BLASTP 2.2.1 [Apr-13-2001]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15645873|ref|NP_208051.1| conserved hypothetical
protein [Helicobacter pylori 26695]
(205 letters)
Database: /home/scwang/download_20020708_db/nr
1,026,957 sequences; 324,149,939 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_208051.1| (NC_000915) conserved hypothetical protein... 418 e-116
ref|NP_223898.1| (NC_000921) putative [Helicobacter pylori ... 394 e-109
gb|AAC70895.1| (AF006830) unknown [Actinobacillus actinomyc... 175 2e-43
ref|NP_231150.1| (NC_002505) nicotinate mononucleotide:5,6-... 132 2e-30
ref|NP_245930.1| (NC_002663) unknown [Pasteurella multocida... 131 5e-30
ref|NP_405211.1| (NC_003143) putative Sir2 family protein [... 125 2e-28
ref|NP_623170.1| (NC_003869) NAD-dependent protein deacetyl... 119 3e-26
ref|NP_460191.1| (NC_003197) putative nicotinate-nucleotide... 116 2e-25
ref|NP_455713.1| (NC_003198) putative regulatory protein [S... 116 2e-25
ref|NP_578883.1| (NC_003413) transcriptional regulatory pro... 115 3e-25
ref|NP_287254.1| (NC_002655) putative nicotinic acid mononu... 115 4e-25
ref|NP_070504.1| (NC_000917) transcriptional regulatory pro... 115 4e-25
pdb|1ICI|A Chain A, Crystal Structure Of A Sir2 Homolog-Nad... 115 4e-25
ref|NP_415638.1| (NC_000913) putative nicotinic acid mononu... 115 4e-25
gb|AAC78722.1| (U89687) putative nicotinic acid mononucleot... 114 5e-25
gb|AAF77189.1|AF264911_5 (AF264911) putative transferase [C... 111 4e-24
ref|NP_282200.1| (NC_002163) putative transferase [Campylob... 110 8e-24
ref|NP_215667.1| (NC_000962) hypothetical protein Rv1151c [... 110 1e-23
ref|NP_142870.1| (NC_000961) hypothetical protein [Pyrococc... 110 1e-23
ref|NP_422274.1| (NC_002696) transcriptional regulator, Sir... 108 3e-23
ref|NP_214488.1| (NC_000918) hypothetical protein [Aquifex ... 108 3e-23
ref|NP_302058.1| (NC_002677) conserved hypothetical protein... 107 6e-23
ref|NP_343825.1| (NC_002754) Transcriptional regulatory pro... 105 2e-22
ref|NP_614358.1| (NC_003551) NAD-dependent protein deacetyl... 105 3e-22
ref|NP_148161.1| (NC_000854) hypothetical protein [Aeropyru... 103 9e-22
ref|NP_126882.1| (NC_000868) transcriptional regulatory pro... 100 8e-21
ref|NP_068953.1| (NC_000917) transcriptional regulatory pro... 99 2e-20
ref|NP_376522.1| (NC_003106) 284aa long conserved hypotheti... 99 3e-20
ref|NP_293742.1| (NC_001263) conserved hypothetical protein... 97 9e-20
ref|NP_249816.1| (NC_002516) probable cobalamin biosyntheti... 96 3e-19
ref|NP_519351.1| (NC_003295) CONSERVED HYPOTHETICAL PROTEIN... 92 3e-18
ref|NP_599877.1| (NC_003450) COG0846:NAD-dependent protein ... 92 5e-18
ref|NP_560781.1| (NC_003364) conserved hypothetical protein... 92 5e-18
ref|NP_228300.1| (NC_000853) regulatory protein, SIR2 famil... 89 4e-17
ref|NP_560385.1| (NC_003364) conserved hypothetical protein... 87 2e-16
ref|NP_466261.1| (NC_003210) similar to regulatory proteins... 86 2e-16
ref|NP_472210.1| (NC_003212) similar to regulatory proteins... 86 3e-16
ref|NP_036373.1| (NM_012241) sirtuin 5, isoform 1; sir2-lik... 82 5e-15
ref|NP_112534.1| (NM_031244) sirtuin 5, isoform 2; sir2-lik... 82 5e-15
ref|XP_127299.1| (XM_127299) expressed sequence AV001953 [M... 80 1e-14
ref|NP_346925.1| (NC_003030) Transcriptional regulatory pro... 75 5e-13
ref|NP_604082.1| (NC_003454) SIR2 family protein [Fusobacte... 75 6e-13
ref|NP_656954.1| (NC_003995) sir2, Catalytic domain of the ... 75 6e-13
gb|AAA67853.1| (M32103) ORF-27 [Staphylococcus aureus] 74 8e-13
ref|NP_388846.1| (NC_000964) similar to hypothetical protei... 74 1e-12
ref|NP_372721.1| (NC_002758) hypothetical protein [Staphylo... 73 2e-12
ref|NP_561172.1| (NC_003366) probable transcriptional regul... 70 2e-11
ref|NP_646940.1| (NC_003923) ORFID:MW2123~hypothetical prot... 69 3e-11
ref|NP_623330.1| (NC_003869) NAD-dependent protein deacetyl... 66 3e-10
gb|EAA06047.1| (AAAB01008844) ebiP5574 [Anopheles gambiae s... 66 3e-10
ref|NP_241773.1| (NC_002570) transcriptional regulator [Bac... 64 8e-10
ref|NP_635701.1| (NC_003902) SIR2-like regulatory protein [... 63 2e-09
ref|NP_568207.1| (NM_120959) SIR2-family protein [Arabidops... 63 2e-09
emb|CAC05449.1| (AL391712) SIR2-family protein [Arabidopsis... 62 3e-09
ref|NP_640676.1| (NC_003919) SIR2-like regulatory protein [... 61 7e-09
pir||T35951 probable SIR2 family transcription regulator - ... 59 3e-08
dbj|BAB97472.1| (AP005274) NAD-dependent protein deacetylas... 59 4e-08
ref|NP_624772.1| (NC_003888) putative SIR2-like regulatory ... 57 2e-07
ref|NP_036372.1| (NM_012240) sirtuin 4; sirtuin (silent mat... 54 8e-07
ref|XP_132353.1| (XM_132353) RIKEN cDNA 4930596O17 [Mus mus... 54 1e-06
gb|AAH22653.1| (BC022653) Unknown (protein for IMAGE:421918... 54 1e-06
ref|NP_249888.1| (NC_002516) hypothetical protein [Pseudomo... 51 7e-06
gb|AAB95634.1| (AC003982) unknown function; 60% similar to ... 49 3e-05
ref|NP_062786.1| (NM_019812) sirtuin 1 ((silent mating type... 48 8e-05
pir||T18247 transcription regulatory protein - yeast (Candi... 48 8e-05
gb|AAC73004.1| (AF102869) Sir2 homolog [Trypanosoma brucei] 47 1e-04
ref|NP_036370.2| (NM_012238) sirtuin 1; sirtuin (silent mat... 47 1e-04
emb|CAC04174.1| (AL133551) bA57G10.4 (SIRT1, Sir2-like prot... 47 1e-04
ref|NP_650880.1| (NM_142623) CG5085 gene product [Drosophil... 46 2e-04
dbj|BAB29128.1| (AK014042) data source:MGD, source key:MGI:... 46 2e-04
gb|AAH21439.1|AAH21439 (BC021439) sirtuin 2 (silent mating ... 46 2e-04
ref|NP_071877.1| (NM_022432) silent mating type information... 46 2e-04
gb|AAG22161.1| (AE003730) CG5085 gene product [Drosophila m... 46 2e-04
ref|NP_501912.1| (NM_069511) Yeast regulatory protein SIR2 ... 46 3e-04
ref|NP_200387.1| (NM_124958) transcription regulator Sir2-l... 45 4e-04
ref|NP_510220.1| (NM_077819) SIR [Caenorhabditis elegans] >... 45 4e-04
ref|NP_071878.1| (NM_022433) sirtuin 3; silent mating type ... 45 5e-04
gb|EAA07580.1| (AAAB01008859) agCP1456 [Anopheles gambiae s... 45 5e-04
gb|AAD42226.1|AF159133_1 (AF159133) SIR2-like protein [Oryz... 45 5e-04
sp|O59923|SIR2_CANAL NAD-dependent histone deacetylase SIR2... 45 5e-04
ref|NP_085096.1| (NM_030593) sirtuin 2, isoform 2; SIR2 (si... 45 7e-04
pdb|1J8F|C Chain C, Human Sirt2 Histone Deacetylase 45 7e-04
pdb|1J8F|A Chain A, Human Sirt2 Histone Deacetylase >gi|158... 45 7e-04
ref|NP_036369.2| (NM_012237) sirtuin 2, isoform 1; SIR2 (si... 45 7e-04
gb|AAF46055.1| (AE003435) CG3187 gene product [Drosophila m... 45 7e-04
ref|XP_125746.1| (XM_125746) RIKEN cDNA 2810449N18 [Mus mus... 44 9e-04
gb|AAK67144.1|AF384034_1 (AF384034) SIR2-like histone deace... 43 0.003
gb|AAG32038.1| (AF302272) SIR2L2 [Mus musculus] 42 0.003
ref|NP_510219.1| (NM_077818) SIR [Caenorhabditis elegans] >... 42 0.004
>ref|NP_208051.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
26695]
pir||C64677 conserved hypothetical protein HP1259 - Helicobacter pylori
(strain 26695)
gb|AAD08305.1| (AE000631) conserved hypothetical protein [Helicobacter pylori
26695]
Length = 205
Score = 418 bits (1074), Expect = e-116
Identities = 205/205 (100%), Positives = 205/205 (100%)
Query: 1 MACGKGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNII 60
MACGKGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNII
Sbjct: 1 MACGKGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNII 60
Query: 61 TQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVW 120
TQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVW
Sbjct: 61 TQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVW 120
Query: 121 FGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQ 180
FGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQ
Sbjct: 121 FGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQ 180
Query: 181 NVQCINESAVHAMQDLMPKLIEMAS 205
NVQCINESAVHAMQDLMPKLIEMAS
Sbjct: 181 NVQCINESAVHAMQDLMPKLIEMAS 205
>ref|NP_223898.1| (NC_000921) putative [Helicobacter pylori J99]
pir||A71838 hypothetical protein jhp1180 - Helicobacter pylori (strain J99)
gb|AAD06766.1| (AE001545) putative [Helicobacter pylori J99]
Length = 234
Score = 394 bits (1011), Expect = e-109
Identities = 192/201 (95%), Positives = 198/201 (97%)
Query: 5 KGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNV 64
+GHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNV
Sbjct: 29 EGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNV 88
Query: 65 DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEA 124
DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLA+DK+QLRPDIVWFGE
Sbjct: 89 DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAQDKAQLRPDIVWFGEE 148
Query: 125 VPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQC 184
VPLLKEA+SLVKQ HLLIIIGTSLQVYPAASLYTHA+KDALIYYIDPKAKNA LPQNVQC
Sbjct: 149 VPLLKEAVSLVKQVHLLIIIGTSLQVYPAASLYTHANKDALIYYIDPKAKNARLPQNVQC 208
Query: 185 INESAVHAMQDLMPKLIEMAS 205
INE+AVHAMQDLMPKLIEMAS
Sbjct: 209 INENAVHAMQDLMPKLIEMAS 229
>gb|AAC70895.1| (AF006830) unknown [Actinobacillus actinomycetemcomitans]
Length = 208
Score = 175 bits (444), Expect = 2e-43
Identities = 89/174 (51%), Positives = 115/174 (65%)
Query: 6 GHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVD 65
GH I +V +P ++N ++VL FYN+RRR E PN AHK L ELE+ Y V IITQNV+
Sbjct: 31 GHKIEDVCTPEALQRNRKQVLAFYNERRRNCAEAKPNAAHKVLVELERSYNVQIITQNVE 90
Query: 66 DLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAV 125
DLHERAGS+ +LHLHGEL RS DP+ + D ++ D + +RP IV+FGE+V
Sbjct: 91 DLHERAGSTNVLHLHGELTKARSSFDPDYIVPCMGDQSVNDKDPNGHPMRPHIVFFGESV 150
Query: 126 PLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLP 179
P+L+ AI LV QA ++++IGTSLQVYPA L A K+A IY IDP P
Sbjct: 151 PVLEPAIDLVSQADIVLVIGTSLQVYPANGLVNEAPKNAQIYLIDPNPNTGFNP 204
>ref|NP_231150.1| (NC_002505) nicotinate mononucleotide:5,6-dimethylbenzimidazole
phosphoribosyltransferase [Vibrio cholerae]
pir||E82191 probable nicotinate-nucleotide--dimethylbenzimidazole
phosphoribosyltransferase (EC 2.4.2.21) VC1509
[imported] - Vibrio cholerae (group O1 strain N16961)
gb|AAF94664.1| (AE004229) nicotinate mononucleotide:5,6-dimethylbenzimidazole
phosphoribosyltransferase [Vibrio cholerae]
Length = 259
Score = 132 bits (333), Expect = 2e-30
Identities = 73/157 (46%), Positives = 102/157 (64%), Gaps = 8/157 (5%)
Query: 5 KGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFE--VYPNKAHKALAELEKHYQ--VNII 60
+ H I +VA+P G++++P VL+FYNQRRR+L + PN AH AL +LEK Q V +I
Sbjct: 46 ENHRIEDVATPEGFQRDPDMVLEFYNQRRRKLLSDAIQPNPAHLALGKLEKELQGSVTVI 105
Query: 61 TQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDL---AKDKSQLRPD 117
TQN+D+LHER GS I+H+HGELL R + N ++D+ GDL + +Q+RP
Sbjct: 106 TQNIDNLHERGGSQNIIHMHGELLKARC-PESNQTVEQKEDIRHGDLCHCCQMPAQMRPH 164
Query: 118 IVWFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAA 154
IVWFGE + + + ++QA L + IGTS VYPAA
Sbjct: 165 IVWFGEMPLRMGDIYAALEQADLFVSIGTSGVVYPAA 201
>ref|NP_245930.1| (NC_002663) unknown [Pasteurella multocida]
gb|AAK03077.1| (AE006138) unknown [Pasteurella multocida]
Length = 234
Score = 131 bits (329), Expect = 5e-30
Identities = 83/171 (48%), Positives = 108/171 (62%), Gaps = 14/171 (8%)
Query: 5 KGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHYQVN--II 60
+ H + EVA+P G+ +NP+ V FYN+RR+QLF ++ PN AH ALAELEK N I+
Sbjct: 32 ENHPVDEVATPEGFARNPKLVQRFYNERRKQLFSDQIAPNAAHFALAELEKKLGDNLLIV 91
Query: 61 TQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD--LAKDKSQ-LRPD 117
TQNVD+LHERAGS ++H+HGELL VR K +Y W+ D+ D L +Q LRP
Sbjct: 92 TQNVDNLHERAGSKNLIHMHGELLKVRCVKS-GKIYDWQGDIGEHDKCLCCTPTQILRPH 150
Query: 118 IVWFGEAVPLLKEAI-SLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIY 167
IVWFGE +PL E I + + + I IGTS VYPAA ++AL Y
Sbjct: 151 IVWFGE-MPLEMEKIQTALSECDYFISIGTSGNVYPAAGFV----REALFY 196
>ref|NP_405211.1| (NC_003143) putative Sir2 family protein [Yersinia pestis]
emb|CAC90452.1| (AJ414149) putative Sir2 family protein [Yersinia pestis]
Length = 278
Score = 125 bits (315), Expect = 2e-28
Identities = 72/162 (44%), Positives = 100/162 (61%), Gaps = 8/162 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFE--VYPNKAHKALAELEKHYQVNI--ITQ 62
H + +VA+P G++++P+ V FYN+RRRQL + + PN AH ALA+LE N+ ITQ
Sbjct: 68 HRVEDVATPEGYRRDPELVQRFYNERRRQLQQPDIAPNAAHFALADLEAVLGDNLVLITQ 127
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAGS R++H+HGELL VR + V W+ DL+ + + S LRP IV
Sbjct: 128 NIDNLHERAGSKRVIHMHGELLKVRCTQS-GQVLDWQGDLSADERCHCCQFPSPLRPHIV 186
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAH 161
WFGE + + + +A I IGTS VYPAA +H
Sbjct: 187 WFGEMPMGMDDIYQALAEADFFISIGTSGHVYPAAGFVHESH 228
>ref|NP_623170.1| (NC_003869) NAD-dependent protein deacetylases, Sir2 family
[Thermoanaerobacter tengcongensis]
gb|AAM24774.1| (AE013113) NAD-dependent protein deacetylases, Sir2 family
[Thermoanaerobacter tengcongensis]
Length = 242
Score = 119 bits (297), Expect = 3e-26
Identities = 72/184 (39%), Positives = 111/184 (60%), Gaps = 10/184 (5%)
Query: 5 KGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQ-VNIITQN 63
K ++ E+A+P+ +++NP V ++Y+ RRR + + PNK H +AE E+ ++ V +ITQN
Sbjct: 41 KKYNPEELATPWAFQRNPALVWEWYDYRRRIISKAKPNKCHLLIAEFEERFKNVRVITQN 100
Query: 64 VDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNL--GDLAKDKSQLRPDIVWF 121
VD LHE AGS+ ++ LHG + V+ K E L+ + K S +RPD+VWF
Sbjct: 101 VDGLHEAAGSTNVIELHGNIWKVKCTKCDFRGINREVPLSKIPPECPKCGSIVRPDVVWF 160
Query: 122 GEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASL-YTHAHKDALIYYIDPK----AK 174
GE +P L EA+ L ++A L I+IGTSL V PAASL + + A + + P+ ++
Sbjct: 161 GEPLPSDKLTEAMELSQRADLFIVIGTSLMVQPAASLPFLALERGAFVVEVSPEETPLSR 220
Query: 175 NAHL 178
AHL
Sbjct: 221 KAHL 224
>ref|NP_460191.1| (NC_003197) putative nicotinate-nucleotide
dimethylbenzimidazolephosphoribosltransferase, homolog
of virulence factor [Salmonella typhimurium LT2]
sp|P97013|COBB_SALTY CobB protein
gb|AAL20150.1| (AE008753) putative nicotinate-nucleotide
dimethylbenzimidazolephosphoribosltransferase, homolog
of virulence factor [Salmonella typhimurium LT2]
Length = 273
Score = 116 bits (290), Expect = 2e-25
Identities = 68/161 (42%), Positives = 95/161 (58%), Gaps = 8/161 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHY--QVNIITQ 62
H + +VA+P G+ +NP V FYN RR+QL E+ PN AH ALA+LE+ + ++TQ
Sbjct: 70 HRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQPNAAHLALAKLEEALGDRFLLVTQ 129
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAG+ I+H+HGELL VR + ++ W D+ D + + LRP +V
Sbjct: 130 NIDNLHERAGNRNIIHMHGELLKVRCSQSGQIL-EWNGDVMPEDKCHCCQFPAPLRPHVV 188
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
WFGE + E + A + I IGTS VYPAA A
Sbjct: 189 WFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 229
>ref|NP_455713.1| (NC_003198) putative regulatory protein [Salmonella enterica subsp.
enterica serovar Typhi]
emb|CAD08345.1| (AL627269) putative regulatory protein [Salmonella enterica subsp.
enterica serovar Typhi]
Length = 237
Score = 116 bits (290), Expect = 2e-25
Identities = 68/161 (42%), Positives = 95/161 (58%), Gaps = 8/161 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHY--QVNIITQ 62
H + +VA+P G+ +NP V FYN RR+QL E+ PN AH ALA+LE+ + ++TQ
Sbjct: 34 HRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQPNAAHLALAKLEEALGDRFLLVTQ 93
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAG+ I+H+HGELL VR + ++ W D+ D + + LRP +V
Sbjct: 94 NIDNLHERAGNRNIIHMHGELLKVRCSQSGQIL-EWNGDVMPEDKCHCCQFPAPLRPHVV 152
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
WFGE + E + A + I IGTS VYPAA A
Sbjct: 153 WFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 193
>ref|NP_578883.1| (NC_003413) transcriptional regulatory protein, sir2 [Pyrococcus
furiosus DSM 3638]
gb|AAL81278.1| (AE010224) transcriptional regulatory protein, sir2 [Pyrococcus
furiosus DSM 3638]
Length = 297
Score = 115 bits (288), Expect = 3e-25
Identities = 68/154 (44%), Positives = 92/154 (59%), Gaps = 10/154 (6%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P +K++P+ V +FY R +++ E PN AH ALAELEK + +ITQNVDDLH
Sbjct: 93 ELATPEAFKRDPKLVWEFYKWRIKKILEAKPNPAHIALAELEKMGIIKAVITQNVDDLHR 152
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKD-------LNLGDLAKDKSQLRPDIVWFG 122
AGS ++ LHG + V+ Y E D L K S LRPD+VWFG
Sbjct: 153 EAGSKNVIELHGNIFRVKCTSCSYREYLKESDRIGWLLSQELPRCPKCGSLLRPDVVWFG 212
Query: 123 EAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAA 154
EA+P L A SL K+A +++++GTS VYPAA
Sbjct: 213 EALPEKELTTAFSLAKKADVVLVVGTSGVVYPAA 246
>ref|NP_287254.1| (NC_002655) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli O157:H7
EDL933]
ref|NP_309525.1| (NC_002695) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli O157:H7]
gb|AAG55866.1|AE005321_9 (AE005321) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli O157:H7
EDL933]
dbj|BAB34921.1| (AP002555) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli O157:H7]
Length = 273
Score = 115 bits (287), Expect = 4e-25
Identities = 67/161 (41%), Positives = 95/161 (58%), Gaps = 8/161 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHY--QVNIITQ 62
H + +VA+P G+ ++P+ V FYN RRRQL E+ PN AH ALA+L+ + ++TQ
Sbjct: 70 HRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQ 129
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAG++ ++H+HGELL VR + V W D+ D + + LRP +V
Sbjct: 130 NIDNLHERAGNTNVIHMHGELLKVRCSQS-GQVLDWTGDVTPEDKCHCCQFPAPLRPHVV 188
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
WFGE + E + A + I IGTS VYPAA A
Sbjct: 189 WFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 229
>ref|NP_070504.1| (NC_000917) transcriptional regulatory protein, Sir2 family
[Archaeoglobus fulgidus]
pir||C69459 transcription regulator Sir2 family homolog - Archaeoglobus
fulgidus
gb|AAB89569.1| (AE000987) transcriptional regulatory protein, Sir2 family
[Archaeoglobus fulgidus]
Length = 245
Score = 115 bits (287), Expect = 4e-25
Identities = 71/152 (46%), Positives = 96/152 (62%), Gaps = 7/152 (4%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P + K+P+KV +Y R ++F PNKAH+A AELE+ + +ITQNVDDLHE
Sbjct: 46 ELANPQAFAKDPEKVWKWYAWRMEKVFNAQPNKAHQAFAELERLGVLKCLITQNVDDLHE 105
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAK-DK--SQLRPDIVWFGEAVP 126
RAGS ++HLHG L VR N + E + L K DK S LRP +VWFGE +P
Sbjct: 106 RAGSRNVIHLHGSLRVVRCTSCNN-SFEVESAPKIPPLPKCDKCGSLLRPGVVWFGEMLP 164
Query: 127 --LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
+L A+ V++A ++I+ GTS V PAASL
Sbjct: 165 PDVLDRAMREVERADVIIVAGTSAVVQPAASL 196
>pdb|1ICI|A Chain A, Crystal Structure Of A Sir2 Homolog-Nad Complex
pdb|1ICI|B Chain B, Crystal Structure Of A Sir2 Homolog-Nad Complex
Length = 256
Score = 115 bits (287), Expect = 4e-25
Identities = 71/152 (46%), Positives = 96/152 (62%), Gaps = 7/152 (4%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P + K+P+KV +Y R ++F PNKAH+A AELE+ + +ITQNVDDLHE
Sbjct: 57 ELANPQAFAKDPEKVWKWYAWRMEKVFNAQPNKAHQAFAELERLGVLKCLITQNVDDLHE 116
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAK-DK--SQLRPDIVWFGEAVP 126
RAGS ++HLHG L VR N + E + L K DK S LRP +VWFGE +P
Sbjct: 117 RAGSRNVIHLHGSLRVVRCTSCNN-SFEVESAPKIPPLPKCDKCGSLLRPGVVWFGEMLP 175
Query: 127 --LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
+L A+ V++A ++I+ GTS V PAASL
Sbjct: 176 PDVLDRAMREVERADVIIVAGTSAVVQPAASL 207
>ref|NP_415638.1| (NC_000913) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli K12]
sp|P75960|COBB_ECOLI CobB protein
pir||E64856 hypothetical protein b1120 - Escherichia coli
gb|AAC74204.1| (AE000212) putative nicotinic acid
mononucleotide:5,6-dimethylbenzimidazole (DMB)
phosphoribosyltransferase [Escherichia coli K12]
dbj|BAA35940.1| (D90747) ORF_ID:o238#9 [Escherichia coli]
Length = 279
Score = 115 bits (287), Expect = 4e-25
Identities = 67/161 (41%), Positives = 95/161 (58%), Gaps = 8/161 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHY--QVNIITQ 62
H + +VA+P G+ ++P+ V FYN RRRQL E+ PN AH ALA+L+ + ++TQ
Sbjct: 70 HRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQ 129
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAG++ ++H+HGELL VR + V W D+ D + + LRP +V
Sbjct: 130 NIDNLHERAGNTNVIHMHGELLKVRCSQS-GQVLDWTGDVTPEDKCHCCQFPAPLRPHVV 188
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
WFGE + E + A + I IGTS VYPAA A
Sbjct: 189 WFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 229
>gb|AAC78722.1| (U89687) putative nicotinic acid mononucleotide:5,
6-dimethylbenzimidazole(DMB)phosphoribosyltransferase
[Salmonella typhimurium]
Length = 237
Score = 114 bits (286), Expect = 5e-25
Identities = 67/161 (41%), Positives = 93/161 (57%), Gaps = 8/161 (4%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHYQVN--IITQ 62
H + +VA+P G+ +NP V FYN RR+QL E+ PN AH ALA L+K + ++TQ
Sbjct: 34 HRVEDVATPEGFARNPGLVQTFYNARRQQLQQPEIQPNAAHLALANLKKRLAIAFLLVTQ 93
Query: 63 NVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD---LAKDKSQLRPDIV 119
N+D+LHERAG+ I+ +HGELL VR + ++ W D+ D + + LRP +V
Sbjct: 94 NIDNLHERAGNRNIIQMHGELLKVRCSQSGQIL-EWNGDVMPEDKCHCCQFPAPLRPHVV 152
Query: 120 WFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
WFGE + E + A + I IGTS VYPAA A
Sbjct: 153 WFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 193
>gb|AAF77189.1|AF264911_5 (AF264911) putative transferase [Campylobacter jejuni]
Length = 227
Score = 111 bits (278), Expect = 4e-24
Identities = 73/178 (41%), Positives = 99/178 (55%), Gaps = 7/178 (3%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN--IITQNV 64
+D+MEV S G++KNP+KVLDFY+ RR QL V PN AH+ +A+L++ + N +ITQNV
Sbjct: 31 YDVMEVCSATGFRKNPKKVLDFYDARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQNV 90
Query: 65 DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQ-LRPDIVWFGE 123
DDL ERAG ++HLHG L +R K + + + K KS+ LR +IV F E
Sbjct: 91 DDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKITDKQCPKCKSKDLRHNIVMFEE 150
Query: 124 AVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQN 181
P SL+ Q L I +GTS V P + K L Y K+A+L N
Sbjct: 151 QAPAYATLYSLLNQTSLFISVGTSGAVLPVGRYPSMCEKSILNIY----EKDANLEWN 204
>ref|NP_282200.1| (NC_002163) putative transferase [Campylobacter jejuni]
pir||G81307 probable transferase Cj1050c [imported] - Campylobacter jejuni
(strain NCTC 11168)
emb|CAB73306.1| (AL139077) putative transferase [Campylobacter jejuni]
Length = 233
Score = 110 bits (276), Expect = 8e-24
Identities = 70/165 (42%), Positives = 92/165 (55%), Gaps = 3/165 (1%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN--IITQNV 64
+D+MEV S G++KNP+KVLDFY+ RR QL V PN AH+ +A+L++ + N +ITQNV
Sbjct: 31 YDVMEVCSATGFRKNPKKVLDFYDARRAQLQNVKPNHAHEKIAQLKEKWGKNLFVITQNV 90
Query: 65 DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQ-LRPDIVWFGE 123
DDL ERAG ++HLHG L +R K + + K KS+ LR +IV F E
Sbjct: 91 DDLLERAGCKDVVHLHGFLPELRCLKCEGIFNIGYEKFTDKQCPKCKSKDLRHNIVMFEE 150
Query: 124 AVPLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYY 168
P SL+ Q L I IGTS V P + K L Y
Sbjct: 151 QAPAYATLYSLLHQTSLFISIGTSGAVLPVGQYASMCEKSILNIY 195
>ref|NP_215667.1| (NC_000962) hypothetical protein Rv1151c [Mycobacterium
tuberculosis H37Rv]
ref|NP_335628.1| (NC_002755) sirtuin family protein [Mycobacterium tuberculosis
CDC1551]
pir||H70554 hypothetical protein Rv1151c - Mycobacterium tuberculosis (strain
H37RV)
emb|CAB09010.1| (Z95584) hypothetical protein Rv1151c [Mycobacterium tuberculosis
H37Rv]
gb|AAK45442.1| (AE006996) sirtuin family protein [Mycobacterium tuberculosis
CDC1551]
Length = 237
Score = 110 bits (275), Expect = 1e-23
Identities = 72/202 (35%), Positives = 106/202 (51%), Gaps = 10/202 (4%)
Query: 8 DIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDL 67
D E++S GW +NP++V +Y R + V PN H+A+A + H +V++ITQNVDDL
Sbjct: 32 DPYELSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVSVITQNVDDL 91
Query: 68 HERAGSSRILHLHGELLSVRSEK-----DPNLVYRWEKDLNLGDLAKDKSQL-RPDIVWF 121
HERAGS + HLHG L R + L E + + D L RPDIVWF
Sbjct: 92 HERAGSGAVHHLHGSLFEFRCARCGVPYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWF 151
Query: 122 GEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA-HKDALIYYIDPKAKNAHL 178
GE +P + A+ A +++++GTS VYPAA L A + + ++P+
Sbjct: 152 GEPLPEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSG 211
Query: 179 PQNVQCINESAVHAMQDLMPKL 200
+ I ESA A+ L+ +L
Sbjct: 212 SATIS-IRESASQALPGLLERL 232
>ref|NP_142870.1| (NC_000961) hypothetical protein [Pyrococcus horikoshii]
pir||F71085 hypothetical protein PH0947 - Pyrococcus horikoshii
dbj|BAA30044.1| (AP000004) 249aa long hypothetical protein [Pyrococcus horikoshii]
Length = 249
Score = 110 bits (274), Expect = 1e-23
Identities = 65/154 (42%), Positives = 90/154 (58%), Gaps = 10/154 (6%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P +++NP+ V DFY R +++ + PN AH AL ELEK + +ITQNVDDLH
Sbjct: 46 ELATPEAFERNPKLVWDFYKWRIKKILKAKPNPAHYALVELEKMGILKAVITQNVDDLHR 105
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEK-------DLNLGDLAKDKSQLRPDIVWFG 122
AG+ ++ LHG + VR + E +L K S LRPD+VWFG
Sbjct: 106 EAGTKNLIELHGNIFRVRCTSCEFREHLKESGRIDEILSEDLPKCPKCGSLLRPDVVWFG 165
Query: 123 EAVPL--LKEAISLVKQAHLLIIIGTSLQVYPAA 154
E +P L EA L K+A ++I++GTS VYPAA
Sbjct: 166 EPLPSKELNEAFKLAKEADVVIVVGTSGLVYPAA 199
>ref|NP_422274.1| (NC_002696) transcriptional regulator, Sir2 family [Caulobacter
crescentus CB15]
gb|AAK25442.1| (AE006007) transcriptional regulator, Sir2 family [Caulobacter
crescentus CB15]
Length = 238
Score = 108 bits (271), Expect = 3e-23
Identities = 69/166 (41%), Positives = 91/166 (54%), Gaps = 17/166 (10%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELE-----KHYQVNIIT 61
+D+ EVA+P G+ +NP V DFYN RR L PN AH ALA+LE + ++ + T
Sbjct: 34 YDLNEVATPQGFARNPALVRDFYNARRANLAGARPNAAHDALAQLEAGLARRGGELFLCT 93
Query: 62 QNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRW------EKDLNLGDLAKDKSQLR 115
QNVDDLHE+AG R++H+HGEL R + W + D A+D R
Sbjct: 94 QNVDDLHEKAGCRRVIHMHGELAVTRCH---HCEATWPDTGPLKPDTVCAACARD-GGAR 149
Query: 116 PDIVWFGEAVPLLKEAI-SLVKQAHLLIIIGTSLQVYPAASLYTHA 160
P +VWFGE +PL + I + A L + IGTS VYPAA A
Sbjct: 150 PHVVWFGE-IPLFMDQIEDALSAADLFVSIGTSGSVYPAAGFVAEA 194
>ref|NP_214488.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
pir||C70486 conserved hypothetical protein aq_2170 - Aquifex aeolicus
gb|AAC07893.1| (AE000776) hypothetical protein [Aquifex aeolicus]
Length = 239
Score = 108 bits (271), Expect = 3e-23
Identities = 61/168 (36%), Positives = 100/168 (59%), Gaps = 6/168 (3%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHY-QVNIITQNVDDLHE 69
E+A+P + +NP+ V ++Y+ +R+ + + PN+ HK L ++E+ + +ITQNVD LH+
Sbjct: 37 ELATPEAFFRNPKLVWEWYDWKRQLIAKAQPNEGHKILTKMEEEFPNFYLITQNVDGLHQ 96
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLN--LGDLAKDKSQLRPDIVWFGEAVPL 127
RAGS +++ LHG + VR + N Y + L K LRP +VWFGE++P+
Sbjct: 97 RAGSKKVIELHGNIWKVRCVECGNERYEYTTPLPEIPPKCEKCGGLLRPGVVWFGESLPV 156
Query: 128 --LKEAISLVKQAHLLIIIGTSLQVYPAASL-YTHAHKDALIYYIDPK 172
L A L ++AH+ I++GTS VYPAA L + A + ++P+
Sbjct: 157 DALSRAYELSREAHVFIVVGTSGVVYPAAELPFVAKENGAQVIEVNPE 204
>ref|NP_302058.1| (NC_002677) conserved hypothetical protein [Mycobacterium leprae]
emb|CAC30462.1| (AL583922) conserved hypothetical protein [Mycobacterium leprae]
Length = 237
Score = 107 bits (268), Expect = 6e-23
Identities = 71/207 (34%), Positives = 113/207 (54%), Gaps = 20/207 (9%)
Query: 8 DIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDL 67
D +++S GW++NP++V +Y R + V PN H+A+A ++ +V++ITQNVDDL
Sbjct: 32 DPYQLSSTQGWQRNPERVWGWYLWRHYLVANVKPNDGHRAIAAWQEQIEVSVITQNVDDL 91
Query: 68 HERAGSSRILHLHGELLSVRSEKDPNLVYRWE-KDLNLGDLAKDK------SQLRPDIVW 120
HERAGS+ + HLHG L + N+ Y D+ L D +RP IVW
Sbjct: 92 HERAGSTPVHHLHGSLFKFHCAR-CNVAYTGALPDMPEPVLEVDPPVCYCGGLIRPAIVW 150
Query: 121 FGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA-HKDALIYYIDPK----A 173
FGE +P + A+ + +++++GTS VYPAA L A + A++ ++P+
Sbjct: 151 FGEPLPDEPWRRAVEATETTDVMVVVGTSAIVYPAAGLPELALSRGAVVIEVNPEPTPLT 210
Query: 174 KNAHLPQNVQCINESAVHAMQDLMPKL 200
KNA + I E+A A+ L+ +L
Sbjct: 211 KNATI-----SIRETASQALPGLLQRL 232
>ref|NP_343825.1| (NC_002754) Transcriptional regulatory protein, Sir2 protein
homolog [Sulfolobus solfataricus]
gb|AAK42615.1| (AE006846) Transcriptional regulatory protein, Sir2 protein homolog
[Sulfolobus solfataricus]
Length = 247
Score = 105 bits (263), Expect = 2e-22
Identities = 65/150 (43%), Positives = 92/150 (61%), Gaps = 8/150 (5%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+AS ++K+P+ FY+ R R LFE PNKAH +LAELEK + IITQN+D LH+
Sbjct: 46 ELASIEYFEKDPKNFWGFYSLRMRGLFEAQPNKAHYSLAELEKMGIIKVIITQNIDGLHQ 105
Query: 70 RAGSSRILHLHGEL------LSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGE 123
+AGS ++ LHG + L +R+ N++ EK NL +RPD+V FGE
Sbjct: 106 KAGSKNVIELHGTMRRSYCVLCLRTYDSLNVLSMIEKG-NLPPRCDCGGIIRPDVVLFGE 164
Query: 124 AVPLLKEAISLVKQAHLLIIIGTSLQVYPA 153
V + EA+S+ ++ L+I IG+SL VYPA
Sbjct: 165 PVKNIYEALSIAYESDLVISIGSSLTVYPA 194
>ref|NP_614358.1| (NC_003551) NAD-dependent protein deacetylase, SIR2 family
[Methanopyrus kandleri AV19]
gb|AAM02288.1| (AE010396) NAD-dependent protein deacetylase, SIR2 family
[Methanopyrus kandleri AV19]
Length = 250
Score = 105 bits (262), Expect = 3e-22
Identities = 75/201 (37%), Positives = 111/201 (54%), Gaps = 12/201 (5%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVD 65
+D E+A+P + ++P+KV ++Y RRR++ E PN AH LA +E+ + +ITQNVD
Sbjct: 43 YDPRELATPEAFARDPEKVWEWYLWRRRKIAEAEPNPAHTVLARMERDGLLEAVITQNVD 102
Query: 66 DLHERAGSSRILHLHG-----ELLSVRSEK--DPNLVYRWEKDLNLGDLAKDKSQLRPDI 118
LH+RAGS R++ LHG E +S ++ DP E D + LRP +
Sbjct: 103 GLHQRAGSRRVIELHGNIWRDECVSCEYQRVNDPERGEGLEYDELPPRCPECGDPLRPGV 162
Query: 119 VWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHK-DALIYYIDPKAKN 175
VWFGE +P L EA +L + ++++IGTS +V PAA L A A + I+P ++
Sbjct: 163 VWFGEPLPSDALVEAENLARSCDVMLVIGTSGEVRPAADLPLVAKSCGATLIEINP-SET 221
Query: 176 AHLPQNVQCINESAVHAMQDL 196
A P I E A AM+ L
Sbjct: 222 ALSPHMDVIIRERAASAMEAL 242
>ref|NP_148161.1| (NC_000854) hypothetical protein [Aeropyrum pernix]
pir||D72562 hypothetical protein APE1782 - Aeropyrum pernix (strain K1)
dbj|BAA80785.1| (AP000062) 247aa long hypothetical protein [Aeropyrum pernix]
Length = 247
Score = 103 bits (258), Expect = 9e-22
Identities = 63/153 (41%), Positives = 92/153 (59%), Gaps = 4/153 (2%)
Query: 8 DIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDD 66
D ++A+P + ++P+ V ++Y+ R ++ PNKAH+ LA LE + +ITQNVD
Sbjct: 47 DPRDLATPEAFNRDPRLVWEWYSWRIERVLAAKPNKAHRLLARLEDSGVLKAVITQNVDG 106
Query: 67 LHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNL-GDLAKDKSQLRPDIVWFGEAV 125
LH RAGS R+L LHG +L R + + + EK NL + LRPD+VWFGE +
Sbjct: 107 LHRRAGSRRVLELHGNVLRARCTRCGSKLEWREKPSNLPPSCPRCGGVLRPDVVWFGEPL 166
Query: 126 --PLLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
LL+EA L +++ ++IIIGTS V PA L
Sbjct: 167 DTSLLEEAFGLARRSDVMIIIGTSGAVDPAGLL 199
>ref|NP_126882.1| (NC_000868) transcriptional regulatory protein, Sir2 family
[Pyrococcus abyssi]
pir||C75101 transcription regulatory protein, sir2 family PAB0801 - Pyrococcus
abyssi (strain Orsay)
emb|CAB50112.1| (AJ248286) transcriptional regulatory protein, Sir2 family
[Pyrococcus abyssi]
Length = 250
Score = 100 bits (250), Expect = 8e-21
Identities = 60/155 (38%), Positives = 89/155 (56%), Gaps = 12/155 (7%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P + +NP+ V +FY R ++ + PN AH AL ELE + +ITQNVDDLH
Sbjct: 46 ELATPEAFARNPKLVWEFYKWRINKILKAKPNPAHYALVELEDMGILRAVITQNVDDLHR 105
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDK--------SQLRPDIVWF 121
AG+ ++ LHG + V+ K N ++ L ++ K+ S LRPD+VWF
Sbjct: 106 EAGTRNLIELHGNIFRVKCTK-CNFKEYLKESQRLEEVLKEDLPKCPRCGSLLRPDVVWF 164
Query: 122 GEAVPL--LKEAISLVKQAHLLIIIGTSLQVYPAA 154
GE +P L A L ++A ++++GTS VYPAA
Sbjct: 165 GEPLPREELDRAFKLAEKADAVLVVGTSGLVYPAA 199
>ref|NP_068953.1| (NC_000917) transcriptional regulatory protein, Sir2 family
[Archaeoglobus fulgidus]
pir||H69263 transcription regulator Sir2 family homolog - Archaeoglobus
fulgidus
gb|AAB91115.1| (AE001098) transcriptional regulatory protein, Sir2 family
[Archaeoglobus fulgidus]
Length = 253
Score = 99.4 bits (246), Expect = 2e-20
Identities = 72/207 (34%), Positives = 115/207 (54%), Gaps = 18/207 (8%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVD 65
+D EVAS G+K+NP+ +F + + +LF PN AH A+AELE+ V +ITQN+D
Sbjct: 45 YDPEEVASISGFKRNPRAFWEFSMEMKDKLF-AEPNPAHYAIAELERMGIVKAVITQNID 103
Query: 66 DLHERAGSSRILHLHGELLSVRSEKDPNLVYRWE---KDLNLGDLAKDKS----QLRPDI 118
LH+RAGS R+L LHG + + D + Y W +D N G++ + + ++P +
Sbjct: 104 MLHQRAGSRRVLELHGSMDKLDC-LDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRV 162
Query: 119 VWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASL-YTHAHKDALIYYIDPKAKN 175
V FGE +P L EAI K +++G+SL VYPAA L Y A + ++ +
Sbjct: 163 VLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTM 222
Query: 176 AHLPQNVQCINESAVHAMQDLMPKLIE 202
A +V+ I ++ +++PK++E
Sbjct: 223 ADPIFDVKIIGKAG-----EVLPKIVE 244
>ref|NP_376522.1| (NC_003106) 284aa long conserved hypothetical protein [Sulfolobus
tokodaii]
dbj|BAB65631.1| (AP000983) 284aa long conserved hypothetical protein [Sulfolobus
tokodaii]
Length = 284
Score = 99.0 bits (245), Expect = 3e-20
Identities = 60/152 (39%), Positives = 88/152 (57%), Gaps = 12/152 (7%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+ +KK+P+ +FY R R LF PN+AH ALAELEK + IITQN+D LH+
Sbjct: 80 ELATIEYFKKDPKGFWEFYRLRMRGLFTALPNRAHYALAELEKMGLIRAIITQNIDGLHQ 139
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDK--------SQLRPDIVWF 121
AGS ++ LHG + R N + ++ D L + K+ +RPD+V F
Sbjct: 140 LAGSRNVIELHGNM---RKCYCVNCLKTYDSDTVLDKIDKEGLPPKCECGGVIRPDVVLF 196
Query: 122 GEAVPLLKEAISLVKQAHLLIIIGTSLQVYPA 153
GE V + A+ + ++A L++ IG+SL VYPA
Sbjct: 197 GEPVYNISSALEIAREADLVLAIGSSLTVYPA 228
>ref|NP_293742.1| (NC_001263) conserved hypothetical protein [Deinococcus
radiodurans]
pir||G75570 conserved hypothetical protein - Deinococcus radiodurans (strain
R1)
gb|AAF09608.1|AE001865_5 (AE001865) conserved hypothetical protein [Deinococcus radiodurans]
Length = 246
Score = 97.4 bits (241), Expect = 9e-20
Identities = 68/197 (34%), Positives = 102/197 (51%), Gaps = 11/197 (5%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN--IITQNVDDLH 68
++ASP ++++P V ++Y R R + PN+ H+ LAELE+ + TQNVD LH
Sbjct: 48 DLASPDAYRRDPDLVWEWYAGRYRDVLAAQPNRGHELLAELERRKGPGFFLATQNVDGLH 107
Query: 69 ERAGS----SRILHLHGELLSVRSEKDPNLVYRWEKD-LNLGDLAKDKSQLRPDIVWFGE 123
RAGS ++ LHG LL R E + D L L L+ + ++RP IVWFGE
Sbjct: 108 ARAGSGSAGGELVELHGNLLQARDELTGEVFPLAAPDELTLPPLSPNGQRMRPHIVWFGE 167
Query: 124 AVPL--LKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA-HKDALIYYIDPKAKNAHLPQ 180
+P+ L A A + ++IGTS VYPAA L + + I+P+A + P
Sbjct: 168 YLPVDALDAAQRAFAGAEVALVIGTSSVVYPAAGLAAETLRRGGAVIEINPEATDL-TPD 226
Query: 181 NVQCINESAVHAMQDLM 197
+ ESA ++ L+
Sbjct: 227 ATFSLRESASRGLELLL 243
>ref|NP_249816.1| (NC_002516) probable cobalamin biosynthetic protein [Pseudomonas
aeruginosa]
pir||A83506 probable cobalamin biosynthetic protein PA1125 [imported] -
Pseudomonas aeruginosa (strain PAO1)
gb|AAG04514.1|AE004542_10 (AE004542) probable cobalamin biosynthetic protein [Pseudomonas
aeruginosa]
Length = 250
Score = 95.5 bits (236), Expect = 3e-19
Identities = 70/211 (33%), Positives = 109/211 (51%), Gaps = 18/211 (8%)
Query: 7 HDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHY-QVNIITQNVD 65
+D +A+P + +P V +Y RR ++ V PN AH+A+A L ++TQNVD
Sbjct: 42 YDPAALATPAAFADDPALVWGWYEWRRLKVLGVQPNPAHRAIAALSGRIANTRLVTQNVD 101
Query: 66 DLHERAGSSRILHLHGELLSVR--------SEKDPNLVYRWE-KDLNLGDLAKDKSQLRP 116
DLHERAGS +LHLHG L + R + P+ V E + + Q+RP
Sbjct: 102 DLHERAGSRDVLHLHGSLHAPRCATCAAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRP 161
Query: 117 DIVWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHA-HKDALIYYIDPKA 173
+VWFGEA+P L+EA + + LL+ +GTS V PAA + A A + +++P+
Sbjct: 162 GVVWFGEALPEAALREAFAAACECDLLLSVGTSGVVQPAARIPGLALEHGASVVHVNPQP 221
Query: 174 KNAHLPQNVQCINESAVHAMQDLMPKLIEMA 204
P+ C+ V +++P+L+ A
Sbjct: 222 VRTRHPRE-HCL----VGPAGEVLPELLRRA 247
>ref|NP_519351.1| (NC_003295) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
emb|CAD14932.1| (AL646063) CONSERVED HYPOTHETICAL PROTEIN [Ralstonia solanacearum]
Length = 246
Score = 92.4 bits (228), Expect = 3e-18
Identities = 53/159 (33%), Positives = 85/159 (53%), Gaps = 23/159 (14%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDLHER 70
++A+ ++++P+ V D+Y +RR ++ +V PN AH A+A L V ++TQNVD LH+R
Sbjct: 56 DLATEAAYREHPRMVWDWYQERRARVSQVQPNPAHLAIAALATRKTVALVTQNVDGLHQR 115
Query: 71 AGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDK-----------SQLRPDIV 119
AGS ++ LHG L + +W D+A + + LRP +V
Sbjct: 116 AGSVGVIELHGNLFA----------NKWLDGCGKCDVATAEPGRPPRCAACGAMLRPGVV 165
Query: 120 WFGEAVPLLK--EAISLVKQAHLLIIIGTSLQVYPAASL 156
WFGE +P++ A + +++GTS VYPAA L
Sbjct: 166 WFGERLPVVANYRAEEAANTCDVCLVVGTSGMVYPAAGL 204
>ref|NP_599877.1| (NC_003450) COG0846:NAD-dependent protein deacetylases, SIR2 family
[Corynebacterium glutamicum]
dbj|BAB98037.1| (AP005275) NAD-dependent protein deacetylases, SIR2 family
[Corynebacterium glutamicum ATCC 13032]
Length = 258
Score = 91.7 bits (226), Expect = 5e-18
Identities = 60/164 (36%), Positives = 89/164 (53%), Gaps = 18/164 (10%)
Query: 8 DIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKH---YQVNIITQNV 64
D +AS W+K+P+ + +Y R PN H+A++ E V+I TQN+
Sbjct: 52 DPQAMASIDAWRKDPEPMWAWYRWRAGVAARAEPNAGHQAISYWEGSDTVEHVHITTQNI 111
Query: 65 DDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLN-----LGDLAKDKSQ-----L 114
D+LHERAGSS + HLHG L R + WE D N + LA + + +
Sbjct: 112 DNLHERAGSSDVTHLHGSLFEYRCS---DCATPWEDDKNYPQEPIARLAPPQCEKCGGLI 168
Query: 115 RPDIVWFGEAVPLLKEAIS--LVKQAHLLIIIGTSLQVYPAASL 156
RP +VWFGE +P+ + I+ + +A L+II+GTS V+PAA+L
Sbjct: 169 RPGVVWFGENLPVEEWDIAEQRIAEADLMIIVGTSGIVHPAAAL 212
>ref|NP_560781.1| (NC_003364) conserved hypothetical protein [Pyrobaculum aerophilum]
gb|AAL64963.1| (AE009934) conserved hypothetical protein [Pyrobaculum aerophilum]
Length = 249
Score = 91.7 bits (226), Expect = 5e-18
Identities = 57/149 (38%), Positives = 85/149 (56%), Gaps = 6/149 (4%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHE 69
E+A+P + ++P V +Y R+ ++ P+ H A+AELE V +ITQNVD LH+
Sbjct: 44 ELATPEAFARDPALVWRWYKWRQEVIYNARPSPGHYAIAELEAMGVVRGVITQNVDGLHQ 103
Query: 70 RAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGD--LAKDKSQLRPDIVWFGEAVP- 126
RAGS ++ LHG + R K + VY +K + K LRPD+VWFGE +P
Sbjct: 104 RAGSRLVVELHGSIWRARCVKCGS-VYILDKPVEEVPPLCRKCGGLLRPDVVWFGEPLPQ 162
Query: 127 -LLKEAISLVKQAHLLIIIGTSLQVYPAA 154
+ A+ L + +L+++GTS VYPAA
Sbjct: 163 EAWRAAVELASVSDVLLVVGTSGVVYPAA 191
>ref|NP_228300.1| (NC_000853) regulatory protein, SIR2 family [Thermotoga maritima]
pir||A72370 regulatory protein, SIR2 family - Thermotoga maritima (strain
MSB8)
gb|AAD35575.1|AE001726_9 (AE001726) regulatory protein, SIR2 family [Thermotoga maritima]
Length = 246
Score = 88.6 bits (218), Expect = 4e-17
Identities = 68/172 (39%), Positives = 97/172 (55%), Gaps = 26/172 (15%)
Query: 9 IMEVASPYG-WKKNPQKVLD----------FYNQRRRQLF---EVYPNKAHKALAELEKH 54
I + P G +KK Q V D FY + +F + PN AH LA+LE+
Sbjct: 30 IPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEEK 89
Query: 55 YQVN-IITQNVDDLHERAGSSRILHLHG---ELLSVRSEKD---PNLVYRWE-KDLNLGD 106
+ +ITQN+D LH+RAGS +++ LHG E VR EK +++ + E D+ L D
Sbjct: 90 GLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRCEKKYTVEDVIKKLESSDVPLCD 149
Query: 107 LAKDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
S +RP+IV+FGE +P L+EAI L +A L+I++G+SL VYPAA L
Sbjct: 150 --DCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAEL 199
>ref|NP_560385.1| (NC_003364) conserved hypothetical protein [Pyrobaculum aerophilum]
gb|AAL64567.1| (AE009903) conserved hypothetical protein [Pyrobaculum aerophilum]
Length = 254
Score = 86.7 bits (213), Expect = 2e-16
Identities = 58/150 (38%), Positives = 81/150 (53%), Gaps = 9/150 (6%)
Query: 21 NPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQV-NIITQNVDDLHERAGSSRILHL 79
NP +V D + + F V PN AH ALAE+E+ ++ +ITQNVD LH+ AGS ++ L
Sbjct: 63 NPDEVWDLFVKYLLPAFNVKPNPAHYALAEMERLGKLCAVITQNVDRLHQAAGSKNVIEL 122
Query: 80 HGEL-----LSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVP--LLKEAI 132
HG L + S+ +W K K ++PD+V+FGE +P L+EA
Sbjct: 123 HGALEYAVCTNCGSKYALAEALKWRKS-GAPRCPKCGGVIKPDVVFFGEPLPQDALREAF 181
Query: 133 SLVKQAHLLIIIGTSLQVYPAASLYTHAHK 162
L + A + + IGTSL VYPA L A K
Sbjct: 182 MLAEMAEVFMAIGTSLAVYPANQLPLVAKK 211
>ref|NP_466261.1| (NC_003210) similar to regulatory proteins of the SIR2 family
[Listeria monocytogenes EGD-e]
emb|CAD00952.1| (AL591984) similar to regulatory proteins of the SIR2 family
[Listeria monocytogenes]
Length = 229
Score = 86.3 bits (212), Expect = 2e-16
Identities = 54/180 (30%), Positives = 95/180 (52%), Gaps = 8/180 (4%)
Query: 20 KNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDLHERAGSSRILHL 79
+ P+K F + V PN HK +AE+E V IITQN+D LHE+AGS ++++
Sbjct: 55 REPEKFYQFVTENMYYPNAV-PNVIHKKMAEIETEKDVTIITQNIDGLHEKAGSKKVVNF 113
Query: 80 HGELLSVRSEKDPNLVYRWEKDLNLGDLAKD-KSQLRPDIVWFGEAV--PLLKEAISLVK 136
HG L + V KD D+ D +RPD+V + EA+ + ++++ ++
Sbjct: 114 HGSLYHCYCQNCGMTV--TAKDYLKSDIHTDCGGVIRPDVVLYEEAISESAIDQSLTAIR 171
Query: 137 QAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESAVHAMQDL 196
+A L++I+GTS +V P +L + +K A I+ ++ + LP + + AV +++
Sbjct: 172 KADLIVIVGTSFRVSPFCNLTDYRNKKARIFAVN--KERISLPYPFEMMESDAVKVFEEI 229
>ref|NP_472210.1| (NC_003212) similar to regulatory proteins of the SIR2 family
[Listeria innocua]
emb|CAC98108.1| (AL596173) similar to regulatory proteins of the SIR2 family
[Listeria innocua]
Length = 229
Score = 85.5 bits (210), Expect = 3e-16
Identities = 52/180 (28%), Positives = 94/180 (51%), Gaps = 8/180 (4%)
Query: 20 KNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQVNIITQNVDDLHERAGSSRILHL 79
+ P+K F + + PN H+ +AE+E V +ITQN+D LHE+AGS ++++
Sbjct: 55 REPEKFYQFVTENMYYP-DAVPNTIHRKMAEIEADKNVTVITQNIDGLHEKAGSKKVVNF 113
Query: 80 HGELLSVRSEKDPNLVYRWEKDLNLGDLAKD-KSQLRPDIVWFGEAV--PLLKEAISLVK 136
HG L +K V D D+ D +RPD+V + EA+ + ++++ ++
Sbjct: 114 HGSLYHCYCQKCGRSVS--ASDYLQSDIHADCGGVVRPDVVLYEEAISESAIDQSLAAIR 171
Query: 137 QAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESAVHAMQDL 196
+A L++I+GTS +V P +L + +K A I+ ++ + LP + I AV ++
Sbjct: 172 EADLIVIVGTSFRVSPFCNLTDYRNKKARIFAVN--KERISLPYPFEMIENDAVKVFAEI 229
>ref|NP_036373.1| (NM_012241) sirtuin 5, isoform 1; sir2-like 5; sirtuin type 5;
sirtuin (silent mating type information regulation 2,
S.cerevisiae, homolog) 5; silent mating type information
regulation 2, S.cerevisiae, homolog 5 [Homo sapiens]
gb|AAD40853.1|AF083110_1 (AF083110) sirtuin type 5 [Homo sapiens]
gb|AAH00126.1|AAH00126 (BC000126) sir2-like 5 [Homo sapiens]
Length = 310
Score = 81.6 bits (200), Expect = 5e-15
Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 31/175 (17%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHY-----QVNIITQNVD 65
++A+P + NP +V +FY+ RR + PN H+A+AE E +V +ITQN+D
Sbjct: 84 DLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNID 143
Query: 66 DLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQ------------ 113
+LH +AG+ +L +HG L R + ++ + K +
Sbjct: 144 ELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEK 203
Query: 114 ------------LRPDIVWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAA 154
LRP +VWFGE + +L+E + L +++GTS VYPAA
Sbjct: 204 LPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAA 258
>ref|NP_112534.1| (NM_031244) sirtuin 5, isoform 2; sir2-like 5; sirtuin type 5;
sirtuin (silent mating type information regulation 2,
S.cerevisiae, homolog) 5; silent mating type information
regulation 2, S.cerevisiae, homolog 5 [Homo sapiens]
dbj|BAA91107.1| (AK000355) unnamed protein product [Homo sapiens]
Length = 299
Score = 81.6 bits (200), Expect = 5e-15
Identities = 51/175 (29%), Positives = 82/175 (46%), Gaps = 31/175 (17%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHY-----QVNIITQNVD 65
++A+P + NP +V +FY+ RR + PN H+A+AE E +V +ITQN+D
Sbjct: 84 DLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNID 143
Query: 66 DLHERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQ------------ 113
+LH +AG+ +L +HG L R + ++ + K +
Sbjct: 144 ELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEK 203
Query: 114 ------------LRPDIVWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAA 154
LRP +VWFGE + +L+E + L +++GTS VYPAA
Sbjct: 204 LPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAA 258
>ref|XP_127299.1| (XM_127299) expressed sequence AV001953 [Mus musculus]
gb|AAH31770.1| (BC031770) RIKEN cDNA 0610012J09 gene [Mus musculus]
Length = 310
Score = 80.5 bits (197), Expect = 1e-14
Identities = 52/175 (29%), Positives = 83/175 (46%), Gaps = 31/175 (17%)
Query: 11 EVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQ-----VNIITQNVD 65
++A+P + +NP +V +FY+ RR + PN H A+A+ E + V +ITQN+D
Sbjct: 84 DLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNID 143
Query: 66 DLHERAGSSRILHLHGELLSVRSEKDPNLVYRW--------------EKDLNLGDLAKDK 111
+LH +AG+ +L +HG L R + + E + + DK
Sbjct: 144 ELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDK 203
Query: 112 ----------SQLRPDIVWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAA 154
LRP +VWFGE + +L+E + L +++GTS VYPAA
Sbjct: 204 LPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAA 258
>ref|NP_346925.1| (NC_003030) Transcriptional regulatory protein, Sir2 family
[Clostridium acetobutylicum]
gb|AAK78265.1|AE007542_2 (AE007542) Transcriptional regulatory protein, Sir2 family
[Clostridium acetobutylicum]
Length = 245
Score = 75.1 bits (183), Expect = 5e-13
Identities = 48/156 (30%), Positives = 86/156 (54%), Gaps = 9/156 (5%)
Query: 18 WKKNPQKVLDFYNQRRRQLF-EVYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSR 75
+K + + +FY R + +F + PN AH +LA++E+ ++ I+TQN+D LH+ AGS
Sbjct: 63 FKNHTEDFFEFY--REKMIFKDAKPNAAHYSLAKIEEQGKLKAIVTQNIDGLHQLAGSKN 120
Query: 76 ILHLHGEL---LSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAV--PLLKE 130
+ LHG + + K +L Y + + + K ++PD+V + E + +++
Sbjct: 121 VYELHGSIHRNYCMDCGKSFDLEYVIKSETTIPKCDKCGGIVKPDVVLYEEGLDDSIIQN 180
Query: 131 AISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALI 166
++ + +A LI+ GTSL VYPAA L + + LI
Sbjct: 181 SVKAISEADTLIVGGTSLVVYPAAGLIRYFKGNKLI 216
>ref|NP_604082.1| (NC_003454) SIR2 family protein [Fusobacterium nucleatum subsp.
nucleatum ATCC 25586]
gb|AAL95381.1| (AE010624) SIR2 family protein [Fusobacterium nucleatum subsp.
nucleatum ATCC 25586]
Length = 252
Score = 74.7 bits (182), Expect = 6e-13
Identities = 60/160 (37%), Positives = 81/160 (50%), Gaps = 34/160 (21%)
Query: 16 YGWKKNPQKVL--DFYNQRRRQLFEVY-----------PNKAHKALAELEKHYQVN-IIT 61
Y K P++VL DF+ R +F Y PNK H AL ELEK + +IT
Sbjct: 50 YKDKYRPEEVLSSDFFYSHR-DIFMKYVEKELNIKGLKPNKGHMALVELEKIGILKAVIT 108
Query: 62 QNVDDLHERAGSSRILHLHGEL-----LSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRP 116
QN+DDLH+ +G+ +L LHG L LS D N G + +RP
Sbjct: 109 QNIDDLHQVSGNKNVLELHGSLKRWYCLSCGKTADRNF------SCECGGV------VRP 156
Query: 117 DIVWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAA 154
D+ +GE + ++ EAI ++QA LI+ GTSL VYPAA
Sbjct: 157 DVTLYGENLNQSVVNEAIYQLEQADTLIVAGTSLTVYPAA 196
>ref|NP_656954.1| (NC_003995) sir2, Catalytic domain of the SIR2 like Histonde
deacetylases and ADP ribosyl transferase [Bacillus
anthracis A2012] [Bacillus anthracis str. A2012]
Length = 242
Score = 74.7 bits (182), Expect = 6e-13
Identities = 42/117 (35%), Positives = 67/117 (56%), Gaps = 2/117 (1%)
Query: 41 PNKAHKALAELEKHYQ-VNIITQNVDDLHERAGSSRILHLHGELLSVRSEK-DPNLVYRW 98
PN+ H+ LAELE+ + + I+TQN+D LH+ GS ++ LHG L + K ++
Sbjct: 80 PNRGHRFLAELEEQGKDITILTQNIDGLHQVGGSKHVIDLHGTLQTAHCPKCKMGYDLQY 139
Query: 99 EKDLNLGDLAKDKSQLRPDIVWFGEAVPLLKEAISLVKQAHLLIIIGTSLQVYPAAS 155
D + K L PD+V +G+ +P + AI + + +LI++GTSL+V P AS
Sbjct: 140 MIDHEVPRCEKCNFILNPDVVLYGDTLPQYQNAIKRLYETDVLIVMGTSLKVQPVAS 196
>gb|AAA67853.1| (M32103) ORF-27 [Staphylococcus aureus]
Length = 243
Score = 74.3 bits (181), Expect = 8e-13
Identities = 60/188 (31%), Positives = 99/188 (51%), Gaps = 21/188 (11%)
Query: 21 NPQKVLDFYNQRRRQLF-EVYPNKAHKALAELEKHYQ-VNIITQNVDDLHERAGSSRILH 78
+P+ ++F + +R LF + PN H +A+LE++ Q + +ITQN+D LH AGS +
Sbjct: 64 DPEGFINFCH--KRLLFVDTMPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDE 121
Query: 79 LHGEL------LSVRSEKDPNLVYRWEKDL-NLGDLAKDKSQLRPDIVWFGEAV--PLLK 129
LHG L + +S +++ R K N G +RPDIV +GE + P +
Sbjct: 122 LHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCG------GAIRPDIVLYGEMLDQPTII 175
Query: 130 EAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESA 189
A++ ++ A L+++G+SL V PAA L +H D LI I K + + I++
Sbjct: 176 RALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLI--IINKDRTPYDSDATLVIHDDM 233
Query: 190 VHAMQDLM 197
V ++ LM
Sbjct: 234 VSVVKSLM 241
>ref|NP_388846.1| (NC_000964) similar to hypothetical proteins [Bacillus subtilis]
pir||H69827 conserved hypothetical protein yhdZ - Bacillus subtilis
emb|CAA74510.1| (Y14082) hypothetical protein [Bacillus subtilis]
emb|CAB12804.1| (Z99109) similar to hypothetical proteins [Bacillus subtilis]
Length = 247
Score = 73.6 bits (179), Expect = 1e-12
Identities = 53/144 (36%), Positives = 79/144 (54%), Gaps = 21/144 (14%)
Query: 24 KVLDFYNQRRRQLFEVYPNKAHKALAELEKH-YQVNIITQNVDDLHERAGSSRILHLHGE 82
K + + + FE PN+ H LAELEK QV+I TQN+D LH++AGS + LHG
Sbjct: 63 KFKELFQMKMSGSFE--PNEGHLLLAELEKQGKQVDIFTQNIDGLHKKAGSRHVYELHG- 119
Query: 83 LLSVRSEKDP------NLVYRWEKDL-------NLGDLAKDKSQLRPDIVWFGEAVPLLK 129
S+++ P +L + E+++ N GD+ + L+ D+V FG+AV
Sbjct: 120 --SIQTAACPACGARYDLPHLLEREVPECTAAGNNGDIC--GTVLKTDVVLFGDAVMHFD 175
Query: 130 EAISLVKQAHLLIIIGTSLQVYPA 153
+ QA LL++IGTSL+V PA
Sbjct: 176 TLYEKLDQADLLLVIGTSLEVAPA 199
>ref|NP_372721.1| (NC_002758) hypothetical protein [Staphylococcus aureus subsp.
aureus Mu50]
ref|NP_375310.1| (NC_002745) hypothetical protein, similar to regulatory protein,
SIR2 family [Staphylococcus aureus subsp. aureus N315]
dbj|BAB43289.1| (AP003136) ORFID:SA1999~hypothetical protein, similar to regulatory
protein, SIR2 family [Staphylococcus aureus subsp.
aureus N315]
dbj|BAB58359.1| (AP003364) hypothetical protein [Staphylococcus aureus subsp.
aureus Mu50]
Length = 243
Score = 73.2 bits (178), Expect = 2e-12
Identities = 60/188 (31%), Positives = 98/188 (51%), Gaps = 21/188 (11%)
Query: 21 NPQKVLDFYNQRRRQLF-EVYPNKAHKALAELEKHYQ-VNIITQNVDDLHERAGSSRILH 78
+P+ ++F + +R LF + PN H +A+LE++ Q + +ITQN+D LH AGS +
Sbjct: 64 DPEGFINFCH--KRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDE 121
Query: 79 LHGELLSV------RSEKDPNLVYRWEKDL-NLGDLAKDKSQLRPDIVWFGEAV--PLLK 129
LHG L +S +++ R K N G +RPDIV +GE + P +
Sbjct: 122 LHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCG------GAIRPDIVLYGEMLDQPTII 175
Query: 130 EAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESA 189
A++ ++ A L+++G+SL V PAA L +H D LI I K + + I++
Sbjct: 176 RALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLI--IINKDRTPYDSDATLVIHDDM 233
Query: 190 VHAMQDLM 197
V ++ LM
Sbjct: 234 VSVVKSLM 241
>ref|NP_561172.1| (NC_003366) probable transcriptional regulator [Clostridium
perfringens]
dbj|BAB79962.1| (AP003186) probable transcriptional regulator [Clostridium
perfringens]
Length = 244
Score = 69.7 bits (169), Expect = 2e-11
Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 20/171 (11%)
Query: 18 WKKNPQKVLDFYNQRRRQLFEVYPNK----AHKALAELEKHYQVN-IITQNVDDLHERAG 72
+++ P++ +FY + +YPN AH ALA+LE+ ++ I+TQN+D LH+ AG
Sbjct: 61 FERYPEEFFNFYKAKL-----IYPNSKPNDAHIALAKLEEMGKLKAIVTQNIDGLHQMAG 115
Query: 73 SSRILHLHGELL-----SVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVP- 126
S + LHG +L + D + + + K ++PD+V + E +
Sbjct: 116 SKNVFELHGSVLRNYCVDCHTFYDEKFIL---ESKGVPKCTKCGGIVKPDVVLYEEPLDD 172
Query: 127 -LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNA 176
+++ AI + +A LII GTSL VYPAA L + + + I+ + A
Sbjct: 173 NVIRGAIDAISKADTLIIGGTSLVVYPAAGLINYYFRGKNLVLINKSSTQA 223
>ref|NP_646940.1| (NC_003923) ORFID:MW2123~hypothetical protein, similar to
regulatory protein, SIR2 family [Staphylococcus aureus
subsp. aureus MW2]
dbj|BAB95988.1| (AP004829) ORFID:MW2123~hypothetical protein, similar to regulatory
protein, SIR2 family [Staphylococcus aureus subsp.
aureus MW2]
Length = 243
Score = 68.9 bits (167), Expect = 3e-11
Identities = 58/188 (30%), Positives = 98/188 (51%), Gaps = 21/188 (11%)
Query: 21 NPQKVLDFYNQRRRQLF-EVYPNKAHKALAELEKHYQ-VNIITQNVDDLHERAGSSRILH 78
+P+ ++F + +R LF + PN H +A+LE++ Q + +ITQN+D LH AGS +
Sbjct: 64 DPEGFINFCH--KRLLFVDTKPNIVHDWIAKLERNQQSLGVITQNIDGLHSDAGSQHVDE 121
Query: 79 LHGEL------LSVRSEKDPNLVYRWEKDL-NLGDLAKDKSQLRPDIVWFGEAV--PLLK 129
LHG L +S +++ R K N G +RPDIV +GE + P +
Sbjct: 122 LHGTLNRFYCNACHKSYTKSDVIDRTLKHCDNCG------GAIRPDIVLYGEMLDQPTII 175
Query: 130 EAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDALIYYIDPKAKNAHLPQNVQCINESA 189
+++ ++ A L+++G+SL V PAA L ++ D LI I K + + I++
Sbjct: 176 RSLNKIEHADTLVVLGSSLVVQPAAGLISNFKGDNLI--IINKDRTPYDRDATLVIHDDM 233
Query: 190 VHAMQDLM 197
V ++ LM
Sbjct: 234 VSVVKSLM 241
>ref|NP_623330.1| (NC_003869) NAD-dependent protein deacetylases, Sir2 family
[Thermoanaerobacter tengcongensis]
gb|AAM24934.1| (AE013127) NAD-dependent protein deacetylases, Sir2 family
[Thermoanaerobacter tengcongensis]
Length = 250
Score = 65.9 bits (159), Expect = 3e-10
Identities = 44/126 (34%), Positives = 74/126 (57%), Gaps = 20/126 (15%)
Query: 41 PNKAHKALAELEKHYQV-NIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLVYRWE 99
PN+AH L+E+EK + +ITQN+D+LH++AGS ++ +HG + ++ + + E
Sbjct: 85 PNEAHYILSEMEKEGIIAGVITQNIDNLHQKAGSKKVYEVHG------NTREGSCLRCGE 138
Query: 100 K---DLNLGDLAKDK---------SQLRPDIVWFGEAVP-LLKEAISLVKQAHLLIIIGT 146
K +L +AK++ LRPD+V FG+ +P A+ V+++ LLI+IG+
Sbjct: 139 KVSFELLEEKVAKEEIPPRCDRCGGMLRPDVVLFGDPMPHAFDLALKEVQESDLLIVIGS 198
Query: 147 SLQVYP 152
SL V P
Sbjct: 199 SLVVAP 204
>gb|EAA06047.1| (AAAB01008844) ebiP5574 [Anopheles gambiae str. PEST]
Length = 240
Score = 65.9 bits (159), Expect = 3e-10
Identities = 41/149 (27%), Positives = 83/149 (55%), Gaps = 16/149 (10%)
Query: 39 VYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHG---ELLSVRSEKDPNL 94
+ PN H LA LE+ +++ I+TQNVD LH +AGS +++ LHG +++ + S+ +
Sbjct: 79 IAPNVTHYTLARLEREGRISGIVTQNVDRLHGKAGSKQVIELHGSGFDVICIGSQDE--R 136
Query: 95 VYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPL--LKEAISLVKQAHLLIIIGTSLQVYP 152
+ + + + + L+P+IV+FG+ VP+ +++ + ++ ++ ++++G+SL V+
Sbjct: 137 AFEYVQGFKIPPCPQCGGNLKPEIVFFGDNVPMPRIEKVVRMIIESDGVLVLGSSLTVFS 196
Query: 153 AASLYTHAHKDALIYYI--------DPKA 173
+ A + L I DPKA
Sbjct: 197 GYRIILQAKELGLPVAIVNIGATRGDPKA 225
>ref|NP_241773.1| (NC_002570) transcriptional regulator [Bacillus halodurans]
dbj|BAB04626.1| (AP001510) transcriptional regulator [Bacillus halodurans]
Length = 237
Score = 64.3 bits (155), Expect = 8e-10
Identities = 52/157 (33%), Positives = 75/157 (47%), Gaps = 14/157 (8%)
Query: 5 KGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLFEVYPNKAHKALAELEKHYQV-NIITQN 63
+G + +AS N + +DFY R L V P+K + LA EK + +IITQN
Sbjct: 37 QGKNPEALASVDAMDHNREAFIDFYRMRIEGLQGVRPHKGYDVLAAWEKELPITSIITQN 96
Query: 64 VDDLHERAGSSRILHLHGEL-----LSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDI 118
D LHE+AGS +L LHG + ++ D E + G +RP +
Sbjct: 97 TDGLHEQAGSEVVLPLHGSIQRLYCVACGQRYDVARYITNEPYCSCGGF------IRPAV 150
Query: 119 VWFGEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPA 153
V FGE + L A K+A L +++G+SL V PA
Sbjct: 151 VLFGEMLNTDTLALAERHTKEADLFLVLGSSLVVSPA 187
>ref|NP_635701.1| (NC_003902) SIR2-like regulatory protein [Xanthomonas campestris
pv. campestris str. ATCC 33913]
gb|AAM39625.1| (AE012127) SIR2-like regulatory protein [Xanthomonas campestris pv.
campestris str. ATCC 33913]
Length = 293
Score = 63.2 bits (152), Expect = 2e-09
Identities = 47/146 (32%), Positives = 74/146 (50%), Gaps = 35/146 (23%)
Query: 41 PNKAHKALAELEKHYQVNII-TQNVDDLHERAGSSRILHLHGELLSVR----SEKDPNLV 95
PN H ALA LE Q+ ++ TQNVD LH+ AGS ++ LHG L VR ++ P
Sbjct: 83 PNATHHALAALEARGQLELLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCEQRMPRTE 142
Query: 96 YR---------W---------EKDLNLGDLAKDK----------SQLRPDIVWFGEAVP- 126
++ W + D +L ++A D L+PD+V+FGE VP
Sbjct: 143 FQLLLERDNPGWADLEAAQAPDGDADLDNVAFDNFVVPACPACGGVLKPDVVFFGENVPR 202
Query: 127 -LLKEAISLVKQAHLLIIIGTSLQVY 151
++ A + ++ A ++++G+SL VY
Sbjct: 203 ERVERAFAHLQAADAVLVVGSSLMVY 228
>ref|NP_568207.1| (NM_120959) SIR2-family protein [Arabidopsis thaliana]
gb|AAK76547.1| (AY045873) putative SIR2-family protein [Arabidopsis thaliana]
gb|AAM67528.1| (AY122995) putative SIR2-family protein [Arabidopsis thaliana]
Length = 373
Score = 63.2 bits (152), Expect = 2e-09
Identities = 52/180 (28%), Positives = 78/180 (42%), Gaps = 52/180 (28%)
Query: 34 RQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSVR----- 87
R+ P AH ALA LEK ++N +ITQNVD LH RAGS L LHG + +V
Sbjct: 150 RRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGSDP-LELHGTVYTVMCLECG 208
Query: 88 --------------------------------SEKDPNLVYR-----------WEKDLNL 104
SEK + R WE+ ++
Sbjct: 209 FSFPRDLFQDQLKAINPKWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGFHI 268
Query: 105 GDLAKDKSQLRPDIVWFGEAVPLLK--EAISLVKQAHLLIIIGTSLQVYPAASLYTHAHK 162
K K L+PD+++FG+ +P + +A+ + KQ+ +++G+SL A L AH+
Sbjct: 269 PVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAAHE 328
>emb|CAC05449.1| (AL391712) SIR2-family protein [Arabidopsis thaliana]
Length = 451
Score = 62.4 bits (150), Expect = 3e-09
Identities = 52/182 (28%), Positives = 78/182 (42%), Gaps = 54/182 (29%)
Query: 34 RQLFEVYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSVR----- 87
R+ P AH ALA LEK ++N +ITQNVD LH RAGS L LHG + +V
Sbjct: 226 RRFTAAQPGPAHTALASLEKAGRINFMITQNVDRLHHRAGSDP-LELHGTVYTVMCLECG 284
Query: 88 ----------------------------------SEKDPNLVYR-----------WEKDL 102
SEK + R WE+
Sbjct: 285 FSFPRDLFQDQLKAINPKASWAEAIESIDHGDPGSEKSFGMKQRPDGDIEIDEKFWEEGF 344
Query: 103 NLGDLAKDKSQLRPDIVWFGEAVPLLK--EAISLVKQAHLLIIIGTSLQVYPAASLYTHA 160
++ K K L+PD+++FG+ +P + +A+ + KQ+ +++G+SL A L A
Sbjct: 345 HIPVCEKCKGVLKPDVIFFGDNIPKERATQAMEVAKQSDAFLVLGSSLMTMSAFRLCRAA 404
Query: 161 HK 162
H+
Sbjct: 405 HE 406
>ref|NP_640676.1| (NC_003919) SIR2-like regulatory protein [Xanthomonas axonopodis
pv. citri str. 306]
gb|AAM35212.1| (AE011657) SIR2-like regulatory protein [Xanthomonas axonopodis pv.
citri str. 306]
Length = 327
Score = 61.2 bits (147), Expect = 7e-09
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 35/160 (21%)
Query: 41 PNKAHKALAELEKHYQVNII-TQNVDDLHERAGSSRILHLHGELLSVR----SEKDPNLV 95
PN H ALA LE Q+ ++ TQNVD LH+ AGS ++ LHG L VR + P
Sbjct: 117 PNATHHALAALEARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGCERRMPRTE 176
Query: 96 YR---------W---------EKDLNLGDLAKDK----------SQLRPDIVWFGEAVP- 126
++ W + D +L D+A + L+P++V+FGE VP
Sbjct: 177 FQVLLEQANPGWAALEAAQAPDGDADLDDVAFEHFVVPPCPVCGGVLKPNVVFFGENVPR 236
Query: 127 -LLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHKDAL 165
++ A + ++ A ++++G+SL VY A ++ L
Sbjct: 237 ARVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNGL 276
>pir||T35951 probable SIR2 family transcription regulator - Streptomyces
coelicolor (fragment)
Length = 190
Score = 58.9 bits (141), Expect = 3e-08
Identities = 45/127 (35%), Positives = 69/127 (53%), Gaps = 11/127 (8%)
Query: 41 PNKAHKALAELEKH-YQVNIITQNVDDLHERAGSS--RILHLHGE----LLSVRSEKDP- 92
PN AH+A+A+LE+ V ++TQNVD LH+ AG S ++L LHG + + + P
Sbjct: 19 PNAAHRAVADLERRGVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGCGARGPM 78
Query: 93 -NLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQ 149
+++ R E + L+ V FGE + +L EA ++ K + + +GTSLQ
Sbjct: 79 ADVLARIEAGEDDPPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQVFVAVGTSLQ 138
Query: 150 VYPAASL 156
V PAA L
Sbjct: 139 VEPAAGL 145
>dbj|BAB97472.1| (AP005274) NAD-dependent protein deacetylases, SIR2 family
[Corynebacterium glutamicum ATCC 13032]
Length = 308
Score = 58.5 bits (140), Expect = 4e-08
Identities = 47/169 (27%), Positives = 73/169 (42%), Gaps = 40/169 (23%)
Query: 34 RQLFEVYPNKAHKALAELEKH-YQVNIITQNVDDLHERAGSSRILHLHGELLSVR----- 87
R + + PN+ H A+ ELE+H + ++TQNVD LH AG+ ++ LHG+L V
Sbjct: 100 RVMDQARPNRTHYAMVELEQHGFLSGVVTQNVDGLHAEAGTKNLVALHGDLAHVMCLNCG 159
Query: 88 ------------SEKDPNLVYRWEKDLNL----GDLAKDKSQ----------------LR 115
+P V + GD+ D+ Q L+
Sbjct: 160 FGEDRHLFDERLEAANPGYVASIRLEPGAVNPDGDVFLDEEQVRRFTMIGCLRCGSLMLK 219
Query: 116 PDIVWFGEAVPLL--KEAISLVKQAHLLIIIGTSLQVYPAASLYTHAHK 162
PD+V+FGE VP K+ L+ + L+I G+SL V + A +
Sbjct: 220 PDVVYFGEPVPAARKKDLKKLLDASSSLLIAGSSLAVMSGYRIVIEAQR 268
>ref|NP_624772.1| (NC_003888) putative SIR2-like regulatory protein [Streptomyces
coelicolor A3(2)]
emb|CAB56682.1| (AL121596) putative SIR2-like regulatory protein [Streptomyces
coelicolor A3(2)]
Length = 299
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/145 (31%), Positives = 65/145 (44%), Gaps = 35/145 (24%)
Query: 41 PNKAHKALAELEKH-YQVNIITQNVDDLHERAGSSRILHLHGEL----------LSVRSE 89
PN H+++A +H +ITQNVD LH+ AGS ++ LHG L LS R E
Sbjct: 95 PNAGHRSVAAFGRHGLLTGVITQNVDGLHQAAGSEGVVELHGSLDRVVCLSCGVLSPRRE 154
Query: 90 K----------------------DPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVP- 126
D +L D + A L+PD+V+FGE VP
Sbjct: 155 LARRLEEANAGFSPVAAGINPDGDADLTDEQVGDFRVVPCAVCGGVLKPDVVFFGENVPP 214
Query: 127 -LLKEAISLVKQAHLLIIIGTSLQV 150
++ LV+ A L+++G+SL V
Sbjct: 215 RRVEHCRELVRGASSLLVLGSSLTV 239
>ref|NP_036372.1| (NM_012240) sirtuin 4; sirtuin (silent mating type information
regulation 2, S. cerevisiae, homolog) 4; sirtuin type 4;
silent mating type information regulation 2, S.
cerevisiae, homolog 4; sir2-like 4 [Homo sapiens]
gb|AAD40852.1|AF083109_1 (AF083109) sirtuin type 4 [Homo sapiens]
Length = 314
Score = 54.3 bits (129), Expect = 8e-07
Identities = 48/146 (32%), Positives = 71/146 (47%), Gaps = 35/146 (23%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSVR----SEKDPNLV 95
PN AH AL+ EK ++ ++TQNVD LH +AGS R+ LHG + V E+ P V
Sbjct: 121 PNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGV 180
Query: 96 YR---------WEKDLN----LGDLAKDKSQ---------------LRPDIVWFGEAVPL 127
+ W + + GD+ + Q L+PD+V+FG+ V
Sbjct: 181 LQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNP 240
Query: 128 LKEAI--SLVKQAHLLIIIGTSLQVY 151
K VK+A L+++G+SLQVY
Sbjct: 241 DKVDFVHKRVKEADSLLVVGSSLQVY 266
>ref|XP_132353.1| (XM_132353) RIKEN cDNA 4930596O17 [Mus musculus]
Length = 333
Score = 53.9 bits (128), Expect = 1e-06
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 35/146 (23%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHG------------------ 81
PN AH AL+ E+ +++ ++TQNVD LH +AGS R+ LHG
Sbjct: 118 PNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRV 177
Query: 82 --------------ELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPL 127
E V + D L + + + L+PD+V+FG+ V
Sbjct: 178 LQERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNP 237
Query: 128 LKEAI--SLVKQAHLLIIIGTSLQVY 151
K VK+A L+++G+SLQVY
Sbjct: 238 DKVDFVHRRVKEADSLLVVGSSLQVY 263
>gb|AAH22653.1| (BC022653) Unknown (protein for IMAGE:4219186) [Mus musculus]
Length = 342
Score = 53.9 bits (128), Expect = 1e-06
Identities = 43/146 (29%), Positives = 65/146 (44%), Gaps = 35/146 (23%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHG------------------ 81
PN AH AL+ E+ +++ ++TQNVD LH +AGS R+ LHG
Sbjct: 127 PNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRV 186
Query: 82 --------------ELLSVRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPL 127
E V + D L + + + L+PD+V+FG+ V
Sbjct: 187 LQERFQALNPSWSAEAQGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNP 246
Query: 128 LKEAI--SLVKQAHLLIIIGTSLQVY 151
K VK+A L+++G+SLQVY
Sbjct: 247 DKVDFVHRRVKEADSLLVVGSSLQVY 272
>ref|NP_249888.1| (NC_002516) hypothetical protein [Pseudomonas aeruginosa]
pir||A83495 hypothetical protein PA1197 [imported] - Pseudomonas aeruginosa
(strain PAO1)
gb|AAG04586.1|AE004550_2 (AE004550) hypothetical protein [Pseudomonas aeruginosa]
Length = 256
Score = 51.2 bits (121), Expect = 7e-06
Identities = 41/119 (34%), Positives = 64/119 (53%), Gaps = 15/119 (12%)
Query: 41 PNKAHKALAELEKHY-QVNIITQNVDDLHERAGS--SRILHLHGELLSVRSEKDPNLVYR 97
PN H+A+AEL+KH + ++TQN+D H +AGS R++ +HGEL + +
Sbjct: 86 PNAGHEAIAELQKHKPECWVLTQNIDGFHRQAGSPAERLIEIHGELAPLYCQSCGAESGG 145
Query: 98 WEKDLNLGDL----AKDKSQLRPDIVWFGEAVPLLKEAI-----SLVKQAHLLIIIGTS 147
E+ L+ G L A LRP +V F E +P +EAI L K ++++GT+
Sbjct: 146 LEEHLH-GQLPPRCAACGGVLRPPVVLFEEMLP--EEAIDTLYRELRKGFDAVLVVGTT 201
>gb|AAB95634.1| (AC003982) unknown function; 60% similar to Z50177 (PID:g927403)
(PID:g927402) [Homo sapiens]
Length = 326
Score = 49.3 bits (116), Expect = 3e-05
Identities = 47/158 (29%), Positives = 69/158 (42%), Gaps = 47/158 (29%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGEL---------------- 83
PN AH AL+ EK ++ ++TQNVD LH +AGS R+ LHG +
Sbjct: 121 PNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRAYCSVSVFLGSRVL 180
Query: 84 ---------LSVRSEKDPNLVYRWEKDLN----LGDLAKDKSQ---------------LR 115
V E+ L W + + GD+ + Q L+
Sbjct: 181 CLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLK 240
Query: 116 PDIVWFGEAVPLLKEAI--SLVKQAHLLIIIGTSLQVY 151
PD+V+FG+ V K VK+A L+++G+SLQVY
Sbjct: 241 PDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVY 278
>ref|NP_062786.1| (NM_019812) sirtuin 1 ((silent mating type information regulation
2, homolog) 1 (S. cerevisiae); sir2-like 1 [Mus
musculus]
ref|XP_122030.1| (XM_122030) sirtuin 1 ((silent mating type information regulation
2, homolog) 1 [Mus musculus]
gb|AAF24983.1|AF214646_1 (AF214646) Sir2alpha protein [Mus musculus]
Length = 737
Score = 47.8 bits (112), Expect = 8e-05
Identities = 47/163 (28%), Positives = 78/163 (47%), Gaps = 34/163 (20%)
Query: 21 NPQKVLD--FYNQRRRQLF----EVYPNK-----AHKALAELEKHYQV-NIITQNVDDLH 68
+PQ + D ++ + R F E+YP + HK +A +K ++ TQN+D L
Sbjct: 284 DPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLE 343
Query: 69 ERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNL--GDL-------------AKDKSQ 113
+ AG RIL HG + L+ +++ D GD+ + +
Sbjct: 344 QVAGIQRILQCHGSFATASC-----LICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAI 398
Query: 114 LRPDIVWFGEAVP-LLKEAISLVK-QAHLLIIIGTSLQVYPAA 154
++P+IV+FGE +P A+ K + LLI+IG+SL+V P A
Sbjct: 399 MKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVA 441
>pir||T18247 transcription regulatory protein - yeast (Candida albicans)
emb|CAA22018.1| (AL033503) transcription regulatory protein [Candida albicans]
Length = 331
Score = 47.8 bits (112), Expect = 8e-05
Identities = 42/159 (26%), Positives = 69/159 (42%), Gaps = 19/159 (11%)
Query: 26 LDFYNQRRRQLF----EVYPN-----KAHKALAELEKHYQVN-IITQNVDDLHERAG--S 73
+DF+ + + + E+YP K H + L+ + + TQN+D L AG
Sbjct: 63 IDFFKEDPKPFYTLAEELYPGNFAPTKFHHFIKLLQDQGSLKRVYTQNIDTLERLAGVED 122
Query: 74 SRILHLHGELLS-----VRSEKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLL 128
I+ HG S E + + KD + + ++PDIV+FGE +P+
Sbjct: 123 KYIVEAHGSFASNHCVDCHKEMTTETLKTYMKDKKIPSCQHCEGYVKPDIVFFGEGLPVK 182
Query: 129 KEAI--SLVKQAHLLIIIGTSLQVYPAASLYTHAHKDAL 165
+ + + I+ GTSL V+P ASL +K L
Sbjct: 183 FFDLWEDDCEDVEVAIVAGTSLTVFPFASLPGEVNKKCL 221
>gb|AAC73004.1| (AF102869) Sir2 homolog [Trypanosoma brucei]
Length = 351
Score = 47.4 bits (111), Expect = 1e-04
Identities = 32/104 (30%), Positives = 52/104 (49%), Gaps = 8/104 (7%)
Query: 61 TQNVDDLHERAG--SSRILHLHGELLSV-----RSEKDPNLVYRWEKDLNLGDLAKDKSQ 113
TQN+D L G S ++ HG S ++ D N+ + + +
Sbjct: 121 TQNIDGLERACGIPESLLVEAHGSFSSASCVDCHAKYDINIARAETRAGKVPHCNQCGGI 180
Query: 114 LRPDIVWFGEAVP-LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
++PD+V+FGE +P L+++ LL+I+GTSLQV+P A L
Sbjct: 181 VKPDVVFFGENLPEAFFNVAGLIEETELLLILGTSLQVHPFADL 224
>ref|NP_036370.2| (NM_012238) sirtuin 1; sirtuin (silent mating type information
regulation 2, S. cerevisiae, homolog) 1; sirtuin type 1;
sir2-like 1; SIR2alpha [Homo sapiens]
gb|AAD40849.2|AF083106_1 (AF083106) sirtuin type 1 [Homo sapiens]
gb|AAG38486.1|AF235040_1 (AF235040) SIR2alpha protein [Homo sapiens]
Length = 747
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/163 (28%), Positives = 78/163 (47%), Gaps = 34/163 (20%)
Query: 21 NPQKVLD--FYNQRRRQLF----EVYPNK-----AHKALAELEKHYQV-NIITQNVDDLH 68
+PQ + D ++ + R F E+YP + HK +A +K ++ TQN+D L
Sbjct: 292 DPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLE 351
Query: 69 ERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNL--GDL-------------AKDKSQ 113
+ AG RI+ HG + L+ +++ D GD+ + +
Sbjct: 352 QVAGIQRIIQCHGSFATASC-----LICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAI 406
Query: 114 LRPDIVWFGEAVP-LLKEAISLVK-QAHLLIIIGTSLQVYPAA 154
++P+IV+FGE +P A+ K + LLI+IG+SL+V P A
Sbjct: 407 MKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVA 449
>emb|CAC04174.1| (AL133551) bA57G10.4 (SIRT1, Sir2-like proteins (siruitins) type 1)
[Homo sapiens]
emb|CAB66675.1| (AL136741) hypothetical protein [Homo sapiens]
Length = 555
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/163 (28%), Positives = 78/163 (47%), Gaps = 34/163 (20%)
Query: 21 NPQKVLD--FYNQRRRQLF----EVYPNK-----AHKALAELEKHYQV-NIITQNVDDLH 68
+PQ + D ++ + R F E+YP + HK +A +K ++ TQN+D L
Sbjct: 100 DPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLE 159
Query: 69 ERAGSSRILHLHGELLSVRSEKDPNLVYRWEKDLNL--GDL-------------AKDKSQ 113
+ AG RI+ HG + L+ +++ D GD+ + +
Sbjct: 160 QVAGIQRIIQCHGSFATASC-----LICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAI 214
Query: 114 LRPDIVWFGEAVP-LLKEAISLVK-QAHLLIIIGTSLQVYPAA 154
++P+IV+FGE +P A+ K + LLI+IG+SL+V P A
Sbjct: 215 MKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVA 257
>ref|NP_650880.1| (NM_142623) CG5085 gene product [Drosophila melanogaster]
gb|AAL48850.1| (AY071228) RE26822p [Drosophila melanogaster]
Length = 326
Score = 46.2 bits (108), Expect = 2e-04
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 14/115 (12%)
Query: 51 LEKHYQVNIITQNVDDLHERAG--SSRILHLHGEL-----LSVRSEKDPNLVYRWEKDLN 103
L++HY TQN+D L G +I+ HG + R E D + +
Sbjct: 163 LQRHY-----TQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADR 217
Query: 104 LGDLAKDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
L K + ++PDIV+FGE +P + LLII+GTSL+V P ASL
Sbjct: 218 LPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASL 272
>dbj|BAB29128.1| (AK014042) data source:MGD, source key:MGI:1927664,
evidence:ISS~putative~sirtuin 2 (silent mating type
information regulation 2, homolog) 2 (S. cerevisiae)
[Mus musculus]
Length = 352
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/140 (30%), Positives = 62/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLS---V 86
E+YP + + EK + TQN+D L AG ++ HG + V
Sbjct: 100 ELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCV 159
Query: 87 RSEKDPNLVYRWEKDLNLGDLA----KDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ + + +S ++PDIV+FGE +P S + L
Sbjct: 160 NTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDL 219
Query: 141 LIIIGTSLQVYPAASLYTHA 160
LII+GTSLQV P ASL + A
Sbjct: 220 LIIMGTSLQVQPFASLISKA 239
>gb|AAH21439.1|AAH21439 (BC021439) sirtuin 2 (silent mating type information regulation 2,
homolog) 2 (S. cerevisiae) [Mus musculus]
Length = 389
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/140 (30%), Positives = 62/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLS---V 86
E+YP + + EK + TQN+D L AG ++ HG + V
Sbjct: 137 ELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCV 196
Query: 87 RSEKDPNLVYRWEKDLNLGDLA----KDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ + + +S ++PDIV+FGE +P S + L
Sbjct: 197 NTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPPRFFSCMQSDFSKVDL 256
Query: 141 LIIIGTSLQVYPAASLYTHA 160
LII+GTSLQV P ASL + A
Sbjct: 257 LIIMGTSLQVQPFASLISKA 276
>ref|NP_071877.1| (NM_022432) silent mating type information regulation 2,
(S.cerevisiae, homolog)-like; sirtuin 2 [Mus musculus]
ref|XP_133289.1| (XM_133289) similar to silent mating type information regulation 2,
(S.cerevisiae, homolog)-like; sirtuin 2 [Mus musculus]
gb|AAG39256.1| (AF299337) SIR2L2 [Mus musculus]
Length = 389
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/140 (30%), Positives = 62/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLS---V 86
E+YP + + EK + TQN+D L AG ++ HG + V
Sbjct: 137 ELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCV 196
Query: 87 RSEKDPNLVYRWEKDLNLGDLA----KDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ + + +S ++PDIV+FGE +P S + L
Sbjct: 197 NTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKPDIVFFGENLPSRFFSCMQSDFSKVDL 256
Query: 141 LIIIGTSLQVYPAASLYTHA 160
LII+GTSLQV P ASL + A
Sbjct: 257 LIIMGTSLQVQPFASLISKA 276
>gb|AAG22161.1| (AE003730) CG5085 gene product [Drosophila melanogaster]
Length = 355
Score = 46.2 bits (108), Expect = 2e-04
Identities = 38/115 (33%), Positives = 54/115 (46%), Gaps = 14/115 (12%)
Query: 51 LEKHYQVNIITQNVDDLHERAG--SSRILHLHGEL-----LSVRSEKDPNLVYRWEKDLN 103
L++HY TQN+D L G +I+ HG + R E D + +
Sbjct: 132 LQRHY-----TQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADR 186
Query: 104 LGDLAKDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIIIGTSLQVYPAASL 156
L K + ++PDIV+FGE +P + LLII+GTSL+V P ASL
Sbjct: 187 LPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASL 241
>ref|NP_501912.1| (NM_069511) Yeast regulatory protein SIR2 like [Caenorhabditis
elegans]
pir||T24172 hypothetical protein R11A8.4 - Caenorhabditis elegans
emb|CAA94364.1| (Z70310) predicted using Genefinder~Similarity to K.lactis
regulatory protein SIR2 (SW:SIR2_KLULA), contains
similarity to Pfam domain: PF02146 (Sir2 family),
Score=372.6, E-value=1.3e-108, N=1~cDNA EST EMBL:Z14446
comes from this gene~cDNA EST yk352g2>
Length = 607
Score = 45.8 bits (107), Expect = 3e-04
Identities = 35/147 (23%), Positives = 70/147 (46%), Gaps = 14/147 (9%)
Query: 18 WKKNPQKVLDFYNQRRRQLF--EVYPNKAHKALAELEKHYQV-NIITQNVDDLHERAGSS 74
+++NP +F R++F + P+ +H+ + ELE ++ TQN+D L + G
Sbjct: 194 FRENPAPFYNF----AREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIK 249
Query: 75 RILHLHGELLSVRSEK-----DPNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAV--PL 127
R++ HG + D N + + + + + ++P+IV+FGE +
Sbjct: 250 RVVECHGSFSKCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREF 309
Query: 128 LKEAISLVKQAHLLIIIGTSLQVYPAA 154
+ + L+++IG+SL+V P A
Sbjct: 310 HQHVTEDKHKVDLIVVIGSSLKVRPVA 336
>ref|NP_200387.1| (NM_124958) transcription regulator Sir2-like protein [Arabidopsis
thaliana]
dbj|BAB09243.1| (AB009050) transcription regulator Sir2-like protein [Arabidopsis
thaliana]
gb|AAG44850.1|AF283757_1 (AF283757) sir2-like protein [Arabidopsis thaliana]
Length = 473
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/132 (29%), Positives = 67/132 (50%), Gaps = 19/132 (14%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSR--ILHLHGELLSVRSEKDPNLVYR 97
P+ H AL ELE+ + +I+QNVD LH R+G R + LHG+ E P+
Sbjct: 92 PSMTHMALVELERAGILKFVISQNVDGLHLRSGIPREKLSELHGDSFM---EMCPSCGAE 148
Query: 98 WEKDLNLGDLA-----------KDKSQLRPDIVWFGEAVPL--LKEAISLVKQAHLLIII 144
+ +D + + K ++L+ ++ + +A+P + A K+A L++ +
Sbjct: 149 YLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKADLVLCL 208
Query: 145 GTSLQVYPAASL 156
GTSLQ+ PA +L
Sbjct: 209 GTSLQITPACNL 220
>ref|NP_510220.1| (NM_077819) SIR [Caenorhabditis elegans]
pir||T22325 hypothetical protein F46G10.3 - Caenorhabditis elegans
emb|CAA90547.1| (Z50177) contains similarity to Pfam domain: PF02146 (Sir2 family),
Score=320.6, E-value=5.9e-93, N=1 [Caenorhabditis
elegans]
Length = 287
Score = 45.4 bits (106), Expect = 4e-04
Identities = 40/162 (24%), Positives = 64/162 (38%), Gaps = 38/162 (23%)
Query: 38 EVYPNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSVRS-------- 88
+ PN H AL++ E + + +ITQNVD LH +AGS I LHG L V+
Sbjct: 91 QALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIET 150
Query: 89 ---------------------------EKDPNLVYRWEKDLNLGDLAKDKSQLRPDIVWF 121
+ D L E+ + + ++ D+ F
Sbjct: 151 RQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGGLMKTDVTLF 210
Query: 122 GEAV--PLLKEAISLVKQAHLLIIIGTSLQVYPAASLYTHAH 161
GE + +K V + + ++ +GTSL+V + HAH
Sbjct: 211 GENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAH 252
>ref|NP_071878.1| (NM_022433) sirtuin 3; silent mating type information regulation 2,
(S.cerevisiae, homolog)-like 3 [Mus musculus]
gb|AAG33227.1| (AF302278) SIR2L3 [Mus musculus]
gb|AAG39257.1| (AF299338) SIR2L3 isoform A [Mus musculus]
gb|AAG39258.1| (AF299339) SIR2L3 isoform B [Mus musculus]
Length = 257
Score = 45.1 bits (105), Expect = 5e-04
Identities = 43/128 (33%), Positives = 65/128 (50%), Gaps = 15/128 (11%)
Query: 41 PNKAHKALAEL-EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLSV------RSEKD 91
PN H L L +K + + TQN+D L +G +S+++ HG ++ RS
Sbjct: 64 PNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPG 123
Query: 92 PNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVP---LLKEAISLVKQAHLLIIIGTSL 148
++ D + A ++PDIV+FGE +P LL A + A LL+I+GTSL
Sbjct: 124 EDIWADVMAD-RVPRCAVCTGVVKPDIVFFGEQLPARFLLHMADFAL--ADLLLILGTSL 180
Query: 149 QVYPAASL 156
+V P ASL
Sbjct: 181 EVEPFASL 188
>gb|EAA07580.1| (AAAB01008859) agCP1456 [Anopheles gambiae str. PEST]
Length = 278
Score = 45.1 bits (105), Expect = 5e-04
Identities = 54/186 (29%), Positives = 84/186 (45%), Gaps = 33/186 (17%)
Query: 4 GKGHDIMEVASPYGWKKNPQKV--LDFYNQRRRQLF----EVYPNK-----AHKALAELE 52
G +++M+ PY PQ + L++ +Q + F E+YP +H + LE
Sbjct: 45 GLYNNLMKYNLPY-----PQAIFELEYLHQNPKPFFTLAKELYPGTFKPTPSHYFVRLLE 99
Query: 53 -KHYQVNIITQNVDDLHERAG--SSRILHLHGELLSVRSEKDPNLVYRWE--KDLNLGDL 107
K V TQN+D L AG +I+ HG + + + Y E K+ D
Sbjct: 100 QKGLLVRHYTQNIDTLERIAGIPEDKIVEAHGTFYTNHC-LECKIAYSLEFVKEKIFADE 158
Query: 108 AKD---KSQLRPDIVWFGEAVPLLKEAISLVK-----QAHLLIIIGTSLQVYPAASLYTH 159
++PDIV+FGE +P E ++ + LLII+GTSL V P ASL +
Sbjct: 159 VPTCPCGGVIKPDIVFFGEGLP---ERFHMLPHQDFAECDLLIIMGTSLTVQPFASLVEY 215
Query: 160 AHKDAL 165
+ D +
Sbjct: 216 VNDDCV 221
>gb|AAD42226.1|AF159133_1 (AF159133) SIR2-like protein [Oryza sativa subsp. indica] [Oryza
sativa (indica cultivar-group)]
Length = 483
Score = 45.1 bits (105), Expect = 5e-04
Identities = 39/132 (29%), Positives = 66/132 (49%), Gaps = 19/132 (14%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSR--ILHLHGELLSVRSEKDPNLVYR 97
P H AL ELEK ++ +I+QNVD LH R+G R + LHG E P+
Sbjct: 92 PTLTHMALVELEKTGRLKFVISQNVDSLHLRSGLPREKLAELHGNSF---KEICPSCKKE 148
Query: 98 WEKDLNLGDL--------AKDK---SQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIII 144
+ +D + + DK ++L+ ++ + +A+P + A + A L++ +
Sbjct: 149 YLRDFEIETIGLKDTPRRCSDKNCGARLKDTVLDWEDALPPEEMDAAKEQCQTADLVLCL 208
Query: 145 GTSLQVYPAASL 156
GTSLQ+ PA ++
Sbjct: 209 GTSLQITPACNM 220
>sp|O59923|SIR2_CANAL NAD-dependent histone deacetylase SIR2 (Regulatory protein SIR2)
(Silent information regulator 2)
gb|AAC09304.1| (AF045774) SIR2 [Candida albicans]
Length = 515
Score = 45.1 bits (105), Expect = 5e-04
Identities = 34/127 (26%), Positives = 57/127 (44%), Gaps = 25/127 (19%)
Query: 52 EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLS------------------VRSEKD 91
+KH + TQN+D+L +RAG S +++ HG +R ++
Sbjct: 314 DKHKLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAKCVSCQGIFAGEKIYNHIRRKQV 373
Query: 92 PNLVYRWEKDLNLGDLAKDKSQLRPDIVWFGEAVPLLKEAI--SLVKQAHLLIIIGTSLQ 149
P W+ N ++P I +FGE +P + ++Q L ++IGTSL+
Sbjct: 374 PRCAICWK---NTKQAPIHFGAIKPTITFFGEDLPERFHTLMDKDLQQIDLFLVIGTSLK 430
Query: 150 VYPAASL 156
V P AS+
Sbjct: 431 VEPVASI 437
>ref|NP_085096.1| (NM_030593) sirtuin 2, isoform 2; SIR2 (silent mating type
information regulation 2, S.cerevisiae, homolog)-like;
sirtuin (silent mating type information regulation 2,
S.cerevisiae, homolog) 2; silencing information
regulator 2-like; SIR2 (silent matin>
ref|NP_446189.1| (NM_053737) sirtuin 2 (silent mating type information regulation 2,
homolog) 2 (S. cerevisiae) [Rattus norvegicus]
gb|AAD45971.1|AF095714_1 (AF095714) silencing information regulator 2-like protein [Homo
sapiens]
gb|AAH03012.1|AAH03012 (BC003012) SIR2 (silent mating type information regulation 2,
S.cerevisiae, homolog)-like [Homo sapiens]
gb|AAH03547.1|AAH03547 (BC003547) SIR2 (silent mating type information regulation 2,
S.cerevisiae, homolog)-like [Homo sapiens]
gb|AAK51133.1| (AY030277) SIRT2 [Rattus norvegicus]
Length = 352
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/140 (27%), Positives = 64/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAGSSR--ILHLHGELLS---V 86
E+YP + + +K + TQN+D L AG + ++ HG + V
Sbjct: 100 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 159
Query: 87 RSEKDPNLVYRWEKDLNLGDLAKD----KSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ ++ +S ++PDIV+FGE++P S + L
Sbjct: 160 SASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDL 219
Query: 141 LIIIGTSLQVYPAASLYTHA 160
L+++GTSLQV P ASL + A
Sbjct: 220 LLVMGTSLQVQPFASLISKA 239
>pdb|1J8F|C Chain C, Human Sirt2 Histone Deacetylase
Length = 323
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/140 (27%), Positives = 64/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAGSSR--ILHLHGELLS---V 86
E+YP + + +K + TQN+D L AG + ++ HG + V
Sbjct: 104 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 163
Query: 87 RSEKDPNLVYRWEKDLNLGDLAKD----KSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ ++ +S ++PDIV+FGE++P S + L
Sbjct: 164 SASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDL 223
Query: 141 LIIIGTSLQVYPAASLYTHA 160
L+++GTSLQV P ASL + A
Sbjct: 224 LLVMGTSLQVQPFASLISKA 243
>pdb|1J8F|A Chain A, Human Sirt2 Histone Deacetylase
pdb|1J8F|B Chain B, Human Sirt2 Histone Deacetylase
Length = 323
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/140 (27%), Positives = 64/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAGSSR--ILHLHGELLS---V 86
E+YP + + +K + TQN+D L AG + ++ HG + V
Sbjct: 104 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 163
Query: 87 RSEKDPNLVYRWEKDLNLGDLAKD----KSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ ++ +S ++PDIV+FGE++P S + L
Sbjct: 164 SASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDL 223
Query: 141 LIIIGTSLQVYPAASLYTHA 160
L+++GTSLQV P ASL + A
Sbjct: 224 LLVMGTSLQVQPFASLISKA 243
>ref|NP_036369.2| (NM_012237) sirtuin 2, isoform 1; SIR2 (silent mating type
information regulation 2, S.cerevisiae, homolog)-like;
sirtuin (silent mating type information regulation 2,
S.cerevisiae, homolog) 2; silencing information
regulator 2-like; SIR2 (silent matin>
gb|AAD40850.2|AF083107_1 (AF083107) sirtuin type 2 [Homo sapiens]
Length = 389
Score = 44.7 bits (104), Expect = 7e-04
Identities = 39/140 (27%), Positives = 64/140 (44%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAGSSR--ILHLHGELLS---V 86
E+YP + + +K + TQN+D L AG + ++ HG + V
Sbjct: 137 ELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCV 196
Query: 87 RSEKDPNLVYRWEKDLNLGDLAKD----KSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ ++ +S ++PDIV+FGE++P S + L
Sbjct: 197 SASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDL 256
Query: 141 LIIIGTSLQVYPAASLYTHA 160
L+++GTSLQV P ASL + A
Sbjct: 257 LLVMGTSLQVQPFASLISKA 276
>gb|AAF46055.1| (AE003435) CG3187 gene product [Drosophila melanogaster]
Length = 204
Score = 44.7 bits (104), Expect = 7e-04
Identities = 20/42 (47%), Positives = 28/42 (66%), Gaps = 1/42 (2%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHG 81
PN H ALA E+ +V ++TQNVD LH +AGS ++ +HG
Sbjct: 112 PNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHG 153
>ref|XP_125746.1| (XM_125746) RIKEN cDNA 2810449N18 [Mus musculus]
Length = 334
Score = 44.3 bits (103), Expect = 9e-04
Identities = 39/138 (28%), Positives = 68/138 (49%), Gaps = 25/138 (18%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSR--ILHLHGELLSVRSEKDPNLVYR 97
P+K H AL +LE+ ++ +++QNVD LH R+G R + LHG + E+ P +
Sbjct: 91 PSKTHMALVQLERMGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMF---VEECPKCKTQ 147
Query: 98 WEKDLNLG-----------------DLAKDKSQLRPDIVWFGEAVP--LLKEAISLVKQA 138
+ +D +G L + +LR I+ + +++P L A + A
Sbjct: 148 YVRDTVVGTMGLKATGRLCTVAKTRGLRACRGELRDTILDWEDSLPDRDLMLADEASRTA 207
Query: 139 HLLIIIGTSLQVYPAASL 156
L + +GTSLQ+ P+ +L
Sbjct: 208 DLSVTLGTSLQIRPSGNL 225
>gb|AAK67144.1|AF384034_1 (AF384034) SIR2-like histone deacetylase [Zea mays]
Length = 476
Score = 42.7 bits (99), Expect = 0.003
Identities = 38/132 (28%), Positives = 65/132 (48%), Gaps = 19/132 (14%)
Query: 41 PNKAHKALAELEKH-YQVNIITQNVDDLHERAGSSR--ILHLHGELLSVRSEKDPNLVYR 97
P+ H AL ELE+ + +I+QNVD LH R+G R + LHG E P
Sbjct: 92 PSLTHMALVELERAGFLKFVISQNVDSLHLRSGFPREKLAELHGNSF---KEICPCCKTE 148
Query: 98 WEKDLNLGDL--------AKDK---SQLRPDIVWFGEAVP--LLKEAISLVKQAHLLIII 144
+ +D + + DK ++L+ ++ + +A+P + A + A L++ +
Sbjct: 149 YLRDFEIETIGLKDTPRRCSDKNCGARLKDTVLDWDDALPPEEMNLATEHCRSADLVLCL 208
Query: 145 GTSLQVYPAASL 156
GTSLQ+ PA ++
Sbjct: 209 GTSLQITPACNM 220
>gb|AAG32038.1| (AF302272) SIR2L2 [Mus musculus]
Length = 389
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 17/140 (12%)
Query: 38 EVYPNKAHKALAEL------EKHYQVNIITQNVDDLHERAG--SSRILHLHGELLS---V 86
E+YP + + EK + TQN+D L AG ++ HG + V
Sbjct: 137 ELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCV 196
Query: 87 RSEKDPNLVYRWEKDLNLGDLA----KDKSQLRPDIVWFGEAVP--LLKEAISLVKQAHL 140
+ W K+ + + +S ++ DIV+FGE +P S + L
Sbjct: 197 NTSCRKEYTMGWMKEKIFSEATPRCEQCQSVVKLDIVFFGENLPSRFFSCMQSDFSKVDL 256
Query: 141 LIIIGTSLQVYPAASLYTHA 160
LII+GTSLQV P ASL + A
Sbjct: 257 LIIMGTSLQVQPFASLISKA 276
>ref|NP_510219.1| (NM_077818) SIR [Caenorhabditis elegans]
pir||T22324 hypothetical protein F46G10.7 - Caenorhabditis elegans
emb|CAA90546.1| (Z50177) contains similarity to Pfam domain: PF02146 (Sir2 family),
Score=340.4, E-value=6.3e-99, N=1~cDNA EST yk300f10.3
comes from this gene~cDNA EST yk522h8.3 comes from this
gene~cDNA EST yk522h8.5 comes from this gene
[Caenorhabditis elegans]
Length = 287
Score = 42.0 bits (97), Expect = 0.004
Identities = 45/159 (28%), Positives = 63/159 (39%), Gaps = 38/159 (23%)
Query: 41 PNKAHKALAELEKHYQVN-IITQNVDDLHERAGSSRILHLHGELLSV----------RSE 89
PN H AL++ E + +ITQNVD LH +AGS + LHG L V R
Sbjct: 94 PNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQT 153
Query: 90 KDPNLVYR----WEKDLNLGDLAKDKSQLRP---------------------DIVWFGEA 124
L Y E+ + G+LA D + P D+ +FGE
Sbjct: 154 YQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGEN 213
Query: 125 VPLLKE--AISLVKQAHLLIIIGTSLQVYPAASLYTHAH 161
V + K V + ++ +GTSL V HA+
Sbjct: 214 VNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHAN 252
Database: /home/scwang/download_20020708_db/nr
Posted date: Aug 7, 2002 12:55 PM
Number of letters in database: 324,149,939
Number of sequences in database: 1,026,957
Lambda K H
0.319 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 129,581,894
Number of Sequences: 1026957
Number of extensions: 5043353
Number of successful extensions: 12158
Number of sequences better than 1.0e-02: 89
Number of HSP's better than 0.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 11958
Number of HSP's gapped (non-prelim): 104
length of query: 205
length of database: 324,149,939
effective HSP length: 115
effective length of query: 90
effective length of database: 206,049,884
effective search space: 18544489560
effective search space used: 18544489560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 94 (40.8 bits)