BLASTP 2.2.1 [Apr-13-2001]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15644660|ref|NP_206829.1| isocitrate dehydrogenase
(icd) [Helicobacter pylori 26695]
(425 letters)
Database: /var/www/html/HP/blast_new/blast/db/pdbaa
13,198 sequences; 2,899,336 total letters
Searching...........................done
Score E
Sequences producing significant alignments: (bits) Value
pdb|1AI2| Isocitrate Dehydrogenase Complexed With Isocitr... 596 e-171
pdb|4ICD| Phosphorylated Isocitrate Dehydrogenase (E.C.1.... 596 e-171
pdb|1BL5| Isocitrate Dehydrogenase From E. Coli Single Tu... 596 e-171
pdb|6ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant... 595 e-171
pdb|1HJ6|A Chain A, Isocitrate Dehydrogenase S113e Mutant C... 595 e-171
pdb|1IDE| Isocitrate Dehydrogenase Y160f Mutant Steady-St... 595 e-171
pdb|1IDC| Isocitrate Dehydrogenase From E.Coli (Mutant K2... 594 e-171
pdb|1CW7|A Chain A, Low Temperature Structure Of Wild-Type ... 594 e-171
pdb|1GRP| Oxidoreductase, Nadp, Phosphorylation, Glyoxyla... 592 e-170
pdb|1GRO| Oxidoreductase, Nadp, Phosphorylation, Glyoxyla... 590 e-169
pdb|1ISO| Isocitrate Dehydrogenase: Structure Of An Engin... 584 e-168
pdb|1HQS|A Chain A, Crystal Structure Of Isocitrate Dehydro... 525 e-150
pdb|2AYQ|B Chain B, 3-Isopropylmalate Dehydrogenase From Th... 98 2e-21
pdb|1XAC| Chimera Isopropylmalate Dehydrogenase Between B... 97 3e-21
pdb|1GC8|A Chain A, The Crystal Structure Of Thermus Thermo... 97 4e-21
pdb|1DPZ|A Chain A, Stucture Of Modified 3-Isopropylmalate ... 95 1e-20
pdb|1DR0|A Chain A, Structure Of Modified 3-Isopropylmalate... 95 1e-20
pdb|1DR8|A Chain A, Structure Of Modified 3-Isopropylmalate... 95 1e-20
pdb|1G2U|A Chain A, The Structure Of The Mutant, A172v, Of ... 95 1e-20
pdb|1OSJ|A Chain A, Structure Of 3-Isopropylmalate Dehydrog... 95 1e-20
pdb|1XAA| 3-Isopropylmalate Dehydrogenase, Low Temperatur... 95 2e-20
pdb|1IPD| 3-Isopropylmalate Dehydrogenase (E.C.1.1.1.85) 95 2e-20
pdb|1GC9|A Chain A, The Crystal Structure Of Thermus Thermo... 94 2e-20
pdb|1WAL|A Chain A, 3-Isopropylmalate Dehydrogenase (Ipmdh)... 94 3e-20
pdb|1A05|A Chain A, Crystal Structure Of The Complex Of 3-I... 93 5e-20
pdb|1IDM| 3-Isopropylmalate Dehydrogenase, Loop-Deleted C... 93 6e-20
pdb|1CM7|A Chain A, 3-Isopropylmalate Dehydrogenase From Es... 79 1e-15
pdb|1CNZ|A Chain A, 3-Isopropylmalate Dehydrogenase (Ipmdh)... 74 2e-14
pdb|1MHS|A Chain A, Model Of Neurospora Crassa Proton Atpas... 27 3.4
pdb|1LAM| Leucine Aminopeptidase (Unligated) >gi|1127256|... 27 3.4
pdb|1BLL|E Chain E, Leucine Aminopeptidase (E.C.3.4.11.1) C... 27 3.4
pdb|1SUD| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Mutant W... 27 4.4
pdb|1S01| Subtilisin BPN(Prime) 8350 (E.C.3.4.21.14) (Mut... 27 4.4
pdb|1S02| Subtilisn Bpn' (E.C.3.4.21.14) (Mutant With Gln... 27 4.4
pdb|1LW6|E Chain E, Crystal Structure Of The Complex Of Sub... 27 4.4
pdb|1SUP| Mol_id: 1; Molecule: Subtilisin Bpn'; Chain: Nu... 27 4.4
pdb|2SNI|E Chain E, Subtilisin Novo (E.C.3.4.21.14) Complex... 27 4.4
pdb|1SUB| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Mutant W... 27 4.4
pdb|1SBI| Subtilisin Bpn' 8397 (E.C. 3.4.21.14) Mutant (M... 27 4.4
pdb|1UBN|A Chain A, Selenosubtilisin Bpn 27 4.4
pdb|1SBH| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) Mutant ... 27 4.4
pdb|1ES6|A Chain A, Crystal Structure Of The Matrix Protein... 26 7.5
pdb|1DVI|A Chain A, Calpain Domain Vi With Calcium Bound >g... 26 9.7
pdb|2SBT| Subtilisin Novo (E.C.3.4.21.14) 26 9.7
pdb|1SBT| Subtilisin BPN (E.C.3.4.21.14) 26 9.7
pdb|1GOL| Coordinates Of Rat Map Kinase Erk2 With An Argi... 26 9.7
pdb|1AK9| Subtilisin Mutant 8321 26 9.7
pdb|1A2Q| Subtilisin Bpn' Mutant 7186 26 9.7
pdb|1ERK| Structure Of Signal-Regulated Kinase >gi|582250... 26 9.7
pdb|1AQN| Subtilisin Mutant 8324 >gi|2780869|pdb|1AU9| S... 26 9.7
pdb|2ERK| Phosphorylated Map Kinase Erk2 26 9.7
>pdb|1AI2| Isocitrate Dehydrogenase Complexed With Isocitrate, Nadp+, And
Calcium (Flash-Cooled)
pdb|1AI3| Orbital Steering In The Catalytic Power Of Enzymes: Small
Structural Changes With Large Catalytic Consequences
pdb|1IKA| Isocitrate Dehydrogenase (E.C.1.1.1.42) Complexed With
Alpha-Ketoglutarate
pdb|1SJS| Access To Phosphorylation In Isocitrate Dehydrogenase May Occur By
Domain Shifting
pdb|5ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) Complex With Mg2+ And
Isocitrate
pdb|9ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) Complex With NADP+
pdb|3ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42)
Length = 416
Score = 596 bits (1537), Expect = e-171
Identities = 290/416 (69%), Positives = 346/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|4ICD| Phosphorylated Isocitrate Dehydrogenase (E.C.1.1.1.42)
Length = 414
Score = 596 bits (1537), Expect = e-171
Identities = 290/416 (69%), Positives = 346/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 6 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 65
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 66 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 118
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 119 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 178
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 179 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 238
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 239 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 298
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 299 CMNLNGDYISDALAAQVGGIGIAPGANIGDQCALFEATHGTAPKYAGQDKVNPGSIILSA 358
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 359 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 414
>pdb|1BL5| Isocitrate Dehydrogenase From E. Coli Single Turnover Laue
Structure Of Rate-Limited Product Complex, 10 Msec Time
Resolution
Length = 414
Score = 596 bits (1537), Expect = e-171
Identities = 290/416 (69%), Positives = 346/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 6 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 65
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 66 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 118
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 119 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 178
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 179 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 238
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 239 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 298
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 299 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 358
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 359 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 414
>pdb|6ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser 113
Replaced By Asp) (S113D)
Length = 416
Score = 595 bits (1533), Expect = e-171
Identities = 289/416 (69%), Positives = 345/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G R LNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRDLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1HJ6|A Chain A, Isocitrate Dehydrogenase S113e Mutant Complexed With
Isopropylmalate, Nadp+ And Magnesium (Flash-Cooled)
pdb|7ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser 113
Replaced By Glu) (S113E)
pdb|8ICD| Isocitrate Dehydrogenase (E.C.1.1.1.42) (Mutant With Ser 113
Replaced By Glu) (S113E) Complex With Mg2+ And
Isocitrate
Length = 416
Score = 595 bits (1533), Expect = e-171
Identities = 289/416 (69%), Positives = 345/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G R LNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1IDE| Isocitrate Dehydrogenase Y160f Mutant Steady-State Intermediate
Complex (Laue Determination)
pdb|1IDD| Isocitrate Dehydrogenase Y160f Mutant Apo Enzyme
Length = 416
Score = 595 bits (1533), Expect = e-171
Identities = 289/416 (69%), Positives = 346/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDI+AGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIFAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1IDC| Isocitrate Dehydrogenase From E.Coli (Mutant K230m), Steady-State
Intermediate Complex Determined By Laue Crystallography
pdb|1IDF| Isocitrate Dehydrogenase K230m Mutant Apo Enzyme
pdb|1CW1|A Chain A, Crystal Structure Of Isocitrate Dehydrogenase Mutant K230m
Bound To Isocitrate And Mn2+
pdb|1CW4|A Chain A, Crystal Structure Of K230m Isocitrate Dehydrogenase In
Complex With Alpha- Ketoglutarate
Length = 416
Score = 594 bits (1531), Expect = e-171
Identities = 289/416 (69%), Positives = 345/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VH GNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHMGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1CW7|A Chain A, Low Temperature Structure Of Wild-Type Idh Complexed With
Mg-Isocitrate
Length = 416
Score = 594 bits (1531), Expect = e-171
Identities = 289/416 (69%), Positives = 345/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAP YAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPAYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1GRP| Oxidoreductase, Nadp, Phosphorylation, Glyoxylate Bypass Mol_id:
1; Molecule: Isocitrate Dehydrogenase; Chain: Null; Ec:
1.1.1.42; Mutation: N115l
Length = 416
Score = 592 bits (1525), Expect = e-170
Identities = 288/416 (69%), Positives = 345/416 (82%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSL VALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLLVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFP+ GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPDHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1GRO| Oxidoreductase, Nadp, Phosphorylation, Glyoxylate Bypass Mol_id:
1; Molecule: Isocitrate Dehydrogenase; Chain: Null; Ec:
1.1.1.42; Engineered: Yes; Mutation: S113e, N115l
Length = 416
Score = 590 bits (1521), Expect = e-169
Identities = 287/416 (68%), Positives = 344/416 (81%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G R L VALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRELLVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFP+ GIG+KP S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPDHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAPKYAG DKVNPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VTYDF RLMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM 416
>pdb|1ISO| Isocitrate Dehydrogenase: Structure Of An Engineered Nadp+ -->
Nad+ Specificity-Reversal Mutant
Length = 416
Score = 584 bits (1506), Expect = e-168
Identities = 285/416 (68%), Positives = 342/416 (81%), Gaps = 8/416 (1%)
Query: 11 PKEGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYE 70
P +G++IT+++ KL+VP +PIIP+IEGDGIG D+TPAM+KVVD+AV+KAYKGE+KI+W E
Sbjct: 8 PAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWME 67
Query: 71 VFVGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQ 130
++ GEK Q + ++ WL +T++ I Y+V+IKGPLTTP+G G RSLNVALRQ
Sbjct: 68 IYTGEKSTQVYG-------QDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNVALRQ 120
Query: 131 KMDLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQ 189
++DLY+CLRPVR+Y G+PSPVK P+ DMVIFRENSEDIYAGIEW+ SA+A+K+I FL+
Sbjct: 121 ELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLR 180
Query: 190 NELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGA 249
E+ VKKIRFPE GIG+KP+S+EGT+RLVR AIEYAI ND+ SVT VHKGNIMK+TEGA
Sbjct: 181 EEMGVKKIRFPEHCGIGIKPMSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKFTEGA 240
Query: 250 FMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIA 309
F WGY LA++EF ++ID GPW +KNP GKEI+IKD+IADAFLQQILLRP+EY VIA
Sbjct: 241 FKDWGYQLAREEFGGELIDGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIA 300
Query: 310 TMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSA 369
MNLNGDYISDALAA VGGIGIAPGAN+ D +FEATHGTAP AG DK NPGSIILSA
Sbjct: 301 CMNLNGDYISDALAAQVGGIGIAPGANIGDEYALFEATHGTAPDIAGQDKANPGSIILSA 360
Query: 370 EMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425
EMMLRHMGW EAADLIV ME AI +K VT DF LMDGAK +KCSEF +IENM
Sbjct: 361 EMMLRHMGWTEAADLIVKGMEGAINAKTVTKDFESLMDGAKLLKCSEFGDAIIENM 416
>pdb|1HQS|A Chain A, Crystal Structure Of Isocitrate Dehydrogenase From
Bacillus Subtilis
pdb|1HQS|B Chain B, Crystal Structure Of Isocitrate Dehydrogenase From
Bacillus Subtilis
Length = 423
Score = 525 bits (1351), Expect = e-150
Identities = 269/429 (62%), Positives = 328/429 (75%), Gaps = 25/429 (5%)
Query: 13 EGEEITIKDNKLHVPNHPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF 72
+GE+IT+ + L+VPN+PIIPFIEGDG G DI A KV+++AV+KAYKGEKKI W EV+
Sbjct: 3 QGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEAAVEKAYKGEKKITWKEVY 62
Query: 73 VGEKCYQKFKDYKELSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKM 132
GEK Y K +WL +T++ I Y ++IKGPLTTP+G G RSLNVALRQ++
Sbjct: 63 AGEKAYNK---------TGEWLPAETLDVIREYFIAIKGPLTTPVGGGIRSLNVALRQEL 113
Query: 133 DLYVCLRPVRWY-GSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNE 191
DL+V LRPVR++ G PSPVK P+ DMVIFREN+EDIYAGIE+ +GS E +KLI FLQNE
Sbjct: 114 DLFVXLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGSEEVQKLISFLQNE 173
Query: 192 LKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFM 251
L V KIRFPE+SGIG+KP+S+EGT RLVR AI+YAI++ + SVT VHKGNIMK+TEGAF
Sbjct: 174 LNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTLVHKGNIMKFTEGAFK 233
Query: 252 KWGYALAQKEFNAQVI----------DKGPWCSLKNPKNGK---EIIIKDMIADAFLQQI 298
WGY LA+KE+ +V ++G + K + +IIIKD IAD FLQQI
Sbjct: 234 NWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAAGKIIIKDSIADIFLQQI 293
Query: 299 LLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVG--MFEATHGTAPKYAG 356
L RP+E+ V+ATMNLNGDYISDALAA VGGIGIAPGAN+N G +FEATHGTAPKYAG
Sbjct: 294 LTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAG 353
Query: 357 LDKVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSE 416
LDKVNP S+ILS ++L H+GW EAADL++ +MEK I SK VTYDFARLMDGA EVKCSE
Sbjct: 354 LDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIASKVVTYDFARLMDGATEVKCSE 413
Query: 417 FASVMIENM 425
F +I+NM
Sbjct: 414 FGEELIKNM 422
>pdb|2AYQ|B Chain B, 3-Isopropylmalate Dehydrogenase From The Moderate
Facultative Thermophile, Bacillus Coagulans
pdb|2AYQ|A Chain A, 3-Isopropylmalate Dehydrogenase From The Moderate
Facultative Thermophile, Bacillus Coagulans
Length = 366
Score = 97.8 bits (242), Expect = 2e-21
Identities = 84/308 (27%), Positives = 141/308 (45%), Gaps = 53/308 (17%)
Query: 126 VALRQKMDLYVCLRPVRWYGS---PSPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAE 180
+ LR++M L+ LRPV+ Y + SP+K + VD+VI RE + +Y G
Sbjct: 93 LGLRKEMGLFANLRPVKAYATLLNASPLKRERVENVDLVIVRELTGGLYFG--------- 143
Query: 181 AKKLIHFLQNELKVKKIRFP-ESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHK 239
+ + R P E+ + ++E ER++ KA + A K + V K
Sbjct: 144 ------------RPSERRGPGENEVVDTLAYTREEIERIIEKAFQLAQIRRK-KLASVDK 190
Query: 240 GNIMKYTEGAFMKWGYALAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQIL 299
N+++ + W +E + K P ++ + M+ D+ Q++
Sbjct: 191 ANVLESSR----MW------REIAEETAKKYP-----------DVELSHMLVDSTSMQLI 229
Query: 300 LRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANL-NDTVGMFEATHGTAPKYAGLD 358
P ++ VI T N+ GD +SD + + G +G+ P A+L +D GM+E HG+AP AG
Sbjct: 230 ANPGQFDVIVTENMFGDILSDEASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQG 289
Query: 359 KVNPGSIILSAEMMLRH-MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEF 417
K NP +LSA +MLR+ G + A I A++ ++ T D + K V E
Sbjct: 290 KANPLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDGYCTGDLQ--VANGKVVSTIEL 347
Query: 418 ASVMIENM 425
+IE +
Sbjct: 348 TDRLIEKL 355
>pdb|1XAC| Chimera Isopropylmalate Dehydrogenase Between Bacillus Subtilis
(M) And Thermus Thermophilus (T) From N-Terminal: 20% T
Middle 20% M Residual 60% T, Mutated At S82r. Low
Temperature (100k) Structure.
pdb|1XAD| Chimera Isopropylmalate Dehydrogenase Between Bacillus Subtilis
(M) And Thermus Thermophilus (T) From N-Terminal: 20% T
Middle 20% M Residual 60% T, Mutated At S82r. Low
Temperature (150k) Structure
Length = 345
Score = 97.1 bits (240), Expect = 3e-21
Identities = 104/371 (28%), Positives = 158/371 (42%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGS-- 146
+ EA+ S+ GP R +++R+++DL+ LRPV+ + S
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDQNPRELRPEKGLLSIRKQLDLFANLRPVKVFESLS 113
Query: 147 -PSPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+K+ VD VI RE + IY G AEA +
Sbjct: 114 DASPLKKEYIDNVDFVIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFEAARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1GC8|A Chain A, The Crystal Structure Of Thermus Thermophilus 3-
Isopropylmalate Dehydrogenase Mutated At 172th From Ala
To Phe
pdb|1GC8|B Chain B, The Crystal Structure Of Thermus Thermophilus 3-
Isopropylmalate Dehydrogenase Mutated At 172th From Ala
To Phe
Length = 345
Score = 96.7 bits (239), Expect = 4e-21
Identities = 103/371 (27%), Positives = 158/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E+A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFEFARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1DPZ|A Chain A, Stucture Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd711
pdb|1DPZ|B Chain B, Stucture Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd711
Length = 349
Score = 95.1 bits (235), Expect = 1e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFELARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1DR0|A Chain A, Structure Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd708
pdb|1DR0|B Chain B, Structure Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd708
Length = 346
Score = 95.1 bits (235), Expect = 1e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFELARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1DR8|A Chain A, Structure Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd177
pdb|1DR8|B Chain B, Structure Of Modified 3-Isopropylmalate Dehydrogenase At
The C-Terminus, Hd177
Length = 344
Score = 95.1 bits (235), Expect = 1e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFELARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1G2U|A Chain A, The Structure Of The Mutant, A172v, Of 3-Isopropylmalate
Dehydrogenase From Thermus Thermophilus Hb8 : Its
Thermostability And Structure
Length = 345
Score = 95.1 bits (235), Expect = 1e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFEVARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1OSJ|A Chain A, Structure Of 3-Isopropylmalate Dehydrogenase
pdb|1OSJ|B Chain B, Structure Of 3-Isopropylmalate Dehydrogenase
Length = 345
Score = 95.1 bits (235), Expect = 1e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFELARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1XAA| 3-Isopropylmalate Dehydrogenase, Low Temperature (100k) Structure
pdb|1XAB| 3-Isopropylmalate Dehydrogenase, Low Temperature (150k) Structure
pdb|1HEX| 3-Isopropylmalate Dehydrogenase (E.C.1.1.1.85) Complexed With
Beta-Nicotinamide Adenine Dinucleotide, Oxidized (Nad+)
pdb|1OSI|A Chain A, Structure Of 3-Isopropylmalate Dehydrogenase
pdb|1OSI|B Chain B, Structure Of 3-Isopropylmalate Dehydrogenase
pdb|1OSI|C Chain C, Structure Of 3-Isopropylmalate Dehydrogenase
pdb|1OSI|D Chain D, Structure Of 3-Isopropylmalate Dehydrogenase
Length = 345
Score = 94.7 bits (234), Expect = 2e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFEAARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1IPD| 3-Isopropylmalate Dehydrogenase (E.C.1.1.1.85)
Length = 345
Score = 94.7 bits (234), Expect = 2e-20
Identities = 102/375 (27%), Positives = 160/375 (42%), Gaps = 71/375 (18%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGF-RSLN-----VALRQKMDLYVCLRPVRWY 144
T + + + + G + P +G R ++ ++LR+ DL+ LRP + +
Sbjct: 56 P------TRKGVEEAEAVLLGSVGGPKWDGLPRKISPETGLLSLRKSQDLFANLRPAKVF 109
Query: 145 GSP---SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRF 199
SP+KE + VD++I RE + IY G AEA +
Sbjct: 110 PGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY------------ 157
Query: 200 PESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQ 259
SK ER+ R A E A K V+ V K N+++ E
Sbjct: 158 -----------SKPEVERVARVAFEAARKRRKHVVS-VDKANVLEVGEF----------- 194
Query: 260 KEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYIS 319
+ V + G + ++ ++ DA ++ P+ + V+ T N+ GD +S
Sbjct: 195 --WRKTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILS 244
Query: 320 DALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGW 378
D + + G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G
Sbjct: 245 DLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGL 304
Query: 379 VEAADLIVSAMEKAI 393
VE A + A+ KA+
Sbjct: 305 VELARKVEDAVAKAL 319
>pdb|1GC9|A Chain A, The Crystal Structure Of Thermus Thermophilus 3-
Isopropylmalate Dehydrogenase Mutated At 172th From Ala
To Gly
Length = 345
Score = 94.4 bits (233), Expect = 2e-20
Identities = 103/371 (27%), Positives = 157/371 (41%), Gaps = 63/371 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN--VALRQKMDLYVCLRPVRWYGSP- 147
+ EA+ S+ GP + R ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLE 113
Query: 148 --SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESS 203
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 RLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY---------------- 157
Query: 204 GIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFN 263
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 158 -------SKPEVERVARVAFEGARKRRKHVVS-VDKANVLEVGEF-------------WR 196
Query: 264 AQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALA 323
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD +
Sbjct: 197 KTVEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLAS 248
Query: 324 AMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAA 382
+ G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 VLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELA 308
Query: 383 DLIVSAMEKAI 393
+ A+ KA+
Sbjct: 309 RKVEDAVAKAL 319
>pdb|1WAL|A Chain A, 3-Isopropylmalate Dehydrogenase (Ipmdh) Mutant (M219a)from
Thermus Thermophilus
Length = 345
Score = 94.0 bits (232), Expect = 3e-20
Identities = 102/375 (27%), Positives = 160/375 (42%), Gaps = 71/375 (18%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGF-RSLN-----VALRQKMDLYVCLRPVRWY 144
T + + + + G + P +G R ++ ++LR+ DL+ LRP + +
Sbjct: 56 P------TRKGVEEAEAVLLGSVGGPKWDGLPRKISPETGLLSLRKSQDLFANLRPAKVF 109
Query: 145 GSP---SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRF 199
SP+KE + VD++I RE + IY G AEA +
Sbjct: 110 PGLERLSPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY------------ 157
Query: 200 PESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQ 259
SK ER+ R A E A K V+ V K N+++ E
Sbjct: 158 -----------SKPEVERVARVAFEAARKRRKHVVS-VDKANVLEVGEF----------- 194
Query: 260 KEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYIS 319
+ V + G + ++ ++ DA ++ P+ + V+ T N+ GD +S
Sbjct: 195 --WRKTVEEVG--------RGYPDVALEHQYVDAAAMHLVRSPARFDVVVTGNIFGDILS 244
Query: 320 DALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGW 378
D + + G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G
Sbjct: 245 DLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGL 304
Query: 379 VEAADLIVSAMEKAI 393
VE A + A+ KA+
Sbjct: 305 VELARKVEDAVAKAL 319
>pdb|1A05|A Chain A, Crystal Structure Of The Complex Of 3-Isopropylmalate
Dehydrogenase From Thiobacillus Ferrooxidans With
3-Isopropylmalate
pdb|1A05|B Chain B, Crystal Structure Of The Complex Of 3-Isopropylmalate
Dehydrogenase From Thiobacillus Ferrooxidans With
3-Isopropylmalate
Length = 358
Score = 93.2 bits (230), Expect = 5e-20
Identities = 94/388 (24%), Positives = 161/388 (41%), Gaps = 73/388 (18%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
I GDGIG +I A +V+D+ Q A+ +G +C + L +
Sbjct: 4 IAIFAGDGIGPEIVAAARQVLDAVDQAAH------------LGLRCTEGLVGGAALDASD 51
Query: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLN------VALRQKMDLYVCLRPVRWY- 144
L +++ I G + P + + + LR+ +DLY LRP + +
Sbjct: 52 DPLPAASLQLAMAADAVILGAVGGPRWDAYPPAKRPEQGLLRLRKGLDLYANLRPAQIFP 111
Query: 145 ----GSPSPVKEPQKVDMVIFRENSEDIY----AGIEWQEGSAEAKKLIHFLQNELKVKK 196
SP + + VD+++ RE + DIY G+E +G + + ++E++
Sbjct: 112 QLLDASPLRPELVRDVDILVVRELTGDIYFGQPRGLEVIDGKRRGFNTMVYDEDEIR--- 168
Query: 197 IRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYA 256
R+ A A + + V K N+++ T W
Sbjct: 169 --------------------RIAHVAFR-AAQGRRKQLCSVDKANVLETTR----LW--- 200
Query: 257 LAQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGD 316
+E +V P ++ + M D Q++ P+++ V+ T N+ GD
Sbjct: 201 ---REVVTEVARDYP-----------DVRLSHMYVDNAAMQLIRAPAQFDVLLTGNMFGD 246
Query: 317 YISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRHM 376
+SD + + G IG+ P A+L + M+E HG+AP AG DK NP + ILS MMLRH
Sbjct: 247 ILSDEASQLTGSIGMLPSASLGEGRAMYEPIHGSAPDIAGQDKANPLATILSVAMMLRHS 306
Query: 377 GWVEA-ADLIVSAMEKAIKSKKVTYDFA 403
E A + +A+++ + T D A
Sbjct: 307 LNAEPWAQRVEAAVQRVLDQGLRTADIA 334
>pdb|1IDM| 3-Isopropylmalate Dehydrogenase, Loop-Deleted Chimera
Length = 343
Score = 92.8 bits (229), Expect = 6e-20
Identities = 102/369 (27%), Positives = 155/369 (41%), Gaps = 61/369 (16%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVF-VGEKCYQKFKDYKELSPE 90
+ + GDGIG ++T A +KV+ + + G YEVF G F E PE
Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLA----YEVFPFGGAAIDAFG---EPFPE 55
Query: 91 EQWLLPDTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSP--- 147
+ EA+ S+ GP ++LR+ DL+ LRP + +
Sbjct: 56 PTRKGVEEAEAV--LLGSVGGPKWGTGSVRPEQGLLSLRKSQDLFANLRPAKVFPGLERL 113
Query: 148 SPVKEP--QKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGI 205
SP+KE + VD++I RE + IY G AEA +
Sbjct: 114 SPLKEEIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERY------------------ 155
Query: 206 GVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQKEFNAQ 265
SK ER+ R A E A K V+ V K N+++ E +
Sbjct: 156 -----SKPEVERVARVAFEAARKRRKHVVS-VDKANVLEVGEF-------------WRKT 196
Query: 266 VIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAM 325
V + G + ++ ++ DA ++ P+ + V+ T N+ GD +SD + +
Sbjct: 197 VEEVG--------RGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFGDILSDLASVL 248
Query: 326 VGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH-MGWVEAADL 384
G +G+ P A+L +FE HG+AP AG NP + ILSA MML H G VE A
Sbjct: 249 PGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARK 308
Query: 385 IVSAMEKAI 393
+ A+ KA+
Sbjct: 309 VEDAVAKAL 317
>pdb|1CM7|A Chain A, 3-Isopropylmalate Dehydrogenase From Escherichia Coli
pdb|1CM7|B Chain B, 3-Isopropylmalate Dehydrogenase From Escherichia Coli
Length = 363
Score = 79.0 bits (193), Expect = 1e-15
Identities = 98/406 (24%), Positives = 168/406 (41%), Gaps = 73/406 (17%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
I + GDGIG ++ +KV+D AV+ + + Y+V +
Sbjct: 7 IAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDV-----------GGAAIDNHG 54
Query: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGF-------RSLNVALRQKMDLYVCLRPVRWY 144
Q L P T+E + G + P E R + LR+ L+ LRP + Y
Sbjct: 55 QPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114
Query: 145 GSPS---PVKEP---QKVDMVIFRENSEDIYAGI-EWQEGSAEAKKLIHFLQNELKVKKI 197
P++ D++ RE + IY G + +EGS + +K
Sbjct: 115 QGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-------------- 160
Query: 198 RFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYAL 257
+ + ER+ R A E A + VT + K N+++ + +
Sbjct: 161 ------AFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSS----------I 203
Query: 258 AQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDY 317
+E ++ + P ++ + M D Q++ PS++ V+ NL GD
Sbjct: 204 LWREIVNEIATEYP-----------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDI 252
Query: 318 ISDALAAMVGGIGIAPGANLNDT-VGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH- 375
+SD A + G +G+ P A+LN+ G++E G+AP AG + NP + ILS ++LR+
Sbjct: 253 LSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYS 312
Query: 376 MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVM 421
+ +AA I A+ +A++ T D AR GA V E ++
Sbjct: 313 LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDII 355
>pdb|1CNZ|A Chain A, 3-Isopropylmalate Dehydrogenase (Ipmdh) From Salmonella
Typhimurium
pdb|1CNZ|B Chain B, 3-Isopropylmalate Dehydrogenase (Ipmdh) From Salmonella
Typhimurium
Length = 363
Score = 74.3 bits (181), Expect = 2e-14
Identities = 97/406 (23%), Positives = 164/406 (39%), Gaps = 73/406 (17%)
Query: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEE 91
I + GDGIG ++ +KV+D AV+ + + Y+V +
Sbjct: 7 IAVLPGDGIGPEVMAQALKVMD-AVRSRFDMRITTSHYDV-----------GGIAIDNHG 54
Query: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGF-------RSLNVALRQKMDLYVCLRPVRWY 144
L T+E + G + P E R + LR+ L+ LRP + Y
Sbjct: 55 HPLPKATVEGCEQADAILFGSVGGPKWENLPPESQPERGALLPLRKHFKLFSNLRPAKLY 114
Query: 145 GSPS---PVKEP---QKVDMVIFRENSEDIYAGI-EWQEGSAEAKKLIHFLQNELKVKKI 197
P++ D++ RE + IY G + +EGS + +K
Sbjct: 115 QGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-------------- 160
Query: 198 RFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYAL 257
+ + ER+ R A E A + VT + K N+++ + +
Sbjct: 161 ------AFDTEVYHRFEIERIARIAFESARKRRR-KVTSIDKANVLQSS----------I 203
Query: 258 AQKEFNAQVIDKGPWCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDY 317
+E V P ++ + M D Q++ PS++ V+ NL GD
Sbjct: 204 LWREIVNDVAKTYP-----------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDI 252
Query: 318 ISDALAAMVGGIGIAPGANLNDT-VGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH- 375
+SD A + G +G+ P A+LN+ G++E G+AP AG + NP + ILS ++LR+
Sbjct: 253 LSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYS 312
Query: 376 MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVM 421
+ +AA I A+ +A++ T D AR GA V E ++
Sbjct: 313 LDANDAATAIEQAINRALEEGVRTGDLAR---GAAAVSTDEMGDII 355
>pdb|1MHS|A Chain A, Model Of Neurospora Crassa Proton Atpase
pdb|1MHS|B Chain B, Model Of Neurospora Crassa Proton Atpase
Length = 920
Score = 27.3 bits (59), Expect = 3.4
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 7/85 (8%)
Query: 270 GP-WCSLKNPKNGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGG 328
GP W S+ + + I + D++A F S+ S++A + + S + ++GG
Sbjct: 816 GPFWSSIPSWQLSGAIFLVDILATCFTIWGWFEHSDTSIVAVVRIW--IFSFGIFCIMGG 873
Query: 329 IGIAPGANLNDTVGMFEATHGTAPK 353
+ L D+VG HG +PK
Sbjct: 874 VYYI----LQDSVGFDNLMHGKSPK 894
>pdb|1LAM| Leucine Aminopeptidase (Unligated)
pdb|1LCP|A Chain A, Bovine Lens Leucine Aminopeptidase Complexed With
L-Leucine Phosphonic Acid
pdb|1LCP|B Chain B, Bovine Lens Leucine Aminopeptidase Complexed With
L-Leucine Phosphonic Acid
pdb|1LAN|A Chain A, Leucine Aminopeptidase Complex With L-Leucinal
Length = 484
Score = 27.3 bits (59), Expect = 3.4
Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 3/78 (3%)
Query: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366
V+ + L+G S+ A G+ A G NL + A T K+A + + N S
Sbjct: 139 VVVSAKLHG---SEDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSAS 195
Query: 367 LSAEMMLRHMGWVEAADL 384
+ ++ +R W+E ++
Sbjct: 196 IKTDVFIRPKSWIEEQEM 213
>pdb|1BLL|E Chain E, Leucine Aminopeptidase (E.C.3.4.11.1) Complex With
Amastatin
pdb|1LAP| Leucine Aminopeptidase (E.C.3.4.11.1)
pdb|1BPM| Leucine Aminopeptidase (E.C.3.4.11.1)
pdb|1BPN| Leucine Aminopeptidase (E.C.3.4.11.1)
Length = 488
Score = 27.3 bits (59), Expect = 3.4
Identities = 19/78 (24%), Positives = 35/78 (44%), Gaps = 3/78 (3%)
Query: 307 VIATMNLNGDYISDALAAMVGGIGIAPGANLNDTVGMFEATHGTAPKYAGLDKVNPGSII 366
V+ + L+G S+ A G+ A G NL + A T K+A + + N S
Sbjct: 140 VVVSAKLHG---SEDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSAS 196
Query: 367 LSAEMMLRHMGWVEAADL 384
+ ++ +R W+E ++
Sbjct: 197 IKTDVFIRPKSWIEEQEM 214
>pdb|1SUD| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Mutant With Met 50 Replaced
By Phe, Tyr 217 Replaced By Lys, Asn 218 Replaced By
Ser, And Ser 221 Replaced By Cys (M50p,Y217k,
N218s,S221c)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1S01| Subtilisin BPN(Prime) 8350 (E.C.3.4.21.14) (Mutant With Met 50
Replaced By Phe, Asn 76 Replaced By Asp, Gly 169
Replaced By Ala, Gln 206 Replaced By Cys, Tyr 217
Replaced By Lys, And Asn 217 Replaced By Ser) (M50F,
N76D, G169A, Q206C, Y217K, And N218S) In EDTA
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALDNSIGVLGVAPSASL 90
>pdb|1S02| Subtilisn Bpn' (E.C.3.4.21.14) (Mutant With Gln 19 Replaced By
Glu, Gln 271 Replaced By Glu) (Q19E,Q271E)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1LW6|E Chain E, Crystal Structure Of The Complex Of Subtilisin Bpn' With
Chymotrypsin Inhibitor 2 At 1.5 Angstrom Resolution
Length = 281
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1SUP| Mol_id: 1; Molecule: Subtilisin Bpn'; Chain: Null; Synonym:
Subtilisin Novo; Ec: 3.4.21.62; Heterogen: Phenyl Methyl
Sulfonate
pdb|2SIC|E Chain E, Subtilisin BPN' (E.C.3.4.21.14) Complex With Streptomyces
Subtilisin Inhibitor
pdb|3SIC|E Chain E, Subtilisin Bpn' (E.C.3.4.21.62) Complex With A Modified
Ssi (Streptomyces Subtilisin Inhibitor) Where Met 73 Was
Replaced By Lys (Ssi(M73k))
pdb|2ST1| Subtilisin BPN' (BAS) (E.C.3.4.21.14)
pdb|1ST2| Subtilisin BPN' (BASox) - Peroxide Inactivated (E.C.3.4.21.14)
pdb|1SBN|E Chain E, Subtilisin Novo Bpn' (E.C.3.4.21.62) Complex With Eglin C
Mutant With Leu 45 Replaced By Arg (L45r)
pdb|5SIC|E Chain E, Subtilisin Bpn' (E.C.3.4.21.62) Complex With Streptomyces
Subtilisin Inhibitor Mutant With Met 70 Replaced By Gly
And Met 73 Replaced By Lys (Ssi(M70g,M73k))
pdb|1SIB|E Chain E, Subtilisin Novo (Bpn') (E.C.3.4.21.62) Complex With Eglin
C Mutant With Arg 53 Replaced By Lys (R53k)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|2SNI|E Chain E, Subtilisin Novo (E.C.3.4.21.14) Complex With Chymotrypsin
Inhibitor 2 (CI-2)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1SUB| Subtilisin Bpn' Crb-S3 (E.C.3.4.21.62) Mutant With Asn 218
Replaced By Ser, And Ser 221 Replaced By Cys
(N218s,S221c)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1SBI| Subtilisin Bpn' 8397 (E.C. 3.4.21.14) Mutant (M50f, N76d, G169a,
Q206c, N218s)
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALDNSIGVLGVAPSASL 90
>pdb|1UBN|A Chain A, Selenosubtilisin Bpn
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPSASL 90
>pdb|1SBH| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) Mutant (M50f, N76d, G169a,
Q206c, N218s, K256y)
pdb|1YJA| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) (Mutant With Met 50
Replaced By Phe, Asn 76 Replaced By Asp, Gly 169
Replaced By Ala, Gln 206 Replaced By Cys, Asn 218
Replaced By Ser And Lys 256 Replaced By Tyr) (M50f,
N76d, G169a, Q206c, N218s, And K256y) In 20%
Dimethylformamide
pdb|1YJB| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) (Mutant With Met 50
Replaced By Phe, Asn 76 Replaced By Asp, Gly 169
Replaced By Ala, Gln 206 Replaced By Cys, Asn 218
Replaced By Ser And Lys 256 Replaced By Tyr) (M50f,
N76d, G169a, Q206c, N218s, And K256y) In 35%
Dimethylformamide
pdb|1YJC| Subtilisin Bpn' 8397+1 (E.C. 3.4.21.14) (Mutant With Met 50
Replaced By Phe, Asn 76 Replaced By Asp, Gly 169
Replaced By Ala, Gln 206 Replaced By Cys, Asn 218
Replaced By Ser And Lys 256 Replaced By Tyr) (M50f,
N76d, G169a, Q206c, N218s, And K256y) In 50%
Dimethylformamide
Length = 275
Score = 26.9 bits (58), Expect = 4.4
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALDNSIGVLGVAPSASL 90
>pdb|1ES6|A Chain A, Crystal Structure Of The Matrix Protein Of Ebola Virus
Length = 296
Score = 26.2 bits (56), Expect = 7.5
Identities = 21/92 (22%), Positives = 40/92 (42%), Gaps = 10/92 (10%)
Query: 279 KNGKEIIIKDMIADAFLQQILLRPSEYSVIA---TMNLNGDYISDALAAMVGGIGIAPGA 335
K+GK+ D+ + +Q I+ ++ ++ T N+ G + + L + G +
Sbjct: 191 KSGKKGNSADLTSPEKIQAIMTSLQDFKIVPIDPTKNIMGIEVPETLVLKLTGKKVT-SK 249
Query: 336 NLNDTVGMFEATHGTAPKYAGLDKVNPGSIIL 367
N + + PKY GLD V PG + +
Sbjct: 250 NGQPIIPVL------LPKYIGLDPVAPGDLTM 275
>pdb|1DVI|A Chain A, Calpain Domain Vi With Calcium Bound
pdb|1DVI|B Chain B, Calpain Domain Vi With Calcium Bound
Length = 184
Score = 25.8 bits (55), Expect = 9.7
Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 33 PFIEGDGIGSDITPAMIKVVDS-AVQKAYKGEKKIAWYEVFVGEKCYQKF 81
P ++ DG G D + +M+ V+DS K E K W + + Y++F
Sbjct: 48 PDLKTDGFGIDTSRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQGIYKRF 97
>pdb|2SBT| Subtilisin Novo (E.C.3.4.21.14)
Length = 275
Score = 25.8 bits (55), Expect = 9.7
Identities = 21/97 (21%), Positives = 48/97 (48%), Gaps = 6/97 (6%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANLNDTVGMFEATHGTAPKYAGLD 358
PSE N +G +++ +AA+ +G +G+AP + L + +A G +Y+ +
Sbjct: 52 PSETPNFQDDNSHGTHVAGTVAALNNSIGVLGVAPSSALYAVKVLGDAGSG---QYSWII 108
Query: 359 KVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKS 395
+I + +++ +G + + +A++KA+ S
Sbjct: 109 NGIEWAIANNMDVINMSLGGPSGSAALKAAVDKAVAS 145
>pdb|1SBT| Subtilisin BPN (E.C.3.4.21.14)
Length = 275
Score = 25.8 bits (55), Expect = 9.7
Identities = 21/97 (21%), Positives = 48/97 (48%), Gaps = 6/97 (6%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANLNDTVGMFEATHGTAPKYAGLD 358
PSE N +G +++ +AA+ +G +G+AP + L + +A G +Y+ +
Sbjct: 52 PSETPNFQDDNSHGTHVAGTVAALNNSIGVLGVAPSSALYAVKVLGDAGSG---QYSWII 108
Query: 359 KVNPGSIILSAEMMLRHMGWVEAADLIVSAMEKAIKS 395
+I + +++ +G + + +A++KA+ S
Sbjct: 109 NGIEWAIANNMDVINMSLGGPSGSAALKAAVDKAVAS 145
>pdb|1GOL| Coordinates Of Rat Map Kinase Erk2 With An Arginine Mutation At
Position 52
Length = 364
Score = 25.8 bits (55), Expect = 9.7
Identities = 12/50 (24%), Positives = 26/50 (52%)
Query: 288 DMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANL 337
+ + D ++ Q L+ Y ++ T +L+ D+I L ++ G+ AN+
Sbjct: 100 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANV 149
>pdb|1AK9| Subtilisin Mutant 8321
Length = 275
Score = 25.8 bits (55), Expect = 9.7
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPCASL 90
>pdb|1A2Q| Subtilisin Bpn' Mutant 7186
Length = 275
Score = 25.8 bits (55), Expect = 9.7
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPCASL 90
>pdb|1ERK| Structure Of Signal-Regulated Kinase
pdb|3ERK| The Complex Structure Of The Map Kinase Erk2SB220025
pdb|4ERK| The Complex Structure Of The Map Kinase Erk2OLOMOUCINE
Length = 364
Score = 25.8 bits (55), Expect = 9.7
Identities = 12/50 (24%), Positives = 26/50 (52%)
Query: 288 DMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANL 337
+ + D ++ Q L+ Y ++ T +L+ D+I L ++ G+ AN+
Sbjct: 100 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANV 149
>pdb|1AQN| Subtilisin Mutant 8324
pdb|1AU9| Subtilisin Bpn' Mutant 8324 In Citrate
Length = 275
Score = 25.8 bits (55), Expect = 9.7
Identities = 13/39 (33%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 302 PSEYSVIATMNLNGDYISDALAAM---VGGIGIAPGANL 337
PSE + N +G +++ +AA+ +G +G+AP A+L
Sbjct: 52 PSETNPFQDNNSHGTHVAGTVAALNNSIGVLGVAPCASL 90
>pdb|2ERK| Phosphorylated Map Kinase Erk2
Length = 365
Score = 25.8 bits (55), Expect = 9.7
Identities = 12/50 (24%), Positives = 26/50 (52%)
Query: 288 DMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGANL 337
+ + D ++ Q L+ Y ++ T +L+ D+I L ++ G+ AN+
Sbjct: 101 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANV 150
Database: /var/www/html/HP/blast_new/blast/db/pdbaa
Posted date: Dec 20, 2002 11:08 AM
Number of letters in database: 2,899,336
Number of sequences in database: 13,198
Lambda K H
0.317 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,621,818
Number of Sequences: 13198
Number of extensions: 115521
Number of successful extensions: 349
Number of sequences better than 10.0: 51
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 266
Number of HSP's gapped (non-prelim): 56
length of query: 425
length of database: 2,899,336
effective HSP length: 91
effective length of query: 334
effective length of database: 1,698,318
effective search space: 567238212
effective search space used: 567238212
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 55 (25.8 bits)