRNRVKNNVWATGVGGASFI 2272
            KLSDTSTFA +DF ERLEALKNKRFADAIPNAMDVILKYSQRNRVKNNVWATGVGGASFI
Sbjct: 2083 KLSDTSTFARSDFLERLEALKNKRFADAIPNAMDVILKYSQRNRVKNNVWATGVGGASFI 2142

Query: 2273 NGGTGTLYGINVGYDRFIKGVIVGGYAAYGYSGFHANITQSGSSNVNMGVYSRAFIKRSE 2332
            +GGTGTLYGINVGYDRFIKGVIVGGYAAYGYSGFHANITQSGSSNVN+GVYSRAFIKRSE
Sbjct: 2143 SGGTGTLYGINVGYDRFIKGVIVGGYAAYGYSGFHANITQSGSSNVNVGVYSRAFIKRSE 2202

Query: 2333 LTMSLNETWGYNKTFINSYDPLLSIINQSYKYDTWTTDAKINYGYDFMFKDKSVIFKPQI 2392
            LTMSLNETWGYNKTFINSYDPLLSIINQSY+YDTWTTDAKINYGYDFMFKDKSVIFKPQ+
Sbjct: 2203 LTMSLNETWGYNKTFINSYDPLLSIINQSYRYDTWTTDAKINYGYDFMFKDKSVIFKPQV 2262

Query: 2393 GLAYYYIGLSGLRGIMDDPIYNQFRANADPNKKSVLTINFALESRHYFNKNSYYFVIADV 2452
            GL+YYYIGLSGLRGIMDDPIYNQFRANADPNKKSVLTINFALESRHYFNKNSYYFVIADV
Sbjct: 2263 GLSYYYIGLSGLRGIMDDPIYNQFRANADPNKKSVLTINFALESRHYFNKNSYYFVIADV 2322

Query: 2453 GRDLFINSMGDKMVRFIGNNTLSYRDGGRYNTFASIITGGEIRLFKTFYVNAGIGARFGL 2512
            GRDLFINSMGDKMVRFIGNNTLSYRDGGRYNTFASIITGGEIRLFKTFYVNAGIGARFGL
Sbjct: 2323 GRDLFINSMGDKMVRFIGNNTLSYRDGGRYNTFASIITGGEIRLFKTFYVNAGIGARFGL 2382

Query: 2513 DYKDINITGNIGMRYAF 2529
            DYKDINITGNIGMRYAF
Sbjct: 2383 DYKDINITGNIGMRYAF 2399