BLASTP 2.2.1 [Apr-13-2001]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15645004|ref|NP_207174.1| ferrochelatase (hemH)
[Helicobacter pylori 26695]
(334 letters)
Database: /var/www/html/HP/blast_new/blast/db/pdbaa
13,198 sequences; 2,899,336 total letters
Searching...........................done
Score E
Sequences producing significant alignments: (bits) Value
pdb|1HRK|A Chain A, Crystal Structure Of Human Ferrochelata... 147 2e-36
pdb|1AK1| Ferrochelatase From Bacillus Subtilis >gi|75465... 62 1e-10
pdb|1DOZ|A Chain A, Crystal Structure Of Ferrochelatase 62 1e-10
pdb|1C9E|A Chain A, Structure Of Ferrochelatase With Copper... 62 1e-10
pdb|1J97|A Chain A, Phospho-Aspartyl Intermediate Analogue ... 28 1.1
pdb|1F5S|A Chain A, Crystal Structure Of Phosphoserine Phos... 28 1.5
pdb|1BAF|L Chain L, Fab Fragment Of Murine Monoclonal Antib... 27 4.3
pdb|1DKF|B Chain B, Crystal Structure Of A Heterodimeric Co... 26 5.6
pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-S... 25 9.5
pdb|1GT7|A Chain A, L-Rhamnulose-1-Phosphate Aldolase From ... 25 9.5
pdb|1FNT|G Chain G, Crystal Structure Of The 20s Proteasome... 25 9.5
pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase... 25 9.5
pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruv... 25 9.5
pdb|1RYP|G Chain G, Crystal Structure Of The 20s Proteasome... 25 9.5
pdb|1G0U|F Chain F, A Gated Channel Into The Proteasome Cor... 25 9.5
>pdb|1HRK|A Chain A, Crystal Structure Of Human Ferrochelatase
pdb|1HRK|B Chain B, Crystal Structure Of Human Ferrochelatase
Length = 359
Score = 147 bits (370), Expect = 2e-36
Identities = 103/330 (31%), Positives = 176/330 (53%), Gaps = 26/330 (7%)
Query: 17 KSPKEAVILLNMGGPNSLYEVGVFLKNMFDDPFILTIKNNFMRKMVGKMIVNSRIEKSKK 76
+ PK +++LNMGGP +L +V FL +F D ++T+ ++ + I K ++
Sbjct: 1 RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLP---IQNKLAPFIAKRLTPKIQE 57
Query: 77 IYEKLGGKSPLTPITF----ALTERLNKLDPSRF---YTYAMRYTPPYASMVLQDLALKE 129
Y ++GG SP+ T + + L++L P+ Y RY P ++++
Sbjct: 58 QYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDG 117
Query: 130 VESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVR--VIERFYASKKLNKIILNT 187
+E + F+ YPQYS +TT SS N + + +P ++ I+R+ L + +
Sbjct: 118 LERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGR-KPTMKWSTIDRWPTHHLLIQCFADH 176
Query: 188 ILNTLNN---RKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNTPFKE 244
IL L++ K + V++FS H LP SV++ GD Y QE V + E ++ N P++
Sbjct: 177 ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCN-PYR- 234
Query: 245 VLLSYQSKLGPMKWLEPSTEE----LIEKHRKSHIIIYPLAFTIDNSETLYELDMQY-RL 299
L +QSK+GPM WL P T+E L E+ RK +I++ P+AFT D+ ETLYELD++Y ++
Sbjct: 235 --LVWQSKVGPMPWLGPQTDESIKGLCERGRK-NILLVPIAFTSDHIETLYELDIEYSQV 291
Query: 300 MAERLAVKEYLVCPCLNDSIEFAQFIIERV 329
+A+ V+ LN + F++ + + V
Sbjct: 292 LAKECGVENIRRAESLNGNPLFSKALADLV 321
>pdb|1AK1| Ferrochelatase From Bacillus Subtilis
pdb|1C1H|A Chain A, Crystal Structure Of Bacillus Subtilis Ferrochelatase In
Complex With N-Methyl Mesoporphyrin
Length = 310
Score = 61.6 bits (148), Expect = 1e-10
Identities = 56/253 (22%), Positives = 106/253 (41%), Gaps = 21/253 (8%)
Query: 71 IEKSKKIYEKLGGKSPLTPIT----FALTERLNKL-DPSRFYTY-AMRYTPPYASMVLQD 124
++ K YE +GG SPL IT L + LN++ D F Y +++ P+ + +
Sbjct: 40 LQDLKDRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAE 99
Query: 125 LALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYASKKLNKII 184
+ + V + P +S+ + S A + L + +E +Y K
Sbjct: 100 MHKDGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLT--ITSVESWYDEPKFVTYW 157
Query: 185 LNTILNT---LNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNTP 241
++ + T + + ++ +LI S H LP+ + + GD Y + L+ E
Sbjct: 158 VDRVKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAE-----GAG 212
Query: 242 FKEVLLSYQSKLG-PMKWLEPS----TEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQ 296
E + +QS+ P WL P T +L E+ + P+ F D+ E LY+ D +
Sbjct: 213 VSEYAVGWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYE 272
Query: 297 YRLMAERLAVKEY 309
+++ + + Y
Sbjct: 273 CKVVTDDIGASYY 285
>pdb|1DOZ|A Chain A, Crystal Structure Of Ferrochelatase
Length = 309
Score = 61.6 bits (148), Expect = 1e-10
Identities = 56/253 (22%), Positives = 106/253 (41%), Gaps = 21/253 (8%)
Query: 71 IEKSKKIYEKLGGKSPLTPIT----FALTERLNKL-DPSRFYTY-AMRYTPPYASMVLQD 124
++ K YE +GG SPL IT L + LN++ D F Y +++ P+ + +
Sbjct: 39 LQDLKDRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAE 98
Query: 125 LALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYASKKLNKII 184
+ + V + P +S+ + S A + L + +E +Y K
Sbjct: 99 MHKDGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLT--ITSVESWYDEPKFVTYW 156
Query: 185 LNTILNT---LNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNTP 241
++ + T + + ++ +LI S H LP+ + + GD Y + L+ E
Sbjct: 157 VDRVKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAE-----GAG 211
Query: 242 FKEVLLSYQSKLG-PMKWLEPS----TEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQ 296
E + +QS+ P WL P T +L E+ + P+ F D+ E LY+ D +
Sbjct: 212 VSEYAVGWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYE 271
Query: 297 YRLMAERLAVKEY 309
+++ + + Y
Sbjct: 272 CKVVTDDIGASYY 284
>pdb|1C9E|A Chain A, Structure Of Ferrochelatase With Copper(Ii) N-
Methylmesoporphyrin Complex Bound At The Active Site
Length = 306
Score = 61.6 bits (148), Expect = 1e-10
Identities = 56/253 (22%), Positives = 106/253 (41%), Gaps = 21/253 (8%)
Query: 71 IEKSKKIYEKLGGKSPLTPIT----FALTERLNKL-DPSRFYTY-AMRYTPPYASMVLQD 124
++ K YE +GG SPL IT L + LN++ D F Y +++ P+ + +
Sbjct: 36 LQDLKDRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAE 95
Query: 125 LALKEVESLVFFSMYPQYSSTTTLSSFNDAFNALKSLETFRPKVRVIERFYASKKLNKII 184
+ + V + P +S+ + S A + L + +E +Y K
Sbjct: 96 MHKDGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLT--ITSVESWYDEPKFVTYW 153
Query: 185 LNTILNT---LNNRKSQDFVLIFSVHGLPKSVIDAGDTYQQECEHHVSLLKELMQQKNTP 241
++ + T + + ++ +LI S H LP+ + + GD Y + L+ E
Sbjct: 154 VDRVKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAE-----GAG 208
Query: 242 FKEVLLSYQSKLG-PMKWLEPS----TEELIEKHRKSHIIIYPLAFTIDNSETLYELDMQ 296
E + +QS+ P WL P T +L E+ + P+ F D+ E LY+ D +
Sbjct: 209 VSEYAVGWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYE 268
Query: 297 YRLMAERLAVKEY 309
+++ + + Y
Sbjct: 269 CKVVTDDIGASYY 281
>pdb|1J97|A Chain A, Phospho-Aspartyl Intermediate Analogue Of Phosphoserine
Phosphatase
pdb|1J97|B Chain B, Phospho-Aspartyl Intermediate Analogue Of Phosphoserine
Phosphatase
Length = 211
Score = 28.5 bits (62), Expect = 1.1
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 15/136 (11%)
Query: 178 KKLNKIILNTILNTLNNRKSQDFV-----LIFSVHGLPKSVIDAGDTYQQECEHHVSLLK 232
+K K+IL +TL N ++ D + + V + K ++ ++Q VSLLK
Sbjct: 2 EKKKKLILFXFDSTLVNNETIDEIAREAGVEEEVKKITKEAMEGKLNFEQSLRKRVSLLK 61
Query: 233 ELMQQKNTPFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYE 292
+L P ++V + + ++ P + E + +EL K+R + + F I ++ +
Sbjct: 62 DL------PIEKVEKAIK-RITPTEGAEETIKEL--KNRGYVVAVVSGGFDIAVNKIKEK 112
Query: 293 LDMQYRLMAERLAVKE 308
L + Y A RL VK+
Sbjct: 113 LGLDY-AFANRLIVKD 127
>pdb|1F5S|A Chain A, Crystal Structure Of Phosphoserine Phosphatase From
Methanococcus Jannaschii
pdb|1F5S|B Chain B, Crystal Structure Of Phosphoserine Phosphatase From
Methanococcus Jannaschii
Length = 211
Score = 28.1 bits (61), Expect = 1.5
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 15/136 (11%)
Query: 178 KKLNKIILNTILNTLNNRKSQDFV-----LIFSVHGLPKSVIDAGDTYQQECEHHVSLLK 232
+K K+IL +TL N ++ D + + V + K ++ ++Q VSLLK
Sbjct: 2 EKKKKLILFDFDSTLVNNETIDEIAREAGVEEEVKKITKEAMEGKLNFEQSLRKRVSLLK 61
Query: 233 ELMQQKNTPFKEVLLSYQSKLGPMKWLEPSTEELIEKHRKSHIIIYPLAFTIDNSETLYE 292
+L P ++V + + ++ P + E + +EL K+R + + F I ++ +
Sbjct: 62 DL------PIEKVEKAIK-RITPTEGAEETIKEL--KNRGYVVAVVSGGFDIAVNKIKEK 112
Query: 293 LDMQYRLMAERLAVKE 308
L + Y A RL VK+
Sbjct: 113 LGLDY-AFANRLIVKD 127
>pdb|1BAF|L Chain L, Fab Fragment Of Murine Monoclonal Antibody An02 Complex
With Its Hapten (2,2,6,6-Tetramethyl-1-Piperidinyloxy-
Dinitrophenyl)
Length = 214
Score = 26.6 bits (57), Expect = 4.3
Identities = 33/142 (23%), Positives = 59/142 (41%), Gaps = 12/142 (8%)
Query: 91 TFALT-ERLNKLDPSRFYTYAMRYTPPYASMVLQDLALKEVESLVFFSMYPQYSSTTTLS 149
+++LT R+ D + +Y PP V L LK ++ S++P S T
Sbjct: 69 SYSLTISRMEAEDAATYYCQQWSSYPPITFGVGTKLELKRADAAPTVSIFPPSSEQLT-- 126
Query: 150 SFNDAFNALKSLETFRPK-VRVIERFYASKKLNKIILNTILNTLNNRKSQDFVL-IFSVH 207
+ + + L F PK + V + S++ N +LN+ ++ S+D + S
Sbjct: 127 --SGGASVVCFLNNFYPKDINVKWKIDGSER-----QNGVLNSWTDQDSKDSTYSMSSTL 179
Query: 208 GLPKSVIDAGDTYQQECEHHVS 229
L K + ++Y E H S
Sbjct: 180 TLTKDEYERHNSYTCEATHKTS 201
>pdb|1DKF|B Chain B, Crystal Structure Of A Heterodimeric Complex Of Rar And
Rxr Ligand-Binding Domains
Length = 235
Score = 26.2 bits (56), Expect = 5.6
Identities = 22/69 (31%), Positives = 32/69 (45%), Gaps = 12/69 (17%)
Query: 261 PSTEELIEKHRKSHIIIYPL-----AFTIDN-SETLYELDMQYRLMAERLAVKEYLVCPC 314
P ELIEK RK+H +P +T +N SE LD+ L+ K C
Sbjct: 1 PEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTK------C 54
Query: 315 LNDSIEFAQ 323
+ ++EFA+
Sbjct: 55 IIKTVEFAK 63
>pdb|1PKY|A Chain A, Pyruvate Kinase From E. Coli In The T-State
pdb|1PKY|B Chain B, Pyruvate Kinase From E. Coli In The T-State
pdb|1PKY|D Chain D, Pyruvate Kinase From E. Coli In The T-State
pdb|1PKY|C Chain C, Pyruvate Kinase From E. Coli In The T-State
Length = 470
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/26 (42%), Positives = 17/26 (65%)
Query: 6 EKLNNLENNATKSPKEAVILLNMGGP 31
+++ NL N +K+ K A ILL+ GP
Sbjct: 45 QRIQNLRNVMSKTGKTAAILLDTKGP 70
>pdb|1GT7|A Chain A, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|B Chain B, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|C Chain C, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|D Chain D, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|E Chain E, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|F Chain F, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|G Chain G, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|H Chain H, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|I Chain I, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|J Chain J, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|K Chain K, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|L Chain L, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|M Chain M, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|N Chain N, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|O Chain O, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|P Chain P, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|Q Chain Q, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|R Chain R, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|S Chain S, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
pdb|1GT7|T Chain T, L-Rhamnulose-1-Phosphate Aldolase From Escherichia Coli
Length = 274
Score = 25.4 bits (54), Expect = 9.5
Identities = 12/53 (22%), Positives = 27/53 (50%), Gaps = 4/53 (7%)
Query: 244 EVLLSYQSKLGPMKWLEPSTEEL----IEKHRKSHIIIYPLAFTIDNSETLYE 292
E L+ + +G + W+ P T+E+ ++ +K ++++P + TL E
Sbjct: 171 ECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDE 223
>pdb|1FNT|G Chain G, Crystal Structure Of The 20s Proteasome From Yeast In
Complex With The Proteasome Activator Pa26 From
Trypanosome Brucei At 3.2 Angstroms Resolution
pdb|1FNT|U Chain U, Crystal Structure Of The 20s Proteasome From Yeast In
Complex With The Proteasome Activator Pa26 From
Trypanosome Brucei At 3.2 Angstroms Resolution
Length = 287
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/39 (28%), Positives = 24/39 (61%)
Query: 285 DNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIEFAQ 323
DN E +EL++ + ++E + +++ L ++I+FAQ
Sbjct: 205 DNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQ 243
>pdb|1E0T|A Chain A, R292d Mutant Of E. Coli Pyruvate Kinase
pdb|1E0T|B Chain B, R292d Mutant Of E. Coli Pyruvate Kinase
pdb|1E0T|C Chain C, R292d Mutant Of E. Coli Pyruvate Kinase
pdb|1E0T|D Chain D, R292d Mutant Of E. Coli Pyruvate Kinase
Length = 470
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/26 (42%), Positives = 17/26 (65%)
Query: 6 EKLNNLENNATKSPKEAVILLNMGGP 31
+++ NL N +K+ K A ILL+ GP
Sbjct: 45 QRIQNLRNVMSKTGKTAAILLDTKGP 70
>pdb|1E0U|A Chain A, Structure R271l Mutant Of E. Coli Pyruvate Kinase
pdb|1E0U|B Chain B, Structure R271l Mutant Of E. Coli Pyruvate Kinase
pdb|1E0U|C Chain C, Structure R271l Mutant Of E. Coli Pyruvate Kinase
pdb|1E0U|D Chain D, Structure R271l Mutant Of E. Coli Pyruvate Kinase
Length = 470
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/26 (42%), Positives = 17/26 (65%)
Query: 6 EKLNNLENNATKSPKEAVILLNMGGP 31
+++ NL N +K+ K A ILL+ GP
Sbjct: 45 QRIQNLRNVMSKTGKTAAILLDTKGP 70
>pdb|1RYP|G Chain G, Crystal Structure Of The 20s Proteasome From Yeast At 2.4
Angstroms Resolution
pdb|1RYP|U Chain U, Crystal Structure Of The 20s Proteasome From Yeast At 2.4
Angstroms Resolution
pdb|1G65|F Chain F, Crystal Structure Of Epoxomicin:20s Proteasome Reveals A
Molecular Basis For Selectivity Of
Alpha,Beta-Epoxyketone Proteasome Inhibitors
pdb|1G65|T Chain T, Crystal Structure Of Epoxomicin:20s Proteasome Reveals A
Molecular Basis For Selectivity Of
Alpha,Beta-Epoxyketone Proteasome Inhibitors
pdb|1JD2|1 Chain 1, Crystal Structure Of The Yeast 20s Proteasome:tmc-95a
Complex: A Non-Covalent Proteasome Inhibitor
pdb|1JD2|F Chain F, Crystal Structure Of The Yeast 20s Proteasome:tmc-95a
Complex: A Non-Covalent Proteasome Inhibitor
Length = 244
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/39 (28%), Positives = 24/39 (61%)
Query: 285 DNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIEFAQ 323
DN E +EL++ + ++E + +++ L ++I+FAQ
Sbjct: 202 DNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQ 240
>pdb|1G0U|F Chain F, A Gated Channel Into The Proteasome Core Particle
pdb|1G0U|T Chain T, A Gated Channel Into The Proteasome Core Particle
Length = 248
Score = 25.4 bits (54), Expect = 9.5
Identities = 11/39 (28%), Positives = 24/39 (61%)
Query: 285 DNSETLYELDMQYRLMAERLAVKEYLVCPCLNDSIEFAQ 323
DN E +EL++ + ++E + +++ L ++I+FAQ
Sbjct: 206 DNKEKDFELEISWCSLSETNGLHKFVKGDLLQEAIDFAQ 244
Database: /var/www/html/HP/blast_new/blast/db/pdbaa
Posted date: Dec 20, 2002 11:08 AM
Number of letters in database: 2,899,336
Number of sequences in database: 13,198
Lambda K H
0.319 0.136 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,770,293
Number of Sequences: 13198
Number of extensions: 68054
Number of successful extensions: 192
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 175
Number of HSP's gapped (non-prelim): 15
length of query: 334
length of database: 2,899,336
effective HSP length: 89
effective length of query: 245
effective length of database: 1,724,714
effective search space: 422554930
effective search space used: 422554930
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 54 (25.4 bits)