BLASTP 2.2.1 [Apr-13-2001]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15645634|ref|NP_207810.1| conserved hypothetical
protein [Helicobacter pylori 26695]
         (406 letters)

Database: /home/scwang/download_20020708_db/nr
           1,026,957 sequences; 324,149,939 total letters

Searching..................................................done


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ref|NP_207810.1|  (NC_000915) conserved hypothetical protein...   799  0.0
ref|NP_223123.1|  (NC_000921) putative [Helicobacter pylori ...   760  0.0
ref|NP_282735.1|  (NC_002163) hypothetical protein Cj1607 [C...   290  3e-77
ref|NP_420546.1|  (NC_002696) conserved hypothetical protein...   152  7e-36
ref|NP_539780.1|  (NC_003317) 2-C-METHYL-D-ERYTHRITOL 4-PHOS...   150  3e-35
sp|Q08113|ISDF_RHOCA  IspD/ispF bifunctional enzyme [Include...   147  2e-34
ref|NP_654035.1|  (NC_003995) YgbB, YgbB family [Bacillus an...   142  5e-33
emb|CAB51895.1|  (AJ009974) hypothetical protein [Zymomonas ...   140  4e-32
ref|NP_563232.1|  (NC_003366) conserved hypothetical protein...   138  1e-31
sp|Q9RNZ1|ISDF_ZYMMO  IspD/ispF bifunctional enzyme [Include...   136  4e-31
ref|NP_102198.1|  (NC_002678) hypothetical protein [Mesorhiz...   136  4e-31
ref|NP_230180.1|  (NC_002505) conserved hypothetical protein...   136  4e-31
ref|NP_240974.1|  (NC_002570) BH0108~unknown conserved prote...   136  5e-31
ref|NP_354449.1|  (NC_003062) AGR_C_2659p [Agrobacterium tum...   135  7e-31
ref|NP_463767.1|  (NC_003210) similar to B. subtilis YacN pr...   135  7e-31
ref|NP_469613.1|  (NC_003212) similar to B. subtilis YacN pr...   135  9e-31
ref|NP_438831.1|  (NC_000907) conserved hypothetical protein...   135  9e-31
ref|NP_387972.1|  (NC_000964) similar to hypothetical protei...   134  2e-30
ref|NP_623857.1|  (NC_003869) 2C-methyl-D-erythritol 2,4-cyc...   134  2e-30
ref|NP_213652.1|  (NC_000918) hypothetical protein [Aquifex ...   134  2e-30
ref|NP_461850.1|  (NC_003197) 2C-methyl-d-erythritol-2,4-cyc...   134  3e-30
ref|NP_662484.1|  (NC_002932) 2C-methyl-D-erythritol 2,4-cyc...   134  3e-30
ref|NP_457318.1|  (NC_003198) 2C-methyl-D-erythritol 2,4-cyc...   133  4e-30
ref|NP_564819.1|  (NM_105070) expressed protein [Arabidopsis...   133  4e-30
ref|NP_289295.1|  (NC_002655) orf, hypothetical protein [Esc...   133  4e-30
ref|NP_385562.1|  (NC_003047) CONSERVED HYPOTHETICAL PROTEIN...   133  4e-30
pdb|1GX1|A  Chain A, Structure Of 2c-Methyl-D-Erythritol-2,4...   131  1e-29
ref|NP_240231.1|  (NC_002528) hypothetical protein [Buchnera...   131  2e-29
gb|AAM62786.1|  (AY085564) 2C-methyl-D-erythritol 2,4-cyclod...   130  2e-29
ref|NP_519765.1|  (NC_003295) CONSERVED HYPOTHETICAL PROTEIN...   130  3e-29
ref|NP_246548.1|  (NC_002663) unknown [Pasteurella multocida...   130  3e-29
ref|NP_347074.1|  (NC_003030) Putative enzyme of deoxyxylulo...   129  8e-29
gb|AAF65155.1|AF250236_1  (AF250236) 2C-methyl-D-erythritol ...   129  8e-29
ref|NP_252317.1|  (NC_002516) conserved hypothetical protein...   127  2e-28
sp|Q47956|ISPF_HAEDU  2-C-methyl-D-erythritol 2,4-cyclodipho...   127  2e-28
ref|NP_487923.1|  (NC_003272) 2-C-methyl-D-erythritol 2,4-cy...   126  4e-28
ref|NP_274520.1|  (NC_003112) YgbB/YacN family protein [Neis...   125  7e-28
ref|NP_284427.1|  (NC_003116) conserved hypothetical protein...   125  1e-27
ref|NP_406823.1|  (NC_003143) 2C-methyl-D-erythritol 2,4-cyc...   123  3e-27
ref|NP_660743.1|  (NC_004061) hypothetical 16.9 kD protein i...   121  1e-26
ref|NP_440786.1|  (NC_000911) hypothetical protein [Synechoc...   120  2e-26
ref|NP_642053.1|  (NC_003919) 2C-methyl-D-erythritol 2,4-cyc...   120  2e-26
ref|NP_228456.1|  (NC_000853) conserved hypothetical protein...   119  6e-26
ref|NP_637073.1|  (NC_003902) 2C-methyl-D-erythritol 2,4-cyc...   119  6e-26
ref|NP_602588.1|  (NC_003454) 2C-methyl-D-erythritol 2,4-cyc...   115  9e-25
ref|NP_298583.1|  (NC_002488) conserved hypothetical protein...   114  2e-24
gb|AAG35071.1|AF321531_1  (AF321531) 2C-methyl-D-erythritol ...   110  2e-23
ref|NP_218953.1|  (NC_000919) conserved hypothetical protein...   108  1e-22
dbj|BAB86885.1|  (AB082126) 2-C-methyl-D-erythritol 2,4-cycl...    97  4e-19
ref|NP_293954.1|  (NC_001263) conserved hypothetical protein...    96  1e-18
ref|NP_301349.1|  (NC_002677) putative 2-C-methyl-D-erythrit...    94  2e-18
ref|NP_473012.1|  (NC_000910) YgbB protein, 1st euk. member ...    94  2e-18
gb|AAF24570.1|AC007764_12  (AC007764) F22C12.26 [Arabidopsis...    89  1e-16
ref|NP_601858.1|  (NC_003450) COG0245:2C-methyl-D-erythritol...    86  1e-15
ref|NP_218098.1|  (NC_000962) hypothetical protein Rv3581c [...    79  7e-14
ref|NP_623859.1|  (NC_003869) 4-diphosphocytidyl-2-methyl-D-...    72  9e-12
ref|NP_628408.1|  (NC_003888) 2C-methyl-D-erythriol 2,4-cycl...    70  6e-11
sp|Q06755|ISPD_BACSU  2-C-methyl-D-erythritol 4-phosphate cy...    67  3e-10
ref|NP_387971.1|  (NC_000964) similar to hypothetical protei...    66  8e-10
ref|NP_654034.1|  (NC_003995) UPF0007, Uncharacterized prote...    64  3e-09
ref|NP_219946.1|  (NC_000117) YgbB family [Chlamydia trachom...    61  2e-08
ref|NP_563345.1|  (NC_003366) conserved hypothetical protein...    61  3e-08
ref|NP_469612.1|  (NC_003212) similar to nucleotidylyl trans...    60  4e-08
ref|NP_463766.1|  (NC_003210) similar to nucleotidylyl trans...    60  5e-08
ref|NP_213907.1|  (NC_000918) hypothetical protein [Aquifex ...    60  6e-08
ref|NP_602396.1|  (NC_003454) 2-C-methyl-D-erythritol 4-phos...    60  6e-08
ref|NP_224775.1|  (NC_000922) Sugar Nucleotide Phosphorylase...    60  6e-08
ref|NP_297092.1|  (NC_002620) conserved hypothetical protein...    59  1e-07
ref|NP_349781.1|  (NC_003030) 4-diphosphocytidyl-2-methyleri...    57  5e-07
ref|NP_229194.1|  (NC_000853) conserved hypothetical protein...    56  7e-07
ref|NP_224743.1|  (NC_000922) YgbB family hypothetical prote...    55  1e-06
ref|NP_297120.1|  (NC_002620) conserved hypothetical protein...    54  3e-06
ref|NP_565286.1|  (NM_126305) putative sugar nucleotide phos...    52  1e-05
ref|NP_219975.1|  (NC_000117) Sugar Nucleotide Phosphorylase...    51  3e-05
ref|NP_240973.1|  (NC_002570) BH0107~unknown conserved prote...    50  5e-05
ref|NP_438832.1|  (NC_000907) conserved hypothetical protein...    49  1e-04
ref|NP_289296.1|  (NC_002655) orf, hypothetical protein [Esc...    49  1e-04
ref|NP_246547.1|  (NC_002663) unknown [Pasteurella multocida...    49  1e-04
ref|NP_417227.1|  (NC_000913) orf, hypothetical protein [Esc...    47  4e-04
ref|NP_296323.1|  (NC_001263) conserved hypothetical protein...    44  0.003
ref|NP_489207.1|  (NC_003272) 4-diphosphocytidyl-2C-methyl-D...    44  0.003
>ref|NP_207810.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
           26695]
 sp|O25664|ISDF_HELPY IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 pir||D64647 conserved hypothetical protein HP1020 - Helicobacter pylori
           (strain 26695)
 gb|AAD08064.1| (AE000610) conserved hypothetical protein [Helicobacter pylori
           26695]
          Length = 406

 Score =  799 bits (2063), Expect = 0.0
 Identities = 406/406 (100%), Positives = 406/406 (100%)

Query: 1   MSLIRVNGEAFKLSLESLEEDPFETKETLETLIKQTSVVLLAAGESRRFSQTIKKQWLRS 60
           MSLIRVNGEAFKLSLESLEEDPFETKETLETLIKQTSVVLLAAGESRRFSQTIKKQWLRS
Sbjct: 1   MSLIRVNGEAFKLSLESLEEDPFETKETLETLIKQTSVVLLAAGESRRFSQTIKKQWLRS 60

Query: 61  NHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHYPEIKLVKGGASRQESVRNALKI 120
           NHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHYPEIKLVKGGASRQESVRNALKI
Sbjct: 61  NHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHYPEIKLVKGGASRQESVRNALKI 120

Query: 121 IDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKL 180
           IDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKL
Sbjct: 121 IDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKL 180

Query: 181 IQTPQLSHTKALQSALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLF 240
           IQTPQLSHTKALQSALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLF
Sbjct: 181 IQTPQLSHTKALQSALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLF 240

Query: 241 FNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKG 300
           FNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKG
Sbjct: 241 FNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKG 300

Query: 301 GDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILE 360
           GDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILE
Sbjct: 301 GDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILE 360

Query: 361 NLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL 406
           NLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL
Sbjct: 361 NLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL 406
>ref|NP_223123.1| (NC_000921) putative [Helicobacter pylori J99]
 sp|Q9ZM19|ISDF_HELPJ IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 pir||G71936 hypothetical protein jhp0404 - Helicobacter pylori (strain J99)
 gb|AAD05981.1| (AE001474) putative [Helicobacter pylori J99]
          Length = 409

 Score =  760 bits (1963), Expect = 0.0
 Identities = 386/409 (94%), Positives = 398/409 (96%), Gaps = 3/409 (0%)

Query: 1   MSLIRVNGEAFKLSLESLEEDPFETKETLETL---IKQTSVVLLAAGESRRFSQTIKKQW 57
           MSLIRVNGEAFKLSLESLEEDPFETKETLETL   IKQTSVVLLAAGES+RFS+ IKKQW
Sbjct: 1   MSLIRVNGEAFKLSLESLEEDPFETKETLETLETLIKQTSVVLLAAGESKRFSRAIKKQW 60

Query: 58  LRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHYPEIKLVKGGASRQESVRNA 117
           LRS+HTPLWLSVYESFKEALDFKE+ILVVSELDY+YI+RHYP+IKLVKGGASRQESVRNA
Sbjct: 61  LRSHHTPLWLSVYESFKEALDFKEVILVVSELDYVYIQRHYPKIKLVKGGASRQESVRNA 120

Query: 118 LKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREA 177
           LK+IDS YT+TSDVARGLAN+EALK+LFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREA
Sbjct: 121 LKVIDSTYTITSDVARGLANMEALKSLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREA 180

Query: 178 IKLIQTPQLSHTKALQSALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHF 237
           IKLIQTPQLSHTK LQSALNQG FKDESSAILQAFP+ VSYIEGSKDLHKLTTSGDLK F
Sbjct: 181 IKLIQTPQLSHTKTLQSALNQGGFKDESSAILQAFPNSVSYIEGSKDLHKLTTSGDLKFF 240

Query: 238 TLFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGA 297
           T FFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGA
Sbjct: 241 TPFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGA 300

Query: 298 IKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPA 357
           IKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFEL EMGATIFSEIPKITPYKPA
Sbjct: 301 IKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELLEMGATIFSEIPKITPYKPA 360

Query: 358 ILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL 406
           ILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL
Sbjct: 361 ILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQKL 409
>ref|NP_282735.1| (NC_002163) hypothetical protein Cj1607 [Campylobacter jejuni]
 sp|Q9PM68|ISDF_CAMJE IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 pir||E81256 hypothetical protein Cj1607 [imported] - Campylobacter jejuni
           (strain NCTC 11168)
 emb|CAB73595.1| (AL139079) hypothetical protein Cj1607 [Campylobacter jejuni]
          Length = 371

 Score =  290 bits (741), Expect = 3e-77
 Identities = 158/371 (42%), Positives = 237/371 (63%), Gaps = 7/371 (1%)

Query: 33  IKQTSVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYI 92
           + + S+++LAAG S RF+  +KKQ+LR  + PLWL   ++      FK+I++  S + Y+
Sbjct: 1   MSEMSLIMLAAGNSTRFNTKVKKQFLRLGNDPLWLYATKNLSSFYPFKKIVVTSSNITYM 60

Query: 93  YIKRHYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTS 152
             K+     + ++GG +R ES++ AL++IDS + + SDVAR L +      L   L +  
Sbjct: 61  --KKFTKNYEFIEGGDTRAESLKKALELIDSEFVMVSDVARVLVSKNLFDRLIENLDKAD 118

Query: 153 HYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKALQSALNQG-DFKDESSAILQA 211
             CI P L   DT ++ NEAL RE IKLIQTPQ+S TK L+ AL+Q  +F D+S+AI  A
Sbjct: 119 --CITPALKVADTTLFDNEALQREKIKLIQTPQISKTKLLKKALDQNLEFTDDSTAIA-A 175

Query: 212 FPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVL 271
              ++ ++EG ++  KLT   DLK   L   P+ + F G GFD H F +++P++L GV +
Sbjct: 176 MGGKIWFVEGEENARKLTFKEDLKKLDLP-TPSFEIFTGNGFDVHEFGENRPLLLAGVQI 234

Query: 272 DCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQ 331
               GLKAHSDGD L H++ DAILGA   GDIGE +PD D K+KNA+S ELLK   D  +
Sbjct: 235 HPTMGLKAHSDGDVLAHSLTDAILGAAGLGDIGELYPDTDMKFKNANSMELLKQAYDKVR 294

Query: 332 SIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTMEKMGFIGKQEG 391
            IGFEL  +   + ++ PK+  +K A+  N++  L L++ +I++KATT EK+GFIG++EG
Sbjct: 295 EIGFELINIDICVMAQSPKLKDFKQAMQSNIAHTLDLDEFRINVKATTTEKLGFIGRKEG 354

Query: 392 LLVQAHVSMRY 402
           + V + V+++Y
Sbjct: 355 MAVLSSVNLKY 365
>ref|NP_420546.1| (NC_002696) conserved hypothetical protein [Caulobacter crescentus
           CB15]
 sp|Q9A7I5|ISDF_CAUCR IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 gb|AAK23714.1| (AE005847) conserved hypothetical protein [Caulobacter crescentus
           CB15]
          Length = 382

 Score =  152 bits (384), Expect = 7e-36
 Identities = 122/381 (32%), Positives = 185/381 (48%), Gaps = 23/381 (6%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR 96
           SVV++AAG   R      KQW      P+     E+F  A    E+++V +     ++ R
Sbjct: 4   SVVIVAAGSGTRAGPGQAKQWRVLAGRPVLRWSVEAFLAA-GAAEVVVVTTADGEAFLPR 62

Query: 97  HYPEI---KLVKGGASRQESVRNALKIID----SAYTLTSDVARG-------LANIEALK 142
               +   +   GGA+R  SV+  L  +     +   +  D AR        LA + AL 
Sbjct: 63  MLEGLQGWRSTLGGATRALSVQAGLAALSERPGAEPVMIHDAARPFVSRNVILALLGALS 122

Query: 143 NLFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKAL---QSALNQG 199
           +  L L   +        P  + A    + + RE +   QTPQ +    L    +A   G
Sbjct: 123 DADLALPALAVADTLKRQPTGEAA----QTVSREHLWRAQTPQAARRDTLIAAYAAWTHG 178

Query: 200 DFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPAKDTFIGMGFDTHAFI 259
           +  D++  +++A   R++   G   L KLT   D          A+ T +G GFD H + 
Sbjct: 179 EPTDDAQ-VVEAAGGRIALTAGDPLLTKLTYPEDFAMAEHLAGVARVTRVGQGFDAHRWG 237

Query: 260 KDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASS 319
             + + L GV +  +  L  HSD DA LHA+ DAILGAI  GDIG+ FP  DPK+K A+S
Sbjct: 238 PGEEVWLCGVAIKHDETLVGHSDADAGLHALTDAILGAIGEGDIGDHFPPTDPKWKGAAS 297

Query: 320 KELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATT 379
            + LK  +D   + G  L  +  T+  E PKI P++ A+ E L+++L +   ++S+KATT
Sbjct: 298 DQFLKHAVDLVTAKGGALVNVDVTLICERPKIKPHRQAMRERLAEILSIPVDRVSVKATT 357

Query: 380 MEKMGFIGKQEGLLVQAHVSM 400
            EKMGF G+ EGL   A V++
Sbjct: 358 TEKMGFTGRGEGLAASAVVAV 378
>ref|NP_539780.1| (NC_003317) 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE
           CYTIDYLYLTRANSFERASE  / 2-C-METHYL-D-ERYTHRITOL
           2,4-CYCLODIPHOSPHATE SYNTHASE (EC 2.-.-.-) [Brucella
           melitensis]
 sp|Q8YHD8|ISDF_BRUME IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 gb|AAL52044.1| (AE009527) 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE
            / 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE
           (EC 2.-.-.-) [Brucella melitensis]
          Length = 390

 Score =  150 bits (379), Expect = 3e-35
 Identities = 121/389 (31%), Positives = 181/389 (46%), Gaps = 32/389 (8%)

Query: 41  LAAGESRRFSQTIK--KQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRHY 98
           +AAG   R  Q+ +  KQ+       +      +F +      I +V+   D+   +R  
Sbjct: 1   MAAGRGERAGQSAEGPKQYRLIGAEAVLARTLRAFTDCPLIGTIAVVIHPDDHALYRRAV 60

Query: 99  PE----IKLVKGGASRQESVRN---ALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQT 151
           PE    + LV GG +RQES R    ALK     Y L  D  R     + L+ +   L  T
Sbjct: 61  PEKHENVILVTGGPTRQESTRLGLLALKDEAPQYVLIHDGVRPFIGQDLLERIIANL--T 118

Query: 152 SHYCIAPYLPCYDTAI------YYNEALDREAIKLIQTPQL--------SHTKALQSALN 197
               + P L   DT             + R  +   QTPQ         +H KA   A+N
Sbjct: 119 PDNGVLPALAVSDTLKRAAADGMVETTISRTGLFAAQTPQAFPYAPILDAHEKAF--AIN 176

Query: 198 QGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL----KHFTLFFNPAKDTFIGMGF 253
           + DF D++ AI +     V  IEGS D  KLT + D+    K          D   G G+
Sbjct: 177 RTDFTDDA-AIAEWQEIAVRIIEGSADNTKLTWAKDIEMADKRLRQDHAVFPDIRTGNGY 235

Query: 254 DTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPK 313
           D H+F     + L GV +  E  L  HSD D  LHA+ DA+L     GDIG  FP +DP+
Sbjct: 236 DVHSFEPGDHVTLCGVKIPHEAKLNGHSDADVALHALTDALLATRGAGDIGTHFPPSDPQ 295

Query: 314 YKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQI 373
           +K A+S+  ++      +  G  +  +  T+ SE PKI P++ A+ + L  +LG+   ++
Sbjct: 296 WKGAASRIFIEHAAKIVREAGGRIANVDVTLISEAPKIGPHRAAMTQALCDMLGIAADRV 355

Query: 374 SLKATTMEKMGFIGKQEGLLVQAHVSMRY 402
           S+KATT EK+GF+G++EG+   A  ++ Y
Sbjct: 356 SIKATTNEKLGFVGRREGIAAIATATVIY 384
>sp|Q08113|ISDF_RHOCA IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 pir||S34980 hypothetical protein (nifR3 5' region) - Rhodobacter capsulatus
 emb|CAA51072.1| (X72382) ORF2 [Rhodobacter capsulatus]
          Length = 379

 Score =  147 bits (372), Expect = 2e-34
 Identities = 119/381 (31%), Positives = 183/381 (47%), Gaps = 25/381 (6%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR 96
           +V+++AAG   R  + + KQW      P+      +F         ILVV   D + +  
Sbjct: 4   AVIIVAAGRGTRAGEGLPKQWRDLAGRPVLAQTVAAFAGL----GRILVVLHPDDMGLGM 59

Query: 97  HY--PEIKLVKGGASRQESVRNALKII---DSAYTLTSDVARGLANIEALKNLFLTLQQT 151
                 + LV GG++R ESV+NAL+ +   D    L  D AR L        +   L+ T
Sbjct: 60  DLLGGSVVLVAGGSTRSESVKNALEALEGSDVTRVLIHDGARPLVPASVTAAVLAALETT 119

Query: 152 SHYCIAPYLPCYDTAIYYNEA------LDREAIKLIQTPQLSHTKALQSA--LNQGDFKD 203
                AP L   D A++  EA       DRE +   QTPQ      + +A   + G   D
Sbjct: 120 PG--AAPALAVTD-ALWRGEAGLVAGTQDREGLYRAQTPQGFRFPEILAAHRAHPGGAAD 176

Query: 204 ESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPAK----DTFIGMGFDTHAFI 259
           +      A    V+ + G +D  K+T + D           K    D  +G G+D HAF 
Sbjct: 177 DVEVARHAGLS-VAIVPGHEDNLKITYAPDFARAEAILRERKGLTMDVRLGNGYDVHAFC 235

Query: 260 KDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASS 319
           +   +VL GV +     L  HSD D  +HA+ DAI GA+  GDIG  FP +DP++K A+S
Sbjct: 236 EGDHVVLCGVKVPHVKALLGHSDADVGMHALTDAIYGALAEGDIGRHFPPSDPQWKGAAS 295

Query: 320 KELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATT 379
              L      ++S GF +     T+  E PK+ P+  A+   L++++ +E S++S+KATT
Sbjct: 296 WIFLDHAAKLAKSRGFRIGNADVTLICERPKVGPHAVAMAAELARIMEIEPSRVSVKATT 355

Query: 380 MEKMGFIGKQEGLLVQAHVSM 400
            E++GF G++EG+   A V++
Sbjct: 356 SERLGFTGREEGIASIATVTL 376
>ref|NP_654035.1| (NC_003995) YgbB, YgbB family [Bacillus anthracis A2012] [Bacillus
           anthracis str. A2012]
          Length = 158

 Score =  142 bits (359), Expect = 5e-33
 Identities = 69/155 (44%), Positives = 102/155 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD H F + +P+++GG+ +  E GL  HSD D LLH + DA LGAI  GDIG+ FP
Sbjct: 4   IGQGFDVHEFAEGRPLIIGGITIPHEKGLIGHSDADVLLHTIADACLGAIAAGDIGKHFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K+A S  LL+ V +F +  G+EL  +  TI ++ PK+ P+  ++ + +S+LL  
Sbjct: 64  DTDPAFKDADSAVLLQKVWEFVREQGYELGNLDCTIIAQKPKMAPHIESMRKRISELLET 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYK 403
               I++KATT EK+GF G++EG+  QA V ++ K
Sbjct: 124 SIDNINVKATTTEKLGFTGREEGIASQAVVLLQKK 158
>emb|CAB51895.1| (AJ009974) hypothetical protein [Zymomonas mobilis]
          Length = 167

 Score =  140 bits (352), Expect = 4e-32
 Identities = 65/152 (42%), Positives = 100/152 (65%)

Query: 250 GMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPD 309
           G GFD H F     ++LGG+ +  + GL  HSD D  LHA+ DA+LGAI  GDIG  FP 
Sbjct: 10  GSGFDVHCFEAGDHIMLGGIKIPHDHGLAGHSDADVALHALTDALLGAIADGDIGTHFPP 69

Query: 310 NDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLE 369
           +DP++K A+S + L+  +  ++  G  +     T+  E PK+ PY+PA+ ++++Q+LGL 
Sbjct: 70  SDPQWKGANSTQFLEYAVALAKKAGAIIDHADVTVICEAPKVGPYRPAMRKHIAQILGLP 129

Query: 370 KSQISLKATTMEKMGFIGKQEGLLVQAHVSMR 401
           + ++S+KATT EK+GF G++EG+  QA  S+R
Sbjct: 130 EQRVSIKATTTEKLGFTGRKEGIAAQAVTSIR 161
>ref|NP_563232.1| (NC_003366) conserved hypothetical protein [Clostridium
           perfringens]
 sp|Q8XI08|ISPF_CLOPE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 dbj|BAB82022.1| (AP003193) conserved hypothetical protein [Clostridium perfringens]
          Length = 156

 Score =  138 bits (347), Expect = 1e-31
 Identities = 65/148 (43%), Positives = 100/148 (66%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IGMG+D H  ++++ ++LGGV +  E GL  HSD D LLHA++D++LGA   GDIG+ FP
Sbjct: 3   IGMGYDVHKLVENRDLILGGVKIPYEKGLLGHSDADVLLHAIMDSLLGAAALGDIGKHFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DPKYK A S +LL+ V +      +++  + ATI ++ PK+ P+ P + EN+++ L +
Sbjct: 63  DTDPKYKGADSIKLLEFVGELLNKNNYKISNIDATIIAQRPKMAPHIPTMRENIAKALNI 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           +  QI++KATT E +GF G  EG+  Q+
Sbjct: 123 DLDQINVKATTEEGLGFTGSGEGISSQS 150
>sp|Q9RNZ1|ISDF_ZYMMO IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 gb|AAD53897.1|AF176314_7 (AF176314) unknown [Zymomonas mobilis]
          Length = 387

 Score =  136 bits (343), Expect = 4e-31
 Identities = 92/297 (30%), Positives = 140/297 (46%), Gaps = 9/297 (3%)

Query: 104 VKGGASRQESVRNALKII-DSAY--TLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYL 160
           V GG  R++SV N LK   D  Y   L  D AR       +  L   L+ +      P L
Sbjct: 78  VIGGVFRRDSVINGLKAAHDRGYKRVLIHDAARPFLPKTVIDRLLDALKSSK--AAIPVL 135

Query: 161 PCYDTAIYYN-EALDREAIKLIQTPQ---LSHTKALQSALNQGDFKDESSAILQAFPDRV 216
           P  DT +    EA+DR     +QTPQ   L    A   A    D   + + +++AF  ++
Sbjct: 136 PVVDTLVNQEVEAVDRNLFHRVQTPQAFDLETVIAAHQAWTGSDEPTDDAQVVRAFGKKI 195

Query: 217 SYIEGSKDLHKLTTSGDLKHFTLFFNPAKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFG 276
           + + G + L KLT   D             +  G GFD H F     ++LGG+ +  + G
Sbjct: 196 ALVTGDRLLEKLTYPADFSVAEAQMTEKMISVCGSGFDVHCFEAGDHIMLGGIKIPHDHG 255

Query: 277 LKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFE 336
           L  HSD D  LHA+ DA+LGAI  GDIG  FP +DP++K A+S + L+  +  ++  G  
Sbjct: 256 LAGHSDADVALHALTDALLGAIADGDIGTHFPPSDPQWKGANSTQFLEYAVALAKKAGAI 315

Query: 337 LFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTMEKMGFIGKQEGLL 393
           +     T+  E PK+ PY+PA+ + L +  G      + K   ++ +     ++G L
Sbjct: 316 IDHADVTVICEAPKVGPYRPAMRKILPRFWGFLNKGSASKQRQLKSLVLQAAKKGSL 372
>ref|NP_102198.1| (NC_002678) hypothetical protein [Mesorhizobium loti]
 sp|Q98MX9|ISDF_RHILO IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 dbj|BAB47984.1| (AP002994) hypothetical protein [Mesorhizobium loti]
          Length = 407

 Score =  136 bits (343), Expect = 4e-31
 Identities = 114/390 (29%), Positives = 177/390 (45%), Gaps = 31/390 (7%)

Query: 37  SVVLLAAGESRRFSQTI-KKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIK 95
           +VV++AAG   R  Q    KQ+       +     E F        I++ +   D+   +
Sbjct: 15  AVVIVAAGRGARAGQANGPKQYQNIGGRAVIAHTLEIFLAHPRTDRIVVAIHADDHELFR 74

Query: 96  R----HYPEIKLVKGGASRQESVRN---ALKIIDSAYTLTSDVARGLANIEALKNLFLTL 148
           +        +  + GG +RQESVR    ALK       L  D  R   + + +      +
Sbjct: 75  QAAGSQAERVTAIIGGPTRQESVRLGLLALKEHAPGQVLIHDAVRPFVDADLIDRTISAI 134

Query: 149 QQTSHYCIAPYLPCYDT------AIYYNEALDREAIKLIQTPQ--------LSHTKALQS 194
            +       P LP  DT      A    E + R  +   QTPQ         +H KA Q 
Sbjct: 135 GENEG--ALPALPVADTLKRESAAGVVAETVSRSGLHAAQTPQGFPYGPILAAHDKAFQ- 191

Query: 195 ALNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPAKDTF----IG 250
            L + DF D++ AI +     V  + GS D  KLT + D+       +  +  F     G
Sbjct: 192 -LGRLDFTDDA-AIAEWAHIPVKLVPGSPDNVKLTWARDIAMAHQRLSSERTHFPDIRTG 249

Query: 251 MGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDN 310
            G+D HAF     + L GV +  +  L  HSD D  LHA+ DA+L     GDIG  FP +
Sbjct: 250 NGYDVHAFEPGDHVTLCGVAIPHDKKLSGHSDADVGLHALTDALLATCGAGDIGTHFPPS 309

Query: 311 DPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEK 370
           DP++K A+S+  ++      +  G  +     T+  E P++ P++ A+   LS++LG+  
Sbjct: 310 DPQWKGAASRIFVEHAAKVVRQRGGRIANADITLICEAPRVGPHREAMTAALSRMLGISA 369

Query: 371 SQISLKATTMEKMGFIGKQEGLLVQAHVSM 400
            +IS+KATT EK+GF+G++EG+   A  S+
Sbjct: 370 DRISIKATTNEKLGFVGREEGIAAIATASV 399
>ref|NP_230180.1| (NC_002505) conserved hypothetical protein [Vibrio cholerae]
 sp|Q9KUJ1|ISPF_VIBCH 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||D82311 conserved hypothetical protein VC0529 [imported] - Vibrio cholerae
           (group O1 strain N16961)
 gb|AAF93697.1| (AE004139) conserved hypothetical protein [Vibrio cholerae]
          Length = 158

 Score =  136 bits (343), Expect = 4e-31
 Identities = 71/153 (46%), Positives = 99/153 (64%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD H F  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGAI  GDIG  FP
Sbjct: 4   IGHGFDVHRFGGEGPIIIGGVKIPYEQGLIAHSDGDVALHALSDALLGAIAAGDIGRHFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D K+K A S+ELLK V    ++ G+ L     TI ++ PK+ PY  A+   +++ L  
Sbjct: 64  DTDDKWKGADSRELLKDVYRRVKAQGYVLGNADVTIIAQAPKMAPYIQAMCAAIAEDLET 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMR 401
           +   I++KATT EK+GF G++EG+  +A V +R
Sbjct: 124 DLGNINVKATTTEKLGFTGRKEGIACEAVVLLR 156
>ref|NP_240974.1| (NC_002570) BH0108~unknown conserved protein [Bacillus halodurans]
 sp|Q9KGF7|ISPF_BACHD 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 dbj|BAB03827.1| (AP001507) BH0108~unknown conserved protein [Bacillus halodurans]
          Length = 157

 Score =  136 bits (342), Expect = 5e-31
 Identities = 65/148 (43%), Positives = 97/148 (64%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G GFD H F + + +++GGV +  E GL  HSD D LLH + DA LGAI  GDIG+ FP
Sbjct: 4   VGQGFDVHQFAEGRLLIIGGVEIPYEKGLLGHSDADVLLHTIADAALGAIGEGDIGKHFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K+A S +LL  V +  +  G+ L  +  TI ++ PK+ P+ PA+   +++LL  
Sbjct: 64  DTDPHFKDADSAKLLSAVWELVKEKGYTLGNVDCTIIAQKPKMAPHIPAMRARIAELLEA 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           E++Q+++KATT E +GF G+ EG+  QA
Sbjct: 124 EEAQVNVKATTTETLGFTGRGEGIASQA 151
>ref|NP_354449.1| (NC_003062) AGR_C_2659p [Agrobacterium tumefaciens] [Agrobacterium
           tumefaciens str. C58 (Cereon)]
 ref|NP_532133.1| (NC_003304) ISPD/ISPF bifunctional enzyme [Agrobacterium
           tumefaciens str. C58 (U. Washington)]
 sp|Q8UFF4|ISDF_AGRT5 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 gb|AAK87234.1| (AE008069) AGR_C_2659p [Agrobacterium tumefaciens str. C58
           (Cereon)]
 gb|AAL42449.1| (AE009104) ISPD/ISPF bifunctional enzyme [Agrobacterium tumefaciens
           str. C58 (U. Washington)]
          Length = 400

 Score =  135 bits (341), Expect = 7e-31
 Identities = 99/318 (31%), Positives = 159/318 (49%), Gaps = 17/318 (5%)

Query: 101 IKLVKGGASRQESVRNALKIIDS---AYTLTSDVARGLANIEALKNLFLTLQQTSHYCIA 157
           I  V GGA+RQ+SV   L+ + S    + +  D  R     + L+ +   L +     + 
Sbjct: 81  ITTVTGGATRQQSVLAGLEALSSHGLTHVMIHDAVRPFVAADMLERI-AALHRAGAGGVL 139

Query: 158 PYLPCYDTAIY-----YNEALDREAIKLIQTPQ-LSHTKALQS-----ALNQGDFKDESS 206
           P LP  DT          E + R+ +   QTPQ  S++  L +     A  + DF D++S
Sbjct: 140 PALPVTDTLKRGLEDRVVETVSRQGLYAAQTPQSFSYSDILDAHRAAAASGKTDFTDDAS 199

Query: 207 AILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLFFNPA-KDTFIGMGFDTHAFIKDKPMV 265
            I +     V+  EGS D  KLT   D+       + A  D   G G+D H       + 
Sbjct: 200 -IAEWTGLTVTLTEGSVDNVKLTLKRDIAMADEKLSHALPDVRTGNGYDVHQLEAGDGVT 258

Query: 266 LGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKELLKI 325
           L G+ ++ +  LK HSD D  LHA+ DA+L     GDIG+ FP +DP++K A+S+  L+ 
Sbjct: 259 LCGIFIEHDQRLKGHSDADVALHALTDALLATCGAGDIGDHFPPSDPQWKGAASRIFLEH 318

Query: 326 VLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTMEKMGF 385
                +  G  +     ++ +E P+I P++ A+ E LS +LG+   + S+KATT E +GF
Sbjct: 319 AAKVVRDNGGTIMNADVSLIAEAPRIGPHRQAMREALSDMLGIALERCSVKATTNETIGF 378

Query: 386 IGKQEGLLVQAHVSMRYK 403
           +G++EG+   A  ++ Y+
Sbjct: 379 VGRREGIAAIATATVVYQ 396
>ref|NP_463767.1| (NC_003210) similar to B. subtilis YacN protein [Listeria
           monocytogenes EGD-e]
 sp|Q8YAB4|ISPF_LISMO 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAD00763.1| (AL591974) similar to B. subtilis YacN protein [Listeria
           monocytogenes]
          Length = 157

 Score =  135 bits (341), Expect = 7e-31
 Identities = 65/144 (45%), Positives = 95/144 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H    D+ +++GGV +  E GL  HSD D LLHA+ DAI+GAI  GDIG +FP
Sbjct: 4   IGQGYDVHKLAYDRDLIIGGVKIPYEKGLLGHSDADVLLHAITDAIIGAIGAGDIGHFFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D  +K+A S ELL  +    ++ GF L  + ATI +E PK+ PY   +   +++LL  
Sbjct: 64  DTDMVFKDADSAELLAEIWQKVEADGFRLGNLDATIIAEKPKMAPYVEQMKLRIAELLHA 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
           + +Q+++KATT EK+GF G++EG+
Sbjct: 124 DSAQVNVKATTTEKLGFTGREEGI 147
>ref|NP_469613.1| (NC_003212) similar to B. subtilis YacN protein [Listeria innocua]
 sp|Q92F39|ISPF_LISIN 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAC95501.1| (AL596164) similar to B. subtilis YacN protein [Listeria innocua]
          Length = 157

 Score =  135 bits (340), Expect = 9e-31
 Identities = 66/144 (45%), Positives = 95/144 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H    D+ +++GG+ +  E GL  HSD D LLHA+ DAI+GAI   DIG +FP
Sbjct: 4   IGQGYDVHKLDYDRELIIGGIKIPYEKGLLGHSDADVLLHAITDAIIGAIGALDIGHFFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D  YK+A S ELL  +    ++ GF+L  + ATI +E PK+ PY   +   +++LL  
Sbjct: 64  DTDMAYKDADSAELLAEIWRQVEAEGFKLGNLDATIIAEKPKMAPYVELMKRRIAELLHA 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
           E SQ+++KATT EK+GF G++EG+
Sbjct: 124 EPSQVNVKATTTEKLGFTGREEGI 147
>ref|NP_438831.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 sp|P44815|ISPF_HAEIN 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||F64156 hypothetical protein HI0671 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC22331.1| (U32750) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 158

 Score =  135 bits (340), Expect = 9e-31
 Identities = 67/148 (45%), Positives = 98/148 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF +D+P+++GGV +    G  AHSDGD  LHA+ DAILGA   GDIG+ FP
Sbjct: 4   IGHGFDVHAFGEDRPLIIGGVEVPYHTGFIAHSDGDVALHALTDAILGAAALGDIGKLFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D +YKNA S+ LL+      Q  G+++  +  TI ++ PK+ P+  A+   +++ L  
Sbjct: 64  DTDMQYKNADSRGLLREAFRQVQEKGYKIGNVDITIIAQAPKMRPHIDAMRAKIAEDLQC 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           +  Q+++KATT EK+GF G+QEG+  +A
Sbjct: 124 DIEQVNVKATTTEKLGFTGRQEGIACEA 151
>ref|NP_387972.1| (NC_000964) similar to hypothetical proteins [Bacillus subtilis]
 sp|Q06756|ISPF_BACSU 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||S66120 hypothetical protein - Bacillus subtilis
 pir||F69741 gltX 5'-region conserved hypothetical protein yacN - Bacillus
           subtilis
 gb|AAA21795.1| (L14580) unknown [Bacillus subtilis]
 dbj|BAA05325.1| (D26185) unknown [Bacillus subtilis]
 emb|CAB11867.1| (Z99104) similar to hypothetical proteins [Bacillus subtilis]
          Length = 158

 Score =  134 bits (337), Expect = 2e-30
 Identities = 65/150 (43%), Positives = 98/150 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD H  ++ +P+++GG+ +  E GL  HSD D LLH V DA LGA+  GDIG+ FP
Sbjct: 4   IGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHTVADACLGAVGEGDIGKHFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP++K+A S +LL+ V    +  G+ L  +  TI ++ PK+ PY   + + +++ L  
Sbjct: 64  DTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQKPKMLPYIEDMRKRIAEGLEA 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           + SQ+++KATT EK+GF G+ EG+  QA V
Sbjct: 124 DVSQVNVKATTTEKLGFTGRAEGIAAQATV 153
>ref|NP_623857.1| (NC_003869) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Thermoanaerobacter tengcongensis]
 gb|AAM25461.1| (AE013174) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Thermoanaerobacter tengcongensis]
          Length = 160

 Score =  134 bits (337), Expect = 2e-30
 Identities = 69/150 (46%), Positives = 99/150 (66%), Gaps = 1/150 (0%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G+G+D H F + K ++LGG+ +  E GLK HSDGD L+HA+ID ILGA   GDIGE FP
Sbjct: 6   VGIGYDVHRFEEGKKLMLGGIEIPFEKGLKGHSDGDVLIHALIDGILGAAGLGDIGEHFP 65

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D  YK   SK LLK VL+   S  + +  +   + +E PK++PYK  I  +L++LLG+
Sbjct: 66  DTDVAYKEVDSKILLKRVLEL-VSEHYVVNNVDCIVVTERPKLSPYKDRIRTSLAELLGV 124

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
            K ++++KA T E +GF G++EG+   A V
Sbjct: 125 SKERVNVKAKTEEGLGFTGREEGIKAYAVV 154
>ref|NP_213652.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
 sp|O67089|ISPF_AQUAE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||F70382 conserved hypothetical protein aq_957 - Aquifex aeolicus
 gb|AAC07056.1| (AE000715) hypothetical protein [Aquifex aeolicus]
          Length = 156

 Score =  134 bits (337), Expect = 2e-30
 Identities = 66/133 (49%), Positives = 91/133 (67%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD+H F++ K ++LGGV ++ ++GLK HSDGDALLHA+ DAILGA+   DIGE F 
Sbjct: 5   IGFGFDSHEFVEGKLLILGGVEIEKDYGLKGHSDGDALLHAITDAILGALGERDIGEIFK 64

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP++KNA S+  L+  L+     GF +  +   I ++ PKI P+K  I E+LS+LLG+
Sbjct: 65  DTDPRWKNAPSRIFLEKALEVMSEKGFNISNIDCVIVADRPKIAPHKERIKESLSKLLGI 124

Query: 369 EKSQISLKATTME 381
            K +ISLK    E
Sbjct: 125 PKERISLKGKRRE 137
>ref|NP_461850.1| (NC_003197) 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase
           [Salmonella typhimurium LT2]
 sp|Q8ZMF7|ISPF_SALTY 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 gb|AAL21809.1| (AE008833) 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase
           [Salmonella typhimurium LT2]
          Length = 159

 Score =  134 bits (336), Expect = 3e-30
 Identities = 67/148 (45%), Positives = 97/148 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGA   GDIG+ FP
Sbjct: 3   IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K A S+ELL+      Q+ G+ L  +  TI ++ PK+ P+ P +   +++ LG 
Sbjct: 63  DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
              ++++KATT EK+GF G+ EG+  +A
Sbjct: 123 HMDEVNVKATTTEKLGFTGRGEGIACEA 150
>ref|NP_662484.1| (NC_002932) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Chlorobium tepidum TLS]
 gb|AAM72826.1| (AE012915) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Chlorobium tepidum TLS]
          Length = 157

 Score =  134 bits (336), Expect = 3e-30
 Identities = 65/148 (43%), Positives = 93/148 (61%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG+G D H F + + +++GGV +    GL  HSD D LLHA+ DA+LGA   GDIG+ FP
Sbjct: 3   IGIGIDVHQFAEGRKLIIGGVEVPSPIGLLGHSDADVLLHAISDALLGAAALGDIGKHFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D  P YK+A S ELL+ V    +  G++   +   +  E PKI PY   +  N+++ LGL
Sbjct: 63  DTSPDYKDADSMELLRHVCKLLEQEGYKPVNVDTMLLLEKPKIAPYIDQMRRNIARCLGL 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           E + +S+KATT EK+G++G+QEG    A
Sbjct: 123 EINAVSVKATTNEKLGYVGRQEGACAHA 150
>ref|NP_457318.1| (NC_003198) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Salmonella enterica subsp. enterica serovar Typhi]
 sp|Q8Z472|ISPF_SALTI 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAD06035.1| (AL627276) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Salmonella enterica subsp. enterica serovar Typhi]
          Length = 159

 Score =  133 bits (334), Expect = 4e-30
 Identities = 67/148 (45%), Positives = 96/148 (64%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGA   GDIG+ FP
Sbjct: 3   IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K A S+ELL+      Q+ G+ L  +  TI ++ PK+ P+ P +   +++ LG 
Sbjct: 63  DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
               +++KATT EK+GF G+ EG+  +A
Sbjct: 123 HMDDVNVKATTTEKLGFTGRGEGIACEA 150
>ref|NP_564819.1| (NM_105070) expressed protein [Arabidopsis thaliana]
 gb|AAG52445.1|AC010852_2 (AC010852) unknown protein; 376-1789 [Arabidopsis thaliana]
 gb|AAK43969.1|AF370154_1 (AF370154) unknown protein [Arabidopsis thaliana]
 gb|AAL15202.1| (AY059096) unknown protein [Arabidopsis thaliana]
          Length = 231

 Score =  133 bits (334), Expect = 4e-30
 Identities = 80/220 (36%), Positives = 122/220 (55%), Gaps = 8/220 (3%)

Query: 185 QLSHTKALQSALNQGDFKDESSAILQAFPDR-VSYIEGSKDLHKLTTSGDLKHFTLFFNP 243
           Q++    L  A   G ++ + S  L   P   VS    + D+++  TS +    TL F  
Sbjct: 19  QITKKPFLLPATKIGVWRPKKSLSLSCRPSASVSAASSAVDVNESVTS-EKPTKTLPFR- 76

Query: 244 AKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDI 303
                IG GFD H      P+++GG+V+  + G +AHSDGD LLH V+DAILGA+   DI
Sbjct: 77  -----IGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDI 131

Query: 304 GEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLS 363
           G+ FPD+DPK+K A+S   +K  +      G+E+  + AT+  + PKI+P+K  I  NLS
Sbjct: 132 GQIFPDSDPKWKGAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLS 191

Query: 364 QLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYK 403
           +LLG + S ++LKA T EK+  +G+   +     + +  K
Sbjct: 192 KLLGADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMKK 231
>ref|NP_289295.1| (NC_002655) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 ref|NP_311627.1| (NC_002695) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Escherichia coli O157:H7]
 ref|NP_417226.1| (NC_000913) orf, hypothetical protein [Escherichia coli K12]
 sp|P36663|ISPF_ECOLI 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||I55083 hypothetical 16.9K protein (surE-cysC intergenic region) -
           Escherichia coli
 pdb|1JY8|A Chain A, 2c-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase
           (Ispf)
 gb|AAA79837.1| (L07942) ORF0 [Escherichia coli]
 gb|AAA69256.1| (U29579) alternate gene name ygbB; ORF0 of L07942; ORF_f159
           [Escherichia coli]
 gb|AAC75788.1| (AE000358) orf, hypothetical protein [Escherichia coli K12]
 gb|AAF44656.1|AF230738_1 (AF230738) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Escherichia coli]
 dbj|BAA95145.1| (AB038256) 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Escherichia coli]
 gb|AAG57853.1|AE005502_7 (AE005502) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 dbj|BAB37023.1| (AP002562) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Escherichia coli O157:H7]
          Length = 159

 Score =  133 bits (334), Expect = 4e-30
 Identities = 67/148 (45%), Positives = 96/148 (64%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGA   GDIG+ FP
Sbjct: 3   IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K A S+ELL+      Q+ G+ L  +  TI ++ PK+ P+ P +   +++ LG 
Sbjct: 63  DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGC 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
               +++KATT EK+GF G+ EG+  +A
Sbjct: 123 HMDDVNVKATTTEKLGFTGRGEGIACEA 150
>ref|NP_385562.1| (NC_003047) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
 sp|Q92Q90|ISDF_RHIME IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 emb|CAC46035.1| (AL591787) CONSERVED HYPOTHETICAL PROTEIN [Sinorhizobium meliloti]
          Length = 434

 Score =  133 bits (334), Expect = 4e-30
 Identities = 114/395 (28%), Positives = 181/395 (44%), Gaps = 31/395 (7%)

Query: 38  VVLLAAGESRRFSQTIK--KQWLRSNHTPLWLSVYESFKEALDFKEIILVV----SELDY 91
           VV++AAG   R  Q+ +  KQ+      P+     + F        +++V+     EL  
Sbjct: 35  VVIVAAGRGERAGQSAEGPKQYRTIGDRPVIAHTLDIFATWPGAGPVVVVIHPDDEELFA 94

Query: 92  IYIKRHYP--EIKLVKGGASRQESVRNALKIIDSA---YTLTSDVARGLANIEALKNLFL 146
              KR     E+ +V GGA+RQ SV   L+ + +    Y +  D  R   +   L     
Sbjct: 95  AARKRMAGALELTVVHGGATRQLSVLAGLEAVAATGVEYVMIHDAVRPFFDHTLLDRCGA 154

Query: 147 TLQQTSHYCIAPYLPCYDT------AIYYNEALDREAIKLIQTPQLSHTKALQSA----- 195
            L+  +   + P +   DT      A    E + R  +   QTPQ    + + SA     
Sbjct: 155 ALRDGAQ-ALLPAIAVADTLKRTKAAGLVAETVPRTDLYAAQTPQCFRLEPILSAHRRAA 213

Query: 196 -LNQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL----KHFTLFFNPAKDTFIG 250
              + DF D++S I +     V  +EG+ D  KLT   DL    +  T    P  D   G
Sbjct: 214 ASGRSDFTDDAS-IAEWAGIPVLLVEGAVDNFKLTLRRDLSMADEKLTRMAIP--DVRTG 270

Query: 251 MGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDN 310
            G+D H  +    + L GV +     L  HSD D  LHA+ DA+L     GDIG+ FP +
Sbjct: 271 NGYDVHQLVDGDGVTLCGVFIPHGRKLSGHSDADVALHALTDALLATCGAGDIGDHFPPS 330

Query: 311 DPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEK 370
           DP++K A S+  L+      +  G  +     ++ +E PK+ P++  + ENL+ +LG+  
Sbjct: 331 DPQWKGAPSRIFLEHAARIVRERGGTVTNADISLIAEAPKVGPHRQQMRENLAAILGISL 390

Query: 371 SQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQK 405
            + S+KATT EK+GF+G+ EG+   A  ++ Y  +
Sbjct: 391 DRCSIKATTNEKLGFVGRNEGIAAIATATVVYASR 425
>pdb|1GX1|A Chain A, Structure Of 2c-Methyl-D-Erythritol-2,4-Cyclodiphosphate
           Synthase
 pdb|1GX1|B Chain B, Structure Of 2c-Methyl-D-Erythritol-2,4-Cyclodiphosphate
           Synthase
 pdb|1GX1|C Chain C, Structure Of 2c-Methyl-D-Erythritol-2,4-Cyclodiphosphate
           Synthase
          Length = 160

 Score =  131 bits (330), Expect = 1e-29
 Identities = 67/148 (45%), Positives = 94/148 (63%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGA   GDIG+ FP
Sbjct: 4   IGHGFDVHAFGGEGPIIIGGVRIPYEKGLLAHSDGDVALHALTDALLGAAALGDIGKLFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP +K A S+ELL+      Q+ G+ L  +  TI ++ PK  P+ P     +++ LG 
Sbjct: 64  DTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKXLPHIPQXRVFIAEDLGC 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
               +++KATT EK+GF G+ EG+  +A
Sbjct: 124 HXDDVNVKATTTEKLGFTGRGEGIACEA 151
>ref|NP_240231.1| (NC_002528) hypothetical protein [Buchnera sp. APS]
 sp|P57494|ISPF_BUCAI 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 dbj|BAB13117.1| (AP001119) hypothetical protein [Buchnera sp. APS]
          Length = 161

 Score =  131 bits (329), Expect = 2e-29
 Identities = 68/157 (43%), Positives = 101/157 (64%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF   KP+++GGV++ CE GL AHS+GD L+H++IDA+LGA   GDIG +FP
Sbjct: 3   IGYGFDLHAFGSTKPLIIGGVLIPCEKGLIAHSNGDLLIHSLIDALLGATAMGDIGSFFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            N+  YKN  S+ LLK + +    + +++  +  TI +E PK+ PY   +  NLS  L  
Sbjct: 63  SNNYIYKNIDSRILLKKIWNKIILLNYDICNIDITIIAEYPKMLPYIFFMRSNLSLDLNT 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQK 405
           E   IS+K+TT +K+G IG++E +   + V +   +K
Sbjct: 123 EIDNISIKSTTSKKIGCIGRKEAIACHSIVMLIKNKK 159
>gb|AAM62786.1| (AY085564) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Arabidopsis thaliana]
          Length = 231

 Score =  130 bits (328), Expect = 2e-29
 Identities = 79/220 (35%), Positives = 121/220 (54%), Gaps = 8/220 (3%)

Query: 185 QLSHTKALQSALNQGDFKDESSAILQAFPDR-VSYIEGSKDLHKLTTSGDLKHFTLFFNP 243
           Q++    L  A   G ++ + S  L   P   VS    + D+++  TS +    TL F  
Sbjct: 19  QITKKPFLLPATKIGVWRPKKSLSLSCRPSASVSAASSAVDVNESVTS-EKPTKTLPFR- 76

Query: 244 AKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDI 303
                IG GFD H      P+++GG+ +  + G +AHSDGD LLH V+DAILGA+   DI
Sbjct: 77  -----IGHGFDLHRLEPGYPLIIGGIDIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDI 131

Query: 304 GEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLS 363
           G+ FPD+DPK+K A+S   +K  +      G+E+  + AT+  + PKI+P+K  I  NLS
Sbjct: 132 GQIFPDSDPKWKGAASSVFIKEAVRLMDEAGYEIANLDATLILQRPKISPHKETIRSNLS 191

Query: 364 QLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYK 403
           +LLG + S ++LKA T EK+  +G+   +     + +  K
Sbjct: 192 KLLGADPSVVNLKAKTHEKVDSLGENRSIAAHTVILLMKK 231
>ref|NP_519765.1| (NC_003295) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
 sp|Q8XYW2|ISPF_RALSO 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAD15346.1| (AL646065) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
          Length = 168

 Score =  130 bits (327), Expect = 3e-29
 Identities = 62/153 (40%), Positives = 98/153 (63%)

Query: 246 DTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGE 305
           D  IG G+D HA ++ + ++LGGV +    GL  HSD DALLHA+ DA+ GA   GDIG 
Sbjct: 5   DIRIGQGYDVHALVEGRKLILGGVEIPHTRGLLGHSDADALLHAITDALFGAAGLGDIGR 64

Query: 306 WFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQL 365
            FPD DP +  A S+ LL+  +   +  G+++  + AT+ ++ PK+ P+ P ++ NL+  
Sbjct: 65  HFPDTDPAFAGADSRVLLREAVRRVREAGYDVGNVDATVIAQKPKLAPHVPGMVANLAAD 124

Query: 366 LGLEKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           LG+   + ++KA T EK+GF G+++G++ QA V
Sbjct: 125 LGIAPGRCNVKAKTNEKLGFEGREDGIVAQAAV 157
>ref|NP_246548.1| (NC_002663) unknown [Pasteurella multocida]
 sp|P57954|ISPF_PASMU 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 gb|AAK03693.1| (AE006198) unknown [Pasteurella multocida]
          Length = 158

 Score =  130 bits (327), Expect = 3e-29
 Identities = 64/148 (43%), Positives = 98/148 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF  + P+++GGV +  E GL AHSDGD  LHA+ DA+LGA+  GDIG+ FP
Sbjct: 4   IGHGFDVHAFGGEGPIIIGGVAIPYEKGLLAHSDGDVALHALTDALLGAVALGDIGKLFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D +YK A S+ LL+      Q+ G+++  +  TI ++ PK+ P+  A+   +++ L  
Sbjct: 64  DTDMQYKGADSRGLLREAYTQVQAKGYKVGNVDVTIIAQAPKMRPHIDAMRAAIAEDLAC 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           +  Q+++KATT E++GF G+ EG+  +A
Sbjct: 124 DIEQVNVKATTSERLGFTGRGEGIACEA 151
>ref|NP_347074.1| (NC_003030) Putative enzyme of deoxyxylulose pathway (terpenoid
           biosinthesis), YgbB family, similar to yacN B.subtilis
           [Clostridium acetobutylicum]
 sp|Q97LX0|ISPF_CLOAB 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 gb|AAK78414.1|AE007558_4 (AE007558) Putative enzyme of deoxyxylulose pathway (terpenoid
           biosinthesis), YgbB family, similar to yacN B.subtilis
           [Clostridium acetobutylicum]
          Length = 155

 Score =  129 bits (323), Expect = 8e-29
 Identities = 63/148 (42%), Positives = 99/148 (66%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G+G+D H  ++++ ++LGGV +    GL  HSD D L+HA+ID+ILGA   GDIG+ FP
Sbjct: 3   VGIGYDVHKLVENRKLILGGVEIQYSKGLLGHSDADVLVHAIIDSILGAAGLGDIGKLFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D+D KYK  SS +LLK V    +  G+++  + +TI ++ PKI+PY   I ++L  +L +
Sbjct: 63  DSDNKYKGISSLKLLKEVNALIKDKGYKIGNIDSTIIAQKPKISPYIEDIKKSLCNVLDI 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           +   I++KATT E +GF G+ EG+  Q+
Sbjct: 123 DLGSINIKATTEEGLGFTGRGEGISSQS 150
>gb|AAF65155.1|AF250236_1 (AF250236) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Catharanthus roseus]
          Length = 236

 Score =  129 bits (323), Expect = 8e-29
 Identities = 64/155 (41%), Positives = 94/155 (60%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G GFD H      P+++GG+ +  + G +AHSDGD LLH V+DAILGA+   DIG+ FP
Sbjct: 82  VGHGFDLHRLEPGYPLIIGGINIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDIGQIFP 141

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DPK+K A S   +K  +      G+EL  + AT+  + PK++P+K AI +NL QLLG 
Sbjct: 142 DTDPKWKGAPSSVFIKEAVRLMDEAGYELGNLDATLILQRPKVSPHKEAIRQNLCQLLGA 201

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYK 403
           +   ++LKA T EK+  +G+   +     V +  K
Sbjct: 202 DPCVVNLKAKTHEKVDSLGENRSIAAHTVVLLMRK 236
>ref|NP_252317.1| (NC_002516) conserved hypothetical protein [Pseudomonas aeruginosa]
 sp|P57708|ISPF_PSEAE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||A83194 conserved hypothetical protein PA3627 [imported] - Pseudomonas
           aeruginosa (strain PAO1)
 gb|AAG07015.1|AE004782_13 (AE004782) conserved hypothetical protein [Pseudomonas aeruginosa]
          Length = 157

 Score =  127 bits (319), Expect = 2e-28
 Identities = 64/148 (43%), Positives = 98/148 (65%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H F +   + LGGV +  + GL AHSDGD LLHA+ DA+LGA   GDIG+ FP
Sbjct: 3   IGHGYDVHRFGEGDFITLGGVRIPHKHGLVAHSDGDVLLHALSDALLGAAALGDIGKHFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP++K A S+ LL+ V+      G+++  + ATI ++ PK+ P+   +   +++ LG+
Sbjct: 63  DTDPRFKGADSRALLRHVVAIVAEKGWKVGNVDATIVAQAPKMAPHIETMRGLIAEDLGV 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
              Q+++KATT E++GF G++EG+ V A
Sbjct: 123 AVDQVNVKATTTERLGFTGREEGIAVHA 150
>sp|Q47956|ISPF_HAEDU 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||S70845 hypothetical protein 1 - Haemophilus ducreyi
 gb|AAC43539.1| (U32175) hypothetical protein 1 [Haemophilus ducreyi]
          Length = 160

 Score =  127 bits (319), Expect = 2e-28
 Identities = 63/148 (42%), Positives = 95/148 (63%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF + +P+++GGV +    G  AHSDGD  LHA+ DA+LGA   GDIG+ FP
Sbjct: 4   IGHGFDVHAFGEKRPLIIGGVTIPYHTGFIAHSDGDVALHALTDALLGAAALGDIGKLFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D D +YKN  S++LL       Q+ G+++  +  TI ++ PK+ P+   + + ++  L  
Sbjct: 64  DTDQQYKNIDSRKLLIEAYRQVQTKGYQISNIDITIIAQAPKMRPHIDNMRQLIANDLNC 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQA 396
           +  QI++KATT EK+GF G+ EG+  +A
Sbjct: 124 DIDQINIKATTTEKLGFTGRGEGIACEA 151
>ref|NP_487923.1| (NC_003272) 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Nostoc sp. PCC 7120]
 sp|Q8YQF0|ISPF_ANASP 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 dbj|BAB75582.1| (AP003594) 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Nostoc sp. PCC 7120]
          Length = 165

 Score =  126 bits (317), Expect = 4e-28
 Identities = 61/150 (40%), Positives = 96/150 (63%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H  + D+ ++LGGV +  E GL  HSD D L HA++DA+LGA+  GDIG +FP
Sbjct: 7   IGNGYDIHRLVSDRALILGGVHIPHELGLLGHSDADVLTHAIMDAMLGALSLGDIGHYFP 66

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
             DP++  A S  LL  V +  ++ G+ +  + + + +E PK+ P+   + + L+ +L L
Sbjct: 67  PTDPQWAGADSLVLLSQVNELIRTQGWRIGNIDSVVVAERPKLKPHIKTMRDKLADILQL 126

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           E +QI +KATT EK+G +G++EG+   A V
Sbjct: 127 EPNQIGVKATTNEKLGPVGREEGICAYAVV 156
>ref|NP_274520.1| (NC_003112) YgbB/YacN family protein [Neisseria meningitidis MC58]
 sp|Q9JYM5|ISPF_NEIMB 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||G81073 YgbB/YacN family protein NMB1512 [imported] - Neisseria
           meningitidis (group B strain MD58)
 gb|AAF41868.1| (AE002501) YgbB/YacN family protein [Neisseria meningitidis MC58]
          Length = 160

 Score =  125 bits (315), Expect = 7e-28
 Identities = 61/150 (40%), Positives = 95/150 (62%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H   + + ++LGGV +  E GL  HSD DALLHAV DA+LGA   GDIG  FP
Sbjct: 6   IGQGYDVHQLTEGRKLILGGVEIPFEKGLLGHSDADALLHAVTDALLGAAGLGDIGSHFP 65

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D   ++K+A S+ LL+      Q+ G++   +  T+ ++ PK+ P+ P +  N++  LG+
Sbjct: 66  DTAAEFKDADSRVLLRAAYQSVQAQGWQAVNVDTTVIAQKPKLAPHIPQMRANIAADLGI 125

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           + S +++K  T EK+G++G+ EG+  QA V
Sbjct: 126 DISCVNIKGKTNEKLGYLGRMEGIEAQAAV 155
>ref|NP_284427.1| (NC_003116) conserved hypothetical protein [Neisseria meningitidis
           Z2491]
 sp|Q9JTM4|ISPF_NEIMA 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||C81867 conserved hypothetical protein NMA1712 [imported] - Neisseria
           meningitidis (group A strain Z2491)
 emb|CAB84940.1| (AL162756) conserved hypothetical protein [Neisseria meningitidis
           Z2491]
          Length = 160

 Score =  125 bits (313), Expect = 1e-27
 Identities = 61/150 (40%), Positives = 95/150 (62%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H   + + ++LGGV +  E GL  HSD DALLHAV DA+LGA   GDIG  FP
Sbjct: 6   IGQGYDVHQLTEGRKLILGGVEIPFEKGLLGHSDADALLHAVTDALLGAAGLGDIGSHFP 65

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D   ++K+A S+ LL+      Q+ G++   +  T+ ++ PK+ P+ P +  N++  LG+
Sbjct: 66  DTAAEFKDADSRVLLRAAYQSVQAQGWQAVNVDTTVIAQKPKLAPHIPQMRANIAADLGI 125

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           + S +++K  T EK+G++G+ EG+  QA V
Sbjct: 126 DISCVNIKGKTNEKLGYLGRMEGIESQAAV 155
>ref|NP_406823.1| (NC_003143) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Yersinia pestis]
 sp|Q8ZBP7|ISPF_YERPE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAC92590.1| (AJ414156) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Yersinia pestis]
          Length = 162

 Score =  123 bits (309), Expect = 3e-27
 Identities = 66/152 (43%), Positives = 95/152 (62%), Gaps = 2/152 (1%)

Query: 249 IGMGFDTHAFIKDK--PMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEW 306
           IG GFD H F ++   P+++GGV +  E GL AHSDGD  LHA  DA+LGA   GDIG+ 
Sbjct: 3   IGHGFDVHKFGENGSGPLIIGGVRIPYEKGLLAHSDGDVALHAATDALLGAAALGDIGKL 62

Query: 307 FPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLL 366
           FPD DP +K A S+ LL+       + G++L  +  TI ++ PK+ P+ P +  NL++ L
Sbjct: 63  FPDTDPAFKGADSRGLLREAYRRILAKGYKLGNLDITIIAQAPKMAPHIPQMRVNLAEDL 122

Query: 367 GLEKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
                 I++KATT E++GF G+ EG+  +A V
Sbjct: 123 QCHMDDINVKATTTEQLGFTGRGEGIACEAVV 154
>ref|NP_660743.1| (NC_004061) hypothetical 16.9 kD protein in surE-cysC [Buchnera
           aphidicola str. Sg (Schizaphis graminum)]
 gb|AAM67954.1| (AE014116) hypothetical 16.9 kD protein in surE-cysC [Buchnera
           aphidicola str. Sg (Schizaphis graminum)]
          Length = 167

 Score =  121 bits (304), Expect = 1e-26
 Identities = 63/152 (41%), Positives = 96/152 (62%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG GFD HAF   KP+++GGV +    GL AHS+GD L+H++IDA+LGA   GDIG +FP
Sbjct: 3   IGYGFDIHAFGSIKPLIIGGVQIPYNKGLIAHSNGDLLIHSLIDALLGATAMGDIGTFFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
             D KYKN +S+ LLK +        + +  +  TI +E PKI  Y   +  N++  L +
Sbjct: 63  SEDKKYKNINSRILLKYIWKRIYLKNYRISNIDITIITETPKILSYIFLMRSNIASDLNI 122

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHVSM 400
           +  +IS+K+T+ + +G IG++EG+  Q+ V +
Sbjct: 123 KIEKISVKSTSSKMIGCIGRKEGIACQSLVML 154
>ref|NP_440786.1| (NC_000911) hypothetical protein [Synechocystis sp. PCC 6803]
 sp|P73426|ISPF_SYNY3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||S77363 hypothetical protein slr1542 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA17466.1| (D90906) ORF_ID:slr1542~hypothetical protein [Synechocystis sp. PCC
           6803]
          Length = 161

 Score =  120 bits (302), Expect = 2e-26
 Identities = 58/144 (40%), Positives = 92/144 (63%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H  + D+P++LGGV +    GL  HSD D L HA++DA+LGA+  GDIG +FP
Sbjct: 6   IGNGYDIHRLVGDRPLILGGVTIAHHLGLDGHSDADVLTHALMDALLGALSLGDIGHYFP 65

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            +D +++ A S +LL  V       G+ +  +   I +E PK+ P+  A+ ENL+++L +
Sbjct: 66  PSDARWQGADSLKLLAQVHQLILERGWRINNLDNVIVAEQPKLKPHIQAMKENLAKVLTI 125

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
           +   I +KATT E++G  G++EG+
Sbjct: 126 DPDLIGIKATTNERLGPTGREEGI 149
>ref|NP_642053.1| (NC_003919) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Xanthomonas axonopodis pv. citri str. 306]
 gb|AAM36589.1| (AE011804) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Xanthomonas axonopodis pv. citri str. 306]
          Length = 166

 Score =  120 bits (302), Expect = 2e-26
 Identities = 62/150 (41%), Positives = 93/150 (61%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D HAF     ++LGGV +    G+ AHSDGD +LHA+ DA+LGA+  GDIG  FP
Sbjct: 7   IGQGYDVHAFGPGDHVMLGGVRVAHSHGVLAHSDGDVVLHALCDAMLGALALGDIGRHFP 66

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            +D ++K+A S + L+      +  G+ +     T+  E PK+ P+  A+ E ++ LL +
Sbjct: 67  PSDARWKDADSAQFLQHCDGLLRERGWRVGNADITVICERPKVGPHAVAMRERIADLLAI 126

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           E   +S+KATT E++GF G+ EG+  QA V
Sbjct: 127 ELDAVSVKATTSEQLGFTGRGEGIAAQAAV 156
>ref|NP_228456.1| (NC_000853) conserved hypothetical protein [Thermotoga maritima]
 sp|Q9WZB5|ISPF_THEMA 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||F72351 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
 gb|AAD35731.1|AE001738_11 (AE001738) conserved hypothetical protein [Thermotoga maritima]
          Length = 165

 Score =  119 bits (298), Expect = 6e-26
 Identities = 61/149 (40%), Positives = 93/149 (61%), Gaps = 3/149 (2%)

Query: 248 FIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWF 307
           FIG G+D H  ++ + +VL GV +D   G   HSDGD L HA+IDA+LGA   GDIG WF
Sbjct: 7   FIGFGYDRHPLVEGRRLVLAGVEIDAPLGSLGHSDGDVLSHAIIDALLGAGCLGDIGTWF 66

Query: 308 PDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLG 367
           P+   +YK+A+S +LLK  +   +  GF +  + AT+ + I K++PY+  I+ENL     
Sbjct: 67  PET-KEYKDANSLDLLKETVKILEERGFSVVNVDATVVASIVKLSPYREKIVENLKS--A 123

Query: 368 LEKSQISLKATTMEKMGFIGKQEGLLVQA 396
           LE S++++K  +   +GF G++ G+   A
Sbjct: 124 LETSRVNVKFKSGNTLGFEGEERGISAYA 152
>ref|NP_637073.1| (NC_003902) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Xanthomonas campestris pv. campestris str. ATCC 33913]
 gb|AAM40997.1| (AE012271) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Xanthomonas campestris pv. campestris str. ATCC 33913]
          Length = 163

 Score =  119 bits (298), Expect = 6e-26
 Identities = 61/150 (40%), Positives = 91/150 (60%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D HAF     ++LGGV +    G+ AHSDGD +LHA+ DA+LG +  GDIG  FP
Sbjct: 7   IGQGYDVHAFGPGDHLMLGGVRMAHSHGVLAHSDGDVVLHALCDAMLGGLALGDIGVHFP 66

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            +D ++K A S + ++      +  G+ +     T+  E PK+ P+  A+ E ++ LL +
Sbjct: 67  PSDARWKGADSAQFVQHCDQLLRDRGWRVGNADITVICERPKVGPHALAMRERIAGLLAI 126

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           E   +S+KATT EK+GF G+ EG+  QA V
Sbjct: 127 ELDAVSVKATTSEKLGFTGRSEGIAAQAAV 156
>ref|NP_602588.1| (NC_003454) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
 gb|AAL93887.1| (AE010481) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
          Length = 160

 Score =  115 bits (288), Expect = 9e-25
 Identities = 56/144 (38%), Positives = 90/144 (61%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D H  ++ + ++LGGV +    G+  HSDGD LLHA+ DAI+GA+  GDIG  FP
Sbjct: 4   IGNGYDVHKLVEGRKLMLGGVEVPHTKGVLGHSDGDVLLHAITDAIIGALGLGDIGLHFP 63

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           DND   K+  S  LLK + +  +   +++  + + I  + PK+ PY  +I +N++++L +
Sbjct: 64  DNDENLKDIDSAILLKKINNIMKEKNYKIVNLDSIIVMQKPKLRPYIDSIRDNIAKILEI 123

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
               I++KA T EK+GF G + G+
Sbjct: 124 NSELINVKAKTEEKLGFTGDETGV 147
>ref|NP_298583.1| (NC_002488) conserved hypothetical protein [Xylella fastidiosa
           9a5c]
 sp|Q9PDT5|ISPF_XYLFA 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||A82701 conserved hypothetical protein XF1294 [imported] - Xylella
           fastidiosa (strain 9a5c)
 gb|AAF84103.1|AE003962_13 (AE003962) conserved hypothetical protein [Xylella fastidiosa 9a5c]
          Length = 176

 Score =  114 bits (286), Expect = 2e-24
 Identities = 63/150 (42%), Positives = 92/150 (61%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G+D HAF     ++LGGV +    G+ AHSDGD +LHA+ DA+LGA+  GDIG+ FP
Sbjct: 17  IGQGYDVHAFGPGDHVMLGGVRVPHRCGVLAHSDGDVILHALCDAMLGALGLGDIGQHFP 76

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            +D ++K A S   ++      +   + +  + AT   E PKI PY  A+ E +++LL +
Sbjct: 77  PSDVRWKGADSGVFVRHCHLLLRERDWCVGNVDATAICESPKIAPYVNAMREGIARLLEV 136

Query: 369 EKSQISLKATTMEKMGFIGKQEGLLVQAHV 398
           +   +S+KATT E +GFIG+ EGL  Q  V
Sbjct: 137 QPECVSVKATTSEGLGFIGRGEGLAAQVVV 166
>gb|AAG35071.1|AF321531_1 (AF321531) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Arabidopsis thaliana]
          Length = 223

 Score =  110 bits (276), Expect = 2e-23
 Identities = 77/222 (34%), Positives = 117/222 (52%), Gaps = 18/222 (8%)

Query: 185 QLSHTKALQSALNQGDFKDESSAILQAFPDR-VSYIEGSKDLHKLTTSGDLKHFTLFFNP 243
           Q++    L  A   G ++ + S  L   P   VS    + D+++  TS +    TL F  
Sbjct: 19  QITKKPFLLPATKIGVWRPKKSLSLSCRPSASVSAASSAVDVNESVTS-EKPTKTLPFR- 76

Query: 244 AKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDI 303
                IG GFD H      P+++GG+ +  + G +AHSD        +DAILGA+   DI
Sbjct: 77  -----IGHGFDLHRLEPGYPLIIGGIDIPHDRGCEAHSD--------VDAILGALGLPDI 123

Query: 304 GEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLS 363
           G+ FPD+DPK+K A+S   +K  +      G+E+  + AT+  + PKI+P+K  I  NLS
Sbjct: 124 GQIFPDSDPKWKEAASSVFIKEAVRLMDEAGYEIGNLDATLILQRPKISPHKETIRSNLS 183

Query: 364 QLLGLEKSQISLKATTMEKMGFIGKQEGLLVQAHVSMRYKQK 405
           +LLG + S ++LKA T EK+  +G  E   V AH  +   +K
Sbjct: 184 KLLGADPSVVNLKAKTHEKVDSLG--ENRSVAAHTVILLMKK 223
>ref|NP_218953.1| (NC_000919) conserved hypothetical protein [Treponema pallidum]
 sp|O83525|ISDF_TREPA IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol
           4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT);
           2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           (MECPS) (MECD>
 pir||G71314 conserved hypothetical protein TP0512 - syphilis spirochete
 gb|AAC65500.1| (AE001227) conserved hypothetical protein [Treponema pallidum]
          Length = 399

 Score =  108 bits (270), Expect = 1e-22
 Identities = 90/331 (27%), Positives = 152/331 (45%), Gaps = 28/331 (8%)

Query: 96  RHYPEIKLVKGGASRQESVRNALKIIDSA---YTLTSDVARGLANIEALKNLFLTLQQTS 152
           R  P I  V G  +R  SVR  L  + +      L  D AR   ++  + ++   L+ T 
Sbjct: 70  RTRPVILYVPGAHTRSASVRAGLDAMATHAPDVVLVHDGARPFVSVALIHSV---LEATC 126

Query: 153 HYCIA-PYLPCYDT--AIYYNEALD----REAIKLIQTPQ----LSHTKALQSALNQGDF 201
            Y  A P +   DT   +  + +++    R  ++L QTPQ     S   A   A   G+ 
Sbjct: 127 RYGAAVPVIEATDTPKGVAADGSIETHLIRSRVRLAQTPQGFCYASLCAAHHRAATDGEQ 186

Query: 202 KDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFT--------LFFNPAKDTF---IG 250
             + S +   +   V    G +   K+T   DL+           +   P  +     +G
Sbjct: 187 YTDDSELYARYGGTVHVCAGERSNVKITYPEDLEQRASEPALTRGISVLPCTEEGALRVG 246

Query: 251 MGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDN 310
           +G D HA    +P++L G+ +  + G + HSD D L HA IDA+LGA   GDIG +FP  
Sbjct: 247 LGTDMHALCAGRPLILAGIHIPSKKGAQGHSDADVLAHASIDALLGAAGLGDIGTFFPSC 306

Query: 311 DPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEK 370
           D ++K+A S  LL+      ++  + L  + A +  E P + P++ A+  +L+Q L    
Sbjct: 307 DGRWKDAHSCALLRHTWQLVRAACWRLVNLDAVVCLEQPALHPFREAMRASLAQALDTHV 366

Query: 371 SQISLKATTMEKMGFIGKQEGLLVQAHVSMR 401
           +++ +KA T E++G +G    +  Q  V ++
Sbjct: 367 TRVFVKAKTAERLGPVGSGAAVTAQVVVLLK 397
>dbj|BAB86885.1| (AB082126) 2-C-methyl-D-erythritol 2,4-cyclodiphoshate synthase
           [Thermus thermophilus]
          Length = 152

 Score = 96.7 bits (239), Expect = 4e-19
 Identities = 50/133 (37%), Positives = 80/133 (59%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           IG G D+H   + +P+ L G+++    G  AHSDGDA LHA+ DA+L A   GDIG  FP
Sbjct: 3   IGYGEDSHRLEEGRPLYLCGLLIPSPVGALAHSDGDAALHALTDALLSAYGLGDIGLLFP 62

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
           D DP+++   S+  L+  L   ++ G +L +    +  + PK+ P++ A++++LS+LL L
Sbjct: 63  DTDPRWRGERSEVFLREALRLVEARGAKLLQASLVLTLDRPKLGPHRKALVDSLSRLLRL 122

Query: 369 EKSQISLKATTME 381
            + +I L   T E
Sbjct: 123 PQDRIGLTFKTSE 135
>ref|NP_293954.1| (NC_001263) conserved hypothetical protein [Deinococcus
           radiodurans]
 sp|Q9RXS6|ISPF_DEIRA 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||F75542 conserved hypothetical protein - Deinococcus radiodurans  (strain
           R1)
 gb|AAF09818.1|AE001885_2 (AE001885) conserved hypothetical protein [Deinococcus radiodurans]
          Length = 161

 Score = 95.5 bits (236), Expect = 1e-18
 Identities = 49/134 (36%), Positives = 75/134 (55%), Gaps = 1/134 (0%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLD-CEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWF 307
           IG G D H      P+VLGGV +   E G  AHSDGDA+LHAV DA+L  +  GDIG++F
Sbjct: 8   IGYGEDAHRLAPGLPLVLGGVAIPHAELGAVAHSDGDAVLHAVADALLSGLALGDIGQYF 67

Query: 308 PDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLG 367
           PD   ++K   S+ +L   L+  +  G+    +   +  + PK+ P +  I  ++++LLG
Sbjct: 68  PDTAAEWKGMDSRRILAKALELVEERGYRPVNVALVVTLDRPKLGPLRADIAASVAELLG 127

Query: 368 LEKSQISLKATTME 381
           L   ++ +   T E
Sbjct: 128 LPAGEVGVSFKTSE 141
>ref|NP_301349.1| (NC_002677) putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
           synthase [Mycobacterium leprae]
 sp|Q9CCW5|ISPF_MYCLE 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAC29830.1| (AL583918) putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
           synthase [Mycobacterium leprae]
          Length = 158

 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 51/144 (35%), Positives = 77/144 (53%), Gaps = 3/144 (2%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G+GFD H F   +P  L G++     G   HSDGD  +HA+ DA+L A   GDIG  F 
Sbjct: 7   VGLGFDVHVFEPGRPCWLVGLLFPDNDGCAGHSDGDVAVHALCDAVLSAAGQGDIGGLFA 66

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
             DP+++  S  ++L+ V++     G+E+      +    PKI P +      LS LL  
Sbjct: 67  VGDPRWERVSGADMLRHVVELLLRHGYEVVNASVQVIGNRPKIGPRRTEAQRLLSALL-- 124

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
            ++ +S+ ATT E +G  G+ EGL
Sbjct: 125 -RAPVSVAATTTEGLGLTGRGEGL 147
>ref|NP_473012.1| (NC_000910) YgbB protein, 1st euk. member (OO, TP) [Plasmodium
           falciparum]
 sp|O96178|ISPF_PLAFD 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase precursor
           (MECPS) (MECDP-synthase)
 pir||B71615 YgbB protein, 1st euk. member (OO, TP) PFB0420w - malaria parasite
           (Plasmodium falciparum)
 gb|AAC71873.1| (AE001394) YgbB protein, 1st euk. member (OO, TP) [Plasmodium
           falciparum 3D7]
 gb|AAG09818.1|AF279661_1 (AF279661) 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Plasmodium falciparum]
          Length = 240

 Score = 94.4 bits (233), Expect = 2e-18
 Identities = 48/137 (35%), Positives = 85/137 (62%), Gaps = 1/137 (0%)

Query: 262 KPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFPDNDPKYKNASSKE 321
           K + LGGV ++    L +HSDGD + H+++D+ILGA+   DIG  FPD D K KN +S  
Sbjct: 98  KTLTLGGVKINNVLVL-SHSDGDIIYHSIVDSILGALGSLDIGTLFPDKDEKNKNKNSAI 156

Query: 322 LLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGLEKSQISLKATTME 381
            L+          +++  +   + +++PKI+  +  I++N+S +L +++SQIS+K  T E
Sbjct: 157 FLRYARLLIYKKNYDIGNVDINVIAQVPKISNIRKNIIKNISTVLNIDESQISVKGKTHE 216

Query: 382 KMGFIGKQEGLLVQAHV 398
           K+G IG+++ +   A++
Sbjct: 217 KLGVIGEKKAIECFANI 233
>gb|AAF24570.1|AC007764_12 (AC007764) F22C12.26 [Arabidopsis thaliana]
          Length = 161

 Score = 88.6 bits (218), Expect = 1e-16
 Identities = 56/146 (38%), Positives = 81/146 (55%), Gaps = 8/146 (5%)

Query: 185 QLSHTKALQSALNQGDFKDESSAILQAFPDR-VSYIEGSKDLHKLTTSGDLKHFTLFFNP 243
           Q++    L  A   G ++ + S  L   P   VS    + D+++  TS +    TL F  
Sbjct: 19  QITKKPFLLPATKIGVWRPKKSLSLSCRPSASVSAASSAVDVNESVTS-EKPTKTLPFR- 76

Query: 244 AKDTFIGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDI 303
                IG GFD H      P+++GG+V+  + G +AHSDGD LLH V+DAILGA+   DI
Sbjct: 77  -----IGHGFDLHRLEPGYPLIIGGIVIPHDRGCEAHSDGDVLLHCVVDAILGALGLPDI 131

Query: 304 GEWFPDNDPKYKNASSKELLKIVLDF 329
           G+ FPD+DPK+K A+S   +K  + F
Sbjct: 132 GQIFPDSDPKWKGAASSVFIKEAVRF 157
>ref|NP_601858.1| (NC_003450) COG0245:2C-methyl-D-erythritol 2,4-cyclodiphosphate
           synthase [Corynebacterium glutamicum]
 dbj|BAC00053.1| (AP005282) 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
           [Corynebacterium glutamicum ATCC 13032]
          Length = 160

 Score = 85.5 bits (210), Expect = 1e-15
 Identities = 45/143 (31%), Positives = 76/143 (52%), Gaps = 3/143 (2%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G+  D H     KP  +  ++ +   G + HSDGD + HA++DA+L A   GD+G +  
Sbjct: 9   VGIATDAHQIEAGKPCWIACLLFEGVDGCEGHSDGDVVAHAIVDALLSASGLGDLGSFVG 68

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
              P+Y   S  +LLK V +   + G+ +  + A +  + PK  P +    + +S+++G 
Sbjct: 69  VGRPEYDGVSGTQLLKEVRELLSAHGYVIGNVAAQLVGQTPKFGPRREEAQQVISEIIG- 127

Query: 369 EKSQISLKATTMEKMGFIGKQEG 391
             +  SL ATT + MGF G+ EG
Sbjct: 128 --APCSLSATTTDHMGFTGRSEG 148
>ref|NP_218098.1| (NC_000962) hypothetical protein Rv3581c [Mycobacterium
           tuberculosis H37Rv]
 ref|NP_338231.1| (NC_002755) conserved hypothetical protein [Mycobacterium
           tuberculosis CDC1551]
 sp|P96863|ISPF_MYCTU 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||C70607 hypothetical protein Rv3581c - Mycobacterium tuberculosis  (strain
           H37RV)
 emb|CAB07155.1| (Z92774) hypothetical protein Rv3581c [Mycobacterium tuberculosis
           H37Rv]
 gb|AAK48045.1| (AE007169) conserved hypothetical protein [Mycobacterium
           tuberculosis CDC1551]
          Length = 159

 Score = 79.3 bits (194), Expect = 7e-14
 Identities = 47/144 (32%), Positives = 74/144 (50%), Gaps = 3/144 (2%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGEWFP 308
           +G+G D H     +P  L G++     G   HSDGD  +HA+ DA+L A   GDIGE F 
Sbjct: 7   VGLGTDVHPIEPGRPCWLVGLLFPSADGCAGHSDGDVAVHALCDAVLSAAGLGDIGEVFG 66

Query: 309 DNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLGL 368
            +DP+++  S  ++L+ V+      G+ +      +    PKI   +      LS+LL  
Sbjct: 67  VDDPRWQGVSGADMLRHVVVLITQHGYRVGNAVVQVIGNRPKIGWRRLEAQAVLSRLL-- 124

Query: 369 EKSQISLKATTMEKMGFIGKQEGL 392
             + +S+ ATT + +G  G+ EGL
Sbjct: 125 -NAPVSVSATTTDGLGLTGRGEGL 147
>ref|NP_623859.1| (NC_003869) 4-diphosphocytidyl-2-methyl-D-erithritol synthase
           [Thermoanaerobacter tengcongensis]
 gb|AAM25463.1| (AE013174) 4-diphosphocytidyl-2-methyl-D-erithritol synthase
           [Thermoanaerobacter tengcongensis]
          Length = 227

 Score = 72.4 bits (176), Expect = 9e-12
 Identities = 63/221 (28%), Positives = 101/221 (45%), Gaps = 17/221 (7%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR 96
           S V++AAG S R ++++ K +L     P+     ++F E    KEII+V S  +  Y + 
Sbjct: 4   SAVIVAAGRSTRMNKSLNKVYLSIAGKPVLYYSIKAFDEIEWIKEIIVVTSPEETEYCQE 63

Query: 97  HYPE-------IKLVKGGASRQESVRNALKIIDSAYTLTS--DVARGLAN----IEALKN 143
           +  E        K+VKGG  RQ SV N + ++D    + +  D AR L      +EA+K 
Sbjct: 64  NVLEKFYWNKPFKIVKGGEERQYSVYNGISVVDKDCEIVAIHDGARPLVTKEIIMEAIKA 123

Query: 144 LFLTLQQTSHYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSH----TKALQSALNQG 199
            +L         +   +   D   +  +  DR  +  IQTPQ+       KA + AL +G
Sbjct: 124 AYLYKAAAVGVPVKDTIKVADEDNFILDTPDRRYLWAIQTPQVFEKELIVKAHRKALEEG 183

Query: 200 DFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDLKHFTLF 240
               + S +++    +V  +EG     K+TT  DL    LF
Sbjct: 184 FLGTDDSVLVERMGFKVKLVEGDYKNIKITTPEDLVVAELF 224
>ref|NP_628408.1| (NC_003888) 2C-methyl-D-erythriol 2,4-cyclodiphosphate synthase
           [Streptomyces coelicolor A3(2)]
 sp|Q9L0Q7|ISPF_STRCO 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 emb|CAB77328.1| (AL160331) 2C-methyl-D-erythriol 2,4-cyclodiphosphate synthase
           [Streptomyces coelicolor A3(2)]
          Length = 170

 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 44/149 (29%), Positives = 71/149 (47%), Gaps = 4/149 (2%)

Query: 249 IGMGFDTHAFIKDKPMVLGGVVLDCE-FGLKAHSDGDALLHAVIDAILGAIKGGDIGEWF 307
           +G+G D HAF   + +   G+  + E  GL  HSD D + HA  +A+  A   GD+G+ F
Sbjct: 17  VGIGTDIHAFEDGRELWCAGLKWEGEGTGLAGHSDADVVAHAACNALFSAAGAGDLGQHF 76

Query: 308 PDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQLLG 367
               P++  AS   LL       ++ GF +  +   +    PKI   +      LS  +G
Sbjct: 77  GTGRPEWSGASGVTLLAEAARIVRARGFRIGNVAVQVVGARPKIGKRRDEAEAVLSAAVG 136

Query: 368 LEKSQISLKATTMEKMGFIGKQEGLLVQA 396
              + +S+   T + +GF G+ EGL+  A
Sbjct: 137 ---APVSVSGATTDGLGFPGRGEGLMAVA 162
>sp|Q06755|ISPD_BACSU 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 gb|AAA21794.1| (L14580) unknown [Bacillus subtilis]
          Length = 232

 Score = 67.4 bits (163), Expect = 3e-10
 Identities = 62/214 (28%), Positives = 94/214 (42%), Gaps = 19/214 (8%)

Query: 38  VVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR- 96
           VV+ AAG+ +R      K ++     P+ +     F       +IILV++E D  + ++ 
Sbjct: 5   VVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHRQCDKIILVINEQDREHFQQL 64

Query: 97  --HYP---EIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQQ 150
              YP    I+LV GG  RQ SV   LK +      L  D AR     E +  L    +Q
Sbjct: 65  LSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLVHDGARPFIKHEQIDELIAEAEQ 124

Query: 151 TSHYCIAPYLPCYDTA-----IYYNEALDREAIKLIQTPQLSHTKALQSALNQGDFK--- 202
           T    +A  +P  DT      +  +E ++R ++  +QTPQ      L  A  + + K   
Sbjct: 125 TGAAILA--VPVKDTIKRVQDLQVSETIERSSLWAVQTPQAFRLSLLMKAHAEAERKGFL 182

Query: 203 --DESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
             D++S + Q     V  +EGS    KLTT  DL
Sbjct: 183 GTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDL 216
>ref|NP_387971.1| (NC_000964) similar to hypothetical proteins [Bacillus subtilis]
 pir||S66119 conserved hypothetical protein yacM - Bacillus subtilis
 dbj|BAA05324.1| (D26185) unknown [Bacillus subtilis]
 emb|CAB11866.1| (Z99104) similar to hypothetical proteins [Bacillus subtilis]
          Length = 232

 Score = 65.9 bits (159), Expect = 8e-10
 Identities = 61/214 (28%), Positives = 94/214 (43%), Gaps = 19/214 (8%)

Query: 38  VVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR- 96
           VV+ AAG+ +R      K ++     P+ +     F       +IILV++E +  + ++ 
Sbjct: 5   VVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHRQCDKIILVINEQEREHFQQL 64

Query: 97  --HYP---EIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQQ 150
              YP    I+LV GG  RQ SV   LK +      L  D AR     E +  L    +Q
Sbjct: 65  LSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLVHDGARPFIKHEQIDELIAEAEQ 124

Query: 151 TSHYCIAPYLPCYDTA-----IYYNEALDREAIKLIQTPQLSHTKALQSALNQGDFK--- 202
           T    +A  +P  DT      +  +E ++R ++  +QTPQ      L  A  + + K   
Sbjct: 125 TGAAILA--VPVKDTIKRVQDLQVSETIERSSLWAVQTPQAFRLSLLMKAHAEAERKGFL 182

Query: 203 --DESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
             D++S + Q     V  +EGS    KLTT  DL
Sbjct: 183 GTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDL 216
>ref|NP_654034.1| (NC_003995) UPF0007, Uncharacterized protein family UPF0007
           [Bacillus anthracis A2012] [Bacillus anthracis str.
           A2012]
          Length = 226

 Score = 63.9 bits (154), Expect = 3e-09
 Identities = 54/214 (25%), Positives = 101/214 (46%), Gaps = 18/214 (8%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIK- 95
           ++++ AAG+ +R      K +L  N  P+ +    +F++    K II+ ++E +  Y + 
Sbjct: 3   TLIIPAAGQGKRMGAGKNKLFLLINEVPIIVHTLRAFEKDKACKNIIMAINEEERPYFEE 62

Query: 96  --RHYP---EIKLVKGGASRQESVRNALK-IIDSAYTLTSDVARGLANIEALKNLFLTLQ 149
             + YP    ++ ++GGA RQ+SV NA++   D  Y L  D AR     + ++++    +
Sbjct: 63  LMQKYPVEKPVQFIQGGAERQDSVYNAIQHTTDVEYVLVHDGARPFVTNKVIQDVLTAAE 122

Query: 150 QTSHYCIAPYLPCYDTAIYYN-----EALDREAIKLIQTPQLSHTKAL----QSALNQGD 200
           +      A  +P  DT          E ++R  +K +QTPQ      L    +SA     
Sbjct: 123 KYGASICA--VPVKDTVKKVEQGVVVETVERSQLKAVQTPQGFSVSLLLEAHRSAKQSCF 180

Query: 201 FKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
              + +++++    +V  +EGS    K+TT  DL
Sbjct: 181 LGTDDASLVERIGKQVGVVEGSYYNIKVTTPEDL 214
>ref|NP_219946.1| (NC_000117) YgbB family [Chlamydia trachomatis]
 sp|O84441|ISPF_CHLTR 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||C71514 hypothetical protein CT434 - Chlamydia trachomatis (serotype D,
           strain UW3/Cx)
 gb|AAC68033.1| (AE001317) YgbB family [Chlamydia trachomatis]
          Length = 178

 Score = 61.2 bits (147), Expect = 2e-08
 Identities = 39/147 (26%), Positives = 74/147 (49%), Gaps = 4/147 (2%)

Query: 249 IGMGFDTHAFIKD---KPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGE 305
           +G+G D+H F+ D   KP +LGG++ +   G +A+SDGD + HA+ +A       G +G 
Sbjct: 19  VGIGQDSHRFLPDEDPKPCILGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHKGILG- 77

Query: 306 WFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQL 365
              D   K K  +   +       S      +  +  TI  + PK+ P  P++ + ++++
Sbjct: 78  GLADELLKTKGITDSVVYLQEAVASLKPTQRVSHLAITIEGKRPKLLPQLPSMRKRIAEV 137

Query: 366 LGLEKSQISLKATTMEKMGFIGKQEGL 392
           L +    I++ AT+ E +  +G+  G+
Sbjct: 138 LHIPLDSINITATSGEGLTAMGQGYGV 164
>ref|NP_563345.1| (NC_003366) conserved hypothetical protein [Clostridium
           perfringens]
 sp|Q8XHQ3|ISPD_CLOPE 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 dbj|BAB82135.1| (AP003194) conserved hypothetical protein [Clostridium perfringens]
          Length = 225

 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 57/219 (26%), Positives = 100/219 (45%), Gaps = 22/219 (10%)

Query: 39  VLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRH- 97
           V+LA G+ +R    + KQ++  N  P+     ++F+E     EIILV+ + +  Y KR  
Sbjct: 7   VILAGGKGKRMGAEVSKQFIEINGKPIIYYTLKAFEECKGIDEIILVLPKDEIDYFKREI 66

Query: 98  -----YPEIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQQT 151
                +   K+++GG  RQ+SV NAL  I D    L  D AR   + + +++     ++ 
Sbjct: 67  EPRFDFKISKIIEGGKERQDSVYNALNSIGDCDIVLIHDGARAFVSNKIIEDGIKYSREF 126

Query: 152 SHYCIAPYLPCYDTAIYYN------EALDREAIKLIQTPQLSHTKALQSALNQGDFK--- 202
                AP +   DT    N      +  +R ++  +QTPQ      ++   N+   +   
Sbjct: 127 G--AAAPGVMPKDTIKVKNLEGFSVDTPNRASLVAVQTPQCFKYNLIKKGHNKVKNEKIQ 184

Query: 203 -DESSAILQAFPDRVSYIEGSKDLHKLTTSGDL---KHF 237
             + + I++   ++V   EG     K+TT  DL   +HF
Sbjct: 185 VTDDTMIVELLGEKVYLFEGDYKNIKVTTPEDLILAEHF 223
>ref|NP_469612.1| (NC_003212) similar to nucleotidylyl transferase, pyrophosphorylase
           [Listeria innocua]
 sp|Q92F40|ISPD_LISIN 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 emb|CAC95500.1| (AL596164) similar to nucleotidylyl transferase, pyrophosphorylase
           [Listeria innocua]
          Length = 232

 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 53/212 (25%), Positives = 97/212 (45%), Gaps = 15/212 (7%)

Query: 38  VVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRH 97
           ++ LAAG+ +R +    K WL     P+++     F       ++I+V  E +  ++++ 
Sbjct: 5   LIFLAAGQGKRMNAEKNKMWLDLVGEPIFIHALRPFLADNRCSKVIVVCQETERKHVRKL 64

Query: 98  YPE-------IKLVKGGASRQESVRNALKIID-SAYTLTSDVARGLANIEALKNLFLTLQ 149
             +       +++VKGG+ RQ SV   L+     +  L  D AR    ++ +  L L ++
Sbjct: 65  MQQLDVAEDRVEVVKGGSERQYSVAAGLECCGLESVVLVHDGARPFVTLDIIDRLLLGVK 124

Query: 150 QT-SHYCIAPYLPCYDTAIY--YNEALDREAIKLIQTPQLSHTKALQSA--LNQGD--FK 202
           Q  +  C           I+    E +DR+ +  IQTPQ      LQ A  L + D    
Sbjct: 125 QNKAAICAVQVKDTVKRVIHDVVKETVDRDNLWQIQTPQAFELHILQKAHRLAKKDQFLG 184

Query: 203 DESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
            + +++++  P  V+ ++GS    KLTT  D+
Sbjct: 185 TDEASLVERIPYPVAIVQGSYYNIKLTTPEDM 216
>ref|NP_463766.1| (NC_003210) similar to nucleotidylyl transferase, pyrophosphorylase
           [Listeria monocytogenes EGD-e]
 sp|Q8YAB5|ISPD_LISMO 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 emb|CAD00762.1| (AL591974) similar to nucleotidylyl transferase, pyrophosphorylase
           [Listeria monocytogenes]
          Length = 232

 Score = 60.1 bits (144), Expect = 5e-08
 Identities = 55/214 (25%), Positives = 96/214 (44%), Gaps = 19/214 (8%)

Query: 38  VVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRH 97
           +V LAAG+ +R +    K WL     P+++     F       ++I+V  E +  ++K  
Sbjct: 5   LVFLAAGQGKRMNAQKNKMWLELVGEPIFIHALRPFLADNRCSKVIVVCQEEERKHVKEL 64

Query: 98  YPE-------IKLVKGGASRQESVRNALKIIDSA-YTLTSDVARGLANIEALKNLFLTLQ 149
             +       I++VKGG+ RQ SV   L+   +    L  D AR    ++ +  L + ++
Sbjct: 65  MSQLNVAEHRIEIVKGGSERQYSVAAGLERCGTGRVVLVHDGARPFITLDIIDRLLIGVE 124

Query: 150 QTSHYCIAPYLPCYDTAI-----YYNEALDREAIKLIQTPQLSH----TKALQSALNQGD 200
           Q+     A  +   DT          E +DRE +  +QTPQ        KA Q A  +  
Sbjct: 125 QSKAAICA--VKVKDTVKRVMNGVVQETVDRENLWQVQTPQAFELPILRKAHQLARKEQF 182

Query: 201 FKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
              + +++++  P  V+ ++GS    KLTT  D+
Sbjct: 183 LGTDEASLVERIPCPVAIVQGSYYNIKLTTPEDM 216
>ref|NP_213907.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
 sp|O67343|ISPD_AQUAE 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||D70414 conserved hypothetical protein aq_1323 - Aquifex aeolicus
 gb|AAC07307.1| (AE000734) hypothetical protein [Aquifex aeolicus]
          Length = 213

 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 65/212 (30%), Positives = 99/212 (46%), Gaps = 25/212 (11%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALD-FKEIILVVSELDYIYIK 95
           + ++LAAG   R     +KQ+      PL++    S ++ LD F+E+ILV+ E D++   
Sbjct: 3   TAIILAAGRGSRIG--FRKQFATLCGKPLFM---HSLEKVLDIFEEVILVLPE-DFLDKV 56

Query: 96  RHYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHY- 154
           + +P++K V GG  RQ+SV NAL        +  D AR LA     K +FL + Q   Y 
Sbjct: 57  KVHPKVKKVAGGPERQDSVFNALLQATGDIVVIHDSARPLAT----KKMFLEVAQLGDYH 112

Query: 155 --CIAPYLPCYDTAIYYNE-----ALDREAIKLIQTPQLSHTKAL----QSALNQGDFKD 203
              +A   P  DT     E      L+R  I   QTPQ      L      A  +G    
Sbjct: 113 GKVVAS--PARDTLKEVVEGKVIKTLNRSLIWHAQTPQAFRRDILLECHMRAKAEGFVGT 170

Query: 204 ESSAILQAFPDRVSYIEGSKDLHKLTTSGDLK 235
           + +++L+ +   V  +EGS    K+T   DL+
Sbjct: 171 DDASLLERYGYSVGVVEGSYWNVKITYPEDLE 202
>ref|NP_602396.1| (NC_003454) 2-C-methyl-D-erythritol 4-phosphate
           cytidylyltransferase [Fusobacterium nucleatum subsp.
           nucleatum ATCC 25586]
 gb|AAL93695.1| (AE010466) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
          Length = 231

 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 53/220 (24%), Positives = 102/220 (46%), Gaps = 19/220 (8%)

Query: 34  KQTSVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSE----- 88
           K+ + +L AAG+ +R +    KQ+L     PL+ S  +   E  +  +II++ ++     
Sbjct: 10  KKVTFILAAAGQGKRMNLNSPKQFLDYRGEPLFYSSLKLAFENKNINDIIIITNKENLNF 69

Query: 89  -LDYIYIKRHYPEIK-LVKGGASRQESVRNAL-KIIDSAYTLTSDVARGLANIEALKNLF 145
            + Y   K  + ++K +V+GG+ RQ S+ NA+ KI D+   +  D AR     + ++   
Sbjct: 70  MVKYCQNKNLFSKVKYIVEGGSERQYSIYNAIKKIKDTDIVIIQDAARPFLKDKYIEESL 129

Query: 146 LTLQQTSHYCIAPYLPCYDTAIYYN------EALDREAIKLIQTPQLSHTKALQSALNQG 199
             L       I   + C DT    +      E  +R+ + ++ TPQ    + L+ A    
Sbjct: 130 KILNDDCDGAIIG-VKCKDTIKIIDENGIVLETPNRDNLIMVHTPQTFKFEILKKAHQMA 188

Query: 200 DFKD----ESSAILQAFPDRVSYIEGSKDLHKLTTSGDLK 235
           + K+    + +++++    ++  I G  D  K+T   DLK
Sbjct: 189 EEKNILATDDASLVEMISGKIKIIYGDYDNIKITVQEDLK 228
>ref|NP_224775.1| (NC_000922) Sugar Nucleotide Phosphorylase [Chlamydophila
           pneumoniae CWL029]
 ref|NP_300635.1| (NC_002491) sugar nucleotide phosphorylase [Chlamydophila
           pneumoniae J138]
 ref|NP_444721.1| (NC_002179) conserved hypothetical protein [Chlamydophila
           pneumoniae AR39]
 sp|Q9Z7X5|ISPD_CHLPN 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||H72061 sugar nucleotide phosphorylase - Chlamydophila pneumoniae  (strains
           CWL029 and AR39)
 gb|AAD18718.1| (AE001642) Sugar Nucleotide Phosphorylase [Chlamydophila pneumoniae
           CWL029]
 gb|AAF38046.1| (AE002178) conserved hypothetical protein [Chlamydophila pneumoniae
           AR39]
 dbj|BAA98786.1| (AP002547) sugar nucleotide phosphorylase [Chlamydophila pneumoniae
           J138]
          Length = 211

 Score = 59.7 bits (143), Expect = 6e-08
 Identities = 45/162 (27%), Positives = 75/162 (45%), Gaps = 2/162 (1%)

Query: 35  QTSVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYI 94
           ++S++LL+ G+  RF   I KQ+L  N TPL L   +         E+I VV +  Y   
Sbjct: 3   KSSLILLSGGQGTRFGSKIPKQYLPLNGTPLVLHSLKILSSLPQIAEVI-VVCDPSYQET 61

Query: 95  KRHYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHY 154
            + YP +     G  RQ+SV + L+ +   + +  D AR     + + +L  T ++    
Sbjct: 62  FQEYP-VSFAIPGERRQDSVFSGLQQVSYPWVIIHDGARPFIYPDEIHDLLETAEKIGAT 120

Query: 155 CIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKALQSAL 196
            +A  +P           LDR+ + +I TPQ   T+ L+  L
Sbjct: 121 ALASPIPYTIKQRNPVRTLDRDNLAIIHTPQCIKTEILREGL 162
>ref|NP_297092.1| (NC_002620) conserved hypothetical protein [Chlamydia muridarum]
 sp|Q9PJV8|ISPF_CHLMU 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||E81672 conserved hypothetical protein TC0718 [imported] - Chlamydia
           muridarum (strain Nigg)
 gb|AAF39530.1| (AE002340) conserved hypothetical protein [Chlamydia muridarum]
          Length = 178

 Score = 58.9 bits (141), Expect = 1e-07
 Identities = 39/147 (26%), Positives = 72/147 (48%), Gaps = 4/147 (2%)

Query: 249 IGMGFDTHAFIKD---KPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGAIKGGDIGE 305
           +G+G D+H F+     KP VLGG++ +   G +A+SDGD + HA+ +A         +G 
Sbjct: 19  VGIGQDSHRFLPSDNPKPCVLGGIIFENTPGFEANSDGDVVFHAICNAFSSVTHQVILGA 78

Query: 306 WFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENLSQL 365
              D   K K  S   +       S     ++  +  TI  + PK+ P   A+ E ++++
Sbjct: 79  -LADELLKAKGISDSAVYLKEAVASLKPTQKISHLAITIEGQRPKLLPKISAMREKIAEI 137

Query: 366 LGLEKSQISLKATTMEKMGFIGKQEGL 392
           L +    +++ AT+ E +  +G+  G+
Sbjct: 138 LRISLDSVNITATSGEGLTSMGQGHGV 164
>ref|NP_349781.1| (NC_003030) 4-diphosphocytidyl-2-methylerithritol synthase (Sugar
           Nucleotide Phosphorylase family) [Clostridium
           acetobutylicum]
 sp|Q97EC9|ISPD_CLOAB 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 gb|AAK81121.1|AE007813_8 (AE007813) 4-diphosphocytidyl-2-methylerithritol synthase (Sugar
           Nucleotide Phosphorylase family) [Clostridium
           acetobutylicum]
          Length = 229

 Score = 56.6 bits (135), Expect = 5e-07
 Identities = 53/212 (25%), Positives = 94/212 (44%), Gaps = 16/212 (7%)

Query: 39  VLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSE------LDYI 92
           +++AAG   R      KQ++     P+     + F+ +    EII+V +E      +  I
Sbjct: 5   IIMAAGRGSRMKVNKNKQFILIQGKPILAYTIDKFQRSPLIDEIIIVAAESEINFCMQEI 64

Query: 93  YIKRHYPEIK-LVKGGASRQESVRNALKIIDSA-YTLTSDVARGLANIEALKNLFLTLQQ 150
             K  + ++K +V GG+ RQ+SV N LK + SA   L  D AR   + + ++N     ++
Sbjct: 65  VYKYKFNKVKNIVSGGSERQQSVMNGLKAVKSANIVLIHDGARPFVDNKIIENGIKYAEK 124

Query: 151 TSHYCIA----PYLPCYDTAIYYNEALDREAIKLIQTPQL----SHTKALQSALNQGDFK 202
                        +       +  + +DR  +  +QTPQ     S  KA  +A  +G   
Sbjct: 125 YGGAACGVQPKDTIKIKSEDGFSEKTIDRSKLFCVQTPQCFKYDSILKAHINAEKEGILA 184

Query: 203 DESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
            + + I +   ++V   +GS +  K+TT  DL
Sbjct: 185 TDDTMIFEMSGNKVYLYDGSYENLKITTPDDL 216
>ref|NP_229194.1| (NC_000853) conserved hypothetical protein [Thermotoga maritima]
 sp|Q9X1B3|ISPD_THEMA 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||B72259 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
 gb|AAD36464.1|AE001792_4 (AE001792) conserved hypothetical protein [Thermotoga maritima]
          Length = 222

 Score = 56.2 bits (134), Expect = 7e-07
 Identities = 50/208 (24%), Positives = 99/208 (47%), Gaps = 14/208 (6%)

Query: 39  VLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR-- 96
           +LLAAG+  R S+ + KQ+L      L+     +F ++     +++V     +  +++  
Sbjct: 5   ILLAAGKGERMSENVPKQFLEIEGRMLFEYPLSTFLKSEAIDGVVIVTRREWFEVVEKRV 64

Query: 97  -HYPEIKLVKGGASRQESVRNALKIIDS---AYTLTSDVARGLANIEALKNLFLTLQQTS 152
            H   + +V+GG +R +SVR+AL+ ++    +Y L  D AR     + +  +    ++T 
Sbjct: 65  FHEKVLGIVEGGDTRSQSVRSALEFLEKFSPSYVLVHDSARPFLRKKHVSEVLRRARETG 124

Query: 153 HYCIAPYLPCYDTAIYYN----EALDREAIKLIQTPQLSHTKALQSA-LNQGDFKDESSA 207
              +A  L   D  +       E + R+ +  I TPQ    + L+ A  N G++ D++  
Sbjct: 125 AATLA--LKNSDALVRVENDRIEYIPRKGVYRILTPQAFSYEILKKAHENGGEWADDTEP 182

Query: 208 ILQAFPDRVSYIEGSKDLHKLTTSGDLK 235
           + Q    +++ +EG     K+T   DL+
Sbjct: 183 V-QKLGVKIALVEGDPLCFKVTFKEDLE 209
>ref|NP_224743.1| (NC_000922) YgbB family hypothetical protein [Chlamydophila
           pneumoniae CWL029]
 ref|NP_300602.1| (NC_002491) YgbB family hypothetical protein [Chlamydophila
           pneumoniae J138]
 ref|NP_444756.1| (NC_002179) conserved hypothetical protein [Chlamydophila
           pneumoniae AR39]
 sp|Q9Z805|ISPF_CHLPN 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS)
           (MECDP-synthase)
 pir||D72065 conserved hypothetical protein CP0205 [imported] - Chlamydophila
           pneumoniae (strains CWL029 and AR39)
 gb|AAD18687.1| (AE001639) YgbB family hypothetical protein [Chlamydophila
           pneumoniae CWL029]
 gb|AAF38076.1| (AE002181) conserved hypothetical protein [Chlamydophila pneumoniae
           AR39]
 dbj|BAA98753.1| (AP002547) YgbB family hypothetical protein [Chlamydophila
           pneumoniae J138]
          Length = 176

 Score = 55.1 bits (131), Expect = 1e-06
 Identities = 42/150 (28%), Positives = 70/150 (46%), Gaps = 12/150 (8%)

Query: 250 GMGFDTHAFIKD---KPMVLGGVVLDCEFGLKAHSDGDALLHAVIDAILGA----IKGGD 302
           G+G D+H F+ +   KP +LGG++ D   G +A+SDGD + HA+ +AI       I G  
Sbjct: 19  GIGQDSHRFLPESSTKPCILGGIIFDHCPGFQANSDGDIIFHAICNAISSVTNKIILGKV 78

Query: 303 IGEWFPDNDPKYKNASSKELLKIVLDFSQSIGFELFEMGATIFSEIPKITPYKPAILENL 362
             E              +E LK     S     ++  +  TI    PK      A+ +N+
Sbjct: 79  ADELLQTRGITDSGIYLEEALK-----SLKPNQKISHVAITIEGSRPKFLCKLSALRQNI 133

Query: 363 SQLLGLEKSQISLKATTMEKMGFIGKQEGL 392
           +Q++ L  + I + AT+ E +   G  +G+
Sbjct: 134 AQVMNLTPTDIGITATSGEGLSDFGCGDGV 163
>ref|NP_297120.1| (NC_002620) conserved hypothetical protein [Chlamydia muridarum]
 sp|Q9PJT1|ISPD_CHLMU 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||C81669 conserved hypothetical protein TC0747 [imported] - Chlamydia
           muridarum (strain Nigg)
 gb|AAF39554.1| (AE002343) conserved hypothetical protein [Chlamydia muridarum]
          Length = 218

 Score = 54.3 bits (129), Expect = 3e-06
 Identities = 55/184 (29%), Positives = 79/184 (42%), Gaps = 23/184 (12%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR 96
           S+VLL  G   RF+    KQ+      PL L    S+ ++L F + I+VV E  Y  +  
Sbjct: 6   SLVLLGGGRGERFNSPQPKQYTPLCGEPLILHALHSY-QSLPFIQEIVVVCEEHYQELFS 64

Query: 97  HYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIE--------ALKNLFLTL 148
            Y  +K    GA RQ+SV + L+ +   +    D  R              ALK     L
Sbjct: 65  PY-SVKFASPGALRQDSVFSGLQQVSLPWVCVHDGVRPFVYANEVSEVCSAALKTGAAAL 123

Query: 149 QQTSHYCIAPYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKALQSAL---NQGDF--KD 203
             ++ Y I    P           LDR+A+ +I TPQ  +T+ L+  L   N  DF   D
Sbjct: 124 ATSATYTIKSRTPV--------RTLDRDAVAVIHTPQCINTEILKEGLLLANMMDFTLSD 175

Query: 204 ESSA 207
           +S A
Sbjct: 176 DSEA 179
>ref|NP_565286.1| (NM_126305) putative sugar nucleotide phosphorylase [Arabidopsis
           thaliana]
 gb|AAF61714.1|AF230737_1 (AF230737) 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Arabidopsis thaliana]
 dbj|BAB21592.1| (AB037876) 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase
           [Arabidopsis thaliana]
 gb|AAC18936.2| (AC004136) putative sugar nucleotide phosphorylase [Arabidopsis
           thaliana]
          Length = 302

 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 61/243 (25%), Positives = 105/243 (43%), Gaps = 21/243 (8%)

Query: 9   EAFKLSLESLEEDPFETKETLETLIKQTSVVLLAAGESRRFSQTIKKQWLRSNHTPLWLS 68
           +A  LS++      F+    +    K  SV+LLA G+ +R   ++ KQ++     P+ L 
Sbjct: 53  DALLLSIKCSSSTGFDNSNVV-VKEKSVSVILLAGGQGKRMKMSMPKQYIPLLGQPIALY 111

Query: 69  VYESFKEALDFKEIILVVSELDYIYIKRHYPE-----IKLVKGGASRQESVRNALKIID- 122
            + +F    + KEI+ VV +  +  I   Y E     ++    G  RQ+SV + L+ ID 
Sbjct: 112 SFFTFSRMPEVKEIV-VVCDPFFRDIFEEYEESIDVDLRFAIPGKERQDSVYSGLQEIDV 170

Query: 123 -SAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLPCYDTAIYYN------EALDR 175
            S      D AR L N E ++ +           +   +P   T    N      + LDR
Sbjct: 171 NSELVCIHDSARPLVNTEDVEKVLKDGSAVGAAVLG--VPAKATIKEVNSDSLVVKTLDR 228

Query: 176 EAIKLIQTPQLSHTKALQSAL----NQGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTS 231
           + +  +QTPQ+   + L+       ++G    +  +I++     V   +GS    K+TT 
Sbjct: 229 KTLWEMQTPQVIKPELLKKGFELVKSEGLEVTDDVSIVEYLKHPVYVSQGSYTNIKVTTP 288

Query: 232 GDL 234
            DL
Sbjct: 289 DDL 291
>ref|NP_219975.1| (NC_000117) Sugar Nucleotide Phosphorylase [Chlamydia trachomatis]
 sp|O84468|ISPD_CHLTR 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||B71511 probable sugar nucleotide phosphorylase - Chlamydia trachomatis
           (serotype D, strain UW3/Cx)
 gb|AAC68062.1| (AE001320) Sugar Nucleotide Phosphorylase [Chlamydia trachomatis]
          Length = 219

 Score = 50.8 bits (120), Expect = 3e-05
 Identities = 41/160 (25%), Positives = 71/160 (43%), Gaps = 2/160 (1%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR 96
           S+VLL  G+  RF+    KQ+      PL L    ++ + L F + ++VV E  Y  +  
Sbjct: 6   SLVLLGGGKGERFNSLQPKQYTHLCGEPLILHALHAY-QRLPFVQEVVVVCEEQYRELFL 64

Query: 97  HYPEIKLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCI 156
            Y  +K    G  RQ+SV + L+ + + +    D  R     + +  +    ++T    +
Sbjct: 65  PY-SVKFASPGTLRQDSVFSGLQQVSTPWVCIHDGVRPFVYADEVIEVCSAARKTGAAAL 123

Query: 157 APYLPCYDTAIYYNEALDREAIKLIQTPQLSHTKALQSAL 196
           A        +      LDR+A+ +I TPQ   T+ L+  L
Sbjct: 124 ASPATYTIKSCAPVRTLDRDALAVIHTPQCLDTEVLREGL 163
>ref|NP_240973.1| (NC_002570) BH0107~unknown conserved protein [Bacillus halodurans]
 sp|Q9KGF8|ISPD_BACHD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 dbj|BAB03826.1| (AP001507) BH0107~unknown conserved protein [Bacillus halodurans]
          Length = 228

 Score = 50.1 bits (118), Expect = 5e-05
 Identities = 56/214 (26%), Positives = 92/214 (42%), Gaps = 18/214 (8%)

Query: 37  SVVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYI---Y 93
           SVV+ AAG+ +R      KQ++     P+       F++      +++V +E +      
Sbjct: 4   SVVIPAAGQGKRMRAGHNKQFIELGGKPILAHTLAVFEQDDWCTNVVIVANEQEIEEMGE 63

Query: 94  IKRHY---PEIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQ 149
           +   Y      K+V GG  RQESV   LK +      L  D AR     + + +L  T  
Sbjct: 64  LANRYQISKAKKIVAGGRERQESVFAGLKALSQDGLVLIHDGARPFVTEKEIHSLVETAA 123

Query: 150 QTSHYCIAPYLPCYDTAIYYN-----EALDREAIKLIQTPQLSH----TKALQSALNQGD 200
           +T    +A  +P  DT          E + RE +  +QTPQ        +A Q A N+  
Sbjct: 124 KTHAAVLA--VPVKDTIKRVEGEAVLETMPREELWAVQTPQAFDLALIKQAHQKAENEQM 181

Query: 201 FKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
              + +++++     V+ ++GS    KLTT  DL
Sbjct: 182 LGTDDASLMEWLGYSVAVVQGSYFNFKLTTPEDL 215
>ref|NP_438832.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 sp|O05029|ISPD_HAEIN 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||G64156 hypothetical protein HI0672 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC22332.1| (U32750) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 225

 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 65/211 (30%), Positives = 89/211 (41%), Gaps = 20/211 (9%)

Query: 39  VLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELD-YIYIKRH 97
           VL AAG   R      KQ+L      L     +         +IIL VS+ D YI     
Sbjct: 8   VLPAAGVGSRMQADKPKQYLTLLGKTLLEHTLDVMLSYPAVSKIILAVSKDDPYISTLSL 67

Query: 98  YPEIKLVKGGASRQESVRNALKII--DSAYTLTSDVARGLANIEALKNLFLTLQQTSHYC 155
            P+I+LV+GG +R ESV N L  I   +A+ L  D AR       +  L L ++      
Sbjct: 68  DPKIQLVEGGTTRAESVLNGLNAIAEKNAWVLVHDAARPCLQHADIDKL-LAIEDKQGAI 126

Query: 156 IAPYLPCYDTAIYYN------EALDREAIKLIQTPQLSHTKALQSALNQG-----DFKDE 204
           +A  +P  DT    +      +  DR  +    TPQ      L+ AL+ G     +  DE
Sbjct: 127 LA--IPVTDTIKRADNQQCIVKTEDRSQLWQAMTPQFFPVDILRDALSTGIQQGANITDE 184

Query: 205 SSAI-LQAFPDRVSYIEGSKDLHKLTTSGDL 234
           +SAI L  F  R   + G  D  K+T   DL
Sbjct: 185 ASAIELAGF--RPHLVAGRSDNLKVTRPEDL 213
>ref|NP_289296.1| (NC_002655) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 ref|NP_311628.1| (NC_002695) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Escherichia coli O157:H7]
 sp|Q8X7Y4|ISPD_ECO57 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT) (CDP-ME synthetase)
 gb|AAG57854.1|AE005502_8 (AE005502) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 dbj|BAB37024.1| (AP002562) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Escherichia coli O157:H7]
          Length = 236

 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 62/214 (28%), Positives = 91/214 (41%), Gaps = 22/214 (10%)

Query: 39  VLLAAGESRRFSQTIKKQWLR-SNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIK-- 95
           V+ AAG  RR      KQ+L   N T L  SVY         K +++ +S  D  + +  
Sbjct: 11  VVPAAGFGRRMQTECPKQYLSIGNQTILEHSVYALLAHPR-VKRVVIAISPGDSRFAQLP 69

Query: 96  -RHYPEIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQQTSH 153
             ++P+I +V GG  R +SV   LK   D+ + L  D AR   + + L  L L L +TS 
Sbjct: 70  LANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARL-LALSETSR 128

Query: 154 YCIAPYLPCYDT---------AIYYNEALDREAIKLIQTPQLSHTKALQS----ALNQGD 200
                  P  DT         AI +   +DR  +    TPQ    + L      ALN+G 
Sbjct: 129 TGGILAAPVRDTMKRAEPGKNAIAH--TVDRNGLWHALTPQFFPRELLHDCLTRALNEGA 186

Query: 201 FKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
              + ++ L+        +EG  D  K+T   DL
Sbjct: 187 AITDEASALEYCGFHPQLVEGRADNIKVTRPEDL 220
>ref|NP_246547.1| (NC_002663) unknown [Pasteurella multocida]
 sp|P57953|ISPD_PASMU 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 gb|AAK03692.1| (AE006198) unknown [Pasteurella multocida]
          Length = 238

 Score = 48.5 bits (114), Expect = 1e-04
 Identities = 62/216 (28%), Positives = 91/216 (41%), Gaps = 25/216 (11%)

Query: 39  VLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKR-- 96
           V+ AAG   R      KQ+L  +   +              ++IIL V+  D  YI    
Sbjct: 15  VVPAAGIGSRMQMDKPKQYLHIHGKTILEHTLSVLLGYPLIEKIILAVAANDP-YISTCP 73

Query: 97  --HYPEIKLVKGGASRQESVRNALKIIDSA-------YTLTSDVARGLANIEALKNLFLT 147
              +P+I+LV+GG+SR +SV N L  + SA       + +  D AR     + L  L   
Sbjct: 74  LLTHPKIQLVEGGSSRADSVLNGLNAVKSAVQNSEDFWVMVHDAARPCLTHQDLDKLVQV 133

Query: 148 LQQTSHYCIAPYL-----PCYDTAIYYNEALDREAIKLIQTPQL----SHTKALQSALNQ 198
             Q       P         ++  I+Y E  DR  + L QTPQ     +  +AL+ AL Q
Sbjct: 134 EDQNGAILAIPATDTIKRALHNQQIHYTE--DRSQLWLAQTPQFFPIATLAQALEQALAQ 191

Query: 199 G-DFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGD 233
           G    DE+SA ++    R   + G  D  K+T   D
Sbjct: 192 GLQVTDEASA-MEFAGFRPHLVAGRSDNIKVTRPED 226
>ref|NP_417227.1| (NC_000913) orf, hypothetical protein [Escherichia coli K12]
 sp|Q46893|ISPD_ECOLI 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT) (CDP-ME synthetase)
 pir||G65055 hypothetical protein b2747 - Escherichia coli (strain K-12)
 pdb|1INI|A Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C-
           Methylerythritol (Cdp-Me) Synthetase (Ygbp) Involved In
           Mevalonate Independent Isoprenoid Biosynthesis,
           Complexed With Cdp-Me And Mg2+
 pdb|1I52|A Chain A, Crystal Structure Of 4-Diphosphocytidyl-2-C-
           Methylerythritol (Cdp-Me) Synthase (Ygbp) Involved In
           Mevalonate Independent Isoprenoid Biosynthesis
 pdb|1INJ|A Chain A, Crystal Structure Of The Apo Form Of
           4-Diphosphocytidyl-2-C- Methylerythritol (Cdp-Me)
           Synthetase (Ygbp) Involved In Mevalonate Independent
           Isoprenoid Biosynthesis
 gb|AAA69257.1| (U29579) ORF_f236 [Escherichia coli]
 gb|AAC75789.1| (AE000358) orf, hypothetical protein [Escherichia coli K12]
 dbj|BAA90761.1| (AB037143) 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           [Escherichia coli]
 gb|AAF43207.1|AF230736_1 (AF230736) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Escherichia coli]
          Length = 236

 Score = 47.0 bits (110), Expect = 4e-04
 Identities = 61/214 (28%), Positives = 91/214 (42%), Gaps = 22/214 (10%)

Query: 39  VLLAAGESRRFSQTIKKQWLR-SNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIK-- 95
           V+ AAG  RR      KQ+L   N T L  SV+         K +++ +S  D  + +  
Sbjct: 11  VVPAAGFGRRMQTECPKQYLSIGNQTILEHSVHALLAHPR-VKRVVIAISPGDSRFAQLP 69

Query: 96  -RHYPEIKLVKGGASRQESVRNALKII-DSAYTLTSDVARGLANIEALKNLFLTLQQTSH 153
             ++P+I +V GG  R +SV   LK   D+ + L  D AR   + + L  L L L +TS 
Sbjct: 70  LANHPQITVVDGGDERADSVLAGLKAAGDAQWVLVHDAARPCLHQDDLARL-LALSETSR 128

Query: 154 YCIAPYLPCYDT---------AIYYNEALDREAIKLIQTPQLSHTKALQS----ALNQGD 200
                  P  DT         AI +   +DR  +    TPQ    + L      ALN+G 
Sbjct: 129 TGGILAAPVRDTMKRAEPGKNAIAH--TVDRNGLWHALTPQFFPRELLHDCLTRALNEGA 186

Query: 201 FKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
              + ++ L+        +EG  D  K+T   DL
Sbjct: 187 TITDEASALEYCGFHPQLVEGRADNIKVTRPEDL 220
>ref|NP_296323.1| (NC_001263) conserved hypothetical protein [Deinococcus
           radiodurans]
 sp|Q9RR90|ISPD_DEIRA 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 pir||D75254 conserved hypothetical protein - Deinococcus radiodurans  (strain
           R1)
 gb|AAF12141.1|AE002089_4 (AE002089) conserved hypothetical protein [Deinococcus radiodurans]
          Length = 232

 Score = 44.3 bits (103), Expect = 0.003
 Identities = 37/142 (26%), Positives = 62/142 (43%), Gaps = 11/142 (7%)

Query: 102 KLVKGGASRQESVRNALKIIDSAYTLTSDVARGLANIEALKNLFLTLQQTSHYCIAPYLP 161
           + + GG +RQ SVR  L+  ++   L  D AR       +  L   +  T    +A  LP
Sbjct: 71  RAIVGGETRQGSVRRLLEATEAGTVLIHDAARPFVPPPVILALLDAIAATGAATVA--LP 128

Query: 162 CYDTAI-----YYNEALDREAIKLIQTPQLSHTKALQSALNQGDFKD----ESSAILQAF 212
             DT +      + + + RE +  +QTPQ    + L  A  + + +     + + +L   
Sbjct: 129 VADTLVRAEGQSWGQLVPREGLWAVQTPQGFRRELLLQAHARAEAEQYAATDDAGLLARL 188

Query: 213 PDRVSYIEGSKDLHKLTTSGDL 234
             +V  + G   L K+TT GDL
Sbjct: 189 GVQVRLVPGDARLFKVTTPGDL 210
>ref|NP_489207.1| (NC_003272) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Nostoc sp. PCC 7120]
 sp|Q8YLX9|ISPD_ANASP 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
           (4-diphosphocytidyl-2C-methyl-D-erythritol synthase)
           (MEP cytidylyltransferase) (MCT)
 dbj|BAB76866.1| (AP003598) 4-diphosphocytidyl-2C-methyl-D-erythritol synthase
           [Nostoc sp. PCC 7120]
          Length = 228

 Score = 43.9 bits (102), Expect = 0.003
 Identities = 55/217 (25%), Positives = 90/217 (41%), Gaps = 24/217 (11%)

Query: 38  VVLLAAGESRRFSQTIKKQWLRSNHTPLWLSVYESFKEALDFKEIILVVSELDYIYIKRH 97
           +++ AAG  +R      K  L     P+      + + A +   I ++    D+   K  
Sbjct: 3   LLIPAAGVGKRMGCDRNKLLLEVRSQPIIAWTLLAAQAASEISWIGIISQPTDWPDFKSI 62

Query: 98  YPEIKLVK------GGASRQESVRNALKIIDSA--YTLTSDVARGLANIEALKNLFLTLQ 149
              ++L K      GG++RQESV N L+ + +A    L  D AR LA      NL  +  
Sbjct: 63  LANLQLTKPVEFILGGSTRQESVYNGLQALPTAAEQVLIHDGARCLAT----PNLLNSCA 118

Query: 150 QTSHYC--IAPYLPCYDTAIYYNE------ALDREAIKLIQTPQLSHTKALQ----SALN 197
           Q   +C  +   +P  DT    +E        DR  +   QTPQ  + + L+      + 
Sbjct: 119 QAIRHCSGLIAAVPVKDTIKVVDEDGIIQNTPDRRNLWAAQTPQGFNVELLKQCHAEGVR 178

Query: 198 QGDFKDESSAILQAFPDRVSYIEGSKDLHKLTTSGDL 234
           QG    + +A+ +     V  +EG +   K+TT  DL
Sbjct: 179 QGWEVTDDAALFEKCGIEVQIVEGEETNLKVTTPQDL 215
  Database: /home/scwang/download_20020708_db/nr
    Posted date:  Aug 7, 2002 12:55 PM
  Number of letters in database: 324,149,939
  Number of sequences in database:  1,026,957
  
Lambda     K      H
   0.318    0.136    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 239,119,228
Number of Sequences: 1026957
Number of extensions: 9732512
Number of successful extensions: 25063
Number of sequences better than 1.0e-02: 81
Number of HSP's better than  0.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 24957
Number of HSP's gapped (non-prelim): 83
length of query: 406
length of database: 324,149,939
effective HSP length: 123
effective length of query: 283
effective length of database: 197,834,228
effective search space: 55987086524
effective search space used: 55987086524
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 98 (42.4 bits)