BLASTP 2.2.1 [Apr-13-2001]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|15644975|ref|NP_207145.1| conserved hypothetical
protein [Helicobacter pylori 26695]
         (298 letters)

Database: /home/scwang/download_20020708_db/nr
           1,026,957 sequences; 324,149,939 total letters

Searching..................................................done


                                                                   Score     E
Sequences producing significant alignments:                        (bits)  Value

ref|NP_207145.1|  (NC_000915) conserved hypothetical protein...   596  e-170
ref|NP_223040.1|  (NC_000921) putative [Helicobacter pylori ...   547  e-155
ref|NP_281244.1|  (NC_002163) putative ribosomal pseudouridi...   177  1e-43
gb|AAC69259.1|  (AF025970) hypothetical protein [Helicobacte...   163  2e-39
ref|NP_228272.1|  (NC_000853) conserved hypothetical protein...   103  2e-21
ref|NP_078147.1|  (NC_002162) pseudouridine synthase (uracil...    98  1e-19
ref|NP_224915.1|  (NC_000922) predicted Pseudouridine Syntha...    98  1e-19
ref|NP_214204.1|  (NC_000918) hypothetical protein [Aquifex ...    96  6e-19
ref|NP_465768.1|  (NC_003210) similar to putative ribosomal ...    94  2e-18
ref|NP_563038.1|  (NC_003366) conserved hypothetical protein...    92  9e-18
ref|NP_604269.1|  (NC_003454) Ribosomal large subunit pseudo...    91  1e-17
ref|NP_212152.1|  (NC_001318) conserved hypothetical protein...    91  1e-17
ref|NP_223608.1|  (NC_000921) putative [Helicobacter pylori ...    91  1e-17
sp|P70870|RLUD_BORBU  Ribosomal large subunit pseudouridine ...    91  1e-17
ref|NP_326129.1|  (NC_002771) RIBOSOMAL LARGE SUBUNIT PSEUDO...    91  1e-17
ref|NP_207748.1|  (NC_000915) conserved hypothetical protein...    91  2e-17
ref|NP_388802.1|  (NC_000964) similar to hypothetical protei...    91  2e-17
ref|NP_011685.1|  (NC_001139) RNA:Psi-synthase; Pus6p [Sacch...    91  2e-17
ref|NP_471677.1|  (NC_003212) similar to putative ribosomal ...    90  3e-17
ref|XP_130420.1|  (XM_130420) similar to CG6187 gene product...    90  3e-17
ref|NP_347897.1|  (NC_003030) Pseudouridylate synthase famil...    89  5e-17
ref|NP_246658.1|  (NC_002663) SfB [Pasteurella multocida] >g...    89  6e-17
ref|NP_072871.1|  (NC_000908) sfhB protein, putative [Mycopl...    88  1e-16
ref|NP_109980.1|  (NC_000912) similar to RIBOSOMAL LARGE SUB...    88  1e-16
gb|AAF52961.1|  (AE003628) CG6187 gene product [Drosophila m...    87  2e-16
ref|XP_031554.2|  (XM_031554) similar to CG6187 gene product...    87  2e-16
ref|NP_295512.1|  (NC_001263) ribosomal large subunit pseudo...    87  2e-16
ref|NP_609411.1|  (NM_135567) CG6187 gene product [Drosophil...    87  2e-16
emb|CAA70352.1|  (Y09142) product homologous to E.coli YfiI ...    87  2e-16
gb|AAH07697.1|AAH07697  (BC007697) Unknown (protein for IMAG...    87  2e-16
ref|NP_246775.1|  (NC_002663) RsuA [Pasteurella multocida] >...    87  3e-16
ref|NP_623145.1|  (NC_003869) Pseudouridylate synthase, 23S ...    86  4e-16
ref|NP_283696.1|  (NC_003116) putative ribosomal large subun...    86  4e-16
ref|NP_623370.1|  (NC_003869) Pseudouridylate synthase, 23S ...    86  7e-16
ref|NP_457360.1|  (NC_003198) putative RNA pseudouridylate s...    86  7e-16
ref|NP_461885.1|  (NC_003197) putative synthase [Salmonella ...    86  7e-16
sp|P50513|RLUD_ZYMMO  RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE ...    85  9e-16
ref|NP_438344.1|  (NC_000907) sfhB protein (sfhB) [Haemophil...    85  1e-15
ref|NP_014575.1|  (NC_001147) Riboflavin biosynthesis; Rib2p...    84  1e-15
ref|NP_273746.1|  (NC_003112) ribosomal large subunit pseudo...    84  1e-15
ref|NP_592881.1|  (NC_003424) hypothetical protein [Schizosa...    84  2e-15
ref|NP_268269.1|  (NC_002662) pseudouridine synthase [Lactoc...    84  2e-15
ref|NP_662187.1|  (NC_002932) ribosomal large subunit pseudo...    84  2e-15
ref|NP_240218.1|  (NC_002528) ribosomal large subunit pseudo...    84  2e-15
ref|NP_660679.1|  (NC_004061) ribosomal large subunit pseudo...    83  3e-15
ref|NP_230358.1|  (NC_002505) ribosomal large subunit pseudo...    83  3e-15
ref|NP_253234.1|  (NC_002516) pseudouridine synthase [Pseudo...    83  3e-15
ref|NP_228748.1|  (NC_000853) ribosomal large subunit pseudo...    83  3e-15
ref|NP_230535.1|  (NC_002505) pseudouridine synthase Rlu fam...    82  6e-15
ref|NP_294685.1|  (NC_001263) ribosomal large subunit pseudo...    82  6e-15
sp|O50310|YBC5_CHLVI  Hypothetical 36.7 kDa protein in BCHI ...    82  7e-15
sp|Q45826|YMDA_CHLAU  Hypothetical protein in MDH 5'region (...    82  7e-15
ref|NP_603548.1|  (NC_003454) Ribosomal large subunit pseudo...    82  9e-15
ref|NP_420097.1|  (NC_002696) ribosomal large subunit pseudo...    82  9e-15
ref|NP_010248.1|  (NC_001136) Hypothetical ORF; Ydl036cp [Sa...    82  9e-15
gb|EAA14556.1|  (AAAB01008980) ebiP4675 [Anopheles gambiae s...    81  1e-14
ref|NP_406747.1|  (NC_003143) ribosomal large subunit pseudo...    81  1e-14
ref|NP_240167.1|  (NC_002528) ribosomal large subunit pseudo...    80  3e-14
ref|NP_311484.1|  (NC_002695) suppressor of ftsH mutation [E...    80  3e-14
ref|NP_562766.1|  (NC_003366) conserved hypothetical protein...    80  4e-14
dbj|BAA16479.1|  (D90887) similar to [SwissProt Accession Nu...    80  4e-14
ref|NP_417085.1|  (NC_000913) suppressor of ftsH mutation [E...    80  4e-14
ref|NP_245416.1|  (NC_002663) unknown [Pasteurella multocida...    79  5e-14
ref|NP_289346.1|  (NC_002655) Z4107 gene product [Escherichi...    79  5e-14
ref|NP_289149.1|  (NC_002655) suppressor of ftsH mutation [E...    79  5e-14
gb|AAF52959.1|  (AE003628) CG7475 gene product [Drosophila m...    79  5e-14
ref|NP_417271.1|  (NC_000913) orf, hypothetical protein [Esc...    79  5e-14
ref|NP_438775.1|  (NC_000907) conserved hypothetical protein...    79  6e-14
ref|NP_405172.1|  (NC_003143) ribosomal large subunit pseudo...    79  6e-14
ref|NP_655191.1|  (NC_003995) PseudoU_synth_2, RNA pseudouri...    79  6e-14
ref|NP_642429.1|  (NC_003919) pseudouridylate synthase [Xant...    79  6e-14
ref|NP_231662.1|  (NC_002505) ribosomal large subunit pseudo...    79  6e-14
ref|NP_296413.1|  (NC_002620) ribosomal large subunit pseudo...    78  1e-13
ref|NP_539900.1|  (NC_003317) RIBOSOMAL LARGE SUBUNIT PSEUDO...    78  1e-13
ref|NP_356602.1|  (NC_003063) AGR_L_1625p [Agrobacterium tum...    78  1e-13
ref|NP_607042.1|  (NC_003485) conserved hypothetical protein...    78  1e-13
ref|NP_267154.1|  (NC_002662) pseudouridine synthase [Lactoc...    78  1e-13
ref|NP_455681.1|  (NC_003198) ribosomal large subunit pseudo...    78  1e-13
ref|NP_110237.1|  (NC_000912) pseudouridine synthase [Mycopl...    78  1e-13
ref|NP_608079.1|  (NC_003485) conserved hypothetical protein...    78  1e-13
ref|NP_655109.1|  (NC_003995) PseudoU_synth_2, RNA pseudouri...    77  2e-13
ref|NP_270003.1|  (NC_002737) conserved hypothetical protein...    77  2e-13
gb|AAF78056.1|AF263561_1  (AF263561) 23S rRNA pseudouridine ...    77  2e-13
ref|NP_371721.1|  (NC_002758) conserved hypothetical protein...    77  2e-13
ref|NP_415604.1|  (NC_000913) orf, hypothetical protein [Esc...    77  2e-13
ref|NP_220177.1|  (NC_000117) (Pseudouridine Synthase) [Chla...    77  2e-13
ref|NP_190794.1|  (NM_115086) pseudouridine synthase, putati...    77  2e-13
ref|NP_470305.1|  (NC_003212) similar to ribosomal large sub...    77  2e-13
ref|NP_460157.1|  (NC_003197) 23S rRNA pseudouridylate synth...    77  2e-13
ref|NP_354476.1|  (NC_003062) AGR_C_2714p [Agrobacterium tum...    77  3e-13
ref|NP_219609.1|  (NC_000117) predicted pseudouridine synthe...    77  3e-13
ref|NP_532161.1|  (NC_003304) ribosomal large subunit pseudo...    77  3e-13
ref|NP_296760.1|  (NC_002620) RNA pseudouridylate synthase f...    77  3e-13
ref|NP_287220.1|  (NC_002655) orf, hypothetical protein [Esc...    76  4e-13
sp|P44197|YQCB_HAEIN  Hypothetical protein HI1435                  76  4e-13
ref|NP_372374.1|  (NC_002758) conserved hypothetical protein...    76  5e-13
ref|NP_269039.1|  (NC_002737) conserved hypothetical protein...    75  7e-13
ref|NP_645897.1|  (NC_003923) conserved hypothetical protein...    75  7e-13
ref|NP_345413.1|  (NC_003028) ribosomal large subunit pseudo...    75  7e-13
ref|XP_128468.1|  (XM_128468) RIKEN cDNA 2310051D06 gene [Mu...    75  7e-13
gb|AAF32394.1|AF224466_1  (AF224466) putative pseudouridylat...    75  9e-13
ref|NP_438574.1|  (NC_000907) conserved hypothetical protein...    75  9e-13
ref|NP_471291.1|  (NC_003212) similar to conserved hypotheti...    75  9e-13
ref|NP_457133.1|  (NC_003198) ftsH suppressor protein SfhB [...    75  9e-13
ref|NP_337928.1|  (NC_002755) RNA pseudouridylate synthase f...    75  9e-13
ref|NP_465368.1|  (NC_003210) similar to conserved hypotheti...    75  9e-13
ref|NP_358424.1|  (NC_003098) 23S rRNA pseudouridine synthas...    75  9e-13
gb|AAG10501.1|AF279106_63  (AF279106) predicted ribosomal la...    75  9e-13
ref|NP_385495.1|  (NC_003047) PROBABLE RIBOSOMAL LARGE SUBUN...    75  1e-12
pir||T46096  hypothetical protein T25B15.30 - Arabidopsis th...    74  2e-12
ref|NP_245929.1|  (NC_002663) RluC [Pasteurella multocida] >...    74  2e-12
ref|NP_245570.1|  (NC_002663) unknown [Pasteurella multocida...    74  2e-12
ref|NP_637448.1|  (NC_003902) pseudouridylate synthase [Xant...    74  2e-12
ref|NP_073042.1|  (NC_000908) conserved hypothetical protein...    74  2e-12
ref|NP_348732.1|  (NC_003030) Predicted pseudouridylate synt...    74  2e-12
ref|NP_657862.1|  (NC_003995) PseudoU_synth_2, RNA pseudouri...    74  2e-12
ref|NP_217817.1|  (NC_000962) hypothetical protein Rv3300c [...    74  2e-12
ref|NP_519749.1|  (NC_003295) PROBABLE RIBOSOMAL LARGE SUBUN...    74  2e-12
ref|NP_464494.1|  (NC_003210) similar to ribosomal large sub...    74  3e-12
ref|NP_404140.1|  (NC_003143) ribosomal large subunit pseudo...    73  3e-12
ref|NP_251936.1|  (NC_002516) pseudouridine synthase RluA [P...    73  4e-12
ref|NP_251665.1|  (NC_002516) ribosomal large subunit pseudo...    73  4e-12
ref|NP_359416.1|  (NC_003098) Ribosomal large subunit pseudo...    73  4e-12
ref|NP_346438.1|  (NC_003028) ribosomal large subunit pseudo...    72  6e-12
ref|NP_643525.1|  (NC_003919) ribosomal large subunit pseudo...    72  7e-12
ref|NP_603923.1|  (NC_003454) tRNA pseudouridine synthase A ...    72  7e-12
ref|NP_601339.1|  (NC_003450) COG0564:Pseudouridylate syntha...    72  7e-12
ref|NP_345571.1|  (NC_003028) ribosomal large subunit pseudo...    72  1e-11
ref|NP_478072.1|  (NM_058192) ribosomal large subunit pseudo...    72  1e-11
ref|NP_404651.1|  (NC_003143) Conserved hypothetical protein...    72  1e-11
ref|NP_414600.1|  (NC_000913) pseudouridylate synthase; orf,...    71  1e-11
ref|NP_626332.1|  (NC_003888) putative ribosomal large subun...    71  2e-11
ref|NP_371532.1|  (NC_002758) conserved hypothetical protein...    71  2e-11
ref|NP_438215.1|  (NC_000907) conserved hypothetical protein...    71  2e-11
ref|NP_360947.1|  (NC_003103) sfhB protein homolog [Ricketts...    70  2e-11
sp|Q47417|YQCB_ERWCA  Exoenzyme regulation regulon ORF1 >gi|...    70  3e-11
ref|NP_232505.1|  (NC_002506) ribosomal large subunit pseudo...    70  3e-11
ref|NP_645706.1|  (NC_003923) conserved hypothetical protein...    70  3e-11
ref|NP_347651.1|  (NC_003030) Pseudouridylate synthase [Clos...    70  3e-11
ref|NP_221194.1|  (NC_000963) SFHB PROTEIN HOMOLOG (sfhB) [R...    70  3e-11
sp|Q45480|YLYB_BACSU  Hypothetical protein ylyB >gi|1373157|...    70  3e-11
ref|NP_638435.1|  (NC_003902) ribosomal large subunit pseudo...    69  5e-11
ref|NP_216056.1|  (NC_000962) hypothetical protein Rv1540 [M...    69  5e-11
ref|NP_285754.1|  (NC_002655) orf, hypothetical protein [Esc...    69  8e-11
sp|O66114|YLP4_ZYMMO  Hypothetical 24.4 kDa protein in LPD 3...    69  8e-11
ref|NP_231304.1|  (NC_002505) pseudouridine synthase Rlu fam...    69  8e-11
ref|NP_223400.1|  (NC_000921) putative [Helicobacter pylori ...    68  1e-10
ref|NP_484566.1|  (NC_003272) probable pseudouridine synthas...    68  1e-10
ref|NP_281880.1|  (NC_002163) putative ribosomal pseudouridi...    68  1e-10
gb|EAA09234.1|  (AAAB01008898) agCP13979 [Anopheles gambiae ...    68  1e-10
ref|NP_389429.1|  (NC_000964) alternate gene name: ylmL~simi...    68  1e-10
ref|NP_454707.1|  (NC_003198) ribosomal large subunit pseudo...    67  2e-10
ref|NP_459100.1|  (NC_003197) 23S rRNA pseudouridylate 746 s...    67  2e-10
ref|NP_207538.1|  (NC_000915) conserved hypothetical protein...    67  2e-10
pir||B23747  ORFX protein, 5' of ams - Escherichia coli (fra...    67  2e-10
ref|NP_660729.1|  (NC_004061) ribosomal large subunit pseudo...    67  2e-10
ref|NP_243713.1|  (NC_002570) BH2847~unknown conserved prote...    67  3e-10
ref|NP_220643.1|  (NC_000963) unknown [Rickettsia prowazekii...    66  4e-10
ref|NP_298229.1|  (NC_002488) ribosomal large subunit pseudo...    66  5e-10
gb|AAL47436.1|  (AY069882) AT3g52260/T25B15_30 [Arabidopsis ...    66  5e-10
ref|NP_607212.1|  (NC_003485) conserved hypothetical protein...    66  5e-10
ref|NP_273256.1|  (NC_003112) ribosomal large subunit pseudo...    65  7e-10
ref|NP_232134.1|  (NC_002505) ribosomal large subunit pseudo...    65  9e-10
ref|NP_283855.1|  (NC_003116) hypothetical protein NMA1085 [...    65  9e-10
ref|NP_597410.1|  (NC_003232) similarity to HYPOTHETICAL PRO...    65  9e-10
ref|NP_269281.1|  (NC_002737) conserved hypothetical protein...    65  9e-10
ref|NP_282427.1|  (NC_002163) putative ribosomal pseudouridi...    65  9e-10
ref|NP_299883.1|  (NC_002488) pseudouridylate synthase [Xyle...    65  9e-10
ref|NP_273908.1|  (NC_003112) YabO/YceC/SfhB family protein ...    65  9e-10
ref|NP_602133.1|  (NC_003450) COG0564:Pseudouridylate syntha...    65  9e-10
ref|NP_359981.1|  (NC_003103) ribosomal large subunit pseudo...    65  1e-09
ref|NP_282921.1|  (NC_003116) ribosomal large subunit pseudo...    65  1e-09
ref|NP_243408.1|  (NC_002570) BH2542~unknown conserved prote...    64  2e-09
ref|NP_625900.1|  (NC_003888) putative ribosomal pseudouridi...    64  2e-09
ref|NP_419272.1|  (NC_002696) ribosomal large subunit pseudo...    64  2e-09
ref|NP_295407.1|  (NC_001263) pseudouridine synthase, putati...    63  3e-09
ref|NP_102152.1|  (NC_002678) ribosomal large subunit pseudo...    63  5e-09
ref|NP_562120.1|  (NC_003366) ribosomal large subunit pseudo...    63  5e-09
ref|NP_218779.1|  (NC_000919) conserved hypothetical protein...    63  5e-09
ref|NP_199927.1|  (NM_124493) putative protein [Arabidopsis ...    62  8e-09
gb|AAL31256.1|  (AY061753) AT5g51140/MWD22_8 [Arabidopsis th...    62  8e-09
ref|NP_301874.1|  (NC_002677) putative pseudouridine synthas...    62  8e-09
ref|NP_104781.1|  (NC_002678) pseudouridine synthase [Mesorh...    62  8e-09
ref|NP_644614.1|  (NC_003919) pseudouridylate synthase [Xant...    62  8e-09
ref|NP_355395.1|  (NC_003062) AGR_C_4432p [Agrobacterium tum...    62  1e-08
ref|NP_389044.1|  (NC_000964) similar to hypothetical protei...    62  1e-08
ref|NP_533115.1|  (NC_003304) pseudouridine synthase homolog...    62  1e-08
ref|NP_283249.1|  (NC_003116) putative psedouridine synthase...    62  1e-08
ref|NP_420787.1|  (NC_002696) ribosomal large subunit pseudo...    61  1e-08
ref|NP_441760.1|  (NC_000911) hypothetical protein [Synechoc...    61  1e-08
ref|NP_250733.1|  (NC_002516) hypothetical protein [Pseudomo...    61  1e-08
ref|NP_275010.1|  (NC_003112) conserved hypothetical protein...    61  1e-08
ref|NP_493778.1|  (NM_061377) K07E8.7.p [Caenorhabditis eleg...    60  2e-08
ref|NP_519162.1|  (NC_003295) PROBABLE RIBOSOMAL LARGE SUBUN...    60  2e-08
ref|NP_077944.1|  (NC_002162) pseudouridine synthase (uracil...    60  3e-08
ref|NP_386831.1|  (NC_003047) PUTATIVE RIBOSOMAL LARGE SUBUN...    60  3e-08
ref|NP_488120.1|  (NC_003272) ribosomal large chain pseudour...    60  3e-08
dbj|BAB13516.1|  (AB037369) pseudouridine synthase homolog [...    60  3e-08
ref|XP_165571.1|  (XM_165571) hypothetical protein FLJ14494 ...    59  5e-08
gb|AAM61068.1|  (AY084499) unknown [Arabidopsis thaliana]          59  7e-08
ref|NP_440308.1|  (NC_000911) hypothetical protein [Synechoc...    59  9e-08
ref|NP_599568.1|  (NC_003450) COG0564:Pseudouridylate syntha...    59  9e-08
ref|NP_218671.1|  (NC_000919) conserved hypothetical protein...    58  1e-07
ref|NP_116184.1|  (NM_032795) hypothetical protein FLJ14494 ...    58  1e-07
ref|NP_640600.1|  (NC_003919) pseudouridylate synthase [Xant...    57  2e-07
ref|NP_639523.1|  (NC_003902) pseudouridylate synthase [Xant...    57  3e-07
ref|NP_325948.1|  (NC_002771) RIBOSOMAL LARGE SUBUNIT PSEUDO...    55  7e-07
gb|AAD12509.1|  (U02214) Homology to M62747 [Mycoplasma geni...    55  7e-07
ref|NP_635620.1|  (NC_003902) pseudouridylate synthase [Xant...    54  2e-06
ref|XP_134644.1|  (XM_134644) RIKEN cDNA 2410001E19 [Mus mus...    53  4e-06
ref|NP_439586.1|  (NC_000907) conserved hypothetical protein...    52  8e-06
ref|NP_212949.1|  (NC_001318) conserved hypothetical protein...    52  1e-05
ref|NP_266520.1|  (NC_002662) pseudouridine synthase [Lactoc...    51  1e-05
dbj|BAB26589.1|  (AK009926) data source:SPTR, source key:Q9U...    50  3e-05
ref|NP_218593.1|  (NC_000919) conserved hypothetical protein...    49  7e-05
pir||S26602  hypothetical protein 185 - Pseudomonas aerugino...    49  9e-05
gb|AAB07777.1|  (U67934) 44.9 kDa protein C18B11 homolog [Ho...    49  9e-05
gb|AAH12951.1|AAH12951  (BC012951) Unknown (protein for IMAG...    48  1e-04
ref|NP_188575.1|  (NM_112831) unknown protein [Arabidopsis t...    47  2e-04
gb|AAM33173.1|  (AC117072) hypothetical protein [Dictyosteli...    47  2e-04
gb|AAB09035.1|  (U68242) orfEU5; uncharacterized orf upstrea...    47  2e-04
gb|AAA03374.1|  (U02220) unknown [Mycoplasma genitalium]           46  6e-04
ref|NP_224603.1|  (NC_000922) predicted pseudouridine synthe...    45  0.001
gb|AAG24942.1|AF128845_1  (AF128845) RluD [Sinorhizobium mel...    44  0.002
emb|CAC00347.2|  (AL160371) possible hypothetical 46.8 Kd pr...    42  0.008
>ref|NP_207145.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
           26695]
 sp|O25114|Y347_HELPY Hypothetical protein HP0347
 pir||C64563 conserved hypothetical protein HP0347 - Helicobacter pylori
           (strain 26695)
 gb|AAD07404.1| (AE000551) conserved hypothetical protein [Helicobacter pylori
           26695]
          Length = 298

 Score =  596 bits (1537), Expect = e-170
 Identities = 298/298 (100%), Positives = 298/298 (100%)

Query: 1   MPFVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLI 60
           MPFVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLI
Sbjct: 1   MPFVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLI 60

Query: 61  HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY 120
           HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY
Sbjct: 61  HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY 120

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
           ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH
Sbjct: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG
Sbjct: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY 298
           VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY
Sbjct: 241 VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY 298
>ref|NP_223040.1| (NC_000921) putative [Helicobacter pylori J99]
 sp|Q9ZMA1|Y347_HELPJ Hypothetical protein JHP0321
 pir||A71946 hypothetical protein jhp0321 - Helicobacter pylori (strain J99)
 gb|AAD05911.1| (AE001468) putative [Helicobacter pylori J99]
          Length = 293

 Score =  547 bits (1410), Expect = e-155
 Identities = 274/293 (93%), Positives = 281/293 (95%)

Query: 1   MPFVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLI 60
           MPFVEEEFEILKPTKALF VRDVLKCSLKEAQRHLDKQRLKQNQQ VRKSQIIQGVVRLI
Sbjct: 1   MPFVEEEFEILKPTKALFLVRDVLKCSLKEAQRHLDKQRLKQNQQTVRKSQIIQGVVRLI 60

Query: 61  HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY 120
           +FKPNEK + LVFE KDFGVFDKP Q+YTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY
Sbjct: 61  YFKPNEKQEKLVFEAKDFGVFDKPAQIYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDY 120

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
           ETSGLVLAGKTLQS KDLKALFMQKKVKKTYLALAHGLV+KS+ I+KPILTPQNIQKDL 
Sbjct: 121 ETSGLVLAGKTLQSTKDLKALFMQKKVKKTYLALAHGLVDKSIIINKPILTPQNIQKDLR 180

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           IRS+ISPLGK SITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG
Sbjct: 181 IRSQISPLGKPSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKD 293
           VADENAREYLQLKRENNAP LMLHAASLEFEFKGA YKIASPMPERFMPFLKD
Sbjct: 241 VADENAREYLQLKRENNAPTLMLHAASLEFEFKGAHYKIASPMPERFMPFLKD 293
>ref|NP_281244.1| (NC_002163) putative ribosomal pseudouridine synthase
           [Campylobacter jejuni]
 pir||A81418 pseudouridylate synthase (EC 4.2.1.70) rRNA-specific Cj0022c
           [imported] - Campylobacter jejuni (strain NCTC 11168)
 emb|CAB72515.1| (AL139074) putative ribosomal pseudouridine synthase [Campylobacter
           jejuni]
          Length = 300

 Score =  177 bits (449), Expect = 1e-43
 Identities = 111/275 (40%), Positives = 161/275 (58%), Gaps = 9/275 (3%)

Query: 15  KALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVR-KSQIIQGVVRLIHFKPNEKTQALVF 73
           KA   + + LK S+ EAQ+ +DK+RL  +   V  K++I+ G+V LI ++ N K   +VF
Sbjct: 14  KAFQVLMENLKISINEAQKLIDKKRLFCDGILVEEKNKILNGLVELIVYENNPKGVEIVF 73

Query: 74  ETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQ 133
           E +DF + +K   + +HP G     SL D I   +GK A  AHRLD ETSGL+L  K  +
Sbjct: 74  ENEDFAILEKESGILSHPNGRHCKYSLSDEIWHLWGKEACVAHRLDKETSGLILIAKNKK 133

Query: 134 SVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSI 193
           +  DLK+LF +K V+K YLALAHG +E++  +DK I   +N   D+  R +I   GKQ+I
Sbjct: 134 AQIDLKSLFEKKLVQKEYLALAHGKIEENFIVDKAINLTKNYD-DVKTRMQICKEGKQAI 192

Query: 194 TLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLK 253
           T  E L Y P ++ +LL   PLTGR HQIR+HL   +H I+G+ LYG++ +     L  K
Sbjct: 193 TEFEILEYFPKINATLLLCKPLTGRQHQIRVHLHYKNHTILGDPLYGLSKQQIESILDEK 252

Query: 254 -------RENNAPLLMLHAASLEFEFKGAIYKIAS 281
                  +   A  L LH+  L+F++K   + I S
Sbjct: 253 LNPKERLKLTGALRLCLHSYRLKFQYKNQNFDINS 287
>gb|AAC69259.1| (AF025970) hypothetical protein [Helicobacter pylori]
          Length = 83

 Score =  163 bits (412), Expect = 2e-39
 Identities = 80/83 (96%), Positives = 81/83 (97%)

Query: 211 KITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           KITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAP LMLHAASLEF
Sbjct: 1   KITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPTLMLHAASLEF 60

Query: 271 EFKGAIYKIASPMPERFMPFLKD 293
           EFKGA YKIASPMP+RFMPFLKD
Sbjct: 61  EFKGAHYKIASPMPKRFMPFLKD 83
>ref|NP_228272.1| (NC_000853) conserved hypothetical protein [Thermotoga maritima]
 pir||F72373 conserved hypothetical protein - Thermotoga maritima (strain MSB8)
 gb|AAD35547.1|AE001724_5 (AE001724) conserved hypothetical protein [Thermotoga maritima]
          Length = 311

 Score =  103 bits (257), Expect = 2e-21
 Identities = 87/295 (29%), Positives = 145/295 (48%), Gaps = 31/295 (10%)

Query: 9   EILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVV----RLIHFKP 64
           + LK     +  R +++ ++KE +  ++ Q +K+    +++ +I++  +    +    +P
Sbjct: 17  QFLKEKTPSWISRSMIQKAIKEGKVKVNGQ-IKKPSYKLKEGEIVEVDLPEKPQEATVQP 75

Query: 65  NEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--H 116
            E    +++E +D  V DKP  +  HP       +L++ +  H       G    P   H
Sbjct: 76  EEIELKVLYEDRDIIVIDKPGDMIVHPVPSKLSGTLVNALLHHCKDLQGVGGKLRPGIVH 135

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILT-PQNI 175
           RLD ETSG+++  K   + + L   F  +KVKKTY+ L  G     MK D+ ++  P   
Sbjct: 136 RLDKETSGVIVVAKNDFAHQSLSKQFKDRKVKKTYILLVKG----KMKNDEGVIDLPLAR 191

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKIT-PLTGRTHQIRLHLSSVDHRIV 234
              L I+  +   GK++IT    L    F D++ L +  P TGRTHQIR+H+ S+ H I+
Sbjct: 192 HPVLRIKMAVVETGKEAITEYRVLKR--FDDVATLVLAFPKTGRTHQIRVHMKSLGHPIM 249

Query: 235 GEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERF 287
           G+ +YG   E+  E   +KR+      MLHA  L F     G   +  SP+PE F
Sbjct: 250 GDKIYGKPKED--EIFGIKRQ------MLHALKLGFFHPRTGEWMEFVSPLPEDF 296
>ref|NP_078147.1| (NC_002162) pseudouridine synthase (uracil hydrolase) [Ureaplasma
           urealyticum]
 pir||H82907 pseudouridine synthase (uracil hydrolase) UU313 [imported] -
           Ureaplasma urealyticum
 gb|AAF30722.1|AE002128_10 (AE002128) pseudouridine synthase (uracil hydrolase) [Ureaplasma
           urealyticum]
          Length = 299

 Score = 98.2 bits (243), Expect = 1e-19
 Identities = 63/230 (27%), Positives = 122/230 (52%), Gaps = 21/230 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-NAHPAHRLDYETSGLVLAG 129
           ++FE +D  + +KP  +  HP  +    +L + ++ +    N +  HRLD  TSGL++  
Sbjct: 81  IIFEDQDLLIVNKPSGMLVHPTSFHEQNTLANALKYYLKTDNFYITHRLDKNTSGLIIIC 140

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKS---MKIDKPILTPQNIQKDLHIRSKIS 186
           K   ++  L+  FMQK ++K+Y A+ H   +       I++PI    + Q  L +++  S
Sbjct: 141 KNQIALNSLQQQFMQKTIRKSYYAIVHNRFDMQHLHFMINEPI--GHSYQDKLRMKTGNS 198

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA 246
              K++I++V+ L    + + +L++++ +TGRTHQIR+H+  ++H +  + LYG++ ++ 
Sbjct: 199 KNTKEAISIVKVL--EQYKNTALVEVSIITGRTHQIRVHMRYINHPVYNDPLYGIS-KHT 255

Query: 247 REYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASP--MPERFMPFLKDL 294
            EY Q           LH+  + F       K+     MP+ FM  +++L
Sbjct: 256 TEYEQ----------YLHSFYISFNHPSTNKKVEFKINMPKEFMELIREL 295
>ref|NP_224915.1| (NC_000922) predicted Pseudouridine Synthase [Chlamydophila
           pneumoniae CWL029]
 ref|NP_300775.1| (NC_002491) pseudouridine synthase [Chlamydophila pneumoniae J138]
 ref|NP_444579.1| (NC_002179) ribosomal large subunit pseudouridine synthase D
           [Chlamydophila pneumoniae AR39]
 pir||G72043 ribosomal large chain pseudouridine synthase D CP0027 [imported] -
           Chlamydophila pneumoniae (strains CWL029 and AR39)
 gb|AAD18858.1| (AE001653) predicted Pseudouridine Synthase [Chlamydophila
           pneumoniae CWL029]
 gb|AAF37922.1| (AE002166) ribosomal large subunit pseudouridine synthase D
           [Chlamydophila pneumoniae AR39]
 dbj|BAA98926.1| (AP002547) pseudouridine synthase [Chlamydophila pneumoniae J138]
          Length = 325

 Score = 97.8 bits (242), Expect = 1e-19
 Identities = 70/229 (30%), Positives = 115/229 (49%), Gaps = 26/229 (11%)

Query: 53  IQGVVRLIHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG--- 109
           IQ    L+   P       V+E     V +KP  +  HP    +H +L+  +    G   
Sbjct: 66  IQEKEELLELLPEAIPLDKVYEDGMILVINKPRDMVVHPAPGHFHGTLVHALLHEIGERL 125

Query: 110 KNAHP--------AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK 161
           K   P         HRLD +TSGL++  KT Q+ K    LF  K++KK+YLA+  G   +
Sbjct: 126 KEEFPEEPWRPGIVHRLDKDTSGLIITAKTRQAKKVFSELFSTKRLKKSYLAVCIG-KPR 184

Query: 162 SMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQ 221
           S  I   I   QN +K++ + S+    GK+++T  + L++N    +S + ++P TGRTHQ
Sbjct: 185 STTIHTHISRHQNKRKEMTVSSQ----GKEAVTHCQVLAFNG--KLSFVALSPETGRTHQ 238

Query: 222 IRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           +R+H+  +   I+G+ +YG+   N+   L  ++        LHA S++F
Sbjct: 239 LRVHMKHLGTPILGDPVYGIPSMNSSYGLDKQQ--------LHAYSVDF 279
>ref|NP_214204.1| (NC_000918) hypothetical protein [Aquifex aeolicus]
 sp|O67638|YH58_AQUAE Hypothetical protein AQ_1758
 pir||D70451 conserved hypothetical protein aq_1758 - Aquifex aeolicus
 gb|AAC07603.1| (AE000754) hypothetical protein [Aquifex aeolicus]
          Length = 316

 Score = 95.5 bits (236), Expect = 6e-19
 Identities = 77/282 (27%), Positives = 134/282 (47%), Gaps = 19/282 (6%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVV---RLIHFKPNEKTQALVFET 75
           F R  +K  +KE   +++ + +++  + +R+ + +   V     +  KP      +++E 
Sbjct: 29  FSRSYIKKLVKEGLVYVNGEEVRKPSRKLREGERVILHVPEPEPLDVKPENIPINIIYED 88

Query: 76  KDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF------GKNAHPA--HRLDYETSGLVL 127
           +D  V +KP  +  HP   +   +L++ +  H       G    P   HRLD ET+G+++
Sbjct: 89  EDIAVVEKPCGLVVHPSPGYTSGTLVNALLYHIKDLSSIGGVERPGIVHRLDKETAGVMV 148

Query: 128 AGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKIS 186
             K   + ++L   F ++K +K Y  L  GLV+K    ID PI      +K   +R +  
Sbjct: 149 IAKNNTAHRNLVRQFQERKTEKFYKVLVKGLVKKDYGAIDTPIARHPVDRKRFWVRKE-- 206

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA 246
             GK+++T    L      +I+LLK+   TGRTHQIR+H +S+ H ++G+  YG    + 
Sbjct: 207 --GKEALTEYWVLKRYEKYEITLLKVKIHTGRTHQIRVHFASIGHPVLGDRTYGFKSSSV 264

Query: 247 -REYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERF 287
            +E L L  E N  +L+ +        KG         PE F
Sbjct: 265 PKELLSLMGECN--MLIAYHLGFYHPTKGEWMVFEIEEPETF 304
>ref|NP_465768.1| (NC_003210) similar to putative ribosomal large subunit
           pseudouridine synthase [Listeria monocytogenes EGD-e]
 emb|CAD00322.1| (AL591982) similar to putative ribosomal large subunit
           pseudouridine synthase [Listeria monocytogenes]
          Length = 289

 Score = 94.0 bits (232), Expect = 2e-18
 Identities = 72/222 (32%), Positives = 108/222 (48%), Gaps = 29/222 (13%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGL 125
           +++E     V +KP  + THP   +  ++  + +Q +  K     NA   HRLD  TSGL
Sbjct: 80  IIYEDDFLLVVNKPVDMKTHPNDSYETDTCANAVQYYLEKTGQDANALAVHRLDQTTSGL 139

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQNIQKDLH--IR 182
           VL  K   ++  L      + + +TYLA   G     M+ I+KPI       +D H   R
Sbjct: 140 VLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPI------GEDRHHGSR 193

Query: 183 SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
            +ISP G+ ++T V+ L  +   + SL++    TGRTHQIR+HLS + H I+G+ LYG +
Sbjct: 194 RQISPYGQPAVTHVKVLENDNEKNTSLVECQIETGRTHQIRVHLSGIGHPIIGDTLYGGS 253

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEFE--FKGAIYKIASP 282
               R             +MLHA  L     FKG     ++P
Sbjct: 254 PRANR-------------IMLHAEKLHLNHPFKGKEMNFSAP 282
>ref|NP_563038.1| (NC_003366) conserved hypothetical protein [Clostridium
           perfringens]
 dbj|BAB81828.1| (AP003193) conserved hypothetical protein [Clostridium perfringens]
          Length = 298

 Score = 91.7 bits (226), Expect = 9e-18
 Identities = 69/199 (34%), Positives = 97/199 (48%), Gaps = 28/199 (14%)

Query: 61  HFKPNEKTQALVFETKDFGVFDKP-----HQVYTHPKG-------YFYHESLLDCIQSHF 108
           + +P +    +V+E  D  V +K      H   +HP G       Y++ ES  DCI    
Sbjct: 71  NIEPEKMDIEIVYEDSDILVLNKKPFMVVHPTRSHPNGTLANGILYYFKESNQDCI---- 126

Query: 109 GKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDK 167
                   RLD  TSGL++ GK   +   L       K +K YLA+ HG L EK   I++
Sbjct: 127 ---VRLVSRLDMNTSGLIIIGKNQYAHMVLSNEMKTDKFQKRYLAIVHGNLEEKEGTINR 183

Query: 168 PILTPQNIQKDLHIRSKISPLGKQSITLVEPL-SYNPFLDISLLKITPLTGRTHQIRLHL 226
           PI  P        I+  +   G++SIT  + + SYN      L++    TGRTHQIR+HL
Sbjct: 184 PIYRPAEDT----IKRVVDERGQESITHYKVIESYN---GADLVECLLETGRTHQIRVHL 236

Query: 227 SSVDHRIVGEGLYGVADEN 245
           SS+ H I G+ LYG  DE+
Sbjct: 237 SSLGHPIFGDSLYGTEDED 255
>ref|NP_604269.1| (NC_003454) Ribosomal large subunit pseudouridine synthase D
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
 gb|AAL95568.1| (AE010641) Ribosomal large subunit pseudouridine synthase D
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
          Length = 319

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 75/288 (26%), Positives = 134/288 (46%), Gaps = 40/288 (13%)

Query: 4   VEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKS----------QII 53
           V  E+E ++  K  +    + + +    ++ +D   +K N + + K+          +++
Sbjct: 17  VNSEYEGMRLDK--YLSEQIEEATRSYLEKLIDNNFVKVNSKIINKNGRKLKLGEKIEVL 74

Query: 54  QGVVRLIHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQ------SH 107
                 I  +P      +V+E  DF + +K + +  HP    Y  +L++ +       S 
Sbjct: 75  IPEEENIDIEPENIPLNIVYENDDFILINKSYGMVVHPAYGNYTGTLVNALLYYTNNLSS 134

Query: 108 FGKNAHPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK---S 162
              N  P   HRLD +TSGL+L  K   +   L ++F+ K + KTYL +  G   +   S
Sbjct: 135 VNGNIRPGIIHRLDKDTSGLILVAKNNYAHAKLASMFIDKTIHKTYLCIVKGNFSEENLS 194

Query: 163 MKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQI 222
            +I+  I      +K + I  +   +   +  +VE +        SL+++   TGRTHQI
Sbjct: 195 GRIENLIGRDSKDRKKMTIVKENGKIAISNYKVVEQVE-----GYSLVEVAIETGRTHQI 249

Query: 223 RLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           R+H+ S++H I+G+ +YG  D+N      +KR+      MLHA  LEF
Sbjct: 250 RVHMKSINHVILGDSVYGTEDKN------VKRQ------MLHAYKLEF 285
>ref|NP_212152.1| (NC_001318) conserved hypothetical protein [Borrelia burgdorferi]
 pir||B70102 conserved hypothetical protein BB0018 - Lyme disease spirochete
 gb|AAC66413.1| (AE001116) conserved hypothetical protein [Borrelia burgdorferi]
          Length = 336

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 67/245 (27%), Positives = 119/245 (48%), Gaps = 31/245 (12%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG--------KNAHP 114
           +P+    A+++E  +  V +KP  + +HP    + +++++ +  H          +   P
Sbjct: 88  RPSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEKIRP 147

Query: 115 A--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTP 172
              HRLD +TSG+++  K + +++ L   F  K+  K Y+A+  G         +     
Sbjct: 148 GIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIESF--- 204

Query: 173 QNIQKDLHIRSKIS---PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSV 229
             I +D H R K S     GK+++T    L    F + SLL + P TGRTHQ+R+H+  +
Sbjct: 205 --IDRDKHNRKKFSVSKDRGKKALTEYRLLLN--FGEYSLLALKPKTGRTHQLRVHMKYL 260

Query: 230 DHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMPERFM 288
           +  I+G+ +YG  D + ++            LMLH+  LE +  K +  K  S  P+RF+
Sbjct: 261 NFPILGDEVYGRVDGSLKKI----------TLMLHSYKLEIDVGKNSFKKFISEFPKRFV 310

Query: 289 PFLKD 293
            FL +
Sbjct: 311 IFLSN 315
>ref|NP_223608.1| (NC_000921) putative [Helicobacter pylori J99]
 sp|Q9ZKP5|Y956_HELPJ Hypothetical protein JHP0890
 pir||C71876 hypothetical protein jhp0890 - Helicobacter pylori (strain J99)
 gb|AAD06458.1| (AE001518) putative [Helicobacter pylori J99]
          Length = 242

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 65/163 (39%), Positives = 91/163 (54%), Gaps = 24/163 (14%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKA--LFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ 173
           HRLD ETSG++L  K   S   LKA   F  + VKK YLA+  G++E+  +I+ PILT  
Sbjct: 90  HRLDKETSGVILLVKE-NSEFHLKAKKAFKDRAVKKEYLAIVQGIIEEEREINAPILTI- 147

Query: 174 NIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
              K     SKIS  G++++T++ PL        +LLK+   TGRTHQIR+HL  ++H I
Sbjct: 148 ---KTTKAFSKISKKGQEAVTIITPLKI--INKKTLLKVGIKTGRTHQIRVHLKHINHPI 202

Query: 234 VGEGLYGVADENAREYLQLKRENNAPLLMLHA---ASLEFEFK 273
           +G+ LY                ++A  LMLHA   A L +EF+
Sbjct: 203 IGDTLYN------------NEPSSAKRLMLHAHKIALLGYEFE 233
>sp|P70870|RLUD_BORBU Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
          Length = 326

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 67/245 (27%), Positives = 119/245 (48%), Gaps = 31/245 (12%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG--------KNAHP 114
           +P+    A+++E  +  V +KP  + +HP    + +++++ +  H          +   P
Sbjct: 78  RPSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEKIRP 137

Query: 115 A--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTP 172
              HRLD +TSG+++  K + +++ L   F  K+  K Y+A+  G         +     
Sbjct: 138 GIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIESF--- 194

Query: 173 QNIQKDLHIRSKIS---PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSV 229
             I +D H R K S     GK+++T    L    F + SLL + P TGRTHQ+R+H+  +
Sbjct: 195 --IDRDKHNRKKFSVSKDRGKKALTEYRLLLN--FGEYSLLALKPKTGRTHQLRVHMKYL 250

Query: 230 DHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMPERFM 288
           +  I+G+ +YG  D + ++            LMLH+  LE +  K +  K  S  P+RF+
Sbjct: 251 NFPILGDEVYGRVDGSLKKI----------TLMLHSYKLEIDVGKNSFKKFISEFPKRFV 300

Query: 289 PFLKD 293
            FL +
Sbjct: 301 IFLSN 305
>ref|NP_326129.1| (NC_002771) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D
           (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
           [Mycoplasma pulmonis]
 emb|CAC13471.1| (AL445564) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D
           (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
           [Mycoplasma pulmonis]
          Length = 296

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 68/255 (26%), Positives = 122/255 (47%), Gaps = 27/255 (10%)

Query: 51  QIIQGVVRLIHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK 110
           ++I+ + + I  KP +    +V+E +   V +KP  +  HP    Y ++L++ +  HF  
Sbjct: 57  EVIKVIDKTIDLKPEKMDLDIVYEDEHLIVINKPSGLVVHPAPGHYSQTLVNGLIYHFKN 116

Query: 111 NAHP--------AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-K 161
            ++          HR+D +TSGL++  KT Q  + L  +    ++K++Y+A+  G  E K
Sbjct: 117 LSNENGLLRPGIVHRIDKDTSGLLIIAKTNQVHQLLAKMLKNHEIKRSYIAIVEGFFENK 176

Query: 162 SMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQ 221
            + ++ PI   Q  +K + I +  S      + L++   Y     +SL++    TGRTHQ
Sbjct: 177 IVHLNLPIGRSQKDRKKMEITNNNSKNAITHVYLIKQFYYEK-QPLSLVECQLETGRTHQ 235

Query: 222 IRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAAS---LEFEFKGAIYK 278
           IR+HL+   H +  + LYG +  +  +YL   +     L  +H  +   L FE       
Sbjct: 236 IRVHLNYFKHPVWNDPLYGKSFSDYGQYLHAYK-----LFFVHPITNQELTFEI------ 284

Query: 279 IASPMPERFMPFLKD 293
              PMPE F   + +
Sbjct: 285 ---PMPEEFQRIINN 296
>ref|NP_207748.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
           26695]
 sp|O25610|Y956_HELPY Hypothetical protein HP0956
 pir||D64639 conserved hypothetical protein HP0956 - Helicobacter pylori
           (strain 26695)
 gb|AAD07999.1| (AE000604) conserved hypothetical protein [Helicobacter pylori
           26695]
          Length = 242

 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 67/163 (41%), Positives = 90/163 (55%), Gaps = 24/163 (14%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKA--LFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ 173
           HRLD ETSG+VL  K   S   LKA   F  + VKK YLAL  G++E+  +I+ PILT  
Sbjct: 90  HRLDKETSGVVLLVKE-NSEFHLKAKKAFKDRAVKKEYLALTQGIIEEEREINAPILT-- 146

Query: 174 NIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
              K     SKIS  G++++T++ PL        +LLK+   TGRTHQIR+HL  ++H I
Sbjct: 147 --FKTTKAFSKISKKGQEAVTIITPLKI--INKKTLLKVGIKTGRTHQIRVHLKHINHPI 202

Query: 234 VGEGLYGVADENAREYLQLKRENNAPLLMLHA---ASLEFEFK 273
           +G+ LY                + A  LMLHA   A L +EF+
Sbjct: 203 IGDTLYN------------NEPSLAKRLMLHAHKIALLGYEFE 233
>ref|NP_388802.1| (NC_000964) similar to hypothetical proteins [Bacillus subtilis]
 sp|P54604|YHCT_BACSU Hypothetical protein yhcT
 pir||H69823 conserved hypothetical protein yhcT - Bacillus subtilis
 emb|CAA65704.1| (X96983) hypothetical protein [Bacillus subtilis]
 emb|CAB12749.1| (Z99108) similar to hypothetical proteins [Bacillus subtilis]
          Length = 302

 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 68/236 (28%), Positives = 117/236 (48%), Gaps = 19/236 (8%)

Query: 20  VRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRL-IHFKPNEKTQAL------- 71
           ++  LK S    Q  +  Q++K N ++V  + I++   R+ I  + +E +  +       
Sbjct: 25  LKTALKASKPVIQDWMSHQQIKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELD 84

Query: 72  -VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPA-----HRLDYETSGL 125
            +FE     + +KP  + THP       +L + I  H+  N         HRLD +TSG 
Sbjct: 85  ILFEDNHMLIINKPAGIATHPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGA 144

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           ++  K   +   L     +K +K+TY A+A G L  K   I+ PI       +    R +
Sbjct: 145 IVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINPPI----GRDRSHPTRRR 200

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           +SP G+ ++T  + ++ N    +SL+++   TGRTHQIR+HL+S+ H + G+ LYG
Sbjct: 201 VSPGGQTAVTHFKVMASNAKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYG 256
>ref|NP_011685.1| (NC_001139) RNA:Psi-synthase; Pus6p [Saccharomyces cerevisiae]
 sp|P53294|YG3X_YEAST Hypothetical 46.8 kDa protein in CLC1-PDS2 intergenic region
 pir||S64480 hypothetical protein YGR169c - yeast (Saccharomyces cerevisiae)
 emb|CAA97195.1| (Z72954) ORF YGR169c [Saccharomyces cerevisiae]
          Length = 404

 Score = 90.9 bits (224), Expect = 2e-17
 Identities = 55/185 (29%), Positives = 91/185 (48%), Gaps = 17/185 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           +VFE +   V DKP  +  HP G FY  ++ + ++ H G +A P +RLD  TSGL++  K
Sbjct: 121 IVFEDESILVIDKPSGIPVHPTGQFYQNTITELLKLH-GVDALPCYRLDKITSGLLILAK 179

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKS-MKIDKPILTPQNIQKDLHIRSKISPL- 188
             QS  +++     + + K YLA   G    S + +D         +    +  +++P+ 
Sbjct: 180 NSQSAGEIQKSIRSRDMIKIYLARVKGRFPHSELILDNENAAETTFEDTSKVTVEMTPIY 239

Query: 189 --------------GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
                          K +IT   P+ Y    D +++   P+TGRTHQIR+HL+ + H IV
Sbjct: 240 SIDPKRQFPVGLSTSKDAITKFYPIRYFSHADETVVACKPITGRTHQIRIHLARLGHPIV 299

Query: 235 GEGLY 239
            + +Y
Sbjct: 300 NDSVY 304
>ref|NP_471677.1| (NC_003212) similar to putative ribosomal large subunit
           pseudouridine synthase [Listeria innocua]
 emb|CAC97573.1| (AL596172) similar to putative ribosomal large subunit
           pseudouridine synthase [Listeria innocua]
          Length = 289

 Score = 90.1 bits (222), Expect = 3e-17
 Identities = 71/222 (31%), Positives = 107/222 (47%), Gaps = 29/222 (13%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGL 125
           +++E     V +KP  + TH    +  ++  + +Q +  K     NA   HRLD  TSGL
Sbjct: 80  IIYEDDFLLVVNKPVGMKTHANDSYETDTCANAVQYYLEKTGQEANALAVHRLDQTTSGL 139

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQNIQKDLH--IR 182
           VL  K   ++  L      + + +TYLA   G     M+ I+KPI       +D H   R
Sbjct: 140 VLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPI------GEDRHHGSR 193

Query: 183 SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
            +ISP G+ ++T V+ L  +   + SL++    TGRTHQIR+HLS + H I+G+ LYG  
Sbjct: 194 RQISPYGQPAVTHVKVLENDNENNTSLVECQIETGRTHQIRVHLSGIGHPIIGDTLYG-- 251

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEFE--FKGAIYKIASP 282
                        + A  +MLHA  L     FKG     ++P
Sbjct: 252 -----------GSSRANRIMLHAEKLHLNHPFKGKEMNFSAP 282
>ref|XP_130420.1| (XM_130420) similar to CG6187 gene product [Mus musculus]
          Length = 519

 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 59/217 (27%), Positives = 110/217 (50%), Gaps = 8/217 (3%)

Query: 25  KCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALVFETKDFGVFDKP 84
           + +++  + HL+++ ++     ++ +  ++  V         +   L+ E  D  V DKP
Sbjct: 158 EAAVRAGRLHLNEEPVQDLSIVLKDNDFLRNTVHRHEPPVTAEPIHLLAENNDVVVIDKP 217

Query: 85  HQVYTHPKGYFYHESLLDCI-QSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFM 143
             +  HP G F H +++  + + H  K  HP HRLD  TSG+++  KT    + +     
Sbjct: 218 SSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFAKTAAVSEKIHEQVR 277

Query: 144 QKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYN 202
            ++++K Y+    G   +K +   +PIL    +   + +  ++ P GK   T+ + LSYN
Sbjct: 278 DRQLEKEYVCRVAGEFPDKEVICKEPILV---VSYKVGV-CRVDPRGKPCETVFQRLSYN 333

Query: 203 PFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
                S+++  PLTGRTHQIR+HL  + H I+ + +Y
Sbjct: 334 G--RSSVVQCRPLTGRTHQIRVHLQFLGHPILNDPIY 368
>ref|NP_347897.1| (NC_003030) Pseudouridylate synthase family protein, yabo
           B.subtilis ortholog [Clostridium acetobutylicum]
 gb|AAK79237.1|AE007639_10 (AE007639) Pseudouridylate synthase family protein, yabo B.subtilis
           ortholog [Clostridium acetobutylicum]
          Length = 299

 Score = 89.4 bits (220), Expect = 5e-17
 Identities = 77/231 (33%), Positives = 113/231 (48%), Gaps = 28/231 (12%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF---GKNA--HPAHRL 118
           P +    +V+E  D  V +KP  +  HP   + H +L + +  +F   G+N      +RL
Sbjct: 76  PEKMDLNIVYEDSDIIVLNKPANMIVHPTKNYQHGTLSNGLLYYFREKGENCIVRLVNRL 135

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK--IDKPILTPQNIQ 176
           D +TSGLVL  K   S   L         KK Y+A+  G +  S+K  IDKPI      +
Sbjct: 136 DMDTSGLVLVAKNQFSHMALARDMKLDTFKKEYIAVVRGNLS-SLKGTIDKPIYK----E 190

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           ++  IR  I   G++SIT  E +    + +   +K+   TGRTHQIR+HLSS+ + I+G+
Sbjct: 191 EEEPIRRTIDDRGQESITHFEVVER--YKNADKVKLVLETGRTHQIRVHLSSIGNPIIGD 248

Query: 237 GLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPE 285
            LYG   E       +KR+       LHA  L+F     G I  I   +PE
Sbjct: 249 SLYGEESE------LIKRQ------ALHAFKLQFPHPRDGRIVNIEVKLPE 287
>ref|NP_246658.1| (NC_002663) SfB [Pasteurella multocida]
 sp|Q9CKA6|RLUD_PASMU Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
 gb|AAK03803.1| (AE006208) SfB [Pasteurella multocida]
          Length = 324

 Score = 89.0 bits (219), Expect = 6e-17
 Identities = 71/292 (24%), Positives = 136/292 (46%), Gaps = 18/292 (6%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRL---IHFKPNEKTQALVFET 75
           + R  LK  +++   H++   +   +  V   + I+ VV +     F+P      +V+E 
Sbjct: 30  YSRSRLKTWIEQNLVHVNGDVVNVPRAKVYGGEQIEIVVEIDDDTRFEPENLPLNIVYED 89

Query: 76  KDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP-----AHRLDYETSGLVLAGK 130
            D  V +KP     HP       ++L+ +  H+   A        HRLD +T+GL++  K
Sbjct: 90  DDILVINKPKDFVVHPGAGNASGTVLNALLYHYPAIAEVPRAGIVHRLDKDTTGLMVIAK 149

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGK 190
           T+ +   L     ++K+ + Y A+A G++ K   +D+P+   ++  K  H+   + P+GK
Sbjct: 150 TIPAQTKLVRDLQKRKITREYEAIACGIMTKGGMVDQPM--ARHPTKRTHM--AVHPMGK 205

Query: 191 QSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG----VADENA 246
            ++T    +    F + + L++   TGRTHQIR+H++ + H ++G+  YG         +
Sbjct: 206 PAVTHYRIM--ERFRNYTRLRLRLETGRTHQIRVHMAHIAHPLLGDQTYGGRPRPPKNAS 263

Query: 247 REYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY 298
            E +Q  R+     L      L     G + +  +P+P  F+  ++ L   Y
Sbjct: 264 EELMQTLRDFKRQALHAIMLRLAHPITGELMEWHAPLPTDFVELVEALKADY 315
>ref|NP_072871.1| (NC_000908) sfhB protein, putative [Mycoplasma genitalium]
 sp|P47451|Y209_MYCGE Hypothetical protein MG209
 pir||A64223 probable pseudouridine synthase - Mycoplasma genitalium
 gb|AAC71427.1| (U39700) sfhB protein, putative [Mycoplasma genitalium]
          Length = 308

 Score = 88.2 bits (217), Expect = 1e-16
 Identities = 60/188 (31%), Positives = 92/188 (48%), Gaps = 6/188 (3%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN-AHPAHRLDYETSGLVLAG 129
           ++FE KD  V +KP  + THP  +    SLL     H  KN  +  HRLD +TSG ++  
Sbjct: 82  VLFEDKDLMVINKPSGLLTHPTTFNEKASLLAACIFHNNKNPVYLVHRLDRDTSGAIVVC 141

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEK-SMKIDKPILTPQNIQKDLHIRSKISPL 188
           K   S+ +L+     + +K+ Y+AL H      +  I+ P+    N +    I       
Sbjct: 142 KNQASLLNLQNQLQNRTLKRYYVALVHFPFNALTGSINAPLARVNNNKVMFKIAQTAK-- 199

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENARE 248
            KQ+IT  + ++ N     +L+ +  LTGRTHQIR+HL  + H +  + LYG+  E    
Sbjct: 200 AKQAITKFKVINQNE--KAALISLELLTGRTHQIRVHLKFIQHPVYNDPLYGIKSEKKDS 257

Query: 249 YLQLKREN 256
           Y Q    N
Sbjct: 258 YGQFLHAN 265
>ref|NP_109980.1| (NC_000912) similar to RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE
           SYNTHASE D [Mycoplasma pneumoniae]
 sp|P75485|Y209_MYCPN Hypothetical protein MG209 homolog (H10_orf309)
 pir||S73869 hypothetical protein yceC - Mycoplasma pneumoniae (strain ATCC
           29342)
 gb|AAB96191.1| (AE000053) similar to RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE
           SYNTHASE D [Mycoplasma pneumoniae]
          Length = 309

 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 67/215 (31%), Positives = 102/215 (47%), Gaps = 19/215 (8%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPA---H 116
           +  +P +    +++E +   V +KP+ + +HP  +   ESLL     H   N  P    H
Sbjct: 71  VEVQPYDFPLDILYEDEQIMVVNKPNGLISHPTSFNESESLLGAALFHC--NHQPVFLVH 128

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK-SMKIDKPILTPQNI 175
           RLD +TSG+++  K   S+  L+    Q+ +K+ YLAL H  ++  S  I  P+    N 
Sbjct: 129 RLDRDTSGVIMLAKNQSSLLHLQKQLQQRVMKRYYLALVHFPLDSLSGTISAPLERVGN- 187

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
            K +      S   K + T    L+ N     +L+K   LTGRTHQIR+HL  + H +  
Sbjct: 188 NKVMWKVGNSSNKAKNAFTKFTVLNQNE--KAALIKCELLTGRTHQIRVHLQFIKHPVYN 245

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           + LYG+  E A EY Q           LHA  + F
Sbjct: 246 DPLYGLKSEQATEYGQ----------YLHAQQISF 270
>gb|AAF52961.1| (AE003628) CG6187 gene product [Drosophila melanogaster]
          Length = 569

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 69/233 (29%), Positives = 111/233 (47%), Gaps = 22/233 (9%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRK------SQIIQGVVRLIHFKPNEKTQALV 72
           FVR+      +E +R L+  +L  N + V K      + ++  VV         +   +V
Sbjct: 214 FVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQPIKIV 273

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCI-QSHFGKNAHPAHRLDYETSGLVLAGKT 131
           +  KD  V +KP  +  HP G + H +++  + + H  KN    HRLD  TSGL+L G+T
Sbjct: 274 YMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRT 333

Query: 132 LQSVKDLKALFMQKKVKKTYLA-----LAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
            +  ++L+     ++V+K Y+         G+VE + KID        +   + +  K+S
Sbjct: 334 AEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEKIDV-------VSYKIGV-CKVS 385

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           P GK   T  + +       I L K  PLTGR HQIR+HL  + + I  + LY
Sbjct: 386 PKGKDCKTTFKRIGEVGSDSIVLCK--PLTGRMHQIRVHLQFLGYPISNDPLY 436
>ref|XP_031554.2| (XM_031554) similar to CG6187 gene product [Homo sapiens]
 dbj|BAB71059.1| (AK055971) unnamed protein product [Homo sapiens]
          Length = 545

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 55/171 (32%), Positives = 91/171 (53%), Gaps = 8/171 (4%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCI-QSHFGKNAHPAHRLDYETSGLVLAG 129
           L+ E +D  V DKP  +  HP G F H +++  + + H  K  HP HRLD  TSG+++  
Sbjct: 225 LLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFA 284

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPL 188
           KT    + +      ++++K Y+    G    + +   +PIL    +   + +  ++ P 
Sbjct: 285 KTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEEVTCKEPILV---VSYKVGV-CRVDPR 340

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           GK   T+ + LSYN     S+++  PLTGRTHQIR+HL  + H I+ + +Y
Sbjct: 341 GKPCETVFQRLSYNG--QSSVVRCRPLTGRTHQIRVHLQFLGHPILNDPIY 389
>ref|NP_295512.1| (NC_001263) ribosomal large subunit pseudouridine synthase D
           [Deinococcus radiodurans]
 pir||C75353 ribosomal large subunit pseudouridine synthase D - Deinococcus
           radiodurans (strain R1)
 gb|AAF11343.1|AE002020_2 (AE002020) ribosomal large subunit pseudouridine synthase D
           [Deinococcus radiodurans]
          Length = 338

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 69/228 (30%), Positives = 115/228 (50%), Gaps = 28/228 (12%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCI--------QSHF----GK 110
           +P +    ++FE +     +KP  + THP       +L++ +        Q  F    G 
Sbjct: 90  EPEDVPLDVIFEDEHLIAINKPPGMVTHPAPGVISGTLVNALLGRMSLPEQQDFDGPDGY 149

Query: 111 NAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGL--VEKSMKIDKP 168
                HRLD +TSG+++  KT+ +   L A F  ++ KKTYLA+A G    E+ +++D P
Sbjct: 150 RPGIVHRLDKDTSGVIVVAKTVAAHARLAAAFKDRETKKTYLAIAAGAWKAERPVQVDAP 209

Query: 169 ILTPQNIQKDLHIRSKISPLG-KQSITLVEPLSYNP---FLDISLLKITPLTGRTHQIRL 224
           I   Q IQ+    R  +   G +++ TL  PL  +P      ++L++  P TGRTHQIR+
Sbjct: 210 IGRHQ-IQRQ---RMTVGGAGAREAQTLFTPLDAHPDGHGRTLALVRAQPRTGRTHQIRV 265

Query: 225 HLSSVDHRIVGEGLYGVADENA------REYLQLKRENNAPLLMLHAA 266
           HL+ +   I+G+ +YG A E         ++L++    +  +L L AA
Sbjct: 266 HLAHLGSPILGDAVYGRASEIMPRHALHAQFLEVPHPVSGDILHLQAA 313
>ref|NP_609411.1| (NM_135567) CG6187 gene product [Drosophila melanogaster]
 gb|AAL13915.1| (AY058686) LD40728p [Drosophila melanogaster]
          Length = 547

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 69/233 (29%), Positives = 111/233 (47%), Gaps = 22/233 (9%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRK------SQIIQGVVRLIHFKPNEKTQALV 72
           FVR+      +E +R L+  +L  N + V K      + ++  VV         +   +V
Sbjct: 160 FVREFRAAPPEEYERSLEAGKLTVNSEKVPKDYKIKHNDLLANVVHRHEVPVTSQPIKIV 219

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCI-QSHFGKNAHPAHRLDYETSGLVLAGKT 131
           +  KD  V +KP  +  HP G + H +++  + + H  KN    HRLD  TSGL+L G+T
Sbjct: 220 YMDKDIVVVNKPASIPVHPCGRYRHNTVVFILAKEHNLKNLRTIHRLDRLTSGLLLFGRT 279

Query: 132 LQSVKDLKALFMQKKVKKTYLA-----LAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
            +  ++L+     ++V+K Y+         G+VE + KID        +   + +  K+S
Sbjct: 280 AEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEKIDV-------VSYKIGV-CKVS 331

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           P GK   T  + +       I L K  PLTGR HQIR+HL  + + I  + LY
Sbjct: 332 PKGKDCKTTFKRIGEVGSDSIVLCK--PLTGRMHQIRVHLQFLGYPISNDPLY 382
>emb|CAA70352.1| (Y09142) product homologous to E.coli YfiI [Borrelia burgdorferi]
          Length = 309

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 67/249 (26%), Positives = 120/249 (47%), Gaps = 35/249 (14%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG--------KNAHP 114
           +P+    A+++E  +  V +KP  + +HP    + +++++ +  H          +   P
Sbjct: 78  RPSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEKIRP 137

Query: 115 A--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTP 172
              HRLD +TSG+++  K + +++ L   F  K++ K Y+A+  G         +     
Sbjct: 138 GIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRINKVYIAIVKGNFNSFFGSIESF--- 194

Query: 173 QNIQKDLHIRSKIS---PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSV 229
             I +D H R K S     GK+++T    L    F + SLL + P TGRTHQ+R+H+  +
Sbjct: 195 --IDRDKHNRKKFSVSKDRGKKALTEYRLLLN--FGEYSLLALKPKTGRTHQLRVHMKYL 250

Query: 230 DHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMPER-- 286
           +  I+G+ +YG  D +  +            LMLH+  LE +  K +  K  S  P+R  
Sbjct: 251 NFPILGDEVYGRVDGSLEKI----------TLMLHSYKLEIDVGKNSFKKFISEFPKRIC 300

Query: 287 --FMPFLKD 293
             F+ FL++
Sbjct: 301 YFFVKFLQE 309
>gb|AAH07697.1|AAH07697 (BC007697) Unknown (protein for IMAGE:3953315) [Homo sapiens]
          Length = 554

 Score = 87.4 bits (215), Expect = 2e-16
 Identities = 55/171 (32%), Positives = 91/171 (53%), Gaps = 8/171 (4%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCI-QSHFGKNAHPAHRLDYETSGLVLAG 129
           L+ E +D  V DKP  +  HP G F H +++  + + H  K  HP HRLD  TSG+++  
Sbjct: 234 LLAENEDVVVVDKPSSIPVHPCGRFRHNTVIFILGKEHQLKELHPLHRLDRLTSGVLMFA 293

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPL 188
           KT    + +      ++++K Y+    G    + +   +PIL    +   + +  ++ P 
Sbjct: 294 KTAAVSERIHEQVRDRQLEKEYVCRVEGEFPTEEVTCKEPILV---VSYKVGV-CRVDPR 349

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           GK   T+ + LSYN     S+++  PLTGRTHQIR+HL  + H I+ + +Y
Sbjct: 350 GKPCETVFQRLSYNG--QSSVVRCRPLTGRTHQIRVHLQFLGHPILNDPIY 398
>ref|NP_246775.1| (NC_002663) RsuA [Pasteurella multocida]
 gb|AAK03920.1| (AE006221) RsuA [Pasteurella multocida]
          Length = 219

 Score = 86.7 bits (213), Expect = 3e-16
 Identities = 65/210 (30%), Positives = 108/210 (50%), Gaps = 19/210 (9%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGY-FYHESLLDCIQSHFGKNAHPAHRLDYET 122
           P +    +V     F V +KP  + + P     Y++S +  ++  +G    PAHRLD  T
Sbjct: 9   PTDPYLDIVHYDDHFVVINKPSGLLSVPGNQPQYYDSAMSRVKEKYGF-CEPAHRLDMST 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHI 181
           SGL+L   +  + ++LK  F +++ KK Y AL  G +E+   +++ P++     +     
Sbjct: 68  SGLILFALSKVADRELKRQFREREPKKHYQALVWGHLEEDQGEVNLPLICDWENRP---- 123

Query: 182 RSKIS-PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           R KI    GK ++TL E L+  P  + + +K+TP+TGR+HQ+RLH+ ++ H I+G+  Y 
Sbjct: 124 RQKICFERGKPALTLYEVLARYP-NNTTRVKLTPITGRSHQLRLHMLALGHPILGDKFYA 182

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEF 270
                A           +P L LHA  L F
Sbjct: 183 PPQAKAL----------SPRLCLHAEQLAF 202
>ref|NP_623145.1| (NC_003869) Pseudouridylate synthase, 23S RNA-specific
           [Thermoanaerobacter tengcongensis]
 gb|AAM24749.1| (AE013110) Pseudouridylate synthase, 23S RNA-specific
           [Thermoanaerobacter tengcongensis]
          Length = 309

 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 77/292 (26%), Positives = 137/292 (46%), Gaps = 31/292 (10%)

Query: 17  LFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGV--VRLIHFKPNEKTQALVFE 74
           L + R  +K  ++E    ++ + +K + +     ++I  +     I   P      +++E
Sbjct: 28  LDYSRSYIKKLIEEGLVLVNGKNVKPSYKVKEDDEVIVNIKEAEKIEVVPENIPLDILYE 87

Query: 75  TKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP---------AHRLDYETSGL 125
            +D  V +KP  +  HP    Y  +L++ +  H  KN             HRLD +TSG+
Sbjct: 88  DEDIIVINKPQGMVVHPAPGNYSGTLVNALLYHC-KNLSGINGILRPGIVHRLDKDTSGV 146

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLV-EKSMKIDKPILTPQNIQKDLHIRSK 184
           ++  K  ++   L     ++ V K Y+A+  G++ E+  KI+ PI      +K    R  
Sbjct: 147 MVVAKNDKAHMSLSNQIKERSVLKKYVAIVEGVIKEEEGKIEAPIGRHPVDRK----RMA 202

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADE 244
           +   G+ ++TL + L    F + + ++ T  TGRTHQIR+HLS + H +VG+ +YG   +
Sbjct: 203 VVQDGRYALTLYKVLER--FKNNTFVEATIKTGRTHQIRVHLSYIGHPVVGDPVYGYKKQ 260

Query: 245 NAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFLKDL 294
                 + K E  A    LH+  L F    KG   +  +P+P+ F   L+ L
Sbjct: 261 ------KFKLEGQA----LHSKVLGFIHPTKGVYMEFEAPLPDYFTRLLEIL 302
>ref|NP_283696.1| (NC_003116) putative ribosomal large subunit pseudouridine synthase
           D [Neisseria meningitidis Z2491]
 pir||D81937 probable ribosomal large subunit pseudouridine synthase D NMA0908
           [imported] - Neisseria meningitidis (group A strain
           Z2491)
 emb|CAB84185.1| (AL162754) putative ribosomal large subunit pseudouridine synthase
           D [Neisseria meningitidis Z2491]
          Length = 374

 Score = 86.3 bits (212), Expect = 4e-16
 Identities = 68/234 (29%), Positives = 113/234 (48%), Gaps = 18/234 (7%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F P      +V+E     V +KP  +  HP    +  +LL+ + +H  +      A   H
Sbjct: 98  FVPEPMALDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQIPRAGIVH 157

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD ETSGL++  KTL +   L     ++ VK+ Y A+A+G+V    KI+        I 
Sbjct: 158 RLDKETSGLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANGIVPFDGKIE------TQIG 211

Query: 177 KDLHIRSKISPL---GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
           +D H R K++ +   GK ++T V+ L    +L  S ++ +  TGRTHQIR+H+   +H +
Sbjct: 212 RDPHNRLKMAVVKFGGKPAVTHVKVL--ERYLAHSYIECSLETGRTHQIRVHMREANHPL 269

Query: 234 VGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPE 285
            G+ +YG       + ++   ++      LHA  L F     G      +P+P+
Sbjct: 270 AGDPVYGNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIPD 323
>ref|NP_623370.1| (NC_003869) Pseudouridylate synthase, 23S RNA-specific
           [Thermoanaerobacter tengcongensis]
 gb|AAM24974.1| (AE013131) Pseudouridylate synthase, 23S RNA-specific
           [Thermoanaerobacter tengcongensis]
          Length = 268

 Score = 85.5 bits (210), Expect = 7e-16
 Identities = 66/229 (28%), Positives = 107/229 (45%), Gaps = 28/229 (12%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HPAHRL 118
           P E   ++ +E  +  + DKP  +  HP   +   +L + +  +F K        P +RL
Sbjct: 52  PQEMDLSICYEDDEILIVDKPAGMVVHPTRRYREGTLANGVAYYFEKKGIKTLIRPVNRL 111

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQ--KKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           D  TSG+V+  K     +     ++Q  K + K Y A+ +G +E    ID PI      +
Sbjct: 112 DKGTSGIVIFAK-----EPFMQYYLQIVKPMSKFYYAIVNGKLEGEGIIDVPIKR----K 162

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
             + I  ++S  G ++IT  + L      + SLLKI   TGRTHQIR+HL+ + H IVG+
Sbjct: 163 SFMTIEREVSEEGDRAITYYKSLKATE--EFSLLKIKIATGRTHQIRVHLNYIGHPIVGD 220

Query: 237 GLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPE 285
            LYG        Y++       P L  +  +     K  +  + +P+PE
Sbjct: 221 DLYG----EPTSYIE------RPALHAYRVTFFHPLKEKVISVYAPLPE 259
>ref|NP_457360.1| (NC_003198) putative RNA pseudouridylate synthase [Salmonella
           enterica subsp. enterica serovar Typhi]
 emb|CAD06078.1| (AL627276) putative RNA pseudouridylate synthase [Salmonella
           enterica subsp. enterica serovar Typhi]
          Length = 260

 Score = 85.5 bits (210), Expect = 7e-16
 Identities = 63/221 (28%), Positives = 103/221 (46%), Gaps = 26/221 (11%)

Query: 91  PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G+  H S LD          ++   G++   AHRLD  TSG++L G + ++ + L   
Sbjct: 17  PAGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRRLAQQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP-------LGKQSIT 194
           F Q  ++K Y A+  G +     +D P++  ++   D   R   +P        G  ++ 
Sbjct: 77  FEQHHIRKRYHAIVRGWLIDDAVLDYPLVEERDKIADKFAREDKAPQPAVTQYRGLATVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN--AREYLQL 252
           +  P    P     L+++ P TGR HQ+R HL+ + H I+G+  +G   +N  A E+   
Sbjct: 137 MAVPTGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSAAEHFAC 196

Query: 253 KRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFL 291
           +R      LMLHA+ LE    F G    I + + E +M  L
Sbjct: 197 RR------LMLHASRLELTHPFTGQPLIIQAGLDETWMQVL 231
>ref|NP_461885.1| (NC_003197) putative synthase [Salmonella typhimurium LT2]
 gb|AAL21844.1| (AE008835) putative synthase [Salmonella typhimurium LT2]
          Length = 260

 Score = 85.5 bits (210), Expect = 7e-16
 Identities = 63/221 (28%), Positives = 103/221 (46%), Gaps = 26/221 (11%)

Query: 91  PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G+  H S LD          ++   G++   AHRLD  TSG++L G + ++ + L   
Sbjct: 17  PAGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRRLAQQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP-------LGKQSIT 194
           F Q  ++K Y A+  G +     +D P++  ++   D   R   +P        G  ++ 
Sbjct: 77  FEQHHIRKRYHAIVRGWLMDDAVLDYPLVEERDKIADKFAREDKAPQPAVTQYRGLATVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN--AREYLQL 252
           +  P    P     L+++ P TGR HQ+R HL+ + H I+G+  +G   +N  A E+   
Sbjct: 137 MAVPTGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSAAEHFAC 196

Query: 253 KRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFL 291
           +R      LMLHA+ LE    F G    I + + E +M  L
Sbjct: 197 RR------LMLHASRLELTHPFTGQPLIIQAGLDETWMQAL 231
>sp|P50513|RLUD_ZYMMO RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE D (PSEUDOURIDYLATE
           SYNTHASE) (URACIL HYDROLYASE)
 pir||S60168 hypothetical protein X - Zymomonas mobilis
 dbj|BAA09443.1| (D50832) homologue of E. coli ClpB5' ORF [Zymomonas mobilis]
          Length = 317

 Score = 85.1 bits (209), Expect = 9e-16
 Identities = 66/223 (29%), Positives = 106/223 (46%), Gaps = 18/223 (8%)

Query: 58  RLIHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH-------FGK 110
           R  H +P +    +VFE +   V +KP  +  HP    Y  +L++ +  H        G 
Sbjct: 71  RPAHNEPQDIPLEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGG 130

Query: 111 NAHPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKP 168
            A P   HR+D +TSGL++  KT  +   L A F    + + Y A+  G       +D P
Sbjct: 131 VARPGIVHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGNPSLQGHVDAP 190

Query: 169 ILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSS 228
           +      ++ + I S     GK+++T        P  + SL++    TGRTHQ+R+H+SS
Sbjct: 191 LARSSVNRQKMAIVS--DGRGKRAVT--HYCMITPLKNASLIECRLETGRTHQVRVHMSS 246

Query: 229 VDHRIVGEGLYGVADENAREYLQ-LKRENNAPLLMLHAASLEF 270
           + H ++G+ +YG + +     LQ L  +  A    LHAA L F
Sbjct: 247 IGHSLLGDPVYGRSKKAHHALLQSLAFQRQA----LHAAHLGF 285
>ref|NP_438344.1| (NC_000907) sfhB protein (sfhB) [Haemophilus influenzae Rd]
 sp|P44445|RLUD_HAEIN Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||F64144 hypothetical protein HI0176 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC21845.1| (U32702) sfhB protein (sfhB) [Haemophilus influenzae Rd]
          Length = 324

 Score = 84.7 bits (208), Expect = 1e-15
 Identities = 60/237 (25%), Positives = 114/237 (47%), Gaps = 15/237 (6%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGL 125
           +V+E  D  V +KP  +  HP     + ++L+ +  H+        A   HRLD +T+GL
Sbjct: 85  IVYEDDDIIVINKPKDLVVHPGAGNPNGTVLNALLYHYPPIVEVPRAGIVHRLDKDTTGL 144

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           ++  KT+ +   L     ++K+ + Y A+A G++ K   +D+P+               +
Sbjct: 145 MVVAKTIPAQTKLVRDLQKRKITREYEAVASGIMTKGGTVDQPMAR----HATKRTLMAV 200

Query: 186 SPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG---VA 242
            P+GK ++T    +    + + + L++   TGRTHQIR+H++ + H ++G+  YG     
Sbjct: 201 HPMGKPAVTHYRIM--ENYRNYTRLRLRLETGRTHQIRVHMAHIAHPLLGDQTYGGRPRP 258

Query: 243 DENARE-YLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSFFY 298
            +NA E ++++ R      L      L     G + +  +P+P+ F+  L  L   Y
Sbjct: 259 PKNASEDFMEVLRNFKRQALHAVMLRLAHPITGEMMEWYAPLPDDFVELLNALKADY 315
>ref|NP_014575.1| (NC_001147) Riboflavin biosynthesis; Rib2p [Saccharomyces
           cerevisiae]
 sp|Q12362|RIB2_YEAST DRAP DEAMINASE
 pir||S50972 RIB2 protein - yeast (Saccharomyces cerevisiae)
 emb|CAA79742.1| (Z21618) DRAP deaminase [Saccharomyces cerevisiae]
 emb|CAA99076.1| (Z74808) ORF YOL066c [Saccharomyces cerevisiae]
          Length = 591

 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 55/175 (31%), Positives = 90/175 (51%), Gaps = 5/175 (2%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           +VFE +D  V DKP  +  HP G +   ++   ++   G + HP +RLD  TSGL+   K
Sbjct: 163 IVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLERQLGYSVHPCNRLDKPTSGLMFLAK 222

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKS-MKIDKPILTPQNIQKDLHIRSKIS-PL 188
           T      +      ++V K Y+A   G      +++DKP+ +  N +  L+   ++S   
Sbjct: 223 TPLGADRMGDQMKAREVTKEYVARVKGEFPIGIVEVDKPVRS-VNPKVALNAVCEMSDEN 281

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVAD 243
            K + T+ + +SY+     S++K  PLTGRTHQIR+HL  +   I  + +Y   D
Sbjct: 282 AKHAKTVFQRVSYDG--QTSIVKCKPLTGRTHQIRVHLQYLGFPIANDPIYSNPD 334
>ref|NP_273746.1| (NC_003112) ribosomal large subunit pseudouridine synthase D
           [Neisseria meningitidis MC58]
 pir||A81168 ribosomal large chain pseudouridine synthase D NMB0704 [imported] -
           Neisseria meningitidis (group B strain MD58)
 gb|AAF41121.1| (AE002425) ribosomal large subunit pseudouridine synthase D
           [Neisseria meningitidis MC58]
          Length = 374

 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 67/233 (28%), Positives = 111/233 (46%), Gaps = 18/233 (7%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F P      +V+E     V +KP  +  HP    +  +LL+ + +H  +      A   H
Sbjct: 98  FVPEPMALDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQVPRAGIVH 157

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD ETSGL++  KTL +   L     ++ VK+ Y A+A+G+V    KI+        I 
Sbjct: 158 RLDKETSGLMVVAKTLPAQNSLVRQLQERTVKRIYRAVANGIVPFDGKIE------TQIG 211

Query: 177 KDLHIRSKISPL---GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
           +D H R K++ +   GK ++T V+ L    +L  S ++ +  TGRTHQIR+H+   +H +
Sbjct: 212 RDPHNRLKMAVVKFGGKPAVTHVKVL--ERYLTHSYIECSLETGRTHQIRVHMREANHPL 269

Query: 234 VGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMP 284
             + +YG       + ++   ++      LHA  L F     G      +P+P
Sbjct: 270 AADPVYGNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIP 322
>ref|NP_592881.1| (NC_003424) hypothetical protein [Schizosaccharomyces pombe]
 sp|Q09709|YA32_SCHPO Hypothetical protein C18B11.02c in chromosome I
 pir||S58301 hypothetical protein SPAC18B11.02c - fission yeast
           (Schizosaccharomyces pombe)
 pir||T37912 hypothetical protein SPAC18B11.02c - fission yeast
           (Schizosaccharomyces pombe)
 emb|CAA90587.1| (Z50728) hypothetical protein [Schizosaccharomyces pombe]
          Length = 394

 Score = 84.0 bits (206), Expect = 2e-15
 Identities = 53/178 (29%), Positives = 99/178 (54%), Gaps = 9/178 (5%)

Query: 65  NEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-HPAHRLDYETS 123
           +++   +V E + + V DKP  V  HP G + H ++L  +      +  +P +RLD  TS
Sbjct: 101 SDQPVGIVHEDESYVVIDKPAGVPVHPTGRYNHNTVLHILMKENKCSLLYPCNRLDRLTS 160

Query: 124 GLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKI--DKPILTPQNIQKDLHI 181
           GL+   K+ ++ ++++   + K +KK Y+A   G    S ++  D P+LT   +   L +
Sbjct: 161 GLMFFSKSPKAAEEMRVHMISKSLKKEYVARVIGEFPNSGEVICDAPLLT---VAPTLGL 217

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
            ++I P GK++ T+ + ++++    + L K  PLTGRTHQ+R+HL  + + I  + +Y
Sbjct: 218 -NRIHPDGKEASTVFKRIAFDGHTSLVLCK--PLTGRTHQLRVHLQYLGYPIANDPIY 272
>ref|NP_268269.1| (NC_002662) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
 gb|AAK06210.1|AE006439_7 (AE006439) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
          Length = 288

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 61/174 (35%), Positives = 95/174 (54%), Gaps = 14/174 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHE-SLLDCIQSHFGKNAHPAHRLDYETSGLVLAG 129
           +++E +   V +KP  + TH  G    E +L + + +   +     HRLD  TSG VL  
Sbjct: 83  ILYEDEHLIVVNKPEGMKTH--GNTADELALQNHVAAAINQEVFVVHRLDQATSGAVLFA 140

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK--IS 186
           K    +  L  +F + K+ + YLAL  G   E    ID+ I       ++ H ++K  +S
Sbjct: 141 KNQFVLPILGKMFEENKIHREYLALVKGHFSENQFTIDRAI------GQNRHDKNKRILS 194

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
             G++++T VE +    F D +L+K T  TGRTHQIR+HLSS++H I+G+ LYG
Sbjct: 195 AKGQKAVTHVEIIK--KFTDKTLVKCTLDTGRTHQIRVHLSSLNHPIIGDALYG 246
>ref|NP_662187.1| (NC_002932) ribosomal large subunit pseudouridine synthase D
           [Chlorobium tepidum TLS]
 gb|AAM72529.1| (AE012889) ribosomal large subunit pseudouridine synthase D
           [Chlorobium tepidum TLS]
          Length = 329

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 77/307 (25%), Positives = 135/307 (43%), Gaps = 35/307 (11%)

Query: 18  FFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLI---------HFKPNEKT 68
           +  + V   +  + Q+ +++QR+  N + V+ +  I+    +             P +  
Sbjct: 17  YLTQQVENATRNKVQKAIEEQRVLVNGKPVKSNYRIKSCDHIHITFLRPPAPELAPEDIP 76

Query: 69  QALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP----------AHRL 118
            ++++E  D  V DK   +  HP    +  +L + I  H GK+A             HRL
Sbjct: 77  ISILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADDLDKTEMRPGIVHRL 136

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKD 178
           D +TSGL++  K   ++  L   F +++V+K Y A+  G+        K  +   +  + 
Sbjct: 137 DKDTSGLIIVAKNPVALHKLATQFARRQVEKVYKAIVWGVPNPPSGTIKTNIGRSHKNRK 196

Query: 179 LHIRSKISPL-GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           +          GK +IT   +VE L+Y   +D++L      TGRTHQIR+HL  + H I+
Sbjct: 197 VMANFPFEGAEGKHAITDYLVVEDLAYFALMDMTLH-----TGRTHQIRVHLQHLGHPIL 251

Query: 235 GEGLYGVADENAREYLQLKR-ENNAPLLM----LHAASLEFE--FKGAIYKIASPMPERF 287
           G+  YG A      + + +   +N   LM    LHA +L F     G      +P+PE  
Sbjct: 252 GDQTYGGATPRTLPFSKSEPFTHNLLELMGRQALHAETLRFRQPTTGEPLAFTAPLPEDM 311

Query: 288 MPFLKDL 294
              L+ +
Sbjct: 312 KTVLEKI 318
>ref|NP_240218.1| (NC_002528) ribosomal large subunit pseudouridine synthase D
           [Buchnera sp. APS]
 sp|P57481|RLUD_BUCAI Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
 dbj|BAB13104.1| (AP001119) ribosomal large subunit pseudouridine synthase D
           [Buchnera sp. APS]
          Length = 312

 Score = 83.6 bits (205), Expect = 2e-15
 Identities = 79/293 (26%), Positives = 127/293 (42%), Gaps = 30/293 (10%)

Query: 23  VLKCSLKEAQRHLDKQRLKQNQQAVRKS-------QIIQGVVRLIH-FK-------PNEK 67
           VL    +E  R   K+ +  NQ  V +S       +I+ G    IH F        P   
Sbjct: 23  VLSKLFREYSRSYLKKLIIMNQVLVNESIVNQPDKKILGGETLTIHPFSKDLLVDIPENI 82

Query: 68  TQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN-----AHPAHRLDYET 122
              +V+E  D  + +KP  +  HP       ++L+ +  H+  +     A   HRLD +T
Sbjct: 83  FLDIVYEDSDILIINKPAGLVVHPGSGNKSGTILNALLYHYKNSKDLPRAGIVHRLDKDT 142

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIR 182
           SGL++  K + S   L  L  +KK+ + Y  + HG +     I+KPI+   N +  + + 
Sbjct: 143 SGLMVIAKNIFSYNHLLLLLKEKKIIREYEGIVHGKMIAGGTINKPIMRHYNRRTCMMVH 202

Query: 183 SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG-- 240
                LGK S+T  + LS   F     +++   TGRTHQIR+H+  + + +VG+  Y   
Sbjct: 203 H----LGKPSVTHYKVLSRFKFHTHIAIRLE--TGRTHQIRVHMLHIKYPLVGDPCYSGF 256

Query: 241 VADENAREYLQLKRENNAPLLMLHA--ASLEFEFKGAIYKIASPMPERFMPFL 291
               N R+  +  +    P   LHA   SL    K  +     P+P+     L
Sbjct: 257 KIQSNYRKDKKTNKIYKFPRQALHANHLSLHHPIKKNVMSWTVPLPQDIQELL 309
>ref|NP_660679.1| (NC_004061) ribosomal large subunit pseudouridine synthase
           [Buchnera aphidicola str. Sg (Schizaphis graminum)]
 gb|AAM67890.1| (AE014110) ribosomal large subunit pseudouridine synthase [Buchnera
           aphidicola str. Sg (Schizaphis graminum)]
          Length = 314

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 61/182 (33%), Positives = 92/182 (50%), Gaps = 11/182 (6%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQN 174
           HR+D +TSG+++  K  +S+  L     +KKV+K Y+AL HGL   S+ K+ +P+L    
Sbjct: 140 HRIDRDTSGVLMLAKKRRSLLSLHKQIREKKVQKKYIALVHGLWPLSLRKVSEPLLKTHL 199

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             K   I   I+  GK + T  +      +L  +L+ ITP TGRTHQIR+H     H I+
Sbjct: 200 KNKQRKI--LINKEGKPAETYFK--IKKQYLFTTLVSITPKTGRTHQIRVHTLHAGHPIL 255

Query: 235 GEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFLK 292
            +  YG  D +      +K +     L+LHA S+ F     G    I +P+   F  +L 
Sbjct: 256 FDKRYGKRDLDC----NIKNKTKINRLLLHATSINFIHPETGKKMHIVAPLDVYFKNYLN 311

Query: 293 DL 294
            L
Sbjct: 312 TL 313
>ref|NP_230358.1| (NC_002505) ribosomal large subunit pseudouridine synthase D
           [Vibrio cholerae]
 pir||G82289 ribosomal large chain pseudouridine synthase D VC0709 [imported] -
           Vibrio cholerae (group O1 strain N16961)
 gb|AAF93874.1| (AE004157) ribosomal large subunit pseudouridine synthase D [Vibrio
           cholerae]
          Length = 324

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 61/226 (26%), Positives = 107/226 (46%), Gaps = 19/226 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP-----AHRLDYETSGL 125
           +V+E  D  V +KP     HP      +++L+ +  H+   A        HRLD +T+GL
Sbjct: 86  IVYEDDDIIVINKPRDFVVHPGAGQADKTVLNALLFHYSPIAEVPRAGIVHRLDKDTTGL 145

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           ++  KT+ +   L     ++ V + Y A+  G +     IDKPI               +
Sbjct: 146 MVVAKTVPAQTRLVRALQKRDVTREYEAIVIGTMTAGGMIDKPI----GRHSTKRTLMSV 201

Query: 186 SPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG----V 241
           SP+GK ++T      +  F + + L++   TGRTHQIR+H++ + H ++G+  YG    +
Sbjct: 202 SPMGKHAVTHYRVAEH--FREHTRLRLRLETGRTHQIRVHMAYLQHPLLGDTAYGGRARI 259

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEFE--FKGAIYKIASPMPE 285
                 E  ++ R+ +     LHA  L+FE    G   +  +P+P+
Sbjct: 260 PKGATEELTEMIRDFDRQ--ALHAVMLKFEHPVTGEELEFHAPVPD 303
>ref|NP_253234.1| (NC_002516) pseudouridine synthase [Pseudomonas aeruginosa]
 sp|P33640|RLUD_PSEAE Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||F83077 pseudouridine synthase PA4544 [imported] - Pseudomonas aeruginosa
           (strain PAO1)
 gb|AAG07932.1|AE004868_3 (AE004868) pseudouridine synthase [Pseudomonas aeruginosa]
          Length = 320

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 67/229 (29%), Positives = 110/229 (47%), Gaps = 19/229 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP-----AHRLDYETSGL 125
           +V+E +   V DKP  +  HP       +LL+ +  H    A+       HRLD +T+GL
Sbjct: 85  IVYEDEHILVIDKPAGLVVHPAAGHQDGTLLNALLYHVPDIANVPRAGIVHRLDKDTTGL 144

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           ++  KTL++   L A    + V + Y A+  G++     ID PI     +Q+    +  +
Sbjct: 145 MVVAKTLEAHTKLVAQLQARSVSRIYEAIVIGVITSGGTIDAPI-GRHGVQRQ---KMAV 200

Query: 186 SPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG----V 241
              GK +++    L    F   +  ++   TGRTHQIR+H+S + + +VG+ +YG    +
Sbjct: 201 VDAGKVAVSHYRVL--ERFRAHTHTRVKLETGRTHQIRVHMSHIGYPLVGDPVYGGRFRI 258

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERFM 288
               ++  +Q  RE   P   LHA  LE +    G   K  SP+PE F+
Sbjct: 259 PPVASQTLVQTLRE--FPRQALHARFLELDHPATGVRMKWESPLPEDFL 305
>ref|NP_228748.1| (NC_000853) ribosomal large subunit pseudouridine synthase C
           [Thermotoga maritima]
 pir||D72316 ribosomal large subunit pseudouridine synthase C - Thermotoga
           maritima (strain MSB8)
 gb|AAD36021.1|AE001757_14 (AE001757) ribosomal large subunit pseudouridine synthase C
           [Thermotoga maritima]
          Length = 304

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 60/205 (29%), Positives = 102/205 (49%), Gaps = 31/205 (15%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF---GKNAHPAHRLDYETSGLVL 127
           +++E   + V +KP  +  HP    +  +L++ +  +    G +    HRLD ETSGL++
Sbjct: 87  VLYEDDHYLVLNKPPNIAIHPGKGVHVATLIEGLLYYGQEKGFSPFLVHRLDKETSGLLV 146

Query: 128 AGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP 187
             K  ++ + L  LF  + ++K Y+ L  G+ E +MKI  P+                  
Sbjct: 147 VAKNREAARILTELFKGRNIEKEYVTLVRGVPENNMKITIPL------------------ 188

Query: 188 LGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA- 246
            G+++++  E +S  P  D+SLL++   TGR HQIR HLS +   +VG+  YG    N  
Sbjct: 189 DGQEAVS--EIVSVKPLKDVSLLRVKIHTGRKHQIRRHLSQIGFPVVGDDTYGDRHFNRE 246

Query: 247 -REYLQLKRENNAPLLMLHAASLEF 270
            R+   LKR+       LH+  ++F
Sbjct: 247 FRKRYGLKRQ------FLHSYRMKF 265
>ref|NP_230535.1| (NC_002505) pseudouridine synthase Rlu family protein [Vibrio
           cholerae]
 pir||G82266 pseudouridine synthase Rlu family protein VC0888 [imported] -
           Vibrio cholerae (group O1 strain N16961)
 gb|AAF94050.1| (AE004173) pseudouridine synthase Rlu family protein [Vibrio
           cholerae]
          Length = 244

 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 58/214 (27%), Positives = 110/214 (51%), Gaps = 23/214 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHES--LLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           +V++ +     +KP  +  H      HE+  ++  ++   G++  P HRLD  TSG+++ 
Sbjct: 4   IVYQDEYLVAVNKPAGMLVHRSWLDKHETEFVMQTLRDQIGQHVFPLHRLDRPTSGVLVF 63

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPI------LTPQNIQKDLHIR 182
             + Q   ++  +F   +++KTY A+  G +E++  +D P+      +  +  ++D   +
Sbjct: 64  ALSSQIASEVMPMFANHEMEKTYHAIVRGWIEEANVLDYPLKEELDKIADKFAKQDKEAQ 123

Query: 183 SKIS---PLGKQSITLVEPLSYNPFLD--ISLLKITPLTGRTHQIRLHLSSVDHRIVGEG 237
           S ++   PL K  +    P++   F      L+++ P TGR HQ+R H++ + H IVG+ 
Sbjct: 124 SAVTAYRPLAKVEL----PIATGKFATTRYCLMEMQPKTGRKHQLRRHMAHLRHPIVGDT 179

Query: 238 LYGVADENAREYLQLKREN-NAPLLMLHAASLEF 270
            +G    N     +L RE+ +A  LMLHA+ L F
Sbjct: 180 THGDGVHN-----RLFREHFSAQRLMLHASELRF 208
>ref|NP_294685.1| (NC_001263) ribosomal large subunit pseudouridine synthase, Rlu
           family [Deinococcus radiodurans]
 pir||H75454 ribosomal large subunit pseudouridine synthase, Rlu family -
           Deinococcus radiodurans (strain R1)
 gb|AAF10535.1|AE001948_4 (AE001948) ribosomal large subunit pseudouridine synthase, Rlu
           family [Deinococcus radiodurans]
          Length = 257

 Score = 82.4 bits (202), Expect = 6e-15
 Identities = 73/242 (30%), Positives = 113/242 (46%), Gaps = 15/242 (6%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHP-KGYFYHESLLDCIQSHFGK-NAHPAHRLDYE 121
           P EK + +V E  DF V  KP    THP +       LL  +Q+  G+ +  P HRLD E
Sbjct: 18  PTEKPRIIV-EHPDFYVVHKPALWLTHPVRARVDVPDLLTFMQAETGETDLAPPHRLDRE 76

Query: 122 TSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPI--LTPQNIQKD 178
           TSG  L  +   + +    LF    V KTYLA+ HG  E   + +D P+  L      K 
Sbjct: 77  TSGAQLLTRDSDAARTFFTLFKTHLVGKTYLAIVHGEPEWDRRTLDAPLGDLGLGGANK- 135

Query: 179 LHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
           + IR  + P GK ++T    +        +L++  P +GR HQIR HL+ +   +VG+ +
Sbjct: 136 IQIRQAVVPDGKPAVTDFRVVGRR--AGHALIECYPRSGRLHQIRAHLAHLGLPMVGDKI 193

Query: 239 YGVADENAREYL------QLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLK 292
           YG   +   +++      +L      P   LHAA + F + GA   +  P+    + + +
Sbjct: 194 YGRDPQVFLDFMEQGQTPELTARLGLPRQALHAARIAFPWAGAQMAVEVPLAPDLVAYWE 253

Query: 293 DL 294
            L
Sbjct: 254 GL 255
>sp|O50310|YBC5_CHLVI Hypothetical 36.7 kDa protein in BCHI 5'region
 pir||T17190 conserved hypothetical protein CAB06297 - Chlorobium vibrioforme
 emb|CAB06297.1| (Z83933) hypothetical protein [Chlorobium vibrioforme]
          Length = 327

 Score = 82.0 bits (201), Expect = 7e-15
 Identities = 72/243 (29%), Positives = 111/243 (45%), Gaps = 26/243 (10%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------- 114
           P +    +++E  D  V DK   +  HP    +  +L + I  H GK+A           
Sbjct: 72  PEDIPITILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADELDKTEMRPG 131

Query: 115 -AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-KSMKIDKPILTP 172
             HRLD +TSGL++  K   ++  L   F  ++V+K Y A+  G+ + +S  I   I   
Sbjct: 132 IVHRLDKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNIGRS 191

Query: 173 QNIQKDLHIRSKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSV 229
              +K +         GK +IT   +VE L Y      SL+ +T  TGRTHQIR+HL  +
Sbjct: 192 HKNRKVMANFPYEGAEGKHAITDYQVVEDLGY-----FSLMDVTLHTGRTHQIRVHLQHL 246

Query: 230 DHRIVGEGLYGVADENAREYLQLK--RENNAPLL---MLHAASLEFE--FKGAIYKIASP 282
            H I+G+  YG A      + + +    N   L+    LHA +L F     G     ++P
Sbjct: 247 GHSILGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSAP 306

Query: 283 MPE 285
           +PE
Sbjct: 307 LPE 309
>sp|Q45826|YMDA_CHLAU Hypothetical protein in MDH 5'region (ORFA)
 emb|CAA61435.1| (X89038) ORFA [Chloroflexus aurantiacus]
          Length = 253

 Score = 82.0 bits (201), Expect = 7e-15
 Identities = 72/234 (30%), Positives = 110/234 (46%), Gaps = 27/234 (11%)

Query: 71  LVFETKDFGVFDKP-----HQVYTHPKGYFYHESLLDCIQSHFGKNAHPA--HRLDYETS 123
           +V+E  D  V +KP     H    HP+G   +  L        G    P   HRLD +TS
Sbjct: 30  VVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHRLDRDTS 89

Query: 124 GLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPI-LTPQNIQKDLHIR 182
           GL++  +  Q+++ L      ++++K Y AL  G   ++  ID PI   P++      +R
Sbjct: 90  GLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRPPETGTIDAPIGRDPRD-----RLR 144

Query: 183 SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
             + P G+ + T    L  + F D SLL++   TGRTHQIR+HL  + + IVG+ +YG  
Sbjct: 145 MAVVPDGRPARTHYRLL--DTFGDYSLLEVQLETGRTHQIRVHLRHLGYPIVGDPVYG-- 200

Query: 243 DENAREYLQLKRENNAPLLMLHAA--SLEFEFKGAIYKIASPMPERFMPFLKDL 294
               R +L L R+       LHAA   L     G   +  +P+P      L+ L
Sbjct: 201 --PRRSHLHLSRQ------FLHAAYLGLVHPRSGRWQEFTAPLPADLQIVLRQL 246
>ref|NP_603548.1| (NC_003454) Ribosomal large subunit pseudouridine synthase D
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
 gb|AAL94847.1| (AE010576) Ribosomal large subunit pseudouridine synthase D
           [Fusobacterium nucleatum subsp. nucleatum ATCC 25586]
          Length = 288

 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 75/256 (29%), Positives = 122/256 (47%), Gaps = 32/256 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVR--LIHFKPNEKTQALVFETKDFGVFDKPH 85
           L+  + +L+ +R+K N + ++K   I  + +      K  +    + +E ++  + +K  
Sbjct: 30  LRNLEIYLNGKRIKNNAKKIKKLNRIVVIEKEKSTGIKAMDIPIDIAYEDENLLIVNKEP 89

Query: 86  QVYTHPKGYFYHESLLDCIQSHF----GKNAHPA--HRLDYETSGLVLAGKTLQSVKDLK 139
            +  HP      ++L + + ++F    GK   P   +RLD  TSGL++  K   +     
Sbjct: 90  YIIVHPTQKKVDKTLANAVVNYFEKTLGKTLVPRFYNRLDMNTSGLIIIAKNAYT----- 144

Query: 140 ALFMQKK--VKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL--GKQSITL 195
             F+Q K  VKKTY  +A G++EK    D  I  P     D   R ++S    GK + T 
Sbjct: 145 QAFLQDKTEVKKTYKVIASGIIEKD---DFFIKIPIGKVGDDLRRIELSEENGGKSAKTH 201

Query: 196 VEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRE 255
           ++ L  N   +I+ L+    TGRTHQIR HLS + H +VG+ LYG   + A+        
Sbjct: 202 IKVLEKNYEKNITFLEARLYTGRTHQIRAHLSLIGHSLVGDELYGGDMKLAKRQ------ 255

Query: 256 NNAPLLMLHAASLEFE 271
                 MLHA  LEF+
Sbjct: 256 ------MLHAYKLEFQ 265
>ref|NP_420097.1| (NC_002696) ribosomal large subunit pseudouridine synthase D
           [Caulobacter crescentus CB15]
 gb|AAK23265.1| (AE005803) ribosomal large subunit pseudouridine synthase D
           [Caulobacter crescentus CB15]
          Length = 270

 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 61/183 (33%), Positives = 97/183 (52%), Gaps = 15/183 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-KSMKIDKPILTPQN 174
           HRLD +TSG++L  KT  +   L      K+ +K+YLA+  G  E K   ID P L  ++
Sbjct: 83  HRLDRDTSGVILTAKTKPAAAMLGKALEAKRFRKSYLAIVAGAPEPKGGMIDSP-LRRES 141

Query: 175 IQKDLHIR--SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHR 232
           I ++ ++R      P  + + +    L++N     +L++++P TGR HQ+R+H++S+   
Sbjct: 142 IGREAYMRVCEPDHPDAETARSRYRTLAHNGL--AALVELSPDTGRMHQLRVHMASIGRP 199

Query: 233 IVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFK-GAIYKIASPMPERFMPFL 291
           + G+  YG A         +     AP LMLHAASL F    G   KI +P+P  F+  L
Sbjct: 200 LAGDSRYGGA--------LMLGGVPAPRLMLHAASLAFPHPLGGERKILAPLPPDFVSML 251

Query: 292 KDL 294
           + L
Sbjct: 252 EAL 254
>ref|NP_010248.1| (NC_001136) Hypothetical ORF; Ydl036cp [Saccharomyces cerevisiae]
 sp|Q12069|YD36_YEAST Hypothetical 53.4 kDa protein in PRP9-NAT1 intergenic region
 pir||S67569 hypothetical protein YDL036c - yeast (Saccharomyces cerevisiae)
 emb|CAA96453.1| (Z71781) unknown [Saccharomyces cerevisiae]
 emb|CAA98595.1| (Z74084) ORF YDL036c [Saccharomyces cerevisiae]
          Length = 462

 Score = 81.6 bits (200), Expect = 9e-15
 Identities = 54/177 (30%), Positives = 91/177 (50%), Gaps = 17/177 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           ++FE  +  V DKP  +  HP G +   ++   +Q++ G   +P +RLD  TSGL+   K
Sbjct: 190 VIFEDDNIMVIDKPSGIPVHPTGRYRFNTITKMLQNNLGFVVNPCNRLDRLTSGLMFLAK 249

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHG-------LVEKSMKIDKPILTPQNIQKDLHIRS 183
           T +   ++      ++V K Y+A   G       +VEK +K+ +P L        L+   
Sbjct: 250 TPKGADNIGDQLKAREVTKEYVAKVVGEFPETEVIVEKPLKLIEPRLA-------LNAVC 302

Query: 184 KISPLG-KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           ++   G K + T+   +SY+     S++K  PLTGR+HQIR+HL  + H I  + +Y
Sbjct: 303 QMDEKGAKHAKTVFNRISYDG--KTSIVKCKPLTGRSHQIRVHLQYLGHPIANDPIY 357
>gb|EAA14556.1| (AAAB01008980) ebiP4675 [Anopheles gambiae str. PEST]
          Length = 472

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 59/229 (25%), Positives = 108/229 (46%), Gaps = 14/229 (6%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAV------RKSQIIQGVVRLIHFKPNEKTQALV 72
           F R+      +E +R +    L  N + V      + + ++  +V         +   +V
Sbjct: 84  FAREFRAHPAEEYERCIKAGTLTVNYEKVPTDYRLKHNDLLANIVHRHEVPVTSQPITIV 143

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAGKT 131
               D  V +KP  +  HP G + H +++  +   +  KN    HRLD  TSGL+L G++
Sbjct: 144 HMDDDIVVVNKPASIPVHPCGRYRHNTVVFILAKEYNLKNLRTIHRLDRLTSGLLLFGRS 203

Query: 132 LQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPLGK 190
            +  + ++     ++V+K Y+    G   +  ++  +PI   + +   + +  K+SP GK
Sbjct: 204 PKKARQMEHQIRNRQVQKEYICRVEGEFPDGIIECKEPI---EVVSYKIGV-CKVSPKGK 259

Query: 191 QSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           +  T  + L +N    + L K  PLTGR HQIR+HL  + + +V + LY
Sbjct: 260 ECTTTFQKLGFNGNSSVVLCK--PLTGRMHQIRVHLQYLGYPVVNDPLY 306
>ref|NP_406747.1| (NC_003143) ribosomal large subunit pseudouridine synthase D
           [Yersinia pestis]
 emb|CAC92511.1| (AJ414156) ribosomal large subunit pseudouridine synthase D
           [Yersinia pestis]
          Length = 325

 Score = 81.3 bits (199), Expect = 1e-14
 Identities = 53/182 (29%), Positives = 96/182 (52%), Gaps = 11/182 (6%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRL 118
           P E    +V+E  D  V +KP  +  HP       ++L+ +  ++ +      A   HRL
Sbjct: 79  PQEIPLDIVYEDNDILVINKPRGLVVHPGAGNPDGTVLNALLHYYPEIMDVPRAGIVHRL 138

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKD 178
           D +T+GL++  KT+ +   L      +++ + Y A+A G +    ++D+PI   ++  K 
Sbjct: 139 DKDTTGLMVVAKTVPAQTRLVEALQAREITREYEAVAIGNMTAGGRVDEPI--SRHSTKR 196

Query: 179 LHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
            H+   + P+GK + T    + +  F   + L++   TGRTHQIR+H+S ++H +VG+ L
Sbjct: 197 THMA--VHPMGKPATTHYRIMEH--FRAHTRLRLRLETGRTHQIRVHMSHINHPLVGDQL 252

Query: 239 YG 240
           YG
Sbjct: 253 YG 254
>ref|NP_240167.1| (NC_002528) ribosomal large subunit pseudouridine synthase C
           [Buchnera sp. APS]
 sp|P57430|RLUC_BUCAI Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 dbj|BAB13053.1| (AP001119) ribosomal large subunit pseudouridine synthase C
           [Buchnera sp. APS]
          Length = 314

 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 58/158 (36%), Positives = 82/158 (51%), Gaps = 13/158 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGL-VEKSMKIDKPILTPQ- 173
           HR+D +TSG+++  K   S+  L     +KK+KK Y+AL HGL  +   KI +P+L  Q 
Sbjct: 140 HRIDRDTSGVLILAKKRTSLVSLHEQLREKKIKKEYIALVHGLWPDHIKKISEPLLKIQF 199

Query: 174 -NIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHR 232
            N QK + I  K    GK S T  +      F   +LL I P TGRTHQIR+H     H 
Sbjct: 200 KNKQKMVLIDKK----GKPSETYFQ--IKKKFSSSTLLSIIPKTGRTHQIRVHALHAGHP 253

Query: 233 IVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           I  +  YG  D +A     +K  +    L+LH++ + F
Sbjct: 254 IFFDKRYGKNDLDA----DIKNNHKINRLLLHSSGVHF 287
>ref|NP_311484.1| (NC_002695) suppressor of ftsH mutation [Escherichia coli O157:H7]
 dbj|BAB36880.1| (AP002562) suppressor of ftsH mutation [Escherichia coli O157:H7]
          Length = 326

 Score = 80.1 bits (196), Expect = 3e-14
 Identities = 51/184 (27%), Positives = 98/184 (52%), Gaps = 11/184 (5%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F+P +    +V+E +D  V +KP  +  HP       ++L+ +  ++        A   H
Sbjct: 77  FEPQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVH 136

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD +T+GL++  KT+ +   L     ++++ + Y A+A G +     +D+PI   ++  
Sbjct: 137 RLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPI--SRHPT 194

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           K  H+   + P+GK ++T    + +  F   + L++   TGRTHQIR+H++ + H +VG+
Sbjct: 195 KRTHMA--VHPMGKPAVTHYRIMEH--FRVHTRLRLRLETGRTHQIRVHMAHITHPLVGD 250

Query: 237 GLYG 240
            +YG
Sbjct: 251 PVYG 254
>ref|NP_562766.1| (NC_003366) conserved hypothetical protein [Clostridium
           perfringens]
 dbj|BAB81556.1| (AP003192) conserved hypothetical protein [Clostridium perfringens]
          Length = 306

 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 68/235 (28%), Positives = 116/235 (48%), Gaps = 26/235 (11%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--HPA--HRLDYET 122
           +V+E +D  V +KP  +  HP    Y  +L++ +  H     G N    P   HR+D +T
Sbjct: 84  IVYEDEDVIVVNKPKGMVVHPAPGNYTGTLVNALLHHCDDLSGINGVIRPGIVHRIDKDT 143

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHI 181
           SG+++  K   + + L   F    +K+ Y A+  G  +K    ID P+       +D  +
Sbjct: 144 SGILVVAKNDNAHQKLAEQFKDHSIKREYYAIVEGRFKKEGGTIDAPL---GRHHRD-RL 199

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
           +  +   GK+++T  E L    F   SL+K T  TGRTHQIR+H++ + H ++G+ +YG+
Sbjct: 200 KYAVVKDGKRAVTHYEVLKV--FNSCSLVKCTLETGRTHQIRVHMAFIGHPLLGDTVYGL 257

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFLKDL 294
                ++  +L +E      +LHA +L F     G   +  S +PE F   ++ L
Sbjct: 258 -----KKQKKLSQEGQ----VLHAKTLGFIHPTTGEYVEFDSELPEYFEKIVEKL 303
>dbj|BAA16479.1| (D90887) similar to [SwissProt Accession Number P33643]~start codon
           is not identified yet [Escherichia coli]
          Length = 352

 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 50/184 (27%), Positives = 98/184 (53%), Gaps = 11/184 (5%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F+P +    +V+E +D  + +KP  +  HP       ++L+ +  ++        A   H
Sbjct: 121 FEPQDIPLDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVH 180

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD +T+GL++  KT+ +   L     ++++ + Y A+A G +     +D+PI   ++  
Sbjct: 181 RLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPI--SRHPT 238

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           K  H+   + P+GK ++T    + +  F   + L++   TGRTHQIR+H++ + H +VG+
Sbjct: 239 KRTHMA--VHPMGKPAVTHYRIMEH--FRVHTRLRLRLETGRTHQIRVHMAHITHPLVGD 294

Query: 237 GLYG 240
            +YG
Sbjct: 295 PVYG 298
>ref|NP_417085.1| (NC_000913) suppressor of ftsH mutation [Escherichia coli K12]
 sp|P33643|RLUD_ECOLI Ribosomal large subunit pseudouridine synthase D (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||E65037 ftsH suppressor protein SfhB - Escherichia coli (strain K-12)
 gb|AAA92957.1| (U50134) SfhB [Escherichia coli]
 gb|AAC75643.1| (AE000346) suppressor of ftsH mutation [Escherichia coli K12]
          Length = 326

 Score = 79.7 bits (195), Expect = 4e-14
 Identities = 50/184 (27%), Positives = 98/184 (53%), Gaps = 11/184 (5%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F+P +    +V+E +D  + +KP  +  HP       ++L+ +  ++        A   H
Sbjct: 77  FEPQDIPLDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVH 136

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD +T+GL++  KT+ +   L     ++++ + Y A+A G +     +D+PI   ++  
Sbjct: 137 RLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPI--SRHPT 194

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           K  H+   + P+GK ++T    + +  F   + L++   TGRTHQIR+H++ + H +VG+
Sbjct: 195 KRTHMA--VHPMGKPAVTHYRIMEH--FRVHTRLRLRLETGRTHQIRVHMAHITHPLVGD 250

Query: 237 GLYG 240
            +YG
Sbjct: 251 PVYG 254
>ref|NP_245416.1| (NC_002663) unknown [Pasteurella multocida]
 gb|AAK02563.1| (AE006084) unknown [Pasteurella multocida]
          Length = 243

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 58/196 (29%), Positives = 89/196 (44%), Gaps = 20/196 (10%)

Query: 91  PKGYFYHESLLDCIQSHF---------GKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G   H S LD  ++ F         G++ +P HRLD  TSG++L   + +    L   
Sbjct: 18  PAGMLVHRSWLDRHETQFVMQTLRDQIGQHVYPIHRLDRPTSGVLLFALSSEVANLLCLQ 77

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP-------LGKQSIT 194
           F  K+V+K+YLA+  G +    +ID P+    +   D   +   +P       LG   + 
Sbjct: 78  FENKQVQKSYLAIVRGYLVGEGRIDYPLKVQLDKIADKFAQDDKAPQEAVTDYLGLAKVE 137

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKR 254
           +   +   P    SL+++ P TGR HQ+R H+  + H I+G+  YG   +N      L  
Sbjct: 138 MPYCVKKYPTTRYSLVRLIPHTGRKHQLRRHMKHLFHPILGDTQYGDLHQNR----ALTT 193

Query: 255 ENNAPLLMLHAASLEF 270
                 LMLHA  L F
Sbjct: 194 HTGVQRLMLHAERLIF 209
>ref|NP_289346.1| (NC_002655) Z4107 gene product [Escherichia coli O157:H7 EDL933]
 ref|NP_311678.1| (NC_002695) hypothetical protein [Escherichia coli O157:H7]
 gb|AAG57905.1|AE005507_6 (AE005507) Z4107 gene product [Escherichia coli O157:H7 EDL933]
 dbj|BAB37074.1| (AP002563) hypothetical protein [Escherichia coli O157:H7]
          Length = 260

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 61/226 (26%), Positives = 103/226 (44%), Gaps = 26/226 (11%)

Query: 91  PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G+  H S LD          ++   G++   AHRLD  TSG++L G + ++ + L   
Sbjct: 17  PSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP-------LGKQSIT 194
           F Q +++K Y A+  G + +   +D P++   +   D   R    P        G  ++ 
Sbjct: 77  FEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN--AREYLQL 252
           +       P     L+++ P TGR HQ+R HL+ + H I+G+  +G   +N    E+  L
Sbjct: 137 MPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGL 196

Query: 253 KRENNAPLLMLHAA--SLEFEFKGAIYKIASPMPERFMPFLKDLSF 296
           +R      LMLHA+  SL   F G    I + + + +M  L    +
Sbjct: 197 QR------LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
>ref|NP_289149.1| (NC_002655) suppressor of ftsH mutation [Escherichia coli O157:H7
           EDL933]
 gb|AAG57707.1|AE005490_2 (AE005490) suppressor of ftsH mutation [Escherichia coli O157:H7
           EDL933]
          Length = 326

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 51/184 (27%), Positives = 97/184 (52%), Gaps = 11/184 (5%)

Query: 62  FKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAH 116
           F+P +    +V+E +D  V +KP  +  HP       + L+ +  ++        A   H
Sbjct: 77  FEPQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDGTXLNALLHYYPPIADVPRAGIVH 136

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD +T+GL++  KT+ +   L     ++++ + Y A+A G +     +D+PI   ++  
Sbjct: 137 RLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPI--SRHPT 194

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           K  H+   + P+GK ++T    + +  F   + L++   TGRTHQIR+H++ + H +VG+
Sbjct: 195 KRTHMA--VHPMGKPAVTHYRIMEH--FRVHTRLRLRLETGRTHQIRVHMAHITHPLVGD 250

Query: 237 GLYG 240
            +YG
Sbjct: 251 PVYG 254
>gb|AAF52959.1| (AE003628) CG7475 gene product [Drosophila melanogaster]
          Length = 506

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 52/171 (30%), Positives = 89/171 (51%), Gaps = 8/171 (4%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           +V   +D  V +KP  +  HP G + H +++  +   F  KN    HRLD  TSGL+L G
Sbjct: 151 IVHMDEDIVVVNKPASIPVHPCGRYRHNTVVFILAKEFNLKNLRTIHRLDRLTSGLLLFG 210

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLV-EKSMKIDKPILTPQNIQKDLHIRSKISPL 188
           ++ +  + ++     ++V+K Y+    G+  +  ++  +PI   + +   + +  K+S  
Sbjct: 211 RSPKKARQMEQQIRNRQVEKEYICRVEGVFPDGIVECKEPI---EVVSYKIGV-CKVSAK 266

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           GK   T  + LS N    + L K  PLTGR HQIR+HL  + + I+ + LY
Sbjct: 267 GKDCTTTFQKLSQNGTTSVVLCK--PLTGRMHQIRVHLQYLGYPILNDPLY 315
>ref|NP_417271.1| (NC_000913) orf, hypothetical protein [Escherichia coli K12]
 sp|Q46918|YQCB_ECOLI Hypothetical protein yqcB
 pir||C65061 hypothetical protein b2791 - Escherichia coli (strain K-12)
 gb|AAB40441.1| (U29581) corresponds to hypothetical protein from E. carotovora PIR
           Accession Number S45108; 2 ORFs in E. coli; ORF_f260
           [Escherichia coli]
 gb|AAC75833.1| (AE000363) orf, hypothetical protein [Escherichia coli K12]
          Length = 260

 Score = 79.3 bits (194), Expect = 5e-14
 Identities = 61/226 (26%), Positives = 103/226 (44%), Gaps = 26/226 (11%)

Query: 91  PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G+  H S LD          ++   G++   AHRLD  TSG++L G + ++ + L   
Sbjct: 17  PSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP-------LGKQSIT 194
           F Q +++K Y A+  G + +   +D P++   +   D   R    P        G  ++ 
Sbjct: 77  FEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN--AREYLQL 252
           +       P     L+++ P TGR HQ+R HL+ + H I+G+  +G   +N    E+  L
Sbjct: 137 MPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGL 196

Query: 253 KRENNAPLLMLHAA--SLEFEFKGAIYKIASPMPERFMPFLKDLSF 296
           +R      LMLHA+  SL   F G    I + + + +M  L    +
Sbjct: 197 QR------LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
>ref|NP_438775.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 sp|P44782|RLUA_HAEIN Ribosomal large subunit pseudouridine synthase A (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||E64155 yabO protein homolog HI0617 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC22276.1| (U32744) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 219

 Score = 79.0 bits (193), Expect = 6e-14
 Identities = 58/208 (27%), Positives = 107/208 (50%), Gaps = 19/208 (9%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGY-FYHESLLDCIQSHFGKNAHPAHRLDYET 122
           P E    ++++     V +KP  + + P     Y++S +  ++  FG    PAHRLD  T
Sbjct: 9   PLEPYLDIIYQDNHLCVVNKPSGLLSVPGNQPQYYDSAMSRVKEKFGF-CEPAHRLDMAT 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHI 181
           SG+++   +  + ++LK  F +++ KK Y A+  G +E    +++ P++     +     
Sbjct: 68  SGIIVFALSKAADRELKRQFREREPKKHYQAIVWGHLENDYGEVNLPMICDWENRP---- 123

Query: 182 RSKIS-PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           R ++   LGK+++T  E L+  P  + + +K+TP+TGR+HQ+RLH+ ++ H I+G+  Y 
Sbjct: 124 RQRLDFVLGKRAVTKFEVLARLPN-NSTRVKLTPVTGRSHQLRLHMLALGHPILGDKFYS 182

Query: 241 VADENAREYLQLKRENNAPLLMLHAASL 268
                            +P L LHA  L
Sbjct: 183 HPQAKVM----------SPRLCLHAEEL 200
>ref|NP_405172.1| (NC_003143) ribosomal large subunit pseudouridine synthase C
           [Yersinia pestis]
 emb|CAC90413.1| (AJ414149) ribosomal large subunit pseudouridine synthase C
           [Yersinia pestis]
          Length = 320

 Score = 79.0 bits (193), Expect = 6e-14
 Identities = 60/171 (35%), Positives = 86/171 (50%), Gaps = 12/171 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L      K ++K YLAL  G  +   K I  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      K+S  GK S T  +      F   +L+K +P+TGRTHQIR+H     H I 
Sbjct: 199 IMQSGERVVKVSSEGKPSETRFK--IEERFEHATLVKASPVTGRTHQIRVHALHAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPM 283
            +  YG      RE+ Q  +      L LHAA+L FE    G   +I +P+
Sbjct: 257 FDDRYGY-----REFDQQLQGTGLHRLFLHAAALRFEHPNTGETMRIEAPL 302
>ref|NP_655191.1| (NC_003995) PseudoU_synth_2, RNA pseudouridylate synthase [Bacillus
           anthracis A2012] [Bacillus anthracis str. A2012]
          Length = 307

 Score = 79.0 bits (193), Expect = 6e-14
 Identities = 56/178 (31%), Positives = 91/178 (50%), Gaps = 14/178 (7%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HPAHRLDYETSGL 125
           +V+E     + +KP ++ THP       +L + +  H+            HRLD +T+G 
Sbjct: 87  VVYEDDHVLIVNKPEKMDTHPAEKGGMGTLANLVAFHYQMKGLETKVRHIHRLDKDTTGG 146

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLH--IR 182
           V+  K   +   +  L M++K+K+TY AL  G V+K    ID  I       +D H   R
Sbjct: 147 VVFAKHRIAGAIMDRLLMERKIKRTYAALVEGKVKKKQGTIDAAI------GRDRHHATR 200

Query: 183 SKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            ++SP G Q+IT  +   Y    +++ + +   TGRTHQIR+H+S   + +VG+ LYG
Sbjct: 201 RRVSPKGDQAITYYKVEEYFKKQNVTFVTLQLETGRTHQIRVHMSYNGNPLVGDVLYG 258
>ref|NP_642429.1| (NC_003919) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
 gb|AAM36965.1| (AE011847) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
          Length = 328

 Score = 79.0 bits (193), Expect = 6e-14
 Identities = 68/239 (28%), Positives = 112/239 (46%), Gaps = 27/239 (11%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAG 129
           A+VFE       +KP  V +H        ++         ++    HRLD +TSGL++  
Sbjct: 101 AIVFEDARLLALNKPSGVASHGGSGISFGAIETLRALRPNQSLELVHRLDRDTSGLLIVA 160

Query: 130 KTLQSVKDLKALFMQ------KKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIR 182
           K   ++ +L+AL  +      + + K YL L  G + +  M +D P+        + H++
Sbjct: 161 KKRSALTELQALMREDDRVEGRGITKRYLTLLVGRMPDGVMTVDAPLHIGLRQGGERHVQ 220

Query: 183 SKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             ++ +GK S++   L+E    + + ++ +      TGRTHQIR+H   + H + G+  Y
Sbjct: 221 --VNAIGKPSLSHFKLLERRGGHSYCEVRIE-----TGRTHQIRVHAQHLGHPVAGDDKY 273

Query: 240 GVADEN--AREYLQLKRENNAPLLMLHAASLEFEFKG--AIYKIASPMPERFMPFLKDL 294
           G AD N   R+ L LKR      L LHAASLEF        Y +++P+       L  L
Sbjct: 274 GEADVNKRLRDQLGLKR------LFLHAASLEFALDAGKTPYVLSAPLAPELAEALDQL 326
>ref|NP_231662.1| (NC_002505) ribosomal large subunit pseudouridine synthase C
           [Vibrio cholerae]
 sp|Q9KQH0|RLUC_VIBCH Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||G82126 ribosomal large chain pseudouridine synthase C VC2028 [imported] -
           Vibrio cholerae (group O1 strain N16961)
 gb|AAF95176.1| (AE004277) ribosomal large subunit pseudouridine synthase C [Vibrio
           cholerae]
          Length = 315

 Score = 79.0 bits (193), Expect = 6e-14
 Identities = 59/211 (27%), Positives = 104/211 (48%), Gaps = 16/211 (7%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQS--HFGKNAHPAHRLDY 120
           K  E    +V+E     + +KP     H  G   H   ++ +++     +     HR+D 
Sbjct: 89  KVAELEHCIVYEDDHLLILNKPSGTAVHG-GSGLHFGAIEALRALRPQARFLELVHRIDR 147

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQNIQKDL 179
           +TSG++L  K   +++ L+A F +K V+K Y AL  G  +   K ++ P+L     + ++
Sbjct: 148 DTSGILLVAKKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLL-----KNEV 202

Query: 180 HIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           +   +++P GK S T    L    F + +L++ +P+TGRTHQIR+H   + H I  +  Y
Sbjct: 203 NSIVRVNPNGKPSETRFRIL--EKFAEATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRY 260

Query: 240 GVADENAREYLQLKRENNAPLLMLHAASLEF 270
           G      R +     +     L LHAA+++F
Sbjct: 261 G-----DRRFDAYTAQFGIERLFLHAANIQF 286
>ref|NP_296413.1| (NC_002620) ribosomal large subunit pseudouridine synthase D
           [Chlamydia muridarum]
 pir||A81748 ribosomal large chain pseudouridine synthase D TC0029 [imported] -
           Chlamydia muridarum (strain Nigg)
 gb|AAF38920.1| (AE002271) ribosomal large subunit pseudouridine synthase D
           [Chlamydia muridarum]
          Length = 345

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 75/287 (26%), Positives = 125/287 (43%), Gaps = 23/287 (8%)

Query: 3   FVEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHF 62
           FV +E  I +  K L    +    +  + Q  L + R+    Q      + QG +  +  
Sbjct: 24  FVVDERLIGRLDKGLVLHNNAYSRAFYQQQIDLGRVRVNGRVQTRASYLLSQGDLVDLEL 83

Query: 63  KPNEKTQAL---------VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---K 110
              E   +L         V+E     V +KP  +  HP       +++  +    G   K
Sbjct: 84  VEEETPSSLTPENIPLDKVYEDNMILVINKPRNMVVHPAPGHVQGTVVHALLHEIGERLK 143

Query: 111 NAHP--------AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKS 162
              P         HRLD +TSGL++  KT ++      LF  K++KK Y+A+      + 
Sbjct: 144 QEFPEEPWRPGIVHRLDKDTSGLLITVKTRRAKAVYSELFSSKQMKKMYIAICINSPAQK 203

Query: 163 MKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQI 222
             I   I      +K++ + SK +  GK++IT    L+ N  L  S++ + P TGRTHQ+
Sbjct: 204 -HIHTRIARHPVKRKEMTVLSKDTEGGKEAITHCHVLASNGRL--SVVALYPETGRTHQL 260

Query: 223 RLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLE 269
           R+H+  +   I+G+ +YGV   N R  L  ++ +   L+  H  S E
Sbjct: 261 RVHMKHLGTPILGDPVYGVPSINFRYGLDKQQLHAYSLVFTHPESAE 307
>ref|NP_539900.1| (NC_003317) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE C
           [Brucella melitensis]
 gb|AAL52164.1| (AE009538) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE C
           [Brucella melitensis]
          Length = 343

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 64/237 (27%), Positives = 113/237 (47%), Gaps = 17/237 (7%)

Query: 68  TQALVFETKDFGVFDKPHQVYTHP-KGYFYH-ESLLDCIQSHFGKNAHPAHRLDYETSGL 125
           +Q L++E     VF+KP  +      G   H + +L+  +S  G+     HR+D +TSG+
Sbjct: 109 SQMLLYEDPKIFVFNKPAGLAVQGGSGVTRHIDGMLEAWRSKKGEKPRLVHRIDRDTSGV 168

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK-SMKIDKPILTPQNIQKD-LHIRS 183
           ++  +T  + + L A F ++  KKTY AL  G+  K   KI   ++  Q    D + +  
Sbjct: 169 LVVARTRGAAQALTASFRERDTKKTYWALVKGVPRKREDKISTWLVKEQTPDGDKMRVCQ 228

Query: 184 KISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
              P    +++   ++E    N    ++ L++ P TGRTHQ+R+H + + H I+G+  Y 
Sbjct: 229 HGEPDSDHAVSYYRIIEKAGNN----LAWLEMEPYTGRTHQLRVHAAYIGHPIIGDPKYF 284

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEF-EFKGAIYKIASPMPERFMPFLKDLSF 296
            AD+N      +++      L LHA  +      G I  + +P+P   +     L F
Sbjct: 285 EADQNWEFPGGIQKR-----LHLHARRIRIPNPSGGIIDVTAPLPPHMVQSWNLLGF 336
>ref|NP_356602.1| (NC_003063) AGR_L_1625p [Agrobacterium tumefaciens] [Agrobacterium
           tumefaciens str. C58 (Cereon)]
 ref|NP_534526.1| (NC_003305) ribosomal large subunit pseudouridine synthase A
           [Agrobacterium tumefaciens str. C58 (U. Washington)]
 gb|AAK89387.1| (AE008280) AGR_L_1625p [Agrobacterium tumefaciens str. C58
           (Cereon)]
 gb|AAL44842.1| (AE009334) ribosomal large subunit pseudouridine synthase A
           [Agrobacterium tumefaciens str. C58 (U. Washington)]
          Length = 222

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 65/214 (30%), Positives = 106/214 (49%), Gaps = 19/214 (8%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHP-KGYFYHESLLDCIQSHFGKNAHPAHRL 118
           I+  P +    +V    D  V DKP  + + P +     +SL+  +Q  F K A   +RL
Sbjct: 9   IYNPPLDPWLTIVHRDDDLLVLDKPSGLLSVPGRDPALSDSLMTRVQKQFPK-ALMINRL 67

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-KSMKIDKPILTPQNIQK 177
           D +TSG+VL     ++   + A F +++ +K+Y+A+  G V  +  ++D P+     I  
Sbjct: 68  DKDTSGIVLMSLNRKAHAAIAAQFEKRETRKSYVAIVWGTVAGEEGEVDLPLA----IDP 123

Query: 178 DLHIRSKIS-PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           D   R ++    GK + +L   L   P L  + L +TPLTGRTHQ+R+H+ ++ H I+G+
Sbjct: 124 DNKPRHRVDHENGKPAQSLWRVLERLP-LPATRLALTPLTGRTHQLRVHMKALGHPILGD 182

Query: 237 GLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
             Y   +              AP LMLHA  + F
Sbjct: 183 EFYAEGEALTA----------APRLMLHAQEVGF 206
>ref|NP_607042.1| (NC_003485) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
 gb|AAL97541.1| (AE010018) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
          Length = 296

 Score = 78.2 bits (191), Expect = 1e-13
 Identities = 52/179 (29%), Positives = 89/179 (49%), Gaps = 15/179 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYET 122
           +++E     + +KP  +  HP      E++++ +  H    +           HR+D +T
Sbjct: 76  IIYEDDALAIINKPQGMVVHPSAGHPSETMVNALMYHIKDLSSINGVVRPGIVHRIDKDT 135

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHI 181
           SGL++  KT  + + L      KK  + YLA+ HG L      I+ PI   +  +K   +
Sbjct: 136 SGLLMVAKTDAAHQALTEELKAKKSLRKYLAIVHGNLPNDRGMIEAPIGRSEKDRKKQAV 195

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            +K    GK+++T    L    F D SL+++   TGRTHQIR+H++ + H + G+ LYG
Sbjct: 196 TAK----GKEAVTRFTVLER--FGDYSLVELQLETGRTHQIRVHMAYIGHPVAGDPLYG 248
>ref|NP_267154.1| (NC_002662) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
 gb|AAK05096.1|AE006334_2 (AE006334) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
          Length = 301

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 55/179 (30%), Positives = 91/179 (50%), Gaps = 15/179 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYET 122
           +++E  D  V +KP  +  HP       +L++ I  H    +           HR+D +T
Sbjct: 79  IIYEDSDVAVVNKPQGMVVHPAAGHASGTLVNAIMYHIKDLSSINGVIRPGIVHRIDKDT 138

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHI 181
           SGL++  K  ++ + L A    K  K+ YLA+ HG +      I+ PI   +N+ KD   
Sbjct: 139 SGLLMIAKNDKAHESLAAQLKDKTSKRRYLAIVHGEIANDKGTIEAPI--GRNL-KDRKK 195

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           ++ +S  GK ++T  E L    F   +L+ +   TGRTHQIR+H++ + H + G+ LYG
Sbjct: 196 QAVVSG-GKPAVTHFEVLER--FYGYTLIALRLETGRTHQIRVHMNYIGHPVAGDPLYG 251
>ref|NP_455681.1| (NC_003198) ribosomal large subunit pseudouridine synthase C (EC
           4.2.1.70) [Salmonella enterica subsp. enterica serovar
           Typhi]
 emb|CAD08312.1| (AL627269) ribosomal large subunit pseudouridine synthase C (EC
           4.2.1.70) [Salmonella enterica subsp. enterica serovar
           Typhi]
          Length = 319

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 61/184 (33%), Positives = 95/184 (51%), Gaps = 14/184 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L     +K ++K YLAL  G  +  +K +  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      ++S  GK S T  +      F   +L++ +P+TGRTHQIR+H     H I 
Sbjct: 199 ILQSGERIVRVSQEGKPSETRFKVEERYAF--ATLVRCSPVTGRTHQIRVHTQYAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPL--LMLHAASLEFEFKGA--IYKIASPMPERFMPF 290
            +  YG      RE+ Q   E    L  L LHAA+L+F   G   + +I +PM ++    
Sbjct: 257 FDDRYG-----DREFDQQLTEAGTGLKRLFLHAAALKFTHPGTGDVMRIEAPMDKQLKRC 311

Query: 291 LKDL 294
           L+ L
Sbjct: 312 LEVL 315
>ref|NP_110237.1| (NC_000912) pseudouridine synthase [Mycoplasma pneumoniae]
 sp|P75230|Y370_MYCPN Hypothetical protein MG370 homolog (G12_orf326)
 pir||S73620 hypothetical protein G12_orf326 - Mycoplasma pneumoniae  (strain
           ATCC 29342)
 gb|AAB95942.1| (AE000027) pseudouridine synthase [Mycoplasma pneumoniae]
          Length = 326

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 63/211 (29%), Positives = 97/211 (45%), Gaps = 20/211 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP----------AHRLDY 120
           ++FE +   V DKP  V   P       +L + +  H G N +           AHR+D 
Sbjct: 89  VIFEDEQLIVVDKPAGVVCQPDAKHELFNLANSLLKHCGYNQYFKNSLSFIPRFAHRIDR 148

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
            T GLV+  KT Q++++L+A+F    + K Y  L  G         K        Q  + 
Sbjct: 149 NTCGLVIGAKTNQALQELEAVFRHNLLMKQYQGLVFGPFNFK-GTQKAYWAKDAYQALVT 207

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           +++K  P  K   T+ E   Y   LD+SLL I  ++G+THQIR  L+ ++ ++VG+  Y 
Sbjct: 208 VKAKPFPNAKPITTIFENSKYLTKLDLSLLTIRLVSGKTHQIRACLNLLNTQLVGDRKY- 266

Query: 241 VADENAREYLQLKREN-NAPLLMLHAASLEF 270
                  + LQ K  N +     LHA +L F
Sbjct: 267 -------QLLQFKNRNRDFKHQALHATNLSF 290
>ref|NP_608079.1| (NC_003485) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
 gb|AAL98578.1| (AE010114) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
          Length = 272

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 65/204 (31%), Positives = 99/204 (47%), Gaps = 24/204 (11%)

Query: 72  VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKT 131
           ++E +   + +KP  + TH        +LL+ + ++ G+  +  HRLD ETSG +L  KT
Sbjct: 61  LYEDEHIIIVNKPEGMKTHGNDPT-ELALLNHVSAYTGQTCYVVHRLDKETSGAILFAKT 119

Query: 132 LQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN-IQKDLHIRSK--ISPL 188
              +  L  L  ++ + + YLAL HG       +D P +T  + I +  H R K  + P+
Sbjct: 120 PFILPILNRLLEKRDIHREYLALVHG------SLDSPRVTYHHPIGRHRHDRRKRVVDPI 173

Query: 189 -GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAR 247
            GK++IT V  L  N     SLL     TGRTHQIR+HL+   H + G+ LY        
Sbjct: 174 NGKKAITEV-TLVKNFHKTASLLNCQLQTGRTHQIRVHLAHQGHVLFGDPLYS------- 225

Query: 248 EYLQLKRENNAPLLMLHAASLEFE 271
                  + +   LMLHA  L  +
Sbjct: 226 -----NGKKDCARLMLHAYQLRLK 244
>ref|NP_655109.1| (NC_003995) PseudoU_synth_2, RNA pseudouridylate synthase [Bacillus
           anthracis A2012] [Bacillus anthracis str. A2012]
          Length = 297

 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 70/245 (28%), Positives = 113/245 (45%), Gaps = 39/245 (15%)

Query: 44  QQAVRKSQIIQGVVRLIHFKPNEKTQAL---------VFETKDFGVFDKPHQVYTHPKGY 94
           Q A  + Q+  G    I F   E+++ +         V+E     V +K   + T P   
Sbjct: 48  QHASVRHQLQVGEELRIFFPVEERSEGMIAEDIPLCIVYEDDAVLVINKEANMSTIPSRE 107

Query: 95  FYHESLLDCIQSHFGKN-----AHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKK 149
               S+ + + SH+ K       H   RLD +TSGL+L  K       L     QK VK+
Sbjct: 108 HPSGSVANALLSHYDKQYLPSTVHIVTRLDRDTSGLMLIAKNRFVHHLLSKQHQQKAVKR 167

Query: 150 TYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSIT---LVEPLSYNPFL 205
           TY A+ HG +VE+   ID PI      + D  I   +   G++++T   +++  ++   +
Sbjct: 168 TYEAIVHGEMVEREGTIDAPI----GRKSDSIIERTVCEEGQRAVTHFRVIDSANHKTHV 223

Query: 206 DISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHA 265
            + L      TGRTHQIR+HL+ + H ++G+ LYG   +      ++KR+       LH+
Sbjct: 224 SLELD-----TGRTHQIRVHLAHIGHPLLGDNLYGGKRD------EMKRQ------ALHS 266

Query: 266 ASLEF 270
            SL F
Sbjct: 267 TSLTF 271
>ref|NP_270003.1| (NC_002737) conserved hypothetical protein [Streptococcus pyogenes]
           [Streptococcus pyogenes M1 GAS]
 gb|AAK34724.1| (AE006626) conserved hypothetical protein [Streptococcus pyogenes
           M1 GAS]
          Length = 272

 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 65/204 (31%), Positives = 99/204 (47%), Gaps = 24/204 (11%)

Query: 72  VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKT 131
           ++E +   + +KP  + TH        +LL+ + ++ G+  +  HRLD ETSG +L  KT
Sbjct: 61  LYEDEHIIIVNKPEGMKTHGNDPT-ELALLNHVSAYTGQTCYVVHRLDKETSGAILFAKT 119

Query: 132 LQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN-IQKDLHIRSK--ISPL 188
              +  L  L  ++ + + YLAL HG       +D P +T  + I +  H R K  + P+
Sbjct: 120 PFILPILNRLLEKRDIHREYLALVHG------SLDSPRVTYHHPIGRHRHDRRKRVVDPI 173

Query: 189 -GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAR 247
            GK++IT V  L  N     SLL     TGRTHQIR+HL+   H + G+ LY        
Sbjct: 174 NGKKAITEV-TLVKNFHKTASLLTCQLQTGRTHQIRVHLAHQGHVLFGDPLYS------- 225

Query: 248 EYLQLKRENNAPLLMLHAASLEFE 271
                  + +   LMLHA  L  +
Sbjct: 226 -----NGKKDCARLMLHAYQLRLK 244
>gb|AAF78056.1|AF263561_1 (AF263561) 23S rRNA pseudouridine synthase [secondary endosymbiont
           of Glycaspis brimblecombei]
          Length = 314

 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 57/216 (26%), Positives = 107/216 (49%), Gaps = 13/216 (6%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHP 114
           + ++P      +V+E  +  V +KP  +  HP       ++L+ +   + +      A  
Sbjct: 64  MRWQPQNIPLNIVYEDDEIIVINKPRDLVVHPGAGNPDGTVLNALLYRYPEIINVPRAGI 123

Query: 115 AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN 174
            HRLD +T+GL++  KT+ +   L      +++ + Y A+ +G +     +D+PI   ++
Sbjct: 124 VHRLDKDTTGLMVIAKTIPAQTHLVEALQLREITREYEAVVNGRMTAGGTVDEPIA--RH 181

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             K  H+   I PLGK +IT    + +  F   + L++   +GRTHQIR+H++ ++H +V
Sbjct: 182 PTKRTHMA--IHPLGKPAITHYRVMEH--FRAHTRLRLRLESGRTHQIRVHMAHINHPLV 237

Query: 235 GEGLYGVADENAREYLQLKRE--NNAPLLMLHAASL 268
           G+ +YG      +   +  R+  NN     LHA  L
Sbjct: 238 GDPVYGGRPRPLKGVSEEFRQVMNNFDRQALHATML 273
>ref|NP_371721.1| (NC_002758) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
 ref|NP_374313.1| (NC_002745) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 dbj|BAB42292.1| (AP003132) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 dbj|BAB57359.1| (AP003361) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
          Length = 305

 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 62/233 (26%), Positives = 106/233 (44%), Gaps = 23/233 (9%)

Query: 20  VRDVLKCSLKEAQRHLDKQRLK---QNQQAVRKSQIIQGVVRLIHFKPNEKTQALVFETK 76
           ++D +K  L  A   + K   K    +   V + ++++  +      P      + +E  
Sbjct: 34  IQDWIKAGLVVANDKVVKSNYKVKLNDHIVVTEKEVVEADIL-----PENLNLDIYYEDD 88

Query: 77  DFGVFDKPHQVYTHPKGYFYHESLLDCIQ------SHFGKNAHPA--HRLDYETSGLVLA 128
           D  V  KP  +  HP    Y  +L++ +       S       P   HR+D +TSGL++ 
Sbjct: 89  DVAVVYKPKGMVVHPSPGHYTNTLVNGLMYQIKNLSGINGEIRPGIVHRIDMDTSGLLMV 148

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKISP 187
            K   + + L    M K VK+ Y+AL HG +      ID PI   +N ++ + +      
Sbjct: 149 AKNDIAHRGLVEQLMDKSVKRKYIALVHGNIPHDYGTIDAPIGRNKNDRQSMAVVDD--- 205

Query: 188 LGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            GK+++T    L +  F D +L++    TGRTHQIR+H+  +   +VG+  YG
Sbjct: 206 -GKEAVTHFNVLEH--FKDYTLVECQLETGRTHQIRVHMKYIGFPLVGDPKYG 255
>ref|NP_415604.1| (NC_000913) orf, hypothetical protein [Escherichia coli K12]
 sp|P23851|RLUC_ECOLI Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||C64852 probable pseudouridylate synthase yceC - Escherichia coli
 gb|AAC74170.1| (AE000209) orf, hypothetical protein [Escherichia coli K12]
 dbj|BAA35894.1| (D90744) Hypothetical 36.0 kd protein in rne-rpmF intergenic region
           (orfx). [Escherichia coli]
          Length = 319

 Score = 77.4 bits (189), Expect = 2e-13
 Identities = 61/184 (33%), Positives = 94/184 (50%), Gaps = 14/184 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L     +K ++K YLAL  G  +  +K +  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      ++S  GK S T  +      F   +L++ +P+TGRTHQIR+H     H I 
Sbjct: 199 ILQSGERIVRVSQEGKPSETRFKVEERYAF--ATLVRCSPVTGRTHQIRVHTQYAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPL--LMLHAASLEFEFKGA--IYKIASPMPERFMPF 290
            +  YG      RE+ +   E    L  L LHAA+L+F   G   + +I +PM E     
Sbjct: 257 FDDRYG-----DREFDRQLTEAGTGLNRLFLHAAALKFTHPGTGEVMRIEAPMDEGLKRC 311

Query: 291 LKDL 294
           L+ L
Sbjct: 312 LQKL 315
>ref|NP_220177.1| (NC_000117) (Pseudouridine Synthase) [Chlamydia trachomatis]
 pir||D71487 probable (pseudouridine synthase) - Chlamydia trachomatis
           (serotype D, strain UW3/Cx)
 gb|AAC68253.1| (AE001336) (Pseudouridine Synthase) [Chlamydia trachomatis]
          Length = 334

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 60/209 (28%), Positives = 101/209 (47%), Gaps = 14/209 (6%)

Query: 72  VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---KNAHP--------AHRLDY 120
           V+E     V +KP  +  HP       +++  +    G   K   P         HRLD 
Sbjct: 91  VYEDDMMLVINKPRDMVVHPAPGHTQGTVVHALLHEIGERLKQEFPEEPWRPGIVHRLDK 150

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
           +TSGL++  KT ++      LF  K+VKK Y+A+      +  +I   I      +K++ 
Sbjct: 151 DTSGLLITVKTRRAKALYSELFATKQVKKLYVAICINAPSQE-RIHTRIARHPLKRKEMT 209

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           + S  +  GK++IT  + L+ N  L  S++ + P TGRTHQ+R+H+  +   I+G+ +YG
Sbjct: 210 VLSTHAEGGKEAITHCQVLATNGRL--SVVALYPETGRTHQLRVHMKHLGTPILGDPVYG 267

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLE 269
           +   N R  L  ++ +   L+  H  S E
Sbjct: 268 IPSINFRYGLDKQQLHAYSLVFAHPESAE 296
>ref|NP_190794.1| (NM_115086) pseudouridine synthase, putative [Arabidopsis thaliana]
          Length = 346

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 59/200 (29%), Positives = 94/200 (46%), Gaps = 34/200 (17%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAH-----------PAHRLD 119
           +++E  D    +KP  +   P G F   ++L  +Q  FGKN             P HRL 
Sbjct: 99  VLYEDDDLIALNKPSGLQVLPGGLFQQRTVLTQLQWCFGKNDSYIGSRESPHPVPVHRLG 158

Query: 120 YETSGLVLAGKTLQSVKDLKALFMQ-----------------KKVKKTYLALAHGLVEKS 162
             TSG++L  KT  +   L A F +                 +K+ K Y ALA G+VE+ 
Sbjct: 159 RGTSGILLCAKTKLAKTKLAAYFAEGTSLVGSGNLDQECGTGRKLSKIYRALADGIVEED 218

Query: 163 MKIDKP---ILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRT 219
             + K    ++    + + L++ S   P GK + + V  L  +   + SL+K+   +GR 
Sbjct: 219 EVVIKQPIGVVRYPGVAQGLYVAS---PEGKPAFSKVFVLERDREKNCSLVKVEIQSGRP 275

Query: 220 HQIRLHLSSVDHRIVGEGLY 239
           HQIR+HL+ + H +VG+ LY
Sbjct: 276 HQIRIHLAYMGHPLVGDPLY 295
>ref|NP_470305.1| (NC_003212) similar to ribosomal large subunit pseudouridine
           synthetase [Listeria innocua]
 emb|CAC96199.1| (AL596167) similar to ribosomal large subunit pseudouridine
           synthetase [Listeria innocua]
          Length = 296

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 64/208 (30%), Positives = 103/208 (48%), Gaps = 20/208 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HPAHRLDYETSGL 125
           +VFE     + +KP  + + P  Y    S+ + ++ H+         H   RLD ETSGL
Sbjct: 82  VVFEDDFLLIINKPAGMASIPSQYHPTGSVANFVKGHYENQGLTSAIHIVTRLDRETSGL 141

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           +L  K   +   L +   Q  +K+ Y A   G L E++  I+ PI      +KD+ I  +
Sbjct: 142 MLIAKNRYAHARLSSFLQQGLLKRRYQAFTSGTLEEEAGSIEAPIG-----RKDVSIMER 196

Query: 185 -ISPLGKQSITLVEPLS-YNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
            ++P GK + T  E L  YN F     L I   TGRTHQIR+H S + H ++G+ +YG  
Sbjct: 197 FVTPEGKYAKTNYEVLMRYNGF---DHLAIQLETGRTHQIRVHFSYIGHPLIGDDMYG-- 251

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEF 270
               +E L+ +  ++  L ++H  + E+
Sbjct: 252 --GDQELLKRQALHSCHLHLVHPVTEEY 277
>ref|NP_460157.1| (NC_003197) 23S rRNA pseudouridylate synthase [Salmonella
           typhimurium LT2]
 gb|AAL20116.1| (AE008751) 23S rRNA pseudouridylate synthase [Salmonella
           typhimurium LT2]
          Length = 319

 Score = 77.0 bits (188), Expect = 2e-13
 Identities = 59/173 (34%), Positives = 90/173 (51%), Gaps = 14/173 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L     +K ++K YLAL  G  +  +K +  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      ++S  GK S T  +      F   +L++ +P+TGRTHQIR+H     H I 
Sbjct: 199 ILQSGERIVRVSQEGKPSETRFKVEERYAF--ATLVRCSPVTGRTHQIRVHTQYAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPL--LMLHAASLEFEFKGA--IYKIASPM 283
            +  YG      RE+ Q   E    L  L LHAA+L+F   G   + +I +PM
Sbjct: 257 FDDRYG-----DREFDQQLTEAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPM 304
>ref|NP_354476.1| (NC_003062) AGR_C_2714p [Agrobacterium tumefaciens] [Agrobacterium
           tumefaciens str. C58 (Cereon)]
 gb|AAK87261.1| (AE008072) AGR_C_2714p [Agrobacterium tumefaciens str. C58
           (Cereon)]
          Length = 314

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 64/223 (28%), Positives = 108/223 (47%), Gaps = 19/223 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHP-KGYFYH-ESLLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           L+ E     VF+KP  +      G   H + LL+   S  G+     HRLD +TSG+++ 
Sbjct: 81  LLHEDDKVLVFNKPAGIAVQGGSGVNRHIDGLLEAWTSPKGEKPRLVHRLDRDTSGVLVV 140

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKISP 187
            +T  + + L A F ++  KKTY AL  G+  K   KI   ++  Q    D   R +I+ 
Sbjct: 141 ARTRGAAQKLTAAFRERDTKKTYWALVRGVPRKHQDKISTWLVKEQTPDGD---RMRIAK 197

Query: 188 LGKQSITLVEPLSYNPFLD-----ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
            G++       +SY   +D     ++ L++ P TGRTHQ+R+H   + H I+G+  Y + 
Sbjct: 198 HGEEGAD--HAISYYRVIDTAAQNLAWLEMEPYTGRTHQLRVHALHMGHPIIGDPKYYID 255

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMP 284
           D N      +++      L LHA  ++     G   ++++P+P
Sbjct: 256 DPNWDFPGGVQKR-----LHLHARHIDIPHPNGGRLRVSAPLP 293
>ref|NP_219609.1| (NC_000117) predicted pseudouridine synthetase family [Chlamydia
           trachomatis]
 pir||A71557 probable pseudouridine synthetase - Chlamydia trachomatis
           (serotype D, strain UW3/Cx)
 gb|AAC67697.1| (AE001284) predicted pseudouridine synthetase family [Chlamydia
           trachomatis]
          Length = 303

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 63/190 (33%), Positives = 91/190 (47%), Gaps = 18/190 (9%)

Query: 111 NAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL 170
           N H  HRLD +TSG +L  K  ++   +  LF  +++ K Y+AL  G   +   I     
Sbjct: 97  NVHLVHRLDRDTSGCILFAKHAKASSLITQLFKNREIDKRYIALVFGQPRQESGIITTYT 156

Query: 171 TP--QNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSS 228
            P  + I   L   +  +  GK +IT  E L+  P    +LL   P+TGRTHQIRLH+ +
Sbjct: 157 APCYRRIGAVLFGNTDQNS-GKITITKWEILTRYP--KYTLLLCRPVTGRTHQIRLHMKT 213

Query: 229 VDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPER 286
           + H IVG+  YG            ++  N    +LHAASL F   F     +++S  P +
Sbjct: 214 IGHPIVGDVDYG----------NQEQPKNVVRTLLHAASLAFISPFSNEKIEVSSLTPSQ 263

Query: 287 F-MPFLKDLS 295
              PF  D S
Sbjct: 264 DPYPFYADFS 273
>ref|NP_532161.1| (NC_003304) ribosomal large subunit pseudouridine synthase C
           [Agrobacterium tumefaciens str. C58 (U. Washington)]
 gb|AAL42477.1| (AE009107) ribosomal large subunit pseudouridine synthase C
           [Agrobacterium tumefaciens str. C58 (U. Washington)]
          Length = 329

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 64/223 (28%), Positives = 108/223 (47%), Gaps = 19/223 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHP-KGYFYH-ESLLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           L+ E     VF+KP  +      G   H + LL+   S  G+     HRLD +TSG+++ 
Sbjct: 96  LLHEDDKVLVFNKPAGIAVQGGSGVNRHIDGLLEAWTSPKGEKPRLVHRLDRDTSGVLVV 155

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKISP 187
            +T  + + L A F ++  KKTY AL  G+  K   KI   ++  Q    D   R +I+ 
Sbjct: 156 ARTRGAAQKLTAAFRERDTKKTYWALVRGVPRKHQDKISTWLVKEQTPDGD---RMRIAK 212

Query: 188 LGKQSITLVEPLSYNPFLD-----ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
            G++       +SY   +D     ++ L++ P TGRTHQ+R+H   + H I+G+  Y + 
Sbjct: 213 HGEEGAD--HAISYYRVIDTAAQNLAWLEMEPYTGRTHQLRVHALHMGHPIIGDPKYYID 270

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMP 284
           D N      +++      L LHA  ++     G   ++++P+P
Sbjct: 271 DPNWDFPGGVQKR-----LHLHARHIDIPHPNGGRLRVSAPLP 308
>ref|NP_296760.1| (NC_002620) RNA pseudouridylate synthase family protein [Chlamydia
           muridarum]
 gb|AAF73552.1| (AE002305) RNA pseudouridylate synthase family protein [Chlamydia
           muridarum]
          Length = 274

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 59/186 (31%), Positives = 92/186 (48%), Gaps = 15/186 (8%)

Query: 111 NAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL 170
           + H  HRLD +TSG +L  K  +++  +  LF  +++ K Y+AL  G   +   I     
Sbjct: 97  HVHLVHRLDRDTSGCILFAKHEKAITPITQLFKTRQIDKRYIALVFGHPRQQSGIITTYT 156

Query: 171 TPQNIQKDLHIRSKISP-LGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSV 229
            P + +    +       LGK++IT  E L++  +   +LL   P+TGRTHQIRLH+ ++
Sbjct: 157 APCHRRIGAVLFGNTDEKLGKKTITEWEVLTH--YSKYALLLCRPITGRTHQIRLHMKTI 214

Query: 230 DHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERF 287
            H IVG+  YG    N  +   + R       +LHA SL F   F     +++S  P+  
Sbjct: 215 GHPIVGDIDYG----NKEQPKHVVRP------LLHANSLCFISPFSKKKIEVSSLTPDTL 264

Query: 288 MPFLKD 293
            PF  D
Sbjct: 265 YPFDAD 270
>ref|NP_287220.1| (NC_002655) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 ref|NP_309491.1| (NC_002695) hypothetical protein [Escherichia coli O157:H7]
 gb|AAG55832.1|AE005319_1 (AE005319) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 dbj|BAB34887.1| (AP002555) hypothetical protein [Escherichia coli O157:H7]
          Length = 319

 Score = 76.3 bits (186), Expect = 4e-13
 Identities = 60/184 (32%), Positives = 94/184 (50%), Gaps = 14/184 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L     +K ++K YLAL  G  +  +K +  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      ++S  GK S T  +      F   +L++ +P+TGRTHQIR+H     H I 
Sbjct: 199 ILQSGERIVRVSQEGKPSETRFKVEERYAF--ATLVRCSPVTGRTHQIRVHTQYAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPL--LMLHAASLEFEFKGA--IYKIASPMPERFMPF 290
            +  YG      RE+ +   E    L  L LHAA+L+F   G   + +I +PM +     
Sbjct: 257 FDDRYG-----DREFDRQLTEAGTGLNRLFLHAAALKFTHPGTGEVMRIEAPMDDGLKRC 311

Query: 291 LKDL 294
           L+ L
Sbjct: 312 LQKL 315
>sp|P44197|YQCB_HAEIN Hypothetical protein HI1435
          Length = 239

 Score = 76.3 bits (186), Expect = 4e-13
 Identities = 58/196 (29%), Positives = 89/196 (44%), Gaps = 20/196 (10%)

Query: 91  PKGYFYHESLLDCIQSHF---------GKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G   H S LD  ++ F         G++  P HRLD  TSG++L   + +    +   
Sbjct: 17  PAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPI------LTPQNIQKDLHIRSKISPL-GKQSIT 194
           F QK V+K+YLA+  G ++   +ID P+      +  +  Q+D   +  I+   G + + 
Sbjct: 77  FEQKYVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAITDYEGLKIVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKR 254
           +  P         SL+K+ P TGR H +R H+  V H I G+  YG   +N      L  
Sbjct: 137 MPYPAGRYQTARYSLVKLIPHTGRKHXLRXHMKHVFHPIXGDTQYGDLHQNR----ALMS 192

Query: 255 ENNAPLLMLHAASLEF 270
                 L LH+ SL F
Sbjct: 193 HLGCSRLFLHSDSLSF 208
>ref|NP_372374.1| (NC_002758) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
 ref|NP_374957.1| (NC_002745) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 ref|NP_646608.1| (NC_003923) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
 dbj|BAB42936.1| (AP003135) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 dbj|BAB58012.1| (AP003363) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
 dbj|BAB95656.1| (AP004828) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
          Length = 273

 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 60/203 (29%), Positives = 95/203 (46%), Gaps = 9/203 (4%)

Query: 61  HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLD-CIQSHFGKNAHPAHRLD 119
           ++ P+ +   + +E  D  +  KP  V THP       +L++  I +       P HRLD
Sbjct: 66  NYVPSYRYAQIKYEDDDMAIVMKPKGVKTHPNDLKESNTLMNHVIYTIDSDYVEPIHRLD 125

Query: 120 YETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-KSMKIDKPILTPQNIQKD 178
            ET GL++  K     K L  +     + + Y A    L+  K   ID PI       K 
Sbjct: 126 QETVGLLIVAKNPLMKKILDRMLEDNDITRIYKANVKALLPLKPQTIDMPI----GKDKF 181

Query: 179 LHIRSKISPLGKQSITLVEPLSYNPFLD-ISLLKITPLTGRTHQIRLHLSSVDHRIVGEG 237
              + ++SP G+++IT +  L+     + +  L+I   TGRTHQIR+HL+ + H ++G+ 
Sbjct: 182 HSNKRRVSPTGQRAITHI--LTSKMIKEAVCQLEIKLDTGRTHQIRVHLAEIGHPVIGDP 239

Query: 238 LYGVADENAREYLQLKRENNAPL 260
           LYG +     E    K E   PL
Sbjct: 240 LYGDSTLRQLELESYKIEFVHPL 262
>ref|NP_269039.1| (NC_002737) conserved hypothetical protein [Streptococcus pyogenes]
           [Streptococcus pyogenes M1 GAS]
 gb|AAK33760.1| (AE006533) conserved hypothetical protein [Streptococcus pyogenes
           M1 GAS]
          Length = 296

 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 51/179 (28%), Positives = 88/179 (48%), Gaps = 15/179 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYET 122
           +++E     + +KP  +  HP       ++++ +  H    +           HR+D +T
Sbjct: 76  IIYEDDALAIINKPQGMVVHPSAGHPSGTMVNALMYHIKDLSSINGVVRPGIVHRIDKDT 135

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHI 181
           SGL++  KT  + + L      KK  + YLA+ HG L      I+ PI   +  +K   +
Sbjct: 136 SGLLMVAKTDAAHQALAEELKAKKSLRKYLAIVHGNLPNDRGMIEAPIGRSEKDRKKQAV 195

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            +K    GK+++T    L    F D SL+++   TGRTHQIR+H++ + H + G+ LYG
Sbjct: 196 TAK----GKEAVTRFTVLER--FGDYSLVELQLETGRTHQIRVHMAYIGHPVAGDPLYG 248
>ref|NP_645897.1| (NC_003923) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
 dbj|BAB94945.1| (AP004825) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
          Length = 305

 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 55/173 (31%), Positives = 84/173 (47%), Gaps = 10/173 (5%)

Query: 70  ALVFETKDFGVFDKP-HQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           A+V++TK   V   P H   T   G  Y    L  I           HR+D +TSGL++ 
Sbjct: 91  AVVYKTKGMVVHPSPGHYTNTLVNGLMYQIKNLSGINGEIRPGI--VHRIDMDTSGLLMV 148

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKISP 187
            K   + + L    M K VK+ Y+AL HG +      ID PI   +N ++ + +      
Sbjct: 149 AKNDIAHRGLVEQLMDKSVKRKYIALVHGNIPHDYGTIDAPIGRNKNDRQSMAVVDD--- 205

Query: 188 LGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            GK+++T    L +  F D +L++    TGRTHQIR+H+  +   +VG+  YG
Sbjct: 206 -GKEAVTHFNVLEH--FKDYTLVECQLETGRTHQIRVHMKYIGFPLVGDPKYG 255
>ref|NP_345413.1| (NC_003028) ribosomal large subunit pseudouridine synthase D
           [Streptococcus pneumoniae TIGR4]
 gb|AAK75053.1| (AE007398) ribosomal large subunit pseudouridine synthase D
           [Streptococcus pneumoniae TIGR4]
          Length = 295

 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 66/236 (27%), Positives = 106/236 (43%), Gaps = 29/236 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVR------KSQIIQGVVRLIHFKPNEKTQ--------ALVF 73
           L E  R L  +++K  Q  V       K  + +G V   H    E  +         +V+
Sbjct: 19  LSELSRSLANEQIKSGQVLVNGQVKKAKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVY 78

Query: 74  ETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--HPA--HRLDYETSGL 125
           + +D  V +KP  +  HP       +L++ +  H     G N    P   HR+D +TSGL
Sbjct: 79  QDEDVAVVNKPQGMVVHPSAGHTSGTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGL 138

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           ++  K   +   L      KK  + Y A+ HG L      I+ PI   +  +K   + +K
Sbjct: 139 LMIAKNDDAHLALAQELKDKKSLRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAK 198

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
               GK ++T    L    F D SL+++   TGRTHQIR+H++ + H + G+ +YG
Sbjct: 199 ----GKPAVTRFHVLER--FGDYSLVELQLETGRTHQIRVHMAYIGHPVAGDEVYG 248
>ref|XP_128468.1| (XM_128468) RIKEN cDNA 2310051D06 gene [Mus musculus]
 gb|AAH18186.1|AAH18186 (BC018186) Unknown (protein for MGC:25610) [Mus musculus]
          Length = 306

 Score = 75.5 bits (184), Expect = 7e-13
 Identities = 62/236 (26%), Positives = 109/236 (45%), Gaps = 25/236 (10%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYE 121
           ++V+++ DF V +K   +    K +    +L   ++ HF + A P         H+LD+ 
Sbjct: 10  SIVYQSSDFLVVNKHWDLRIDSKTWRETLTLQKQLRHHFPELADPDTCYGFRFCHQLDFS 69

Query: 122 TSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHI 181
           TSG +       +       F +++V K YLAL  G V++S       +   + +   H 
Sbjct: 70  TSGALCVALNKAAAGSAYKCFKERRVTKAYLALVRGHVQESQVTINYAIGRNSTEGRTHT 129

Query: 182 RSKISPLG----KQSITLVEPLSYNPFLD--ISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
                  G    K S+T +  L +  +    +S + + PLTGRTHQ+R+H S++ H IVG
Sbjct: 130 MCIEGTHGCENPKPSLTELLVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPIVG 189

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFL 291
           +  YG A++         +E+    +MLHA  L    +    ++ +  P+ F+P L
Sbjct: 190 DLTYGQAED---------QEDQPFRMMLHAFYLRIPTQAE--RVEACTPDPFLPAL 234
>gb|AAF32394.1|AF224466_1 (AF224466) putative pseudouridylate synthase [Haemophilus ducreyi]
          Length = 250

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 46/182 (25%), Positives = 92/182 (50%), Gaps = 11/182 (6%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPA---- 115
           I F+P      +V E  D  + +KP  +  HP       ++L+ +  ++   A       
Sbjct: 75  IRFEPQNIPLNIVHEDDDIIIINKPKNLVVHPGAGNPDGTVLNALLYYYPPIAEVPRAGI 134

Query: 116 -HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN 174
            HRLD +T+GL++  K + +   L     ++++ + Y A+A G++ +  K+D+P+     
Sbjct: 135 IHRLDKDTTGLMVVAKNIPAQTHLVTALQKRRITREYEAIASGIMTQGGKVDEPMARHPT 194

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
            +  +     + P+GK +IT    +    F + + L++   TGRTHQIR+H++ + H ++
Sbjct: 195 KRTAM----AVHPMGKPAITHYRIM--ERFRNYTRLRLRLETGRTHQIRVHMAHIAHPLL 248

Query: 235 GE 236
           G+
Sbjct: 249 GD 250
>ref|NP_438574.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 sp|P44433|RLUC_HAEIN Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||G64151 hypothetical protein HI0412 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC22071.1| (U32724) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 322

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 53/157 (33%), Positives = 79/157 (49%), Gaps = 10/157 (6%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           HRLD +TSG++L  K   ++++L      K V+K YLAL  G  +  +K+ +  L    +
Sbjct: 146 HRLDRDTSGILLIAKKRSALRNLHEQLRVKTVQKDYLALVRGQWQSHIKVIQASLLKNEL 205

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
                I  ++S  GK S T         +++ +L+K +P+TGRTHQIR+H     H I  
Sbjct: 206 SSGERI-VRVSEQGKPSETRFS--IEERYINATLVKASPVTGRTHQIRVHTQYAGHPIAL 262

Query: 236 EGLYGVAD-ENAREYLQLKRENNAPLLMLHAASLEFE 271
           +  YG  D +     L L R      L LHA S+ FE
Sbjct: 263 DDKYGDKDFDKQMNELGLNR------LFLHAFSIRFE 293
>ref|NP_471291.1| (NC_003212) similar to conserved hypothetical proteins [Listeria
           innocua]
 emb|CAC97187.1| (AL596170) similar to conserved hypothetical proteins [Listeria
           innocua]
          Length = 302

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 67/236 (28%), Positives = 103/236 (43%), Gaps = 30/236 (12%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--HRLDYET 122
           + FE KD  V +KP  +  HP       +L++ +  H            P   HR+D +T
Sbjct: 81  IYFEDKDMLVVNKPEGMVVHPSAGHASGTLVNALLFHCDDLSGINGKIRPGIVHRIDKDT 140

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPI-LTPQNIQKDLH 180
           SGL++  K   + + L      K   + Y+AL HG +V +   I+ PI    ++ QK   
Sbjct: 141 SGLLMVAKNDHAHESLAKQLKDKTSDREYIALVHGDIVHQKGTIEAPIGRAKEDRQKMAV 200

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           +R      GK++ T  E +   P   +   K+   TGRTHQIR+HL  + H + G+  YG
Sbjct: 201 VRD-----GKEARTHFEVIERLPGYTLINCKLD--TGRTHQIRVHLKYIGHPLAGDPKYG 253

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIA--SPMPERFMPFLKDL 294
                       K         LHAA L F+      ++   +P+P+ F   LK L
Sbjct: 254 P-----------KNTIKGNGQFLHAAKLGFDHPTTNERMTFEAPLPDSFEQALKSL 298
>ref|NP_457133.1| (NC_003198) ftsH suppressor protein SfhB [Salmonella enterica
           subsp. enterica serovar Typhi]
 ref|NP_461593.1| (NC_003197) pseudouridine synthase (pseudouridines 1911, 1915, 1917
           in 23S RNA) [Salmonella typhimurium LT2]
 gb|AAL21552.1| (AE008821) pseudouridine synthase (pseudouridines 1911, 1915, 1917
           in 23S RNA) [Salmonella typhimurium LT2]
 emb|CAD05842.1| (AL627276) ftsH suppressor protein SfhB [Salmonella enterica subsp.
           enterica serovar Typhi]
          Length = 326

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 50/186 (26%), Positives = 96/186 (50%), Gaps = 11/186 (5%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHP 114
           I F+  +    +V+E  D  V +KP  +  HP       ++L+ +  ++        A  
Sbjct: 75  IRFEAQDIPLDIVYEDDDILVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGI 134

Query: 115 AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN 174
            HRLD +T+GL++  KT+ +   L      +++ + Y A+A G +     +++PI   ++
Sbjct: 135 VHRLDKDTTGLMVVAKTVPAQTRLVESLQLREITREYEAVAIGHMTAGGTVNEPI--SRH 192

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             K  H+   + P+GK ++T    + +  F   + L++   TGRTHQIR+H++ + H +V
Sbjct: 193 PTKRTHM--SVHPMGKPAVTHYRIMEH--FRVHTRLRLRLETGRTHQIRVHMAHITHPLV 248

Query: 235 GEGLYG 240
           G+ +YG
Sbjct: 249 GDQVYG 254
>ref|NP_337928.1| (NC_002755) RNA pseudouridylate synthase family protein
           [Mycobacterium tuberculosis CDC1551]
 gb|AAK47742.1| (AE007148) RNA pseudouridylate synthase family protein
           [Mycobacterium tuberculosis CDC1551]
          Length = 305

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 58/202 (28%), Positives = 105/202 (51%), Gaps = 16/202 (7%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           ++ +  D  V DKPH + T P+G    ++ L  ++   G     PAHRLD  T+G++L  
Sbjct: 87  VLHQDADIVVVDKPHFLATMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFT 146

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
              +     + +F +  V+KTYLA A   V   + + + ++  + +++  H+++   P  
Sbjct: 147 TRREVRGSYQTMFARGLVRKTYLARAP--VAPGLALPR-LVRSRIVKRRGHLQAVCEPGV 203

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREY 249
             + TLVE ++ +      L ++TP TGRTHQ+R+H++++   I+G+ LY      A  Y
Sbjct: 204 PNAETLVERIARD-----GLYRLTPTTGRTHQLRVHMAALGIPIMGDPLYPNVISVAAHY 258

Query: 250 LQLKRENNAPLLMLHAASLEFE 271
                  + PL +L A  +EF+
Sbjct: 259 F------STPLQLL-AQRIEFD 273
>ref|NP_465368.1| (NC_003210) similar to conserved hypothetical proteins [Listeria
           monocytogenes EGD-e]
 emb|CAC99921.1| (AL591981) similar to conserved hypothetical proteins [Listeria
           monocytogenes]
          Length = 303

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 68/236 (28%), Positives = 102/236 (42%), Gaps = 30/236 (12%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--HRLDYET 122
           + FE KD  V +KP  +  HP       +L++ +  H            P   HR+D +T
Sbjct: 81  IYFEDKDMLVVNKPEGMVVHPSAGHASGTLVNALLFHCDDLSGINGKIRPGIVHRIDKDT 140

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPI-LTPQNIQKDLH 180
           SGL++  K   + + L      K   + Y+AL HG +V +   I+ PI    ++ QK   
Sbjct: 141 SGLLMVAKNDHAHESLAKQLKDKTSDREYIALVHGDIVHQKGTIEAPIGRAKEDRQKMAV 200

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           +R      GK++ T  E L   P   +   K+   TGRTHQIR+HL  + H + G+  YG
Sbjct: 201 VRD-----GKEARTHFEVLERLPGYTLINCKLD--TGRTHQIRVHLKYIGHPLAGDPKYG 253

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIA--SPMPERFMPFLKDL 294
                       K         LHAA L F+      ++   +P+P  F   LK L
Sbjct: 254 P-----------KNTIKGNGQFLHAAKLGFDHPTTNERMTFEAPLPSSFEKALKSL 298
>ref|NP_358424.1| (NC_003098) 23S rRNA pseudouridine synthase (supresses ftsH(ts)
           mutants) [Streptococcus pneumoniae R6]
 gb|AAK99634.1| (AE008458) 23S rRNA pseudouridine synthase (supresses ftsH(ts)
           mutants) [Streptococcus pneumoniae R6]
          Length = 295

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 66/236 (27%), Positives = 106/236 (43%), Gaps = 29/236 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVR------KSQIIQGVVRLIHFKPNEKTQ--------ALVF 73
           L E  R L  +++K  Q  V       K  + +G V   H    E  +         +V+
Sbjct: 19  LSELSRSLANEQIKSGQVLVNGQVKKAKYTVQEGDVVTYHVPEPEVLEYVAEDLPLEIVY 78

Query: 74  ETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--HPA--HRLDYETSGL 125
           + +D  V +KP  +  HP       +L++ +  H     G N    P   HR+D +TSGL
Sbjct: 79  QDEDVAVVNKPQGMVVHPSAGHTSGTLVNALMYHIKDLSGINGVLRPGIVHRIDKDTSGL 138

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           ++  K   +   L      KK  + Y A+ HG L      I+ PI   +  +K   + +K
Sbjct: 139 LMIAKNDDAHLVLAQELKDKKSLRKYWAIVHGNLPNDRGVIEAPIGRSEKDRKKQAVTAK 198

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
               GK ++T    L    F D SL+++   TGRTHQIR+H++ + H + G+ +YG
Sbjct: 199 ----GKPAVTRFHVLER--FGDYSLVELQLETGRTHQIRVHMAYIGHPVAGDEVYG 248
>gb|AAG10501.1|AF279106_63 (AF279106) predicted ribosomal large subunit pseudouridine synthase
           D [uncultured proteobacterium EBAC31A08]
          Length = 310

 Score = 75.1 bits (183), Expect = 9e-13
 Identities = 71/234 (30%), Positives = 111/234 (47%), Gaps = 21/234 (8%)

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGLVL 127
           FE +DF + +KP  +  HP    Y  +L + +   F +      +   HRLD +TSG++L
Sbjct: 82  FENEDFIIINKPAGLIMHPGSGCYDGTLANGLIYKFPELINIPRSGIVHRLDKDTSGILL 141

Query: 128 AGKTLQSVKDLKALFMQ-KKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
             +  +S ++     MQ ++V K Y ++  G    S  I++PI   +N +  + IR    
Sbjct: 142 VARN-ESFRNFFINEMQERRVVKKYTSIVIGSTLGSFSIEEPIGRDKNNRTKMAIRED-- 198

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY----GVA 242
             GK ++T V+ L  N   + S+L I   TGRTHQIR+HLSS    I+G+  Y     +A
Sbjct: 199 --GKDALTFVK-LKEN-IGNYSVLDIRIETGRTHQIRVHLSSKKLPIIGDKTYDPSRSIA 254

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPERFMPFLKDL 294
            +   E + + R    P   LHA  L F  +    I+    P P      L +L
Sbjct: 255 RDTPEELINIIR--GFPRQALHATHLSFNDQKTNNIFSFDIPTPNDMEELLLEL 306
>ref|NP_385495.1| (NC_003047) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           C PROTEIN [Sinorhizobium meliloti]
 emb|CAC45968.1| (AL591787) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           C PROTEIN [Sinorhizobium meliloti]
          Length = 330

 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 58/206 (28%), Positives = 98/206 (47%), Gaps = 17/206 (8%)

Query: 98  ESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG 157
           + +L+   S  G+     HRLD +TSG+++  +T  + + L A F ++  KKTY AL  G
Sbjct: 126 DKMLEAWTSQKGEKPRLVHRLDRDTSGVLVVARTRGAAQQLTAAFRERDTKKTYWALVRG 185

Query: 158 LVEK-SMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLD-----ISLLK 211
           +  K   KI   ++       D   R +I+  G+        +SY   ++     ++ L+
Sbjct: 186 VPRKREDKISTWLVKEPTPDGD---RVRIAKHGEDGAD--HAISYYRIVEQAGQNLAWLE 240

Query: 212 ITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFE 271
           + P TGRTHQ+R+H + + H I+G+  Y  AD N      ++       L LHA  ++  
Sbjct: 241 MEPYTGRTHQLRVHAAHIGHPIIGDPKYFEADVNWTFPGGMQNR-----LHLHARHIDIP 295

Query: 272 F-KGAIYKIASPMPERFMPFLKDLSF 296
              G   KI +P+P+  +     L F
Sbjct: 296 HPNGGRLKITAPLPQHMVQSWNLLGF 321
>pir||T46096 hypothetical protein T25B15.30 - Arabidopsis thaliana
 emb|CAC07917.1| (AL132972) putative protein [Arabidopsis thaliana]
          Length = 376

 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 61/207 (29%), Positives = 96/207 (45%), Gaps = 41/207 (19%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAH-----------PAHRLD 119
           +++E  D    +KP  +   P G F   ++L  +Q  FGKN             P HRL 
Sbjct: 99  VLYEDDDLIALNKPSGLQVLPGGLFQQRTVLTQLQWCFGKNDSYIGSRESPHPVPVHRLG 158

Query: 120 YETSGLVLAGKTLQSVKDLKALFMQ-----------------KKVKKTYLALAHGLVEKS 162
             TSG++L  KT  +   L A F +                 +K+ K Y ALA G+VE+ 
Sbjct: 159 RGTSGILLCAKTKLAKTKLAAYFAEGTSLVGSGNLDQECGTGRKLSKIYRALADGIVEED 218

Query: 163 --------MKIDKPI--LTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKI 212
                   + I +PI  +    + + L++ S   P GK + + V  L  +   + SL+K+
Sbjct: 219 EARPFLLFVVIKQPIGVVRYPGVAQGLYVAS---PEGKPAFSKVFVLERDREKNCSLVKV 275

Query: 213 TPLTGRTHQIRLHLSSVDHRIVGEGLY 239
              +GR HQIR+HL+ + H +VG+ LY
Sbjct: 276 EIQSGRPHQIRIHLAYMGHPLVGDPLY 302
>ref|NP_245929.1| (NC_002663) RluC [Pasteurella multocida]
 sp|Q9CM51|RLUC_PASMU Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 gb|AAK03076.1| (AE006138) RluC [Pasteurella multocida]
          Length = 326

 Score = 74.3 bits (181), Expect = 2e-12
 Identities = 65/228 (28%), Positives = 108/228 (46%), Gaps = 19/228 (8%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQS--HFGKNAHPAHRLDY 120
           K ++  + ++FE +   V +KP  +  H  G      +++ +++     +     HRLD 
Sbjct: 93  KVSQLEKQILFEDECLLVLNKPSGIAVHG-GSGLSFGVIEALRTLRPDARFLELVHRLDR 151

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
           +TSG++L  K   +++ L     +K V+K YLAL  G  +   K+ K  L    +     
Sbjct: 152 DTSGILLVAKKRSALRSLHEQLREKTVQKDYLALVRGQWQSHCKVVKAPLLKNELSSGER 211

Query: 181 IRSKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEG 237
           I  ++S  GK S T   + E   Y      +L+K +P+TGRTHQIR+H     H I  + 
Sbjct: 212 I-VRVSEQGKPSETRFSIEERYEY-----ATLVKASPVTGRTHQIRVHTQYAGHPIALDD 265

Query: 238 LYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPM 283
            YG  D++  E +    +     L LHA S+ FE    G   +I +P+
Sbjct: 266 KYG--DKHFDEQM---TQLGLTRLFLHAFSIRFEHPKTGETLRINAPL 308
>ref|NP_245570.1| (NC_002663) unknown [Pasteurella multocida]
 gb|AAK02717.1| (AE006099) unknown [Pasteurella multocida]
          Length = 220

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 64/213 (30%), Positives = 103/213 (48%), Gaps = 23/213 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           L+++  DF V DKP  +  H        + L   Q    +     HRLD  TSGL+L   
Sbjct: 6   LIYQHPDFVVIDKPCGISVHKDEEAVGLTTLVAQQLDVPQ-VWLVHRLDKITSGLLLLAL 64

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL-G 189
             ++ + L  LF + +++KTYLAL+    +K     K  L   ++QK      K+ P   
Sbjct: 65  NQRAARALSLLFAEHRIQKTYLALSQHKPKK-----KQGLIVGDMQKARRGAWKLCPTKT 119

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY-GVADENARE 248
             +IT    ++  P L + +LK  P TG+THQ+R+ + S+   I+G+ LY G + +  R 
Sbjct: 120 NPAITRFHSINCEPNLRLFILK--PQTGKTHQLRVAMKSLGSPILGDALYAGNSAKIDRT 177

Query: 249 YLQLKRENNAPLLMLHAASLEFEFKGAIYKIAS 281
           Y             LHA  L+F+++G ++ I S
Sbjct: 178 Y-------------LHAYRLQFDYQGQVFDIQS 197
>ref|NP_637448.1| (NC_003902) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
 gb|AAM41372.1| (AE012314) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
          Length = 327

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 59/211 (27%), Positives = 100/211 (46%), Gaps = 21/211 (9%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAG 129
           A+VFE       +KP  V +H        ++         +     HRLD +TSGL++  
Sbjct: 101 AIVFEDARLLALNKPTGVASHGGSGISFGAIETLRALRPNQTLELVHRLDRDTSGLLIVA 160

Query: 130 KTLQSVKDLKALFMQ------KKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIR 182
           K   ++ +L+AL  +      + + K YL L  G + +  M +D P+        + H++
Sbjct: 161 KKRSALTELQALMREDDRVDGRSITKRYLTLLVGRMPDGVMSVDAPLHIGLRQGGERHVQ 220

Query: 183 SKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             ++ +GK S++   L+E    + + ++ +      TGRTHQIR+H   + H + G+  Y
Sbjct: 221 --VNAIGKPSLSHFRLLERRGGHSYCEVRIE-----TGRTHQIRVHAQHLGHAVAGDDKY 273

Query: 240 GVADENAREYLQLKRENNAPLLMLHAASLEF 270
           G  + N R    L+ +     L LHAASLEF
Sbjct: 274 GDPEVNKR----LRDQVGLRRLFLHAASLEF 300
>ref|NP_073042.1| (NC_000908) conserved hypothetical protein [Mycoplasma genitalium]
 sp|P47610|Y370_MYCGE Hypothetical protein MG370
 pir||I64240 hypothetical protein homolog MG370 - Mycoplasma genitalium
 gb|AAC71597.1| (U39719) conserved hypothetical protein [Mycoplasma genitalium]
          Length = 323

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 61/211 (28%), Positives = 96/211 (44%), Gaps = 20/211 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK--------NAHP--AHRLDY 120
           ++FE ++  V DKP  +   P       +L + +  H G         N +P  AHR+D 
Sbjct: 90  IIFEDENIIVVDKPTGIVCQPDKKHSIINLSNMLLKHCGYRQFDSNKLNFYPQFAHRIDR 149

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLH 180
            TSG+V+  KT +++K+L  +F    + K Y  L  G     + +        N    + 
Sbjct: 150 NTSGIVIGAKTNKALKELNKVFKNNHLTKRYKGLVFGQFNH-LGLQTAYWKKDNNNGIVT 208

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           ++ K  P  K+  T  E  SY    D+SL+ I  ++GRTHQIR  L+   +++VG+  Y 
Sbjct: 209 VKWKPFPEAKKISTFFENSSYIAQKDMSLITIRLISGRTHQIRACLNLFSNQLVGDKKYS 268

Query: 241 VADENAREYLQLKRENNA-PLLMLHAASLEF 270
           +        +Q K  NN      LHA  L F
Sbjct: 269 L--------IQFKNRNNKYKHQALHAYELVF 291
>ref|NP_348732.1| (NC_003030) Predicted pseudouridylate synthase, YLYB B.subtilis
           ortholog [Clostridium acetobutylicum]
 gb|AAK80072.1|AE007712_8 (AE007712) Predicted pseudouridylate synthase, YLYB B.subtilis
           ortholog [Clostridium acetobutylicum]
          Length = 305

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 73/308 (23%), Positives = 140/308 (44%), Gaps = 38/308 (12%)

Query: 4   VEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRL-IHF 62
           +EEE+E  +    ++  ++    S    Q  + K+++  N +AV+ +  ++    +    
Sbjct: 8   IEEEYENQRID--VYLAQEFENISRSHIQDLIGKKKVFVNGKAVKSNYKLKSRDNVEFEI 65

Query: 63  KPNEKTQA--------LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GK 110
             NE+ +         +V+E +D  V +K   +  HP    Y+ +L++ +  H     G 
Sbjct: 66  PDNEELKIEAENIPLDIVYEDRDIVVVNKAQGMVVHPAPGNYNGTLVNALLYHCKDLSGI 125

Query: 111 NA--HPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLV-EKSMKI 165
           N    P   HR+D +TSG+++  K   + K+L     +  + + Y A+  G++ E    +
Sbjct: 126 NGVLRPGIVHRIDKDTSGILVVAKNDAAHKNLANQLKEHSMNRVYRAVVEGIIKEDEGTV 185

Query: 166 DKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLH 225
           DKP L    +++   ++  +   G+ ++T  + L    + + +L++    TGRTHQIR+H
Sbjct: 186 DKP-LARHPVER---VKIAVVKGGRNAVTHYKVLER--YRNSTLIECKLETGRTHQIRVH 239

Query: 226 LSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPM 283
           ++ + H +VG+ LYG            K+  N    MLHA  L F    KG   +     
Sbjct: 240 MAYIGHALVGDPLYGYK----------KQRFNLEGQMLHAQKLGFIHPTKGKYMEFEREA 289

Query: 284 PERFMPFL 291
           P  F   +
Sbjct: 290 PSHFQKII 297
>ref|NP_657862.1| (NC_003995) PseudoU_synth_2, RNA pseudouridylate synthase [Bacillus
           anthracis A2012] [Bacillus anthracis str. A2012]
          Length = 302

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 62/239 (25%), Positives = 109/239 (44%), Gaps = 28/239 (11%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--H 113
           +  +P +    + +E  D  V +KP  +  HP       +L++ +  H     G N    
Sbjct: 72  LDIQPEDMNLEIYYEDADVLVVNKPRSMVVHPAPGHTSGTLVNGLMHHCTDLSGINGVMR 131

Query: 114 PA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPIL 170
           P   HR+D +TSGL++  K   + + L    + K V + Y A+ HG++      ID PI 
Sbjct: 132 PGIVHRIDKDTSGLLMVAKNDMAHESLVNQLVAKTVTRRYKAIVHGVIPHDKGTIDAPIA 191

Query: 171 TPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVD 230
             +  ++ + +       GK ++T  + L    F D +L++    TGRTHQIR+H+  + 
Sbjct: 192 RDKKERQSMTVDEN----GKHAVTHFQVLER--FKDFTLVECRLETGRTHQIRVHMKYIG 245

Query: 231 HRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERF 287
           + + G+  YG      ++ L +  +       LHA  L F+    G   +  +P+PE F
Sbjct: 246 YPLAGDPKYG-----PKKTLDMNGQ------ALHAGILGFDHPRTGEYIQFEAPIPEVF 293
>ref|NP_217817.1| (NC_000962) hypothetical protein Rv3300c [Mycobacterium
           tuberculosis H37Rv]
 pir||F70533 probable deaminase - Mycobacterium tuberculosis (strain H37RV)
 emb|CAB09445.1| (Z96070) hypothetical protein Rv3300c [Mycobacterium tuberculosis
           H37Rv]
          Length = 305

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 50/170 (29%), Positives = 93/170 (54%), Gaps = 9/170 (5%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           ++ +  D  V DKPH + T P+G    ++ L  ++   G     PAHRLD  T+G++L  
Sbjct: 87  VLHQDADIVVVDKPHFLATMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFT 146

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
              +     + +F +  V+KTYLA A   V   + + + ++  + +++  H+++   P  
Sbjct: 147 TRREVRGSYQTMFARGLVRKTYLARAP--VAPGLALPR-LVRSRIVKRRGHLQAVCEPGV 203

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             + TLVE ++ +      L ++TP TGRTHQ+R+H++++   I+G+ LY
Sbjct: 204 PNAETLVERIARD-----GLYRLTPTTGRTHQLRVHMAALGIPIMGDPLY 248
>ref|NP_519749.1| (NC_003295) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           D PROTEIN [Ralstonia solanacearum]
 emb|CAD15330.1| (AL646065) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           D PROTEIN [Ralstonia solanacearum]
          Length = 358

 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 55/176 (31%), Positives = 86/176 (48%), Gaps = 9/176 (5%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGL 125
           +V+E     V +KP  +  HP    +  ++L+ +   + +      A   HRLD ETSGL
Sbjct: 118 VVYEDDTLLVINKPAGLVVHPAAGNWSGTVLNGLLHRYPQAAGLPRAGIVHRLDKETSGL 177

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           ++  +TL +  DL      + VK+TYLAL  G   ++  ID PI      +  + I    
Sbjct: 178 MVVARTLPAQTDLVRQLQARTVKRTYLALVWGETPEAGTIDAPIGRDPRDRTRMAIIETA 237

Query: 186 SPLGKQSITLVEPLSYNPF--LDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           S  GK + T  + L         +SL++    TGRTHQIR+H  S  H ++G+ +Y
Sbjct: 238 S--GKPARTHFKTLDVVDLGRAQVSLVQCQLETGRTHQIRVHFESEGHPLLGDPVY 291
>ref|NP_464494.1| (NC_003210) similar to ribosomal large subunit pseudouridine
           synthetase [Listeria monocytogenes EGD-e]
 emb|CAC99047.1| (AL591977) similar to ribosomal large subunit pseudouridine
           synthetase [Listeria monocytogenes]
          Length = 296

 Score = 73.6 bits (179), Expect = 3e-12
 Identities = 66/227 (29%), Positives = 106/227 (46%), Gaps = 35/227 (15%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HPAHRLDYETSGL 125
           +VFE     + +KP  + + P  Y  + S+ + ++ H+         H   RLD ETSGL
Sbjct: 82  IVFEDDFLLIINKPAGMASIPSQYHPNGSVANFVKGHYEAQGLTNAIHIVTRLDRETSGL 141

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           +L  K   +   L     +  +K+ Y A   G LVE+   I+ PI      +K++ I  +
Sbjct: 142 MLIAKNRFAHARLSTFLQKGLLKRRYQAFISGVLVEQKGSIEAPIG-----RKEVSIMER 196

Query: 185 -ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVAD 243
            ++P GK + T  E L+     D   +++   TGRTHQIR+H S + H ++G+ +YG  D
Sbjct: 197 FVTPEGKYAKTNYEVLARYRAFDHVAIQLE--TGRTHQIRVHFSYIGHPLIGDDMYG-GD 253

Query: 244 ENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPF 290
            N      LKR+       LH+  L          +  P+ E +M F
Sbjct: 254 TNL-----LKRQ------ALHSCHLH---------LVHPLTEEYMAF 280
>ref|NP_404140.1| (NC_003143) ribosomal large subunit pseudouridine synthase A
           [Yersinia pestis]
 emb|CAC89354.1| (AJ414143) ribosomal large subunit pseudouridine synthase A
           [Yersinia pestis]
          Length = 206

 Score = 73.2 bits (178), Expect = 3e-12
 Identities = 56/202 (27%), Positives = 104/202 (50%), Gaps = 21/202 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHP-KGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAG 129
           ++++ K   V +KP  + + P +     +S++  +Q+ F   A   HRLD  TSG+++  
Sbjct: 3   VLYQDKHIMVVNKPSGLLSVPGRAPENKDSVMTRVQNDF-PTAESVHRLDMATSGVIVVA 61

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILT--PQNIQKDLHIRSKIS 186
            T  + ++LK  F +++ KKTY+A   G L +    ID P++   P   ++ +   +   
Sbjct: 62  LTKAAERELKRQFREREPKKTYIARVWGHLAQDEGLIDLPLICDWPNRPKQKVCYET--- 118

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA 246
             GK + T  + +S +     + +K++P+TGR+HQ+R+H+ ++ H I+G+G Y   +  A
Sbjct: 119 --GKSAQTEYQVISRDDD-GSTRVKLSPITGRSHQLRVHMLAMGHPILGDGFYAHPEAKA 175

Query: 247 REYLQLKRENNAPLLMLHAASL 268
                      A  L LHA  L
Sbjct: 176 M----------ASRLQLHAQQL 187
>ref|NP_251936.1| (NC_002516) pseudouridine synthase RluA [Pseudomonas aeruginosa]
 pir||H83239 pseudouridine synthase RluA PA3246 [imported] - Pseudomonas
           aeruginosa (strain PAO1)
 gb|AAG06634.1|AE004747_7 (AE004747) pseudouridine synthase RluA [Pseudomonas aeruginosa]
          Length = 211

 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 44/149 (29%), Positives = 80/149 (53%), Gaps = 22/149 (14%)

Query: 102 DCIQSHFGKNAHP----AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG 157
           DC+ +   +N +P     HRLD+ETSGL++  +   S ++L   F  ++ +K Y AL  G
Sbjct: 36  DCLVTRLQENGYPEARIVHRLDWETSGLMVLARDADSHRELSRQFHDRETEKAYTALCWG 95

Query: 158 L-------VEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLL 210
           L       +E  ++ D P   P+++    H        G+ ++T    +  +     S +
Sbjct: 96  LPELDSGRIELPLRYDPP-TKPRHVVDFEH--------GRHALTFWRVIERHE--RWSRV 144

Query: 211 KITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           ++TP+TGR+HQ+R+H+ S+ H ++G+ LY
Sbjct: 145 ELTPITGRSHQLRVHMLSIGHPLLGDRLY 173
>ref|NP_251665.1| (NC_002516) ribosomal large subunit pseudouridine synthase C
           [Pseudomonas aeruginosa]
 pir||G83273 ribosomal large subunit pseudouridine synthase C PA2975 [imported]
           - Pseudomonas aeruginosa (strain PAO1)
 gb|AAG06363.1|AE004723_7 (AE004723) ribosomal large subunit pseudouridine synthase C
           [Pseudomonas aeruginosa]
          Length = 318

 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 68/231 (29%), Positives = 111/231 (47%), Gaps = 14/231 (6%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQS--HFGKNAHPAHRLDYETSGLVL 127
           A+V+E K   V +KP  +  H  G      +++  +      K+    HRLD +TSGL++
Sbjct: 96  AIVYEDKALIVVNKPAGIAVHG-GSGVSAGVIEVFRQLRPDAKDIELVHRLDRDTSGLLM 154

Query: 128 AGKTLQSVKDL-KALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
             K    ++ L +AL  +K V K Y AL  G      K  +  L   N++    +  +++
Sbjct: 155 IAKKRSMLRHLHEALRGEKIVDKRYHALVRGHWPAGKKNVRAPLLKNNLRSGERM-VEVN 213

Query: 187 PLGKQSITLVEPLS-YNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN 245
             GK ++T    L  +  F   +L++  P+TGRTHQIR+H     H I G+  YG  DE 
Sbjct: 214 VEGKDALTEFRVLRRFGDFA--TLVEARPITGRTHQIRVHAKHAGHAIAGDPKYG--DE- 268

Query: 246 AREYLQLKRENNAPLLMLHAASLEFEF-KGAIYKIASPMPERFMPFLKDLS 295
             ++ +  RE     L LHAA L      G + ++ +P+ E +   L+ L+
Sbjct: 269 --DFSREIRELGGKRLFLHAAQLRVPLPDGQVLELEAPVDEMWQRSLERLN 317
>ref|NP_359416.1| (NC_003098) Ribosomal large subunit pseudouridine synthase D
           [Streptococcus pneumoniae R6]
 gb|AAL00627.1| (AE008547) Ribosomal large subunit pseudouridine synthase D
           [Streptococcus pneumoniae R6]
          Length = 291

 Score = 72.8 bits (177), Expect = 4e-12
 Identities = 73/251 (29%), Positives = 118/251 (46%), Gaps = 39/251 (15%)

Query: 37  KQRLKQNQQAVRKSQIIQ-GVVRLIHFKPNEKTQAL-----------VFETKDFGVFDKP 84
           K+ +  NQ+ VR ++I+  G V  + F   +  Q             V++ +   + +KP
Sbjct: 37  KKHILINQEEVRWNEIVNPGDVCQLTFDEEDYPQKTIPWGNPDLVQEVYQDQHLIIVNKP 96

Query: 85  HQVYTHPKGYFYHE-SLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFM 143
             + TH  G   +E +LL+ + ++ G+  +  HRLD ETSGLVL  K    +  L  L  
Sbjct: 97  EGMKTH--GNQPNEIALLNHVSTYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLE 154

Query: 144 QKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSK---ISPLGKQSITLVEPL- 199
           +K++ + Y AL  G + +     K ++    I +D H R K    +  GK + T V  L 
Sbjct: 155 KKEISREYWALVDGNINR-----KELVFRDKIGRDRHDRRKRIVDAKNGKYAETHVSRLK 209

Query: 200 SYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAP 259
            ++    ++  K+   TGRTHQIR+HL   +  I+G+ LY    + +R            
Sbjct: 210 QFSNKTSLAHCKLK--TGRTHQIRVHLLHHNLPILGDPLYNSKSKTSR------------ 255

Query: 260 LLMLHAASLEF 270
            LMLHA  L F
Sbjct: 256 -LMLHAFRLSF 265
>ref|NP_346438.1| (NC_003028) ribosomal large subunit pseudouridine synthase, RluD
           subfamily [Streptococcus pneumoniae TIGR4]
 gb|AAK76078.1| (AE007490) ribosomal large subunit pseudouridine synthase, RluD
           subfamily [Streptococcus pneumoniae TIGR4]
          Length = 291

 Score = 72.4 bits (176), Expect = 6e-12
 Identities = 71/253 (28%), Positives = 115/253 (45%), Gaps = 43/253 (16%)

Query: 37  KQRLKQNQQAVRKSQIIQ-GVVRLIHFKPNEKTQAL-----------VFETKDFGVFDKP 84
           K+ +  NQ+ V   +I+  G V  + F   + +Q             V++ +   + +KP
Sbjct: 37  KKHILINQEEVHWKEIVNPGDVCQLTFDEEDYSQKTIPWGNPDLVQEVYQDQHLIIVNKP 96

Query: 85  HQVYTHPKGYFYHE-SLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFM 143
             + TH  G   +E +LL+ + ++ G+  +  HRLD ETSGLVL  K    +  L  L  
Sbjct: 97  EGMKTH--GNQPNEIALLNHVSTYVGQTCYVVHRLDMETSGLVLFAKNPFILPILNRLLE 154

Query: 144 QKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIR------SKISPLGKQSITLVE 197
           +K++ + Y AL  G + +     K ++    I +D H R      +K     +  ++ ++
Sbjct: 155 KKEISREYWALVDGNINR-----KELVFRDKIGRDRHDRRKRIVDAKNGQYAETHVSRLK 209

Query: 198 PLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENN 257
             S    L    LK    TGRTHQIR+HLS  +  I+G+ LY    + +R          
Sbjct: 210 QFSNKTSLAHCKLK----TGRTHQIRVHLSHHNLPILGDPLYNSKSKTSR---------- 255

Query: 258 APLLMLHAASLEF 270
              LMLHA  L F
Sbjct: 256 ---LMLHAFRLSF 265
>ref|NP_643525.1| (NC_003919) ribosomal large subunit pseudouridine synthase D
           [Xanthomonas axonopodis pv. citri str. 306]
 gb|AAM38061.1| (AE011967) ribosomal large subunit pseudouridine synthase D
           [Xanthomonas axonopodis pv. citri str. 306]
          Length = 331

 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 80/303 (26%), Positives = 133/303 (43%), Gaps = 48/303 (15%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRL---IHFKPNEKTQALVFET 75
           F R  L   +K     LD + + + +  +R  + +Q  V L    H  P +   ++++E 
Sbjct: 38  FSRSRLSEWIKSGDALLDGE-MARPRDTLRGGESVQVQVVLETQTHAAPQDIPLSVLYED 96

Query: 76  KDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGLVLAGK 130
           +   V DKP  +  HP       +L++ +            A   HRLD +TSG+++  +
Sbjct: 97  EQVLVIDKPAGLVVHPGAGNPDRTLVNALLFRDPALASVPRAGVVHRLDKDTSGVMVVAR 156

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL-- 188
           T+Q+   L      ++V + YLA+  G +      + PI        D H R ++     
Sbjct: 157 TVQAQTALVEQLSAREVHRQYLAVVVGALVSGGTANAPI--------DRHPRDRLKMAVR 208

Query: 189 --GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA- 242
             G+ ++T   L E    +  L+  L      TGRTHQIR+H++ +   IVG+ LYG A 
Sbjct: 209 DDGRDAVTHYRLRERFRAHTALECRLE-----TGRTHQIRVHMAHLKSPIVGDPLYGGAL 263

Query: 243 -------DENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMP---ERFMPF 290
                  DE   E    KR+       LHA +LEF     G   + ++P+P   +R M  
Sbjct: 264 KLPKGATDELVHELRTFKRQ------ALHAETLEFLHPVSGEPVRASAPVPADLQRLMTV 317

Query: 291 LKD 293
           L++
Sbjct: 318 LRE 320
>ref|NP_603923.1| (NC_003454) tRNA pseudouridine synthase A [Fusobacterium nucleatum
           subsp. nucleatum ATCC 25586]
 gb|AAL95222.1| (AE010610) tRNA pseudouridine synthase A [Fusobacterium nucleatum
           subsp. nucleatum ATCC 25586]
          Length = 289

 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 71/276 (25%), Positives = 134/276 (47%), Gaps = 45/276 (16%)

Query: 4   VEEEFEILKPTKALFFVRDVLK-CSLKEAQRHLDKQRLKQNQQAVRKS-QIIQGVVRLI- 60
           ++EE+E ++  +   F+R  LK  +L E  + L K ++K N + + +  +++ G V  I 
Sbjct: 6   IDEEYEKVRVDR---FLRKHLKNINLSEIYKMLRKGKIKVNNKKISQDYRLVLGDVVFIF 62

Query: 61  ---HFKPNEKT--------------QALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDC 103
              +FK N +               + +VFE ++  V +K      H KG  +  SLL+ 
Sbjct: 63  LPENFKENNEEKFIELSQERKEKLKEMIVFENENLFVINKLLGDVVH-KGSGHDISLLEE 121

Query: 104 IQSHFGKN-AHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKS 162
            +S++  N  +  +R+D  TSGL++  K +++ +++        + K Y  L +G +EK 
Sbjct: 122 FRSYYSNNNINFVNRIDKLTSGLIIGAKNIKTAREVAKEIQADNIIKRYYILVNGKIEKD 181

Query: 163 -------MKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITP 214
                  +K D+  +   +I+K+ +         K+SIT  + +  +N +   +LL+   
Sbjct: 182 NFILENYLKKDEEKVIVSDIEKEGY---------KKSITYFKKIKEHNKY---TLLEAEL 229

Query: 215 LTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYL 250
            TGRTHQ+R  L+ + + IVG+  YG  +     YL
Sbjct: 230 KTGRTHQLRAQLNHIGNNIVGDTKYGKDEREDMMYL 265
>ref|NP_601339.1| (NC_003450) COG0564:Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum]
 dbj|BAB99531.1| (AP005280) Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum ATCC 13032]
          Length = 310

 Score = 72.0 bits (175), Expect = 7e-12
 Identities = 59/170 (34%), Positives = 81/170 (46%), Gaps = 14/170 (8%)

Query: 117 RLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQ 176
           RLD  TSG+++   + +    LK  F  + V KTY AL  G  +    +   I  P    
Sbjct: 140 RLDVGTSGVMVVAASERGYTVLKRAFRDRTVDKTYHALVQGHPDP---LTGTIEAPIGRH 196

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
                R  ++  GK ++T  E L    F + +LLKI   TGRTHQIR+H S++ H   G+
Sbjct: 197 PSAGWRFAVTTEGKHAVTHYETLE--AFQEATLLKIHLETGRTHQIRVHFSALHHPCCGD 254

Query: 237 GLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMP 284
            +YG +D    E L L R+       LHA SL F     G   +I SP P
Sbjct: 255 PMYG-SDPALSERLGLNRQ------WLHAVSLGFNHPADGRWMEIVSPYP 297
>ref|NP_345571.1| (NC_003028) ribosomal large subunit pseudouridine synthase, RluD
           subfamily [Streptococcus pneumoniae TIGR4]
 ref|NP_358600.1| (NC_003098) 23S rRNA pseudouridine synthase [Streptococcus
           pneumoniae R6]
 gb|AAK75211.1| (AE007411) ribosomal large subunit pseudouridine synthase, RluD
           subfamily [Streptococcus pneumoniae TIGR4]
 gb|AAK99810.1| (AE008473) 23S rRNA pseudouridine synthase [Streptococcus
           pneumoniae R6]
          Length = 298

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 64/237 (27%), Positives = 111/237 (46%), Gaps = 32/237 (13%)

Query: 71  LVFETKDFGVFDKPHQVYTHP------------KGYFYHESLLDCIQSHFGKNAHPAHRL 118
           +++E   F V +KP+ V + P            KGY+         Q++  +  H   RL
Sbjct: 78  ILYEDDHFLVLNKPYGVASIPSVNHSNTIANFIKGYYVK-------QNYENQQVHIVTRL 130

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKD 178
           D +TSGL+L  K   +   L     +K ++K Y AL  G  +  ++ +  I+ P    +D
Sbjct: 131 DRDTSGLMLFAKHGYAHARLDKQLQKKSIEKRYFALVKG--DGHLEPEGEIIAPIARDED 188

Query: 179 LHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
             I  +++  GK + T  + ++   + +I L+ I   TGRTHQIR+H S +   ++G+ L
Sbjct: 189 SIITRRVAKGGKYAHTSYKIVA--SYGNIHLVYIHLHTGRTHQIRVHFSHIGFPLLGDDL 246

Query: 239 YGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLS 295
           YG + E+      ++R+     L  H  S    F     ++ SP+P+ F   +  LS
Sbjct: 247 YGGSLEDG-----IQRQ----ALHCHYLSFYHPFLEQDLQLESPLPDDFSNLITQLS 294
>ref|NP_478072.1| (NM_058192) ribosomal large subunit pseudouridine synthase C like
           [Homo sapiens]
 emb|CAB53055.1| (AL031033) C321D2.1 (Ribosomal Large Subunit Pseudouridine Synthase
           (EC 4.2.1.70, Pseudouridylate Synthase, Uracil
           Hydrolase) LIKE protein) [Homo sapiens]
 gb|AAK61255.1|AE006465_1 (AE006465) ribosomal large subunit pseudouridine synthase C like
           [Homo sapiens]
 gb|AAH11783.1|AAH11783 (BC011783) Unknown (protein for MGC:19600) [Homo sapiens]
          Length = 312

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 61/236 (25%), Positives = 104/236 (43%), Gaps = 25/236 (10%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYE 121
           ++V+ ++DF V +K   V    K +    +L   ++  F + A P         H+LD+ 
Sbjct: 10  SIVYRSRDFLVVNKHWDVRIDSKAWRETLTLQKQLRYRFPELADPDTCYGFRFCHQLDFS 69

Query: 122 TSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHI 181
           TSG +       +       F +++V K YLAL  G +++S       +   + +   H 
Sbjct: 70  TSGALCVALNKAAAGSAYRCFKERRVTKAYLALLRGHIQESRVTISHAIGRNSTEGRAHT 129

Query: 182 RSKISPLG----KQSITLVEPLSYNPFLD--ISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
                  G    K S+T +  L +  +    +S + + PLTGRTHQ+R+H S++ H +VG
Sbjct: 130 MCIEGSQGCENPKPSLTDLVVLEHGLYAGDPVSKVLLKPLTGRTHQLRVHCSALGHPVVG 189

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFL 291
           +  YG             RE+    +MLHA  L         ++ +P P  F+P L
Sbjct: 190 DLTYGEVS---------GREDRPFRMMLHAFYLRIPTDTECVEVCTPDP--FLPSL 234
>ref|NP_404651.1| (NC_003143) Conserved hypothetical protein [Yersinia pestis]
 emb|CAC89880.1| (AJ414146) Conserved hypothetical protein [Yersinia pestis]
          Length = 257

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 53/194 (27%), Positives = 92/194 (47%), Gaps = 20/194 (10%)

Query: 91  PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G+  H S LD          ++   G++ +  HRLD  TSG++L   +    + L   
Sbjct: 17  PAGWLVHRSWLDRNETVFVMQTVRDQIGQHVYTVHRLDRPTSGVLLMALSSDVARMLSLQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGK----QSITLVE 197
           F Q +++KTY A+  G V +   +D  +    +   D   +S  +P       +++  VE
Sbjct: 77  FEQHQIQKTYHAVVRGYVLEGGTVDYAMAEELDKIADKFAKSDKAPQPSVSHYEALAQVE 136

Query: 198 -PLSYNPF--LDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKR 254
            PL+   +     SL+ + P TGR HQ+R H++ + H I+G+  +G    + R+   + +
Sbjct: 137 VPLAIGRYETARYSLVALKPETGRKHQLRRHMAHIRHPIIGDSTHG----DLRQNRGVAQ 192

Query: 255 ENNAPLLMLHAASL 268
                 LMLHA+ L
Sbjct: 193 HFGCSRLMLHASHL 206
>ref|NP_414600.1| (NC_000913) pseudouridylate synthase; orf, hypothetical protein
           [Escherichia coli K12]
 sp|P39219|RLUA_ECOLI Ribosomal large subunit pseudouridine synthase A (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||B64727 yabO protein - Escherichia coli
 gb|AAC73169.1| (AE000116) pseudouridylate synthase [Escherichia coli K12]
          Length = 219

 Score = 71.2 bits (173), Expect = 1e-11
 Identities = 58/213 (27%), Positives = 101/213 (47%), Gaps = 29/213 (13%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYH-ESLLDCIQSHFGKNAHPAHRLDYET 122
           P E    ++++     V +KP  + + P     H +S++  IQ  + + A   HRLD  T
Sbjct: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMAT 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLAL-------AHGLVEKSMKIDKPILTPQNI 175
           SG+++   T  + ++LK  F +++ KK Y+A        A GLV+  +  D P    Q +
Sbjct: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
             +          GK + T  E + Y    + + + + P+TGR+HQ+R+H+ ++ H I+G
Sbjct: 128 CYE---------TGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASL 268
           +  Y   +  A           AP L+LHA  L
Sbjct: 178 DRFYASPEARAM----------APRLLLHAEML 200
>ref|NP_626332.1| (NC_003888) putative ribosomal large subunit pseudouridine synthase
           [Streptomyces coelicolor A3(2)]
 pir||T34943 probable ribosomal large subunit pseudouridine synthase -
           Streptomyces coelicolor
 emb|CAB51982.1| (AL109663) putative ribosomal large subunit pseudouridine synthase
           [Streptomyces coelicolor A3(2)]
          Length = 314

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 67/213 (31%), Positives = 100/213 (46%), Gaps = 22/213 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQ--------SHFGKNAHPAHRLDYET 122
           +V + +D  V  KP  V  HP   +   +++  +         S   +     HRLD  T
Sbjct: 87  IVHDDEDVVVVVKPVGVAAHPSPGWSGPTVIGGLAAAGYRVSTSGAAERQGIVHRLDVGT 146

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK-SMKIDKPILTPQNIQKDLHI 181
           SGL+   K+ ++   LK  F ++ V K Y  L  G  +  S  ID PI   ++ Q D   
Sbjct: 147 SGLMAVAKSERAYTSLKRQFKERTVDKRYHTLVQGHPDPTSGTIDAPI--GRHPQHDY-- 202

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
           +  ++  GK S+T  + +    F   SLL +   TGRTHQIR+H+++  H  VG+  YG 
Sbjct: 203 KWAVTAEGKPSVTHYDLIE--AFRAASLLDVKLETGRTHQIRVHMAAHRHPCVGDLTYG- 259

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEFEFKG 274
           AD    + L+L R+       LHA  L FE  G
Sbjct: 260 ADPTLAKRLRLTRQ------WLHAVRLGFEHPG 286
>ref|NP_371532.1| (NC_002758) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
 ref|NP_374129.1| (NC_002745) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 dbj|BAB42107.1| (AP003132) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus N315]
 dbj|BAB57170.1| (AP003361) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus Mu50]
          Length = 284

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 16/198 (8%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH---FGKNAHP-- 114
           ++  P  +   +++E     +  KP+     P     HESL++ +  H    G+N +P  
Sbjct: 66  VNLIPYARKLEVLYEDAFIIIVTKPNNQNCTPSREHPHESLIEQVLYHCQEHGENINPHI 125

Query: 115 AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN 174
             RLD  T+G+V+  K       +  LF +  +KK Y  L +G    S  I+  I     
Sbjct: 126 VTRLDRNTTGIVIFAK----YGHIHHLFSKVNLKKIYTCLVYGKTHTSGIIEANIRR--- 178

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             KD  I  +++  GK + T  E ++ N     SL K+   TGRTHQIR+H   + H IV
Sbjct: 179 -SKDSIITREVASDGKYAKTSYEVINQND--KYSLCKVHLHTGRTHQIRVHFQHIGHPIV 235

Query: 235 GEGLY-GVADENAREYLQ 251
           G+ LY G  D+   + LQ
Sbjct: 236 GDSLYDGFHDKIHGQVLQ 253
>ref|NP_438215.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 sp|P43930|Y042_HAEIN Hypothetical protein HI0042
 pir||B64000 hypothetical protein HI0042 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC21720.1| (U32689) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 224

 Score = 70.9 bits (172), Expect = 2e-11
 Identities = 56/203 (27%), Positives = 92/203 (44%), Gaps = 21/203 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           +V++  DF + +K   +  H       + L + +            HRLD  TSGL++  
Sbjct: 5   VVYQHSDFIIINKSEGISVHKDQE--EQGLTELVAKQLNVPKVWLVHRLDKVTSGLLILA 62

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
              +S  +   LF + K+ KTYLAL++   +K   +    +           ++K +P  
Sbjct: 63  LNAESAAEFSRLFSEHKIHKTYLALSNQKPKKKQGLIIGDMKKAREGAWKLCQTKDNP-- 120

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREY 249
             +IT  E +S  P L + +LK  P TG+THQ+R+ + S+   I+G+GLYG         
Sbjct: 121 --AITRFESVSCEPNLRLFILK--PQTGKTHQLRVAMKSLGSPILGDGLYG--------- 167

Query: 250 LQLKRENNAPLLMLHAASLEFEF 272
              K         LHA  LEF++
Sbjct: 168 ---KNTEKIDRTYLHATQLEFDY 187
>ref|NP_360947.1| (NC_003103) sfhB protein homolog [Rickettsia conorii]
 gb|AAL03848.1| (AE008677) sfhB protein homolog [Rickettsia conorii]
          Length = 313

 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 62/242 (25%), Positives = 115/242 (46%), Gaps = 29/242 (11%)

Query: 21  RDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQA--------LV 72
           R+ ++ ++K++Q  ++   +      V+++ II     L  FK  E+ +         ++
Sbjct: 28  RNQIQKAIKDSQVLVNDVIISDPDVLVKENDII-----LFSFKEPEELKIAAANVALDII 82

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--HRLDYETSG 124
           +E  D  V +K   +  HP    + ++L++ +  H       G +  P   HRLD +T+G
Sbjct: 83  YEDDDLIVINKAAGMTVHPGAGHHDDTLVNALLHHTKNLSDIGSSERPGIVHRLDKDTTG 142

Query: 125 LVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSK 184
           L++  K  ++   L     Q++V + Y  L  G++     + K      NI +    R K
Sbjct: 143 LMVVAKNNKAHMLLANQIEQRQVIRKYKVLVWGVINPLEGVIK-----NNIGRSRSDRQK 197

Query: 185 ISPL---GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
           ++ L   GK+++T  + L       IS+++    TGRTHQIR+ LS + H +VG+  YG 
Sbjct: 198 MTILKYGGKEAVTHYKILELFYKGSISMVECKLSTGRTHQIRVQLSHLKHSVVGDQTYGN 257

Query: 242 AD 243
            D
Sbjct: 258 ND 259
>sp|Q47417|YQCB_ERWCA Exoenzyme regulation regulon ORF1
 pir||S45107 hypothetical protein 1 - Erwinia carotovora
 emb|CAA55982.1| (X79474) ORF1 [Pectobacterium carotovorum]
          Length = 376

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 54/207 (26%), Positives = 93/207 (44%), Gaps = 21/207 (10%)

Query: 80  VFDKPHQVYTH-PKGYFYHESLLD---------CIQSHFGKNAHPAHRLDYETSGLVLAG 129
           ++   H V  + P G+  H S LD          ++   G++ +  HRLD  TSG++L  
Sbjct: 119 IYQDEHLVAVNKPSGWLVHRSWLDRKEKVVVMQTVRDQIGQHVYTVHRLDRPTSGVLLLA 178

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
            + +  + L   F   +++KTY A+  G V     ID  +    +   D       +P  
Sbjct: 179 LSSEVARALSQQFESHQMQKTYHAVVRGYVLDDGVIDYALTEELDKIADKFTNPDKAPQP 238

Query: 190 K----QSITLVE---PLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
                +S+   E    +   P    SL+++ P TGR HQ+R H+S + H I+G+  +G  
Sbjct: 239 AVTHYRSLAQAEMPVAIGRYPTARYSLMELKPQTGRKHQLRRHMSHIHHPIIGDTAHG-- 296

Query: 243 DENAREYLQLKRENNAPLLMLHAASLE 269
             + R    ++   +   LMLHA+ L+
Sbjct: 297 --DLRHNRGMESHFSCGRLMLHASELQ 321
>ref|NP_232505.1| (NC_002506) ribosomal large subunit pseudouridine synthase A
           [Vibrio cholerae]
 pir||C82498 ribosomal large chain pseudouridine synthase A VCA0104 [imported] -
           Vibrio cholerae (group O1 strain N16961)
 gb|AAF96018.1| (AE004353) ribosomal large subunit pseudouridine synthase A [Vibrio
           cholerae]
          Length = 221

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 67/233 (28%), Positives = 108/233 (45%), Gaps = 38/233 (16%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF--GKNAHPAHRLDYETSGLVLA 128
           +V++     V +KP +  + P G   H+S+L  +++ F   +     HRLD  TSGL++ 
Sbjct: 20  IVYQDDAIVVVNKPAEFLSVP-GVHVHDSVLTRLKAQFTQAEGVFALHRLDMSTSGLLVF 78

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKIS- 186
             T ++ K L+  F+ + V+K Y+AL  G L E   +I  P+        D   R K+  
Sbjct: 79  ALTRRANKQLQKQFISRAVQKRYVALIEGKLSETQGEIQLPLCG----DLDDRPRQKVCW 134

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLS---SVDHRIVGEGLYGVAD 243
             GK ++T  E +      + + + + P TGRTHQ+R+H +    ++  IVG+ LYG+ D
Sbjct: 135 QQGKPALTHWETVQVEQ--NRTRVYLYPHTGRTHQLRVHCAHHLGLNAPIVGDDLYGLQD 192

Query: 244 ENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFLKDLSF 296
           +                L LHA  L F         A P  ++ M F  D  F
Sbjct: 193 KR---------------LFLHAEQLSF---------AHPYTKQPMTFQVDADF 221
>ref|NP_645706.1| (NC_003923) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
 dbj|BAB94754.1| (AP004825) conserved hypothetical protein [Staphylococcus aureus
           subsp. aureus MW2]
          Length = 284

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 16/198 (8%)

Query: 60  IHFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HP 114
           ++  P  +   +++E     +  KP+     P     HESL++ +  H  +N      H 
Sbjct: 66  VNLIPYARKLEVLYEDAFIIIVTKPNNQNCTPSREHPHESLIEQVLYHCQENGENINPHI 125

Query: 115 AHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQN 174
             RLD  T+G+V+  K       +  LF +  +KK Y  L +G    S  I+  I     
Sbjct: 126 VTRLDRNTTGIVIFAK----YGYIHHLFSKVNLKKIYTCLVYGKTHTSGIIEANIRR--- 178

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             KD  I  +++  GK + T  E ++ N     SL K+   TGRTHQIR+H   + H IV
Sbjct: 179 -SKDSIITREVASDGKYAKTSYEVINQND--KYSLCKVHLHTGRTHQIRVHFQHIGHPIV 235

Query: 235 GEGLY-GVADENAREYLQ 251
           G+ LY G  D+   + LQ
Sbjct: 236 GDSLYDGFHDKIHGQVLQ 253
>ref|NP_347651.1| (NC_003030) Pseudouridylate synthase [Clostridium acetobutylicum]
 gb|AAK78991.1|AE007617_3 (AE007617) Pseudouridylate synthase [Clostridium acetobutylicum]
          Length = 318

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 45/136 (33%), Positives = 72/136 (52%), Gaps = 10/136 (7%)

Query: 114 PAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ 173
           P +RLD  TSG+V+ GK  +++K L  +  ++++KK Y AL  G ++    I +  +   
Sbjct: 137 PCNRLDRNTSGIVIYGKNFEALKCLNEMIRERRIKKYYYALVKGKIKDG--IYEAYIKKD 194

Query: 174 NIQKDLHIRSKISPLGKQ---SITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVD 230
                  I +  +P  KQ    I  VE      F++I L     LTGR+HQ+R HLS + 
Sbjct: 195 VSSNKSEIINTPAPGAKQISMEIKCVETCGTFSFIEIEL-----LTGRSHQLRAHLSHLG 249

Query: 231 HRIVGEGLYGVADENA 246
           + I+G+  YG+ D N+
Sbjct: 250 NPILGDPKYGIKDINS 265
>ref|NP_221194.1| (NC_000963) SFHB PROTEIN HOMOLOG (sfhB) [Rickettsia prowazekii]
 pir||F71646 sfhB protein homolog (sfhB) RP846 - Rickettsia prowazekii
 emb|CAA15270.1| (AJ235273) SFHB PROTEIN HOMOLOG (sfhB) [Rickettsia prowazekii]
          Length = 313

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 66/258 (25%), Positives = 120/258 (45%), Gaps = 28/258 (10%)

Query: 4   VEEEFEILKPTKALFFVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQII--QGVVRLIH 61
           V +E    +  KAL  +  + K S  + Q+ +    ++ N   +  S ++  +    L  
Sbjct: 6   VPKELNNTRLDKALSLL--LKKVSRNQVQKAIKNYCVQVNGVIISDSDVLVKENDTILFS 63

Query: 62  FKPNEK--------TQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------ 107
           FK  E+        T  +++E  D  V +K   +  HP    +  +L++ +  H      
Sbjct: 64  FKEPEELKITAANITLDIIYEDDDLIVINKAAGMTVHPGIRHHDNTLVNALLHHTKYLSD 123

Query: 108 FGKNAHPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKI 165
            G    P   HRLD +T+GL++  K  ++   L     Q++V + Y AL  G++     I
Sbjct: 124 IGSAERPGIVHRLDKDTTGLMVVAKNNKTHILLANQIKQRQVIRKYKALVWGVINPLEGI 183

Query: 166 DKPILTPQNIQKDLHIRSKISPL---GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQI 222
            K      N+ ++ + R K++ L   GK+++T  + L       +S+++    TGRTHQI
Sbjct: 184 IK-----NNVGRNRNNRKKMTILKYGGKKAVTYYKTLELFYGGTLSMVECKLSTGRTHQI 238

Query: 223 RLHLSSVDHRIVGEGLYG 240
           R+ LS++ H +VG+  YG
Sbjct: 239 RVQLSNLKHSVVGDQTYG 256
>sp|Q45480|YLYB_BACSU Hypothetical protein ylyB
 gb|AAB57767.1| (U48870) orf-X; hypothetical protein; Method: conceptual
           translation supplied by author [Bacillus subtilis]
          Length = 303

 Score = 70.1 bits (170), Expect = 3e-11
 Identities = 62/235 (26%), Positives = 107/235 (45%), Gaps = 28/235 (11%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--HPA--HRLDYET 122
           + +E +D  V +KP  +  HP       +L++ + +H     G N    P   HR+D +T
Sbjct: 82  IYYEDQDVLVVNKPRGMVVHPAPGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDT 141

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLV-EKSMKIDKPILTPQNIQKDLHI 181
           SGL++  K   + + L    + K V + Y A+ HGL+      ID PI   +  ++ + +
Sbjct: 142 SGLLMVAKNDMAHESLVNQLVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTV 201

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
                  GK ++T    L    F D +L++    TGRTHQIR+H+  +   + G+  YG 
Sbjct: 202 TRD----GKNAVTHFHVL--ERFQDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYG- 254

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERFMPFLKDL 294
                R+ +    +       LHA  L F+    G   +  +P+PE     +++L
Sbjct: 255 ----PRKTIDFNGQ------ALHAGVLGFDHPRTGEYVEFEAPLPEDMAELIENL 299
>ref|NP_638435.1| (NC_003902) ribosomal large subunit pseudouridine synthase D
           [Xanthomonas campestris pv. campestris str. ATCC 33913]
 gb|AAM42359.1| (AE012424) ribosomal large subunit pseudouridine synthase D
           [Xanthomonas campestris pv. campestris str. ATCC 33913]
          Length = 331

 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 82/303 (27%), Positives = 128/303 (42%), Gaps = 48/303 (15%)

Query: 19  FVRDVLKCSLKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRL---IHFKPNEKTQALVFET 75
           F R  L   +K     LD +  +  +  +R  + +Q  V L    H  P +    +++E 
Sbjct: 38  FSRSRLSEWIKSGDALLDGETARP-RDTLRGGETVQVQVVLETQTHAAPQDIPLNVLYED 96

Query: 76  KDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGLVLAGK 130
               V DKP  +  HP       +L++ +            A   HRLD +TSG+++  +
Sbjct: 97  DHVLVIDKPAGLVVHPGAGNPDGTLVNALLFRDPNLAAVPRAGVVHRLDKDTSGVMVVAR 156

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL-- 188
           TLQ+   L      + V + YLA+  G +      D PI        D H R ++     
Sbjct: 157 TLQAQTALVEQLSARDVHRQYLAVVVGALVSGGTADAPI--------DRHPRDRLKMAVR 208

Query: 189 --GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA- 242
             G+ ++T   L E    +  L+  L      TGRTHQIR+H++ +   IVG+ LYG A 
Sbjct: 209 DDGRDAVTHYRLRERFRAHTALECRLE-----TGRTHQIRVHMAHLKSPIVGDPLYGGAL 263

Query: 243 -------DENAREYLQLKRENNAPLLMLHAASLEF--EFKGAIYKIASPMPE---RFMPF 290
                  D    E    KR+       LHA +LEF     G   + ++P+PE   R M  
Sbjct: 264 KLPKGATDTLVAELRGFKRQ------ALHAETLEFLHPVSGEPIRASAPVPEDLQRLMSA 317

Query: 291 LKD 293
           L++
Sbjct: 318 LRE 320
>ref|NP_216056.1| (NC_000962) hypothetical protein Rv1540 [Mycobacterium tuberculosis
           H37Rv]
 ref|NP_336044.1| (NC_002755) pseudouridine synthase, RluD-related protein
           [Mycobacterium tuberculosis CDC1551]
 sp|Q10786|Y04P_MYCTU Hypothetical protein Rv1540
 pir||A70761 hypothetical protein Rv1540 - Mycobacterium tuberculosis  (strain
           H37RV)
 emb|CAA98322.1| (Z74020) hypothetical protein Rv1540 [Mycobacterium tuberculosis
           H37Rv]
 gb|AAK45858.1| (AE007025) pseudouridine synthase, RluD-related protein
           [Mycobacterium tuberculosis CDC1551]
          Length = 308

 Score = 69.3 bits (168), Expect = 5e-11
 Identities = 62/182 (34%), Positives = 87/182 (47%), Gaps = 16/182 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQN 174
           HRLD  TSG+++   + ++   LK  F  + V K Y AL  G  + S   ID PI     
Sbjct: 136 HRLDVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPI----G 191

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             +    +  I+  G+ S+T  + L    F+  SLL +   TGRTHQIR+H +++ H   
Sbjct: 192 RHRGHEWKFAITKNGRHSLTHYDTLE--AFVAASLLDVHLETGRTHQIRVHFAALHHPCC 249

Query: 235 GEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERFMPFLK 292
           G+ +YG AD    + L L R+       LHA SL F     G   +I SP P      LK
Sbjct: 250 GDLVYG-ADPKLAKRLGLDRQ------WLHARSLAFAHPADGRRVEIVSPYPADLQHALK 302

Query: 293 DL 294
            L
Sbjct: 303 IL 304
>ref|NP_285754.1| (NC_002655) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 ref|NP_308089.1| (NC_002695) hypothetical protein [Escherichia coli O157:H7]
 gb|AAG54362.1|AE005182_11 (AE005182) orf, hypothetical protein [Escherichia coli O157:H7
           EDL933]
 dbj|BAB33485.1| (AP002550) hypothetical protein [Escherichia coli O157:H7]
          Length = 219

 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 57/213 (26%), Positives = 99/213 (45%), Gaps = 29/213 (13%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYH-ESLLDCIQSHFGKNAHPAHRLDYET 122
           P E    ++++     V +KP  + + P     H +S++  IQ  + + A   HRLD  T
Sbjct: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMAT 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLAL-------AHGLVEKSMKIDKPILTPQNI 175
           SG+++   T  + ++LK  F ++  KK Y+         A GLV+  +  D P    Q +
Sbjct: 68  SGVIVVALTKAAERELKRQFRERVPKKQYVTRVWGHPSPAEGLVDLPLICDWPNRPKQKV 127

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
             +          GK + T  E + Y    + + + + P+TGR+HQ+R+H+ ++ H I+G
Sbjct: 128 CYET---------GKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASL 268
           +  Y   +  A           AP L+LHA  L
Sbjct: 178 DRFYASPEARAM----------APRLLLHAEML 200
>sp|O66114|YLP4_ZYMMO Hypothetical 24.4 kDa protein in LPD 3'region (ORF4)
 emb|CAA63803.1| (X93605) hypothetical protein [Zymomonas mobilis]
          Length = 219

 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 60/184 (32%), Positives = 91/184 (48%), Gaps = 18/184 (9%)

Query: 108 FGKNAHPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-K 164
           FG    P+  HRLD +TSG +L  +  +  + L   F Q +VKK Y A+  G+ EK+   
Sbjct: 45  FGFKRWPSIVHRLDRDTSGCLLLARNPKMHRRLSEAFSQGQVKKCYWAILEGVPEKNEGT 104

Query: 165 IDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRL 224
           ID P+L   + +    I +     GK+++T  E L+ N     SL+   P TGRTHQ+R+
Sbjct: 105 IDLPLLKISSPKSGWRIVA--DDKGKRAVTHWEILAKNK--GRSLVAFRPETGRTHQLRV 160

Query: 225 HLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF-EFKGAIYKIASPM 283
           H ++      G GL  V D     +    ++ N   +MLHA SLE    +       +P+
Sbjct: 161 HAAT------GLGLPIVGD----PFYSSHKDENISRMMLHAHSLEIARLEKKPIAAEAPL 210

Query: 284 PERF 287
           P+ F
Sbjct: 211 PKAF 214
>ref|NP_231304.1| (NC_002505) pseudouridine synthase Rlu family protein [Vibrio
           cholerae]
 pir||E82173 pseudouridine synthase Rlu family protein VC1668 [imported] -
           Vibrio cholerae (group O1 strain N16961)
 gb|AAF94818.1| (AE004244) pseudouridine synthase Rlu family protein [Vibrio
           cholerae]
          Length = 235

 Score = 68.6 bits (166), Expect = 8e-11
 Identities = 48/163 (29%), Positives = 75/163 (45%), Gaps = 19/163 (11%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           HRLD  TSG++L  +   +  +L   F ++KV+K YLA+     +K   +    +     
Sbjct: 48  HRLDKMTSGILLLARNATAASELSQGFAKRKVEKFYLAIGSKKPKKKQGLICGDMERSRR 107

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
                + S+ +P   Q  +         FL        P TG+THQIR+ L S+   IVG
Sbjct: 108 SSWKLVNSQENPAITQFFSAAAATGERLFL------CKPHTGKTHQIRVALKSIGSAIVG 161

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYK 278
           + +Y  ADE+ R Y             LHA +L F ++G +Y+
Sbjct: 162 DPIYNTADESDRGY-------------LHAFALRFTYQGEVYQ 191
>ref|NP_223400.1| (NC_000921) putative [Helicobacter pylori J99]
 sp|Q9ZL98|Y745_HELPJ Hypothetical protein JHP0682
 pir||B71900 hypothetical protein jhp0682 - Helicobacter pylori (strain J99)
 gb|AAD06270.1| (AE001500) putative [Helicobacter pylori J99]
          Length = 327

 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 73/283 (25%), Positives = 129/283 (44%), Gaps = 33/283 (11%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQAL----VFETKDFGVFDK 83
           +KE      K+ +K+   A+++   I  +   I  KP +K   L    +FE +D  V +K
Sbjct: 33  IKEGLVFCQKKEVKKGGLALKEGDAITLLTPKIVPKPLKKELDLEIEVIFEDEDLLVLNK 92

Query: 84  PHQVYTHPKGYFYHESLLDCIQSH--------FGKNAHPAHRLDYETSGLVLAGKTLQSV 135
           P  +  H        +L+D ++S           +     HRLD +TSG ++  K   + 
Sbjct: 93  PPNLVVHKAPSVKEPTLVDWLKSQNYELSNLGLKERYGIVHRLDKDTSGGIVIAKNNFTH 152

Query: 136 KDLKALFMQKKVKKTYLAL-AHGLVEKSMKIDKPIL-TPQNIQKDLHIRSKISPLGKQSI 193
             L      K + + Y+AL +  L E+ M ++  +   P N  K + +++      + S 
Sbjct: 153 VCLSEQLKTKMMGRYYIALLSTPLKEEKMSVECYLTRNPNNRLKMIALKAAKKEKSRYSK 212

Query: 194 T-LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQL 252
           +     L+    +D+   K+   TGRTHQIR HL  ++  I+G+ LYG+    ++E ++ 
Sbjct: 213 SEFTSLLTSQNGMDLIGAKL--FTGRTHQIRAHLEYLNRHIIGDNLYGLNGVLSKEEIR- 269

Query: 253 KRENNAPLLMLHAASLEFEFKGAIYKIASPMPERF-MPFLKDL 294
                   +MLHA  +EF+   +  K+      RF +P LKD+
Sbjct: 270 --------IMLHAYLIEFKHPRSEQKL------RFKVPLLKDM 298
>ref|NP_484566.1| (NC_003272) probable pseudouridine synthase [Nostoc sp. PCC 7120]
 gb|AAG09315.1| (AF178757) hypothetical protein [Nostoc sp. PCC 7120]
 dbj|BAB72480.1| (AP003582) ORF_ID:alr0522~probable pseudouridine synthase [Nostoc
           sp. PCC 7120]
          Length = 312

 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 52/182 (28%), Positives = 89/182 (48%), Gaps = 18/182 (9%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--HRLDYET 122
           +++E     + +KP  +  HP     H +L++ + +H       G    P   HRLD +T
Sbjct: 82  ILYEDDQLLILNKPAGLVVHPAPGHSHGTLVNALLAHCPDLPGIGGVQRPGIVHRLDKDT 141

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEK-SMKIDKPILTPQNIQKDLHI 181
           +G +   KT  + K ++A    K  ++ YL + +G  +  S K+D PI      +K + +
Sbjct: 142 TGAIAIAKTDIAYKHIQAQLQAKTARREYLGVVYGAPKTASGKVDLPIGRHPQDRKKMAV 201

Query: 182 RSKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
              I   G+ +IT   + E L      + +L+     TGRTHQIR+H + + H IVG+ +
Sbjct: 202 -VPIEEGGRSAITHWQIQERLG-----NFTLIHFQLETGRTHQIRVHSAKMGHPIVGDPV 255

Query: 239 YG 240
           YG
Sbjct: 256 YG 257
>ref|NP_281880.1| (NC_002163) putative ribosomal pseudouridine synthase
           [Campylobacter jejuni]
 pir||G81341 pseudouridylate synthase (EC 4.2.1.70) rRNA-specific Cj0708
           [imported] - Campylobacter jejuni (strain NCTC 11168)
 emb|CAB72982.1| (AL139076) putative ribosomal pseudouridine synthase [Campylobacter
           jejuni]
          Length = 250

 Score = 68.2 bits (165), Expect = 1e-10
 Identities = 50/175 (28%), Positives = 92/175 (52%), Gaps = 10/175 (5%)

Query: 65  NEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSG 124
           ++K +  V + K+  +  +  ++    K Y Y   + + ++  F  NA   +RLD ETSG
Sbjct: 44  SDKARFNVIKAKNPQIIFEDDKIIAINKPYAY---VSEDLEKKF--NAKLLNRLDKETSG 98

Query: 125 LVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSK 184
           ++L  K     K     F + +V K+Y+A+  G++ + +++++PI T   I+      SK
Sbjct: 99  VILLCKDEDFRKLCIEEFKKHRVYKSYIAVLDGVLAEEVEVNEPIFT---IKVKGGALSK 155

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           +S  G  +++++ P+        +L KI   TGRTHQIR+H   + H +VG+  Y
Sbjct: 156 VSKDGLSALSIITPIMMQS--KKTLAKIVIQTGRTHQIRVHAKFIKHGVVGDEKY 208
>gb|EAA09234.1| (AAAB01008898) agCP13979 [Anopheles gambiae str. PEST]
          Length = 273

 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 53/223 (23%), Positives = 102/223 (44%), Gaps = 26/223 (11%)

Query: 61  HFKPNEKTQALVFETKDFGVFDKPHQVYTHPKGY-------FYHESLLDCIQSHFGKNAH 113
           ++K  ++T  +++ + +F V +K H +  +              +   + +Q +   + +
Sbjct: 17  NYKKKDETVDVLYTSGNFLVINKKHDLLINSNDTKKKTVQTIMRKQFPEYVQDNLTHDFY 76

Query: 114 PAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ 173
            AHRLD+ TSG++       + K++  +F +++ +K YLAL  G  +   ++    +   
Sbjct: 77  FAHRLDFATSGILCIPLNKNACKEVCQVFEEQRARKYYLALLRGHTDFDEEVIDIAIGED 136

Query: 174 NIQKDLH------IRSKISPLGKQSIT--LVEPLSYNPFLDISLLKITPLTGRTHQIRLH 225
              KD        +  ++    ++SIT  LV    Y     ++ + + P+TGR HQ+RLH
Sbjct: 137 VRFKDTSKKMCTILEDELCQNPRRSITKVLVLDRGYYNGKPVTKVLLRPITGRRHQLRLH 196

Query: 226 LSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASL 268
            S + H IVG+  Y            LK + + P + LHA  L
Sbjct: 197 CSQIGHVIVGDYTY-----------SLKIDTSPPRMFLHAFRL 228
>ref|NP_389429.1| (NC_000964) alternate gene name: ylmL~similar to hypothetical
           proteins [Bacillus subtilis]
 pir||B69883 conserved hypothetical protein ylyB - Bacillus subtilis
 emb|CAB13420.1| (Z99112) alternate gene name: ylmL~similar to hypothetical proteins
           [Bacillus subtilis]
          Length = 273

 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 60/209 (28%), Positives = 97/209 (45%), Gaps = 26/209 (12%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHF----GKNA--HPA--HRLDYET 122
           + +E +D  V +KP  +  HP       +L++ + +H     G N    P   HR+D +T
Sbjct: 82  IYYEDQDVLVVNKPRGMVVHPAPGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDT 141

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLV-EKSMKIDKPILTPQNIQKDLHI 181
           SGL++  K   + + L    + K V + Y A+ HGL+      ID PI   +  ++ + +
Sbjct: 142 SGLLMVAKNDMAHESLVNQLVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTV 201

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
                  GK ++T    L    F D +L++    TGRTHQIR+H+  +   + G+  YG 
Sbjct: 202 TRD----GKNAVTHFHVL--EGFQDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYG- 254

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEF 270
                R+ +     N  P   LHAAS  F
Sbjct: 255 ----PRKTIDF---NGQP---LHAASFRF 273
>ref|NP_454707.1| (NC_003198) ribosomal large subunit pseudouridine synthase A
           [Salmonella enterica subsp. enterica serovar Typhi]
 emb|CAD01251.1| (AL627265) ribosomal large subunit pseudouridine synthase A
           [Salmonella enterica subsp. enterica serovar Typhi]
          Length = 219

 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 58/213 (27%), Positives = 102/213 (47%), Gaps = 29/213 (13%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYH-ESLLDCIQSHFGKNAHPAHRLDYET 122
           P E    ++++ +   V +KP  + + P     H +S++  IQ  + + A   HRLD  T
Sbjct: 9   PQEPWLVILYQDEHIMVVNKPSGLLSVPGRLEAHKDSIMTRIQRDYPQ-AESVHRLDMAT 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLAL-------AHGLVEKSMKIDKPILTPQNI 175
           SG+++   T  + ++LK  F +++ KK Y+A        A GLV+  +  D P    Q +
Sbjct: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
             +          GK + T    + +    + + + + P+TGR+HQ+R+H+ ++ H I+G
Sbjct: 128 CYE---------TGKPAQTEYNVVEFAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASL 268
           +  Y      + E L L     AP L LHA  L
Sbjct: 178 DQFYA-----SPEALSL-----APRLQLHAEML 200
>ref|NP_459100.1| (NC_003197) 23S rRNA pseudouridylate 746 synthase [Salmonella
           typhimurium LT2]
 gb|AAL19059.1| (AE008698) 23S rRNA pseudouridylate 746 synthase [Salmonella
           typhimurium LT2]
          Length = 219

 Score = 67.4 bits (163), Expect = 2e-10
 Identities = 58/213 (27%), Positives = 102/213 (47%), Gaps = 29/213 (13%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYH-ESLLDCIQSHFGKNAHPAHRLDYET 122
           P E    ++++ +   V +KP  + + P     H +S++  IQ  + + A   HRLD  T
Sbjct: 9   PQEPWLVILYQDEHIMVVNKPSGLLSVPGRLEAHKDSIMTRIQRDYPQ-AESVHRLDMAT 67

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLAL-------AHGLVEKSMKIDKPILTPQNI 175
           SG+++   T  + ++LK  F +++ KK Y+A        A GLV+  +  D P    Q +
Sbjct: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
             +          GK + T    + +    + + + + P+TGR+HQ+R+H+ ++ H I+G
Sbjct: 128 CYE---------TGKPAQTEYNVVEFAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASL 268
           +  Y      + E L L     AP L LHA  L
Sbjct: 178 DRFYA-----SPEALSL-----APRLQLHAEML 200
>ref|NP_207538.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
           26695]
 sp|O25441|Y745_HELPY Hypothetical protein HP0745
 pir||A64613 conserved hypothetical protein HP0745 - Helicobacter pylori
           (strain 26695)
 gb|AAD07795.1| (AE000587) conserved hypothetical protein [Helicobacter pylori
           26695]
          Length = 327

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 75/284 (26%), Positives = 130/284 (45%), Gaps = 35/284 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQAL----VFETKDFGVFDK 83
           +KE      K+ +K+   A+++   I  +   I  KP +K   L    +FE +D  V +K
Sbjct: 33  IKEGLVFCQKKEVKKGGLALKEGDEITLLTPKITPKPLKKELDLEIEVIFEDEDLLVLNK 92

Query: 84  PHQVYTHPKGYFYHESLLDCIQ------SHFGKNAHPA--HRLDYETSGLVLAGKTLQSV 135
           P  +  H        +L+D ++      S+ G        HRLD +TSG ++  K   + 
Sbjct: 93  PPNLVVHKALSVKEPTLVDWLEFKNYELSNLGLKERYGIVHRLDKDTSGGIVIAKNNFTH 152

Query: 136 KDLKALFMQKKVKKTYLAL-AHGLVEKSMKIDKPIL-TPQNIQKDLHIRSKISPLGKQSI 193
             L      K + + Y+AL +  L E+ M ++  +   P N  K + +++      + S 
Sbjct: 153 VHLSEQLKTKMMGRYYIALLSTPLKEEKMSVECYLTRNPNNRLKMIALKAVKKEKSRYSK 212

Query: 194 TLVEPL--SYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQ 251
           +    L  S N   +++L+     TGRTHQIR HL  ++  I+G+ LYG+     +E ++
Sbjct: 213 SEFISLLTSQN---NLNLIGAKLFTGRTHQIRAHLEYLNRHIIGDNLYGLNGALPKEEIR 269

Query: 252 LKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERF-MPFLKDL 294
                    +MLHA  +EF+   +  K+      RF +P LKD+
Sbjct: 270 ---------IMLHAYLIEFKHPRSEQKL------RFKVPLLKDM 298
>pir||B23747 ORFX protein, 5' of ams - Escherichia coli (fragment)
 gb|AAA23442.1| (M62747) orfX [Escherichia coli]
          Length = 285

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 52/154 (33%), Positives = 79/154 (50%), Gaps = 12/154 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMK-IDKPILTPQN 174
           HRLD +TSG++L  K   +++ L     +K ++K YLAL  G  +  +K +  P+L  +N
Sbjct: 141 HRLDRDTSGVLLVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKSVQAPLL--KN 198

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           I +      ++S  GK S T  +      F   +L++ +P+TGRTHQIR+H     H I 
Sbjct: 199 ILQSGERIVRVSQEGKPSETRFKVEERYAF--ATLVRCSPVTGRTHQIRVHTQYAGHPIA 256

Query: 235 GEGLYGVADENAREYLQLKRENNAPL--LMLHAA 266
            +  YG      RE+ +   E    L  L LHAA
Sbjct: 257 FDDRYG-----DREFDRQLTEAGTGLNRLFLHAA 285
>ref|NP_660729.1| (NC_004061) ribosomal large subunit pseudouridine synthase d
           [Buchnera aphidicola str. Sg (Schizaphis graminum)]
 gb|AAM67940.1| (AE014115) ribosomal large subunit pseudouridine synthase d
           [Buchnera aphidicola str. Sg (Schizaphis graminum)]
          Length = 315

 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 55/207 (26%), Positives = 95/207 (45%), Gaps = 14/207 (6%)

Query: 72  VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRLDYETSGLV 126
           ++E  +  + +KP  +  HP       ++L+ +   +            HRLD +TSGL+
Sbjct: 87  IYEDSNILIINKPPGLVVHPGAGNQDGTILNALLYRYTNISSIPRCGIIHRLDKDTSGLM 146

Query: 127 LAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
           +  KT+ S   L  L  ++K+ + Y  +  G +     ++ PI+          I     
Sbjct: 147 VIAKTIFSYNKLVTLLKKRKIIRKYQGIIKGNMISGGIVNYPIMR----HPFKRICMTTD 202

Query: 187 PLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA 246
            LGK+SIT  + +  N F   + +     TGRTHQIR+H+  + + ++G+ LYG  D   
Sbjct: 203 SLGKKSITHYKII--NRFKFHTHVSFRLETGRTHQIRVHMLHIGYPLLGDPLYGGIDYGC 260

Query: 247 ---REYLQLKRENNAPLLMLHAASLEF 270
              +E   + R+ N     LHA  +EF
Sbjct: 261 NYFQENRNIYRKFNLFRQALHADYIEF 287
>ref|NP_243713.1| (NC_002570) BH2847~unknown conserved protein [Bacillus halodurans]
 dbj|BAB06566.1| (AP001516) BH2847~unknown conserved protein [Bacillus halodurans]
          Length = 302

 Score = 66.6 bits (161), Expect = 3e-10
 Identities = 49/178 (27%), Positives = 87/178 (48%), Gaps = 16/178 (8%)

Query: 71  LVFETKDFGVFDKPHQVYT-----HPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGL 125
           +++E   + V +KP  V T     HP+G   +  L    +       H  +RLD +TSGL
Sbjct: 86  VIYENDHYLVVNKPAGVPTIPSRDHPQGTLANGLLNYFQRQKMAATFHAVNRLDKDTSGL 145

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           ++  K   +   L     Q  +K+TY+A+  G +E+    +  I  P   +++  I  ++
Sbjct: 146 LIVAKHQLAHDQLSKQQRQGNIKRTYMAIVQGEIEQQ---EGTITAPIARKEESLITREV 202

Query: 186 SPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
              G+ +IT   +++ L+    + + L      TGRTHQIR+H S + + + G+ LYG
Sbjct: 203 REDGQLAITHFKVIDRLNQGTIVQVQL-----ETGRTHQIRVHFSYLGYPLFGDDLYG 255
>ref|NP_220643.1| (NC_000963) unknown [Rickettsia prowazekii]
 sp|Q9ZDR7|RLUC_RICPR Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 pir||F71680 hypothetical protein RP258 - Rickettsia prowazekii
 emb|CAA14720.1| (AJ235271) unknown [Rickettsia prowazekii]
          Length = 303

 Score = 66.2 bits (160), Expect = 4e-10
 Identities = 59/182 (32%), Positives = 89/182 (48%), Gaps = 19/182 (10%)

Query: 68  TQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQ--SHFGKNAHPAHRLDYETSGL 125
           T  L++E       +KP  + T   G   + S+   ++  ++ G +    HRLD ETSGL
Sbjct: 88  TDYLIYEDDHLIAINKPASLATQG-GSKINLSIDSALKYLNYQGADFKLVHRLDKETSGL 146

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKI 185
           +L  K   S   L   F +K V K Y A+ +G   K++   K      NI K     SKI
Sbjct: 147 LLIAKNYLSSVKLHNAFKEKLVIKKYFAITYGRPVKNVGTVK-----SNIGKSKRRLSKI 201

Query: 186 SPL----GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
           + +    GK +IT   L++ L+ N F    L++  P+TGR HQ+RLH   +   I+G+  
Sbjct: 202 ANIDSDDGKLAITYYKLLKSLNNNLF----LIEFMPVTGRMHQLRLHAQLLGCPILGDDK 257

Query: 239 YG 240
           YG
Sbjct: 258 YG 259
>ref|NP_298229.1| (NC_002488) ribosomal large subunit pseudouridine synthase D
           [Xylella fastidiosa 9a5c]
 pir||F82742 ribosomal large subunit pseudouridine synthase D XF0939 [imported]
           - Xylella fastidiosa (strain 9a5c)
 gb|AAF83749.1|AE003933_1 (AE003933) ribosomal large subunit pseudouridine synthase D
           [Xylella fastidiosa 9a5c]
          Length = 331

 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 66/241 (27%), Positives = 113/241 (46%), Gaps = 35/241 (14%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK-----NAHPAHRL 118
           P +    +++E +   V +KP  +  HP       +L++ +            A   HRL
Sbjct: 85  PQDIPLDILYEDEHVFVLNKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRL 144

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKD 178
           D +TSG+++  +TLQ+   L      ++V + YLA+    +     ++  I   +   +D
Sbjct: 145 DKDTSGVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSGGTVNAAI---ERHPRD 201

Query: 179 LHIRSKISPLGKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
             +R  +S  GK+++T   L E    +  L+  L      TGRTHQIR+H++ + H IVG
Sbjct: 202 -RLRMAVSDTGKEAVTHYRLRERFRAHTALECRLD-----TGRTHQIRVHMAHLRHPIVG 255

Query: 236 EGLYGVADENAREYLQLKRENNAPLLM---------LHAASLEFEFK-GAI-YKIASPMP 284
           + LYG +       L+L +     L++         LHA  LEF    GA+  +I +P+P
Sbjct: 256 DRLYGGS-------LKLPKVGTDALVVMLRGFKRQALHAEVLEFLHPVGALPVRIVAPVP 308

Query: 285 E 285
           E
Sbjct: 309 E 309
>gb|AAL47436.1| (AY069882) AT3g52260/T25B15_30 [Arabidopsis thaliana]
          Length = 294

 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 54/192 (28%), Positives = 87/192 (45%), Gaps = 34/192 (17%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAH-----------PAHRLD 119
           +++E  D    +KP  +   P G F   ++L  +Q  FGKN             P HRL 
Sbjct: 99  VLYEDDDLIALNKPSGLQVLPGGLFQQRTVLTQLQWCFGKNDSYIGSRESPHPVPVHRLG 158

Query: 120 YETSGLVLAGKTLQSVKDLKALFMQ-----------------KKVKKTYLALAHGLVEKS 162
             TSG++L  KT  +   L A F +                 +K+ K Y ALA G+VE+ 
Sbjct: 159 RGTSGILLCAKTKLAKTKLAAYFAEGTSLVGSGNLDQECGTGRKLSKIYRALADGIVEED 218

Query: 163 MKIDKP---ILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRT 219
             + K    ++    + + L++ S   P  K + + V  L  +   + SL+K+   +GR 
Sbjct: 219 EVVIKQPIGVVRYPGVAQGLYVAS---PEWKPAFSKVFVLERDREKNCSLVKVEIQSGRP 275

Query: 220 HQIRLHLSSVDH 231
           HQIR+HL+ + H
Sbjct: 276 HQIRIHLAYMGH 287
>ref|NP_607212.1| (NC_003485) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
 gb|AAL97711.1| (AE010035) conserved hypothetical protein [Streptococcus pyogenes
           MGAS8232]
          Length = 301

 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 54/191 (28%), Positives = 93/191 (48%), Gaps = 18/191 (9%)

Query: 63  KPNEKTQALVF------ETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN----- 111
           +P EK +A+ F      E   F V +KP    + P    +  ++ + I++++  N     
Sbjct: 64  EPFEKLEAIPFDLDIVHEDDHFLVINKPIGFASIPSA-IHSNTIANFIKAYYVDNHYLDQ 122

Query: 112 -AHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL 170
             H   RLD +TSGL+L  K   +   L      + ++K Y AL  G    ++  +  I+
Sbjct: 123 QVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQTRSIEKRYFALVSG--NGTLPDEGDII 180

Query: 171 TPQNIQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITPLTGRTHQIRLHLSSV 229
            P    KD  I   + P+GK + T  + ++ Y+   ++ L+ I   TGRTHQIR+H + +
Sbjct: 181 APIGRSKDSIITRAVDPMGKYAKTSYKVVARYSE--NVHLVDIKLHTGRTHQIRVHFAHI 238

Query: 230 DHRIVGEGLYG 240
              ++G+ LYG
Sbjct: 239 GFPLLGDDLYG 249
>ref|NP_273256.1| (NC_003112) ribosomal large subunit pseudouridine synthase C
           [Neisseria meningitidis MC58]
 pir||H81225 ribosomal large chain pseudouridine synthase C NMB0198 [imported] -
           Neisseria meningitidis (group B strain MD58)
 gb|AAF40655.1| (AE002377) ribosomal large subunit pseudouridine synthase C
           [Neisseria meningitidis MC58]
          Length = 330

 Score = 65.5 bits (158), Expect = 7e-10
 Identities = 74/263 (28%), Positives = 117/263 (44%), Gaps = 33/263 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFK-PNEKTQAL-------VFETKDFG 79
           ++  +  L+K+R K + +      +    VR+   + P+E+  A+       V+E     
Sbjct: 45  IRAGEVRLNKKRCKPDSRIAEGDTVRIPPVRVAEKEMPSERRAAVPARAFDVVYEDDALL 104

Query: 80  VFDKPHQVYTHPKGYFYHESLLDCIQSHF--GKNAHPAHRLDYETSGLVLAGKTLQSVKD 137
           V DKP  V  H  G      +++ ++      K     HRLD +TSGL++  K   ++  
Sbjct: 105 VIDKPSGVAVHG-GSGVSFGVIEQLRRARPEAKYLELVHRLDKDTSGLLMVAKKRSALVK 163

Query: 138 LKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLV 196
           L         KK YLAL  G L + +  +  P+      Q +  +R  +S  G+ + T+ 
Sbjct: 164 LHEAIRNDHPKKIYLALGVGKLPDDNFHVKLPLFKYTGAQGEKMVR--VSADGQSAHTVF 221

Query: 197 EPLSYNPFLD----------ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENA 246
             LS   F D          ++L++ T  TGRTHQIR+HL S    I G+  YG    N 
Sbjct: 222 RVLSR--FSDGILHGVGLSHLTLVRATLKTGRTHQIRVHLQSQGCPIAGDERYGDYQANR 279

Query: 247 R-EYLQLKRENNAPLLMLHAASL 268
           R + L LKR      + LHA+ L
Sbjct: 280 RLQKLGLKR------MFLHASEL 296
>ref|NP_232134.1| (NC_002505) ribosomal large subunit pseudouridine synthase A
           [Vibrio cholerae]
 pir||G82068 ribosomal large subunit pseudouridine synthase A VC2505 [imported]
           - Vibrio cholerae (group O1 strain N16961)
 gb|AAF95647.1| (AE004320) ribosomal large subunit pseudouridine synthase A [Vibrio
           cholerae]
          Length = 245

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 55/210 (26%), Positives = 96/210 (45%), Gaps = 20/210 (9%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETS 123
           P +    +++E +     +KP  + + P     H   +      +  +    HRLD  TS
Sbjct: 9   PKDPWIDVIYEDEHIIAANKPSGLLSVPGRPVEHYDSMWARLVDYCPDVKVVHRLDMSTS 68

Query: 124 GLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILT--PQNIQKDLH 180
           GL+L  K       LK  F  +   K Y A   G++E++  +++ P+    P   ++ + 
Sbjct: 69  GLILFAKGKHMESALKKQFQYRLTHKIYYARVWGVMEQNEGEVNLPLCCDWPNRPKQKVC 128

Query: 181 IRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
                   G+ S+T  + +        +++++ P+TGR+HQ+R+H+ S+ H IVG+ LY 
Sbjct: 129 FEE-----GRDSLTRYQVVKREE--KTTVVRLIPITGRSHQLRVHMQSLGHPIVGDDLY- 180

Query: 241 VADENAREYLQLKRENNAPLLMLHAASLEF 270
            A   A E+        A  L LHAA L F
Sbjct: 181 -APPEAVEF--------ADRLQLHAAELCF 201
>ref|NP_283855.1| (NC_003116) hypothetical protein NMA1085 [Neisseria meningitidis
           Z2491]
 pir||B81874 hypothetical protein NMA1085 [imported] - Neisseria meningitidis
           (group A strain Z2491)
 emb|CAB84348.1| (AL162755) hypothetical protein NMA1085 [Neisseria meningitidis
           Z2491]
          Length = 307

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 48/175 (27%), Positives = 81/175 (45%), Gaps = 11/175 (6%)

Query: 80  VFDKPHQVYTHPKGYFYHESLLDCIQ-----SHFG-KNAHPAHRLDYETSGLVLAGKTLQ 133
           V DKPH +   P G F  E+LL  ++      H   ++  P HRLD +T+G++L      
Sbjct: 106 VVDKPHFLPVIPSGRFLRETLLTRLRLRPELQHLNVEDITPLHRLDKDTAGVMLLSHNPA 165

Query: 134 SVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSI 193
           +    + +F  K V KTY ALA    +    +D      +  +      ++  P    ++
Sbjct: 166 TRGAYQTMFQNKTVWKTYEALAPTRTDLPYPLDVVSRLVRGEKFFTTQEAEGEPNAHTTV 225

Query: 194 TLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENARE 248
            L+E        + SL ++TP TG+ HQ+R+H+  +   ++ + LY V  E   E
Sbjct: 226 ELIENRG-----EFSLYRLTPHTGKKHQLRVHMMGLGMPLLNDALYPVPSEAGSE 275
>ref|NP_597410.1| (NC_003232) similarity to HYPOTHETICAL PROTEIN OF THE FAMILY OF
           PSEUDOURIDINE SYNTHASES YD36_YEAST [Encephalitozoon
           cuniculi]
 emb|CAD26587.1| (AL590445) similarity to HYPOTHETICAL PROTEIN OF THE FAMILY OF
           PSEUDOURIDINE SYNTHASES YD36_YEAST [Encephalitozoon
           cuniculi]
          Length = 318

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 61/208 (29%), Positives = 100/208 (47%), Gaps = 30/208 (14%)

Query: 43  NQQAVRKSQIIQ--GVVR-LIHFK-PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHE 98
           N +AV+ ++I+    V+R  +H   P      ++ E  D+ V +KP  +  HP G +   
Sbjct: 53  NGEAVKPTRILGMGDVIRHTVHIHDPAHPEIGVIKEEGDYIVVNKPPGIPCHPTGGYREY 112

Query: 99  SLLDCIQSHFG-KNAHPAHRLDYETSG-LVLA----GKTLQSVKDLKALFMQKKVKKTYL 152
            +   +   FG +     +RLD   SG L+LA     K L++++D          KK Y+
Sbjct: 113 CVTKAL---FGDEKVACINRLDMPVSGVLILAVRNHSKCLEAIRD---------AKKIYV 160

Query: 153 ALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKI 212
           A  +G+    + +DK I   +   +  H+ +     GK  +TL   L Y      SL++ 
Sbjct: 161 AKVYGMFPDKVDVDKRIGCTEGRYR--HVNAG----GKACLTLFRRLEYRD--GYSLVEC 212

Query: 213 TPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
            P+TGRTHQIR+HL S+   I  + +YG
Sbjct: 213 RPVTGRTHQIRIHLQSIGFPIANDIMYG 240
>ref|NP_269281.1| (NC_002737) conserved hypothetical protein [Streptococcus pyogenes]
           [Streptococcus pyogenes M1 GAS]
 gb|AAK34002.1| (AE006555) conserved hypothetical protein [Streptococcus pyogenes
           M1 GAS]
          Length = 301

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 54/191 (28%), Positives = 92/191 (47%), Gaps = 18/191 (9%)

Query: 63  KPNEKTQALVF------ETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN----- 111
           +P EK +A+ F      E   F V +KP    + P    +  ++ + I++++  N     
Sbjct: 64  EPFEKLEAIPFDLDIVHEDDHFLVINKPIGFASIPSA-IHSNTIANFIKAYYVDNHYLDQ 122

Query: 112 -AHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL 170
             H   RLD +TSGL+L  K   +   L      + ++K Y AL  G     +  +  I+
Sbjct: 123 QVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQTRSIEKRYFALVSG--NGMLPDEGDII 180

Query: 171 TPQNIQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITPLTGRTHQIRLHLSSV 229
            P    KD  I   + P+GK + T  + ++ Y+   ++ L+ I   TGRTHQIR+H + +
Sbjct: 181 APIGRSKDSIITRAVDPMGKYAKTSYKVVARYSE--NVHLVDIKLHTGRTHQIRVHFAHI 238

Query: 230 DHRIVGEGLYG 240
              ++G+ LYG
Sbjct: 239 GFPLLGDDLYG 249
>ref|NP_282427.1| (NC_002163) putative ribosomal pseudouridine synthase
           [Campylobacter jejuni]
 pir||B81336 pseudouridylate synthase (EC 4.2.1.70) rRNA-specific Cj1280c
           [imported] - Campylobacter jejuni (strain NCTC 11168)
 emb|CAB73534.1| (AL139077) putative ribosomal pseudouridine synthase [Campylobacter
           jejuni]
          Length = 322

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 55/186 (29%), Positives = 89/186 (47%), Gaps = 25/186 (13%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCI------QSHFGKN--AHPAHRLDYET 122
           +++E +D  V +KP  +  H      + +L+D +       S+ G    A   HRLD +T
Sbjct: 79  VLYEDEDLLVLNKPSNLVVHGASSVKNATLVDWLIEKKYTLSNLGGEIRAGLVHRLDKDT 138

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL------TPQNIQ 176
           SG +L  K   + + L      K + + YLAL    ++  +K DK I+      +P N  
Sbjct: 139 SGAILIAKNNFTHQKLSEQLADKSMGRIYLAL----IDLPLKEDKIIVEKFLMRSPSNAI 194

Query: 177 KDLHI--RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
           K + I   +K S   K +   V         +++L+     TGRTHQIR HL+S++  I+
Sbjct: 195 KKIAIDKENKFSKNAKSAFINVVKTE-----NLTLMAAKLFTGRTHQIRAHLASLNRYIL 249

Query: 235 GEGLYG 240
           G+ LYG
Sbjct: 250 GDSLYG 255
>ref|NP_299883.1| (NC_002488) pseudouridylate synthase [Xylella fastidiosa 9a5c]
 pir||A82538 pseudouridylate synthase XF2606 [imported] - Xylella fastidiosa
           (strain 9a5c)
 gb|AAF85403.1|AE004067_10 (AE004067) pseudouridylate synthase [Xylella fastidiosa 9a5c]
          Length = 330

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 57/193 (29%), Positives = 87/193 (44%), Gaps = 25/193 (12%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVK--------KTYLALAHGLVEKS-MKID 166
           HRLD +TSGL++  K   ++ +L+AL  +  V         K YL L  G +    M +D
Sbjct: 149 HRLDRDTSGLLIMAKKRAALIELQALMREASVNGKEGRGIAKRYLTLLSGRMPNGVMSVD 208

Query: 167 KPILTPQNIQKDLHIRSKISPLGKQS---ITLVEPLSYNPFLDISLLKITPLTGRTHQIR 223
            P+        + H+R  +   GK S     L+E      + ++ +      TGRTHQIR
Sbjct: 209 APLHINLRQGGERHVR--VHHDGKPSKSRFRLLERRGGQSYCEVLIE-----TGRTHQIR 261

Query: 224 LHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAI--YKIAS 281
           +H   + H + G+  YG  + N R    L+ +     L LHA SLEF        Y + +
Sbjct: 262 VHAQHLGHPVTGDDKYGDQEVNRR----LRDQIGLQRLFLHAVSLEFALDAGSTPYVLNA 317

Query: 282 PMPERFMPFLKDL 294
           P+ E  +  L  L
Sbjct: 318 PLAEDLVAALDRL 330
>ref|NP_273908.1| (NC_003112) YabO/YceC/SfhB family protein [Neisseria meningitidis
           MC58]
 pir||C81148 YabO/YceC/SfhB family protein NMB0867 [imported] - Neisseria
           meningitidis (group B strain MD58)
 gb|AAF41278.1| (AE002439) YabO/YceC/SfhB family protein [Neisseria meningitidis
           MC58]
          Length = 307

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 48/175 (27%), Positives = 81/175 (45%), Gaps = 11/175 (6%)

Query: 80  VFDKPHQVYTHPKGYFYHESLLDCIQ-----SHFG-KNAHPAHRLDYETSGLVLAGKTLQ 133
           V DKPH +   P G F  E+LL  ++      H   ++  P HRLD +T+G++L      
Sbjct: 106 VVDKPHFLPVIPSGRFLRETLLTRLRLRPELQHLNVEDITPLHRLDKDTAGVMLLSHNPA 165

Query: 134 SVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQSI 193
           +    + +F  K V KTY ALA    +    +D      +  +      ++  P    ++
Sbjct: 166 TRGAYQTMFQNKTVWKTYEALAPTRTDLPYPLDVVSRLVRGEKFFTTQEAEGEPNAHTTV 225

Query: 194 TLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENARE 248
            L+E        + SL ++TP TG+ HQ+R+H+  +   ++ + LY V  E   E
Sbjct: 226 ELIENRG-----EFSLYRLTPHTGKKHQLRVHMMGLGMPLLNDALYPVPSEAGSE 275
>ref|NP_602133.1| (NC_003450) COG0564:Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum]
 dbj|BAC00339.1| (AP005283) Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum ATCC 13032]
          Length = 322

 Score = 65.1 bits (157), Expect = 9e-10
 Identities = 51/185 (27%), Positives = 95/185 (50%), Gaps = 15/185 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN-AHPAHRLDYETSGLVLAG 129
           ++ E  D  V DKP  + T P+G    E+ L  ++   G N   PAHRLD  TSG+++  
Sbjct: 97  VIHEDDDILVIDKPPYLATMPRGRHITETALVKMRVLTGNNDLTPAHRLDRLTSGVLVMV 156

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAH---GLV-------EKSMKIDKPILTPQNIQKDL 179
           K  +     + LF +++  KTY A+A    GL+       E  ++ ++ I+    ++  +
Sbjct: 157 KKPELRGAYQTLFARREASKTYEAIAEFVPGLLDDGPAIWESRIEKERGIVQAFVVEGPV 216

Query: 180 HIRSK---ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
           + R++   ++P+     +++E + + P    +   + P TG+THQ+R+H+      I+G+
Sbjct: 217 NARTELVSVTPVEDAEQSILEEM-HGPLPRQARYVLAPSTGKTHQLRIHMRDFAAPILGD 275

Query: 237 GLYGV 241
            LY V
Sbjct: 276 PLYPV 280
>ref|NP_359981.1| (NC_003103) ribosomal large subunit pseudouridine synthase C
           [EC:4.2.1.70] [Rickettsia conorii]
 sp|Q92IS6|RLUC_RICCN Ribosomal large subunit pseudouridine synthase C (Pseudouridylate
           synthase) (Uracil hydrolyase)
 gb|AAL02882.1| (AE008600) ribosomal large subunit pseudouridine synthase C
           [EC:4.2.1.70] [Rickettsia conorii]
          Length = 303

 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 48/132 (36%), Positives = 70/132 (52%), Gaps = 16/132 (12%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           HRLD +TSGL+L  K   S   L   F +K V KTY A+ +G   K++   +      NI
Sbjct: 137 HRLDKKTSGLLLIAKNYLSSVKLHNAFKEKLVVKTYFAVTYGKPIKNVGEVR-----SNI 191

Query: 176 QKDLHIRSKISPL----GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSS 228
           +K      KI+ +    GK +IT   +++ L  N F    L++ TP+TGR HQ+RLH   
Sbjct: 192 EKSKGSTPKITDIDSENGKLAITYYKVLKSLDNNLF----LIEFTPVTGRMHQLRLHAKL 247

Query: 229 VDHRIVGEGLYG 240
           +   I+G+  YG
Sbjct: 248 LGCPILGDDKYG 259
>ref|NP_282921.1| (NC_003116) ribosomal large subunit pseudouridine synthase C
           [Neisseria meningitidis Z2491]
 pir||E81998 pseudouridylate synthase (EC 4.2.1.70) C rRNA-specific NMA0070
           [imported] - Neisseria meningitidis (group A strain
           Z2491)
 emb|CAB83386.1| (AL162752) ribosomal large subunit pseudouridine synthase C
           [Neisseria meningitidis Z2491]
          Length = 330

 Score = 64.7 bits (156), Expect = 1e-09
 Identities = 75/268 (27%), Positives = 118/268 (43%), Gaps = 43/268 (16%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFK-PNEKTQAL-------VFETKDFG 79
           ++  +  L+K+R K + +      +    VR+   + P+E+  A+       V+E     
Sbjct: 45  IRAGEVRLNKKRCKPDSRIAEGDTVRIPPVRVAEKEMPSERRAAVPARAFDVVYEDDALL 104

Query: 80  VFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP-------AHRLDYETSGLVLAGKTL 132
           V DKP  V  H  G      +++ +     + A P        HRLD +TSGL++  K  
Sbjct: 105 VIDKPSGVAVHG-GSGVSFGVIEQL-----RRARPEARYLELVHRLDKDTSGLLMVAKKR 158

Query: 133 QSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSKISPLGKQ 191
            ++  L         KK YLAL  G L + +  +  P+      Q +  +R  +S  G+ 
Sbjct: 159 SALVKLHEAIRNDHPKKIYLALGVGKLPDDNFHVKLPLFKYTGAQGEKMVR--VSEDGQS 216

Query: 192 SITLVEPLSYNPFLD----------ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
           + T+   LS   F D          ++L++ T  TGRTHQIR+HL S    I G+  YG 
Sbjct: 217 AHTVFRVLSR--FSDGILHGVGLSHLTLVRATLKTGRTHQIRVHLQSQGCPIAGDERYGD 274

Query: 242 ADENAR-EYLQLKRENNAPLLMLHAASL 268
              N R + L LKR      + LHA+ L
Sbjct: 275 YQANRRLQKLGLKR------MFLHASEL 296
>ref|NP_243408.1| (NC_002570) BH2542~unknown conserved protein [Bacillus halodurans]
 dbj|BAB06261.1| (AP001515) BH2542~unknown conserved protein [Bacillus halodurans]
          Length = 305

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 56/235 (23%), Positives = 98/235 (40%), Gaps = 27/235 (11%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP--------AHRLDYET 122
           +++E +D  V +KP  +  HP       +L++ +  H    +           HR+D +T
Sbjct: 83  IIYEDEDVAVVNKPRGMVVHPAPGHTTGTLVNALMYHCNDLSSINGVVRPGIVHRIDKDT 142

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHI 181
           SGL++  K  ++ + L      K  ++ Y A+ HG +      ID PI   +  ++ + +
Sbjct: 143 SGLLMIAKNDRAHESLVNQLKAKTTERVYQAIVHGNIPHDHGTIDAPIGRDKVDRQSMTV 202

Query: 182 RSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGV 241
             + S       T++E      F D + ++    TGRTHQIR+H   +   + G+  YG 
Sbjct: 203 TEENSRDAVTHFTVLER-----FGDFTFVECQLETGRTHQIRVHFKYIGFPLAGDPKYGP 257

Query: 242 ADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERFMPFLKDL 294
                      K+  +     LHA  L FE    G   +    MPE     ++ L
Sbjct: 258 -----------KKTLSIDGQALHAQKLGFEHPRTGEFMRFKVEMPEEMKKLIRQL 301
>ref|NP_625900.1| (NC_003888) putative ribosomal pseudouridine synthase [Streptomyces
           coelicolor A3(2)]
 emb|CAB59478.1| (AL132648) putative ribosomal pseudouridine synthase [Streptomyces
           coelicolor A3(2)]
          Length = 324

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 50/171 (29%), Positives = 83/171 (48%), Gaps = 6/171 (3%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-HPAHRLDYETSGLVLAG 129
           +V+      V DKPH + T P+G    ++ L  ++      A   AHRLD  T+GLVL  
Sbjct: 97  IVYRDAHIVVADKPHFLATTPRGGHVTQTALARLRRELDIPALGAAHRLDRLTAGLVLFT 156

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
                    + LF  ++V K Y A+A         +  P      I K+  + +     G
Sbjct: 157 VRPGERGAYQGLFADRRVHKVYEAVA----PYDAALALPRTVRSRILKERGVLAAREVAG 212

Query: 190 K-QSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           +  ++T VE L++ P   +   ++ P TG+THQ+R+HL+++   I+G+ LY
Sbjct: 213 EPNAVTRVELLAHRPEHGLGRYRLVPGTGQTHQLRVHLNALGVPILGDPLY 263
>ref|NP_419272.1| (NC_002696) ribosomal large subunit pseudouridine synthase d
           [Caulobacter crescentus CB15]
 gb|AAK22440.1| (AE005719) ribosomal large subunit pseudouridine synthase d
           [Caulobacter crescentus CB15]
          Length = 342

 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 69/245 (28%), Positives = 112/245 (45%), Gaps = 35/245 (14%)

Query: 63  KPNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKN-------AHPA 115
           +P     ++++E     V DK   +  HP    Y+ +L++ +  H G +       A P 
Sbjct: 97  EPEALPLSILYEDAHLIVVDKAAGMAVHPAPGTYNGTLVNALLHHCGASLSGVGGVARPG 156

Query: 116 --HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ 173
             HRLD +TSG+++A K+  + + L  LF    + + Y+AL  G        + P  T Q
Sbjct: 157 IVHRLDKDTSGVMVAAKSDAAHRGLSTLFATHDIDRLYVALTRGAP------NPPTGTIQ 210

Query: 174 -NIQKDLHIRSKISPL---GKQSITLVEPLSYNPFLDISLLKITPL---TGRTHQIRLHL 226
             I +    R K++ L   G+++IT     +     D  L         TGRTHQIR+H+
Sbjct: 211 TQIGRSPGDRKKMAVLRAGGREAITHYRVEAAFGPADRPLAARVACRLETGRTHQIRVHM 270

Query: 227 SSVDHRIVGEGLYGVADENA--REYLQ---LKRENNAPLLMLHAASLEF--EFKGAIYKI 279
           +S     +G+ +YG A   A  RE ++   L+R+       LHAA L F     G   + 
Sbjct: 271 ASKGSPCLGDPVYGAAQPAAAVRERIEAAGLRRQ------ALHAAVLGFVHPITGETLRF 324

Query: 280 ASPMP 284
            +P+P
Sbjct: 325 ETPLP 329
>ref|NP_295407.1| (NC_001263) pseudouridine synthase, putative [Deinococcus
           radiodurans]
 pir||B75366 probable pseudouridine synthase - Deinococcus radiodurans  (strain
           R1)
 gb|AAF11241.1|AE002010_4 (AE002010) pseudouridine synthase, putative [Deinococcus
           radiodurans]
          Length = 321

 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 63/219 (28%), Positives = 98/219 (43%), Gaps = 17/219 (7%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           +++E  D     KP  + T P G F   +LL  ++  +  +A P HRL   TSGLVL   
Sbjct: 105 VIYEDADLLAVSKPSGLPTMPGGGFLEHTLLHQVRGRW-PDASPLHRLGRGTSGLVLFSL 163

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGK 190
           T Q+   L   +   +V+K Y AL+ G+ E+  + D  +         L      S  GK
Sbjct: 164 TSQAGAALLKDWRAGRVQKVYRALSAGVAEQD-EYDITVPIGPVAHPRLGQVFAASTAGK 222

Query: 191 QSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYL 250
            + +    L      D +L ++   TGR HQIR+HL+S+   +  + LY           
Sbjct: 223 TAHSRARVLERRE--DTTLFEVEIFTGRPHQIRIHLASLGLPLAVDPLYVSGG------- 273

Query: 251 QLKRENNAP---LLMLHAASLEFEF--KGAIYKIASPMP 284
            L R +  P      LHA++L F+    GA   +++P P
Sbjct: 274 -LPRPDALPGDLGYALHASTLTFQHPAHGAALTLSAPAP 311
>ref|NP_102152.1| (NC_002678) ribosomal large subunit pseudouridine synthase C
           [Mesorhizobium loti]
 dbj|BAB47938.1| (AP002994) ribosomal large subunit pseudouridine synthase C
           [Mesorhizobium loti]
          Length = 326

 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 43/154 (27%), Positives = 78/154 (49%), Gaps = 11/154 (7%)

Query: 98  ESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG 157
           + +L+  ++  G+     HRLD +TSG+++  +T  +   L   F  ++ KKTY AL  G
Sbjct: 124 DDMLEAWRNQKGEKPRLVHRLDRDTSGVLVVARTRLAAMKLSEAFRARETKKTYWALVKG 183

Query: 158 LVEK-SMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLD-----ISLLK 211
           +  K   KI   ++       D   R +++  G++       +SY   ++     ++ L+
Sbjct: 184 VPPKREDKISTWLIKEPTEDGD---RVRVAAHGEKGAD--HAVSYYRIIEQAAQTMTWLE 238

Query: 212 ITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADEN 245
           + P TGRTHQ+R+H + +   I+G+  Y  AD N
Sbjct: 239 MEPYTGRTHQLRVHAAYIGCPIIGDPKYFEADTN 272
>ref|NP_562120.1| (NC_003366) ribosomal large subunit pseudouridine synthase C
           [Clostridium perfringens]
 dbj|BAB80910.1| (AP003189) ribosomal large subunit pseudouridine synthase C
           [Clostridium perfringens]
          Length = 324

 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 44/125 (35%), Positives = 66/125 (52%), Gaps = 4/125 (3%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           +RLD  TSG+V  GK  + +K L  +  ++KVKK Y AL  G ++   K +  I     +
Sbjct: 143 NRLDRNTSGIVFFGKNFEGLKLLNEMIRERKVKKYYCALVKGKIQPG-KYEAYISKDDEL 201

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
            K   +     P  K+    V+ L  N     SLL+I  +TGR+HQ+R HL+ + + IVG
Sbjct: 202 NKST-VYDTERPDTKKIKMDVKVLQTNG--AFSLLEIELITGRSHQLRAHLAHLGNPIVG 258

Query: 236 EGLYG 240
           +  YG
Sbjct: 259 DFKYG 263
>ref|NP_218779.1| (NC_000919) conserved hypothetical protein [Treponema pallidum]
 pir||A71338 conserved hypothetical protein TP0339 - syphilis spirochete
 gb|AAC65324.1| (AE001213) conserved hypothetical protein [Treponema pallidum]
          Length = 331

 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 49/182 (26%), Positives = 89/182 (47%), Gaps = 14/182 (7%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           HRLD +TSG++L  + + + + L   F +++V+K YLAL  G+  + + + +  +     
Sbjct: 160 HRLDKDTSGVLLTSRNMHAHEALVRSFKKRQVRKVYLALLQGVPARGVGVIETTIVRDRR 219

Query: 176 QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVG 235
           ++   + S+    GK + T  + +        + ++    TGRTHQIR+H   +   +VG
Sbjct: 220 RRTRFVASEDFSKGKYARTRYKVMKICG--ACAFVQFLLDTGRTHQIRVHARYLGCPVVG 277

Query: 236 EGLYGVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKI--ASPMPERFMPFLKD 293
           + LYG     +R    +        LMLHA ++ F       +I   +P+P RF+  +  
Sbjct: 278 DPLYG-----SRNICGI-----PTTLMLHAYAVRFVLPRTKKRITLVAPIPLRFVRLIHR 327

Query: 294 LS 295
           LS
Sbjct: 328 LS 329
>ref|NP_199927.1| (NM_124493) putative protein [Arabidopsis thaliana]
 dbj|BAA97376.1| (AB023044) gene_id:MWD22.8~similar to unknown protein~sp|Q09709
           [Arabidopsis thaliana]
          Length = 395

 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 56/214 (26%), Positives = 91/214 (42%), Gaps = 15/214 (7%)

Query: 39  RLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALV------FETKDFGVFDKPHQVYTHPK 92
           R+K + + V  S I++   ++ HF    +   ++       +  D     KP  V  HP 
Sbjct: 100 RIKVDGEIVPVSYIVKSSQKITHFLHRHEPPVMIDDVVILHQEPDVVTVCKPASVPVHPC 159

Query: 93  GYFYHESLLDCIQS-HFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTY 151
           G +   +++  + + H      P HRLD   SGL++  +T       +       VKK Y
Sbjct: 160 GQYRKNTIVGILDAEHDLGTLFPIHRLDRLVSGLLIIARTAAKADFFRQQIEGGMVKKRY 219

Query: 152 LALAHGLV-EKSMKIDKPI----LTPQNIQKDLHIRSKISPL-GKQSITLVEPLSYNPFL 205
           +A   G+  E  M +D  I       ++  +D +       + GK + T    +  N   
Sbjct: 220 IAKVIGVFPEDEMIVDANINYNGSEGRSTAEDANSSGDDKKVKGKPACTKFTRIDTNG-- 277

Query: 206 DISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             SL+   P+TGRTHQIR+HL    H I  + LY
Sbjct: 278 THSLVSCEPVTGRTHQIRVHLQYTGHPIANDPLY 311
>gb|AAL31256.1| (AY061753) AT5g51140/MWD22_8 [Arabidopsis thaliana]
          Length = 367

 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 56/214 (26%), Positives = 91/214 (42%), Gaps = 15/214 (7%)

Query: 39  RLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALV------FETKDFGVFDKPHQVYTHPK 92
           R+K + + V  S I++   ++ HF    +   ++       +  D     KP  V  HP 
Sbjct: 72  RIKVDGEIVPVSYIVKSSQKITHFLHRHEPPVMIDDVVILHQEPDVVTVCKPASVPVHPC 131

Query: 93  GYFYHESLLDCIQS-HFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTY 151
           G +   +++  + + H      P HRLD   SGL++  +T       +       VKK Y
Sbjct: 132 GQYRKNTIVGILDAEHDLGTLFPIHRLDRLVSGLLIIARTAAKADFFRQQIEGGMVKKRY 191

Query: 152 LALAHGLV-EKSMKIDKPI----LTPQNIQKDLHIRSKISPL-GKQSITLVEPLSYNPFL 205
           +A   G+  E  M +D  I       ++  +D +       + GK + T    +  N   
Sbjct: 192 IAKVIGVFPEDEMIVDANINYNGSEGRSTAEDANSSGDDKKVKGKPACTKFTRIDTNG-- 249

Query: 206 DISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             SL+   P+TGRTHQIR+HL    H I  + LY
Sbjct: 250 THSLVSCEPVTGRTHQIRVHLQYTGHPIANDPLY 283
>ref|NP_301874.1| (NC_002677) putative pseudouridine synthase [Mycobacterium leprae]
 emb|CAB39580.1| (AL049478) putative pseudouridine synthase [Mycobacterium leprae]
 emb|CAC31581.1| (AL583921) putative pseudouridine synthase [Mycobacterium leprae]
          Length = 308

 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 54/156 (34%), Positives = 76/156 (48%), Gaps = 14/156 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQN 174
           HRLD  TSG++L   + ++   LK  F  + V K Y AL  G  + S   ID PI     
Sbjct: 136 HRLDVGTSGVMLVAISERAYTVLKRAFKCRTVDKRYHALVQGHPDPSSGTIDAPI----G 191

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             +    +  ++  G+ SIT  + L    F+  SLL +   TGRTHQIR H + +     
Sbjct: 192 RHRGHTWKFAVTKDGRHSITHYDTLE--AFVAASLLDVHLETGRTHQIRAHFAELHRPCC 249

Query: 235 GEGLYGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           G+ +YG AD    + L L+R+       LHA SL F
Sbjct: 250 GDLVYG-ADPKLAKRLGLERQ------WLHARSLSF 278
>ref|NP_104781.1| (NC_002678) pseudouridine synthase [Mesorhizobium loti]
 dbj|BAB50567.1| (AP003002) pseudouridine synthase [Mesorhizobium loti]
          Length = 329

 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 51/195 (26%), Positives = 89/195 (45%), Gaps = 28/195 (14%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP---------AHRLDYE 121
           +++E     V +KP  +  HP    +  +L++ +  H G +             HRLD E
Sbjct: 80  VLYEDDALIVINKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVRRPGIVHRLDKE 139

Query: 122 TSGLVLAGKTLQSVKDLKALFMQK----KVKKTYLALAHGLVEKSM-KIDKPILTPQNIQ 176
           TSG+++  KT ++ K L   F        +++ YLAL  G+ ++    +D P+    +  
Sbjct: 140 TSGVMVVAKTDRAHKALSEAFADHGRTGDLERAYLALVWGIPQRPTGTVDAPLGRAAD-- 197

Query: 177 KDLHIRSKISPLGKQS-------ITLVEPLSYNP--FLDISLLKITPLTGRTHQIRLHLS 227
               +R  + P G+           + E    N   F   SL++    TGRTHQIR+H++
Sbjct: 198 ---RVRRAVVPEGRDDARHAVTHFAVQERFGENQQEFATASLVECRLETGRTHQIRVHMA 254

Query: 228 SVDHRIVGEGLYGVA 242
            + H ++G+  YG A
Sbjct: 255 HIGHPVIGDPDYGQA 269
>ref|NP_644614.1| (NC_003919) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
 gb|AAM39150.1| (AE012085) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
          Length = 298

 Score = 62.0 bits (149), Expect = 8e-09
 Identities = 47/159 (29%), Positives = 81/159 (50%), Gaps = 8/159 (5%)

Query: 83  KPHQVYTHPKGYFYHESLLDCIQSHFGKNAH-PAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           KPH +   P G +  E+LL  +       A  P HR+D ET+GLVL      +    +AL
Sbjct: 101 KPHFLPVAPAGAYVRETLLTRLVRRLDNPALVPLHRIDRETAGLVLFSANPATRGIYQAL 160

Query: 142 FMQKKVKKTYLALAHGLVE-KSMKIDKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLS 200
           F +++++K YLA+A  L E +   + +  L P     +   R +       S T++E ++
Sbjct: 161 FRERRIRKHYLAVAAPLPELRFPYVHRSRLEP----GEPFFRMREGVGEPNSETVIEVVA 216

Query: 201 YNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
            N   D    ++ P+TGR HQ+R+H++++   I+ +  Y
Sbjct: 217 RN--ADTWTYRLEPVTGRKHQLRVHMAALGAPILHDRFY 253
>ref|NP_355395.1| (NC_003062) AGR_C_4432p [Agrobacterium tumefaciens] [Agrobacterium
           tumefaciens str. C58 (Cereon)]
 gb|AAK88180.1| (AE008157) AGR_C_4432p [Agrobacterium tumefaciens str. C58
           (Cereon)]
          Length = 340

 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 33/241 (13%)

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---------KNAHPAHRLDYETS 123
           +E +D  V  KP  +  HP    +  +L++ +  H G         K     HRLD ETS
Sbjct: 94  YEDEDLIVLVKPAGLVVHPGAGNWTGTLVNALIYHCGDSLSGIGGVKRPGIVHRLDKETS 153

Query: 124 GLVLAGKTLQSVKDLKALFMQK----KVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDL 179
           G+++  K   + + L A F        +++ Y A+  G            L     +   
Sbjct: 154 GVMVVAKNDNAHRHLAAQFADHGRTGPLERAYKAVVWGRPRTLRGTVDAALGRGTDRTKR 213

Query: 180 HIRSKISPLGKQSIT---LVEPLSYNPFLDI--SLLKITPLTGRTHQIRLHLSSVDHRIV 234
            ++++ S   +++IT   ++E     P      S+++    TGRTHQIR+H++ + H ++
Sbjct: 214 AVKNEDSFDAREAITHYEVMERFHEKPDASCLASMVECRLETGRTHQIRVHMAHIGHPLI 273

Query: 235 GEGLYGVA--------DENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMP 284
           G+  YG A        DE AR  +     N  P   LHA  L FE    G + +  + MP
Sbjct: 274 GDPEYGAAFRTKANLLDEPARSTV-----NRFPRQALHAYLLAFEHPRTGEVMEFETDMP 328

Query: 285 E 285
           E
Sbjct: 329 E 329
>ref|NP_389044.1| (NC_000964) similar to hypothetical proteins [Bacillus subtilis]
 sp|O31613|YJBO_BACSU Hypothetical protein yjbO
 pir||G69844 conserved hypothetical protein yjbO - Bacillus subtilis
 emb|CAB13019.1| (Z99110) similar to hypothetical proteins [Bacillus subtilis]
          Length = 283

 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 49/176 (27%), Positives = 83/176 (46%), Gaps = 12/176 (6%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-----HPAHRLDYETSGL 125
           +++E +   V +K   V + P       S+ + I  H+         H   RLD +TSG+
Sbjct: 68  ILYEDEHVLVINKQPYVSSIPSREHPSGSIANGIIDHYQTTGVRATVHLVTRLDRDTSGI 127

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHG-LVEKSMKIDKPILTPQNIQKDLHIRSK 184
           +L  K   +   L +      VK+ Y A+ HG + +    +D PI        D  I   
Sbjct: 128 MLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPI----GRHPDSIIERT 183

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           ++P G++++T       N   D++ + +   TGRTHQIR+H+S + H + G+ LYG
Sbjct: 184 VTPDGQKAVTHFYVTCAND--DMTSVALQLETGRTHQIRVHMSYLGHPLCGDTLYG 237
>ref|NP_533115.1| (NC_003304) pseudouridine synthase homolog [Agrobacterium
           tumefaciens str. C58 (U. Washington)]
 gb|AAL43431.1| (AE009191) pseudouridine synthase homolog [Agrobacterium
           tumefaciens str. C58 (U. Washington)]
          Length = 325

 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 33/241 (13%)

Query: 73  FETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---------KNAHPAHRLDYETS 123
           +E +D  V  KP  +  HP    +  +L++ +  H G         K     HRLD ETS
Sbjct: 79  YEDEDLIVLVKPAGLVVHPGAGNWTGTLVNALIYHCGDSLSGIGGVKRPGIVHRLDKETS 138

Query: 124 GLVLAGKTLQSVKDLKALFMQK----KVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDL 179
           G+++  K   + + L A F        +++ Y A+  G            L     +   
Sbjct: 139 GVMVVAKNDNAHRHLAAQFADHGRTGPLERAYKAVVWGRPRTLRGTVDAALGRGTDRTKR 198

Query: 180 HIRSKISPLGKQSIT---LVEPLSYNPFLDI--SLLKITPLTGRTHQIRLHLSSVDHRIV 234
            ++++ S   +++IT   ++E     P      S+++    TGRTHQIR+H++ + H ++
Sbjct: 199 AVKNEDSFDAREAITHYEVMERFHEKPDASCLASMVECRLETGRTHQIRVHMAHIGHPLI 258

Query: 235 GEGLYGVA--------DENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMP 284
           G+  YG A        DE AR  +     N  P   LHA  L FE    G + +  + MP
Sbjct: 259 GDPEYGAAFRTKANLLDEPARSTV-----NRFPRQALHAYLLAFEHPRTGEVMEFETDMP 313

Query: 285 E 285
           E
Sbjct: 314 E 314
>ref|NP_283249.1| (NC_003116) putative psedouridine synthase [Neisseria meningitidis
           Z2491]
 pir||A81959 probable psedouridine synthase NMA0422 [imported] - Neisseria
           meningitidis (group A strain Z2491)
 emb|CAB83721.1| (AL162753) putative psedouridine synthase [Neisseria meningitidis
           Z2491]
          Length = 220

 Score = 61.6 bits (148), Expect = 1e-08
 Identities = 54/215 (25%), Positives = 92/215 (42%), Gaps = 25/215 (11%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           ++F  +DF   +KP  +  H        +    IQ    +     HRLD +TSG++L   
Sbjct: 6   ILFRHQDFVAINKPGGISVHQDSGETRLARTLAIQLGV-ERVWLLHRLDKQTSGILLFAL 64

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ--NIQKDLHIRSKISPL 188
             +S   L   F+ K +KKTYLAL+     K     K  +      + K       I+  
Sbjct: 65  NRESASALSGQFVGKSIKKTYLALSDRKPSKKQGWIKGGMEKSRCGMWKLTRNTENIAVT 124

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENARE 248
              SI++ E L         L  + P TG+THQ+R+ + S+   I+G+ LYG  +     
Sbjct: 125 RFHSISIAEKL--------RLFILEPHTGKTHQLRVAMKSLGSPILGDSLYGGTESET-- 174

Query: 249 YLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPM 283
                       + L+A  ++F+++    +I +P+
Sbjct: 175 ------------MFLYAWKIQFDYQNRQIEIVAPL 197
>ref|NP_420787.1| (NC_002696) ribosomal large subunit pseudouridine synthase C
           [Caulobacter crescentus CB15]
 gb|AAK23955.1| (AE005871) ribosomal large subunit pseudouridine synthase C
           [Caulobacter crescentus CB15]
          Length = 331

 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 45/159 (28%), Positives = 75/159 (46%), Gaps = 19/159 (11%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNI 175
           HRLD +TSG++L GKT  +   L   F ++K +KTY A+  G    +  + +  L  + +
Sbjct: 139 HRLDRDTSGVLLLGKTPSAAARLSGAFAKRKAQKTYWAIVAGNPHPTEGVMELHLAKRGV 198

Query: 176 -QKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIV 234
             ++L + ++      Q               ++ + + P TGRTHQ+R H+ ++ H I+
Sbjct: 199 GDRELVVPAQPKDPDAQPAETEFVTISRAGPRVTWMALRPHTGRTHQLRAHMKAMGHPIL 258

Query: 235 GEGLYGVADENAREYLQLKRENNAPL-----LMLHAASL 268
           G+  YG              E +APL     L LHA S+
Sbjct: 259 GDPKYG-------------DEKSAPLSEGLKLQLHARSI 284
>ref|NP_441760.1| (NC_000911) hypothetical protein [Synechocystis sp. PCC 6803]
 sp|P74346|YG29_SYNY3 Hypothetical protein slr1629
 pir||S76181 hypothetical protein - Synechocystis sp. (strain PCC 6803)
 dbj|BAA18440.1| (D90914) ORF_ID:slr1629~hypothetical protein [Synechocystis sp. PCC
           6803]
          Length = 327

 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 57/238 (23%), Positives = 102/238 (41%), Gaps = 35/238 (14%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSH------FGKNAHPA--HRLDYET 122
           +++E +   + +KP  +  HP       ++++ + +H       G    P   HRLD +T
Sbjct: 100 ILYEDEQLIIINKPAGLVVHPGPGHPDGTVVNALLAHCPDLAGIGGVQRPGIVHRLDKDT 159

Query: 123 SGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIR 182
           +G ++  KT  ++ +L+    +K  ++ Y  + +G      +I   +  P         +
Sbjct: 160 TGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYG---SPKEIQGTVNLPVGRHPGDRQK 216

Query: 183 SKISPL---GKQSIT---LVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
             I P+   G++++T   L+E +  + +L+  L      TGRTHQIR+H   + H +VG+
Sbjct: 217 MGIVPVEKGGREAVTHWRLLERIGNHSWLEFQLE-----TGRTHQIRVHSKQMGHPLVGD 271

Query: 237 GLY---GVADENAREYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPMPERFMPFL 291
            LY   G  + N               L  H  SL     G I    +PMP  F   L
Sbjct: 272 NLYTSPGSVNVNL----------PGQALHAHQLSLIHPVSGEIITAIAPMPAHFEKLL 319
>ref|NP_250733.1| (NC_002516) hypothetical protein [Pseudomonas aeruginosa]
 pir||D83391 hypothetical protein PA2043 [imported] - Pseudomonas aeruginosa
           (strain PAO1)
 gb|AAG05431.1|AE004630_8 (AE004630) hypothetical protein [Pseudomonas aeruginosa]
          Length = 300

 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 47/171 (27%), Positives = 85/171 (49%), Gaps = 8/171 (4%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           +++  +   V DKPH +   P G +  ++LL  +    G ++  P HR+D  T+GLVL  
Sbjct: 89  ILYRDEHLLVADKPHFLPVMPAGGYVEQTLLARLARSTGNRDLVPLHRIDRHTAGLVLFS 148

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL-TPQNIQKDLHIRSKISPL 188
               S    +ALF ++++ K Y A+A  L +    +D P+L   + +  +   R +    
Sbjct: 149 TNPGSRGRYQALFRERRIDKCYEAIAPALPQ----LDFPLLRRTRLVPGEPFFRMREGEG 204

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
              S T +E +  N        ++ P+TG+ HQ+R+HL+++   I  +G Y
Sbjct: 205 EPNSETRIEVVERNG--RWWRYRLYPVTGKKHQLRVHLAALGAGIQNDGFY 253
>ref|NP_275010.1| (NC_003112) conserved hypothetical protein [Neisseria meningitidis
           MC58]
 pir||E81014 conserved hypothetical protein NMB2018 [imported] - Neisseria
           meningitidis (group B strain MD58)
 gb|AAF42341.1| (AE002552) conserved hypothetical protein [Neisseria meningitidis
           MC58]
          Length = 220

 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 54/216 (25%), Positives = 91/216 (42%), Gaps = 27/216 (12%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG-KNAHPAHRLDYETSGLVLAG 129
           ++F  +DF   +KP  +  H         L   +    G +     HRLD +TSG++L  
Sbjct: 6   ILFRHQDFVAINKPGGISVHQDSG--ETGLARTLAIQLGVERVWLLHRLDKQTSGILLFA 63

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQ--NIQKDLHIRSKISP 187
              +S   L   F  K +KKTYLAL+     K     K  +      + K       I+ 
Sbjct: 64  LNKESASALSGQFAGKSIKKTYLALSDRKPSKKQGWIKGGMEKSRCGMWKLTRNTENIAV 123

Query: 188 LGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAR 247
               SI++ E L         L  + P TG+THQ+R+ + S+   I+G+ LYG  +    
Sbjct: 124 TRFHSISIAEKL--------RLFILEPHTGKTHQLRVAMKSLGSPILGDSLYGGTESET- 174

Query: 248 EYLQLKRENNAPLLMLHAASLEFEFKGAIYKIASPM 283
                        + L+A  ++F+++    +I +P+
Sbjct: 175 -------------MFLYAWKIQFDYQNRQIEIVAPL 197
>ref|NP_493778.1| (NM_061377) K07E8.7.p [Caenorhabditis elegans]
 sp|O16686|YK27_CAEEL Hypothetical 50.0 kDa protein K07E8.7 in chromosome IV
 pir||T32044 hypothetical protein K07E8.7 - Caenorhabditis elegans
 gb|AAB66153.1| (AF016678) Hypothetical protein K07E8.7 [Caenorhabditis elegans]
          Length = 432

 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 45/173 (26%), Positives = 79/173 (45%), Gaps = 6/173 (3%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-HPAHRLDYETSGLVLAG 129
           ++ ET D  V +KP  +  H  G +   ++L  ++ + G+      HRLD  TSG++L  
Sbjct: 150 VISETDDLFVVEKPPSLPVHTCGQYAIHTVLGQLRVNEGRTGLRVLHRLDRATSGVLLFA 209

Query: 130 KTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLG 189
           K  ++  + K    Q +  K Y+    G+     ++ +  + P  I   +     + P G
Sbjct: 210 KNYETDLEFKTTLKQGEWSKEYICKVDGVFPDEEQVCEQPIGPLVISMGIQC---VRPDG 266

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
           K + +    L  +    +  + I   TGRTHQIR+H   + H I G+ +Y  A
Sbjct: 267 KDAKSRFRKLWSDGTQSVVQVHIE--TGRTHQIRVHSQFLGHPIAGDQIYNSA 317
>ref|NP_519162.1| (NC_003295) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           C PROTEIN [Ralstonia solanacearum]
 emb|CAD14743.1| (AL646062) PROBABLE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           C PROTEIN [Ralstonia solanacearum]
          Length = 331

 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 55/187 (29%), Positives = 84/187 (44%), Gaps = 16/187 (8%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGL-VEKSMKIDKPILTPQN 174
           HRLD ETSG++L  K   ++  L     + ++ K Y A   G+   +   I  P+     
Sbjct: 142 HRLDRETSGVLLLAKKRSALVALHEQIREGQLDKRYFAAVKGVWPHQRQHIKAPLFKYST 201

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
            + +  +R +    G+ S T+   +  + P+   +LL+    TGRTHQIR+HL+     I
Sbjct: 202 PEGERRVRVQAD--GQPSHTVFNRVGVFGPY---TLLEAELKTGRTHQIRVHLAHAGFPI 256

Query: 234 VGEGLYGVADENAREYLQLKRENNAPLL---MLHAASLEFEF--KGAIYKIASPMPERFM 288
           +G+  YG    N      L R N +P L    LHA +L       G I    +P+P    
Sbjct: 257 LGDDKYGDFALNK----ALSRANASPRLARMFLHAHTLRLTHPQSGEIVTFKAPLPAECA 312

Query: 289 PFLKDLS 295
            FL   S
Sbjct: 313 AFLNAFS 319
>ref|NP_077944.1| (NC_002162) pseudouridine synthase (uracil hydrolase) [Ureaplasma
           urealyticum]
 pir||C82933 pseudouridine synthase (uracil hydrolase) UU113 [imported] -
           Ureaplasma urealyticum
 gb|AAF30519.1|AE002111_8 (AE002111) pseudouridine synthase (uracil hydrolase) [Ureaplasma
           urealyticum]
          Length = 315

 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 19/187 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA--HP----------AHRL 118
           +++E K+  V  KP  +  H    + +++L + I+ +  K    HP           HRL
Sbjct: 87  IIYEDKNILVVHKPIGLIVHEDNRYKNDTLQNRIKKYLVKKDEYHPFDESAFVPSLCHRL 146

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPIL--TPQNIQ 176
           D  TSGL++A KT  +++ +  +F    V + Y  L +  + K+  +    +     N  
Sbjct: 147 DLNTSGLIVAAKTANALRVITEMFKNNDVIRIYKCLTYNQLPKNNDVIYNFMYKADDNTM 206

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
              + ++K +       T ++        DI L     LTGRTHQIR  L+ +   IVGE
Sbjct: 207 IVQNFKTKFNKTAITKYTYIDKYKKYFIYDIEL-----LTGRTHQIRAVLNFLHAPIVGE 261

Query: 237 GLYGVAD 243
             Y   D
Sbjct: 262 QKYITKD 268
>ref|NP_386831.1| (NC_003047) PUTATIVE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           PROTEIN [Sinorhizobium meliloti]
 emb|CAC47304.1| (AL591791) PUTATIVE RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE
           PROTEIN [Sinorhizobium meliloti]
          Length = 343

 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 66/249 (26%), Positives = 108/249 (42%), Gaps = 29/249 (11%)

Query: 64  PNEKTQAL----VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---------K 110
           P  K +A+    ++E  D  V  KP  +  HP    +  +L++ +  H G         K
Sbjct: 81  PEPKGEAIPLDVLYEDADLIVLVKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVK 140

Query: 111 NAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQK----KVKKTYLALAHGLVEKSM-KI 165
                HRLD +TSG+++  K   + + L   F        +++ Y A+  G   +   KI
Sbjct: 141 RPGIVHRLDKDTSGVMVVAKNDAAHRHLSDQFADHGRNGPLERAYRAVVWGRPRQLKGKI 200

Query: 166 DKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITPL----TGRTH 220
           D P+    +  K   ++ + S   +++IT  E +  Y+   D + L  T      TGRTH
Sbjct: 201 DAPLGRAGDRTKRA-VKREDSDDAREAITHYEVVERYHEKPDGTSLASTVECHLETGRTH 259

Query: 221 QIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRE---NNAPLLMLHAASLEFEF--KGA 275
           QIR+H++ + H ++G+  YG A       L        N  P   LHA  L+FE    G 
Sbjct: 260 QIRVHMAHIGHPLIGDPDYGAAFRTKANLLPEPARAAVNRFPRQALHAFMLQFEHPATGE 319

Query: 276 IYKIASPMP 284
                +P+P
Sbjct: 320 TMHFETPVP 328
>ref|NP_488120.1| (NC_003272) ribosomal large chain pseudouridine synthase A [Nostoc
           sp. PCC 7120]
 dbj|BAB75779.1| (AP003595) ribosomal large chain pseudouridine synthase A [Nostoc
           sp. PCC 7120]
          Length = 549

 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 61/219 (27%), Positives = 103/219 (46%), Gaps = 19/219 (8%)

Query: 47  VRKSQIIQGVVRLIHFKPN---EKTQA-LVFETKDFGVFDKPHQVYTHPKGYF-YHESLL 101
           V + Q + G + L   KP    EK Q  +++E +     +KP  + + P  Y    +S+L
Sbjct: 317 VERCQPLMGFL-LSGLKPTRNLEKEQINVIYEDEWLIAVNKPSGLLSVPGRYIDTQDSVL 375

Query: 102 DCIQSHFGKNAHPA--HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLV 159
             ++    +    A  HRLD +TSG++L  +  Q+ +     F Q++V K Y A+  G++
Sbjct: 376 SRLRHMLPEEEMLAAVHRLDQDTSGILLLARDSQTYRQFSQQFQQRQVYKVYEAILAGVI 435

Query: 160 EKSMK-IDKPIL-TPQNIQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTG 217
                 ID P+   P+N       +      GK S+T    ++     D + ++  PLTG
Sbjct: 436 NTDTGIIDLPLWGDPEN----RPYQQVDWQRGKPSVTNFREIAREG--DYTRVEFVPLTG 489

Query: 218 RTHQIRLHLSSVDHR---IVGEGLYGVADENAREYLQLK 253
           RTHQ+R+H S V      I+G+  YG   +  R +L  +
Sbjct: 490 RTHQLRVHASDVQGLGVVILGDRFYGCTAKANRLHLHAR 528
>dbj|BAB13516.1| (AB037369) pseudouridine synthase homolog [Sinorhizobium meliloti]
          Length = 264

 Score = 60.1 bits (144), Expect = 3e-08
 Identities = 66/249 (26%), Positives = 108/249 (42%), Gaps = 29/249 (11%)

Query: 64  PNEKTQAL----VFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG---------K 110
           P  K +A+    ++E  D  V  KP  +  HP    +  +L++ +  H G         K
Sbjct: 2   PEPKGEAIPLDVLYEDADLIVLVKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVK 61

Query: 111 NAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQK----KVKKTYLALAHGLVEKSM-KI 165
                HRLD +TSG+++  K   + + L   F        +++ Y A+  G   +   KI
Sbjct: 62  RPGIVHRLDKDTSGVMVVAKNDAAHRHLSDQFADHGRNGPLERAYRAVVWGRPRQLKGKI 121

Query: 166 DKPILTPQNIQKDLHIRSKISPLGKQSITLVEPLS-YNPFLDISLLKITPL----TGRTH 220
           D P+    +  K   ++ + S   +++IT  E +  Y+   D + L  T      TGRTH
Sbjct: 122 DAPLGRAGDRTKRA-VKREDSDDAREAITHYEVVERYHEKPDGTSLASTVECHLETGRTH 180

Query: 221 QIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRE---NNAPLLMLHAASLEFEF--KGA 275
           QIR+H++ + H ++G+  YG A       L        N  P   LHA  L+FE    G 
Sbjct: 181 QIRVHMAHIGHPLIGDPDYGAAFRTKANLLPEPARAAVNRFPRQALHAFMLQFEHPATGE 240

Query: 276 IYKIASPMP 284
                +P+P
Sbjct: 241 TMHFETPVP 249
>ref|XP_165571.1| (XM_165571) hypothetical protein FLJ14494 [Homo sapiens]
 gb|AAH14131.1|AAH14131 (BC014131) hypothetical protein FLJ14494 [Homo sapiens]
          Length = 377

 Score = 59.3 bits (142), Expect = 5e-08
 Identities = 64/249 (25%), Positives = 112/249 (44%), Gaps = 42/249 (16%)

Query: 31  AQRHLDKQRLKQNQQAVRKSQI--------IQGVVR----LIHFKPNEKTQAL----VFE 74
           AQR  +K R ++ +Q  +K  +        +Q +VR    L    PN   +AL    + +
Sbjct: 43  AQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQ 102

Query: 75  TKDFGVFDKPHQVYTH--PKGYFYHESLLDCI----QSHFGKNAHPAHRLDYETSGLVLA 128
            K+  V +KP+ +  H  P        +L  +      H  +  H  HRLD ET+G+++ 
Sbjct: 103 DKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVL 162

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLAL-AHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP 187
                    ++ LF  ++V K Y A+  H  +  +  +D PI+  +   +  H +  +SP
Sbjct: 163 AWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSP 222

Query: 188 L-----GKQ-----------SITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLS-SVD 230
                 GK            ++T  + LS    L  +L+++ P+TG  HQ+R+HLS  +D
Sbjct: 223 SYRMDDGKMVKVRRSRNAQVAVTQYQVLSST--LSSALVELQPITGIKHQLRVHLSFGLD 280

Query: 231 HRIVGEGLY 239
             I+G+  Y
Sbjct: 281 CPILGDHKY 289
>gb|AAM61068.1| (AY084499) unknown [Arabidopsis thaliana]
          Length = 395

 Score = 58.9 bits (141), Expect = 7e-08
 Identities = 55/214 (25%), Positives = 90/214 (41%), Gaps = 15/214 (7%)

Query: 39  RLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALV------FETKDFGVFDKPHQVYTHPK 92
           R+K + + V  S I++   ++ HF    +   ++       +  D     KP  V  HP 
Sbjct: 100 RIKVDGEIVPVSYIVKSSQKITHFLHRHEPPVMIDDVVILHQEPDVVTVCKPASVPVHPC 159

Query: 93  GYFYHESLLDCIQS-HFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTY 151
           G +   +++  + + H        HRLD   SGL++  +T       +       VKK Y
Sbjct: 160 GQYRKNTIVGILDAEHDLGTLFSIHRLDRLVSGLLIIARTAAKADFFRQQIEGGMVKKRY 219

Query: 152 LALAHGLV-EKSMKIDKPI----LTPQNIQKDLHIRSKISPL-GKQSITLVEPLSYNPFL 205
           +A   G+  E  M +D  I       ++  +D +       + GK + T    +  N   
Sbjct: 220 IAKVIGVFPEDEMIVDANINYNGSEGRSTAEDANSSGDDKKVKGKPACTKFTRIDTNG-- 277

Query: 206 DISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
             SL+   P+TGRTHQIR+HL    H I  + LY
Sbjct: 278 THSLVSCEPVTGRTHQIRVHLQYTGHPIANDPLY 311
>ref|NP_440308.1| (NC_000911) hypothetical protein [Synechocystis sp. PCC 6803]
 sp|P72970|YF92_SYNY3 Hypothetical protein slr1592
 pir||S74948 hypothetical protein slr1592 - Synechocystis sp. (strain PCC 6803)
 dbj|BAA16988.1| (D90902) ORF_ID:slr1592~hypothetical protein [Synechocystis sp. PCC
           6803]
          Length = 291

 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 45/172 (26%), Positives = 85/172 (49%), Gaps = 4/172 (2%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNA-HPAHRLDYETSGLVLA 128
           +++   +D    DKP  +   P G F + ++L+ ++  + + +  P HRL   TSGL+L 
Sbjct: 62  SVLHRDEDLWAIDKPSGLPVLPGGDFVYHTVLEQLKIQYPQESLFPLHRLGTGTSGLLLL 121

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL 188
           G++    ++L   F +   +K Y  +  G  +   K +      +     L      S  
Sbjct: 122 GRSTLGRRELSRQFREHICRKIYRTVI-GPCDLPEKFECHQAIGKIPYPQLGYIYAASSH 180

Query: 189 GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
           GK + +    L+ +P  + + L++   TGR HQIR+HL+S+ + ++G+ LYG
Sbjct: 181 GKPAQSYGRILARSP--EKTWLEVEIRTGRPHQIRIHLASLGYPLLGDRLYG 230
>ref|NP_599568.1| (NC_003450) COG0564:Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum]
 dbj|BAB97709.1| (AP005274) Pseudouridylate synthases, 23S RNA-specific
           [Corynebacterium glutamicum ATCC 13032]
          Length = 294

 Score = 58.5 bits (140), Expect = 9e-08
 Identities = 58/226 (25%), Positives = 102/226 (44%), Gaps = 32/226 (14%)

Query: 70  ALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFG--KNAHPAHRLDYETSGLVL 127
           +++FE  +  V +KP  +  H  G  +   +++ ++  F   ++    HRLD +TSGL+L
Sbjct: 88  SVLFEDAELLVINKPAGIPVHG-GTGHGGGVIEALRQKFPQERDLELVHRLDRDTSGLLL 146

Query: 128 AGKTLQSVKDLKALFM--QKKVKKTYLALAHGLVEKSMK-IDKPILTPQNIQKDLHIRSK 184
             KT   +++L+ +    ++++ + YL    G     ++ ID P+   +         + 
Sbjct: 147 VSKTTSVLRELQEILRDREEEIFRGYLLKVEGAWPGDLRQIDVPLKRTE---------TT 197

Query: 185 ISPL--GKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVA 242
           + P   G ++ T  E +   P    +L+K    TGR HQIR+H     H IVG+  YG  
Sbjct: 198 VVPHSDGLRARTYFEVVKRLP--GATLVKAQLATGRKHQIRVHAQYAGHPIVGDPRYG-- 253

Query: 243 DENAREYLQLKRENNAPLLMLHAASLEF-EFKGAIYKIASPMPERF 287
                      R   A  + LHAA L      G   K  +P+P+ +
Sbjct: 254 ----------SRGGRAATMHLHAAELVAPRGAGKRQKFTAPLPKEW 289
>ref|NP_218671.1| (NC_000919) conserved hypothetical protein [Treponema pallidum]
 pir||A71349 conserved hypothetical protein TP0231 - syphilis spirochete
 gb|AAC65220.1| (AE001205) conserved hypothetical protein [Treponema pallidum]
          Length = 216

 Score = 58.2 bits (139), Expect = 1e-07
 Identities = 44/171 (25%), Positives = 80/171 (46%), Gaps = 12/171 (7%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           ++F+       DKP  +   P G      ++D +Q   G    P HRLD +T+G++L  K
Sbjct: 5   IIFQDAAVVAVDKPAGLAVQP-GARVRVCVVDVLQKQLGVRLFPLHRLDKDTAGVLLFAK 63

Query: 131 TLQSVKDLKALFMQKKVKKTYLALAHGLVEKSM-KIDKPILTPQNIQKDLHIRSKISPLG 189
             ++    + +    +V K Y AL  G   +    I  PI T    ++   +R+      
Sbjct: 64  HARAAALYQGILGSMRVIKRYRALCFGRPPRECGDIRVPIRTGTAARRRQVVRA-----A 118

Query: 190 KQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYG 240
             +  ++     + +L+++L      +GRTHQIR+HL+++   I+G+  YG
Sbjct: 119 HTAYRVLRATDTHTYLELTL-----HSGRTHQIRIHLAALGCPIIGDDKYG 164
>ref|NP_116184.1| (NM_032795) hypothetical protein FLJ14494 [Homo sapiens]
 dbj|BAB55086.1| (AK027400) unnamed protein product [Homo sapiens]
          Length = 377

 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 63/249 (25%), Positives = 112/249 (44%), Gaps = 42/249 (16%)

Query: 31  AQRHLDKQRLKQNQQAVRKSQI--------IQGVVR----LIHFKPNEKTQAL----VFE 74
           A+R  +K R ++ +Q  +K  +        +Q +VR    L    PN   +AL    + +
Sbjct: 43  ARRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQ 102

Query: 75  TKDFGVFDKPHQVYTH--PKGYFYHESLLDCI----QSHFGKNAHPAHRLDYETSGLVLA 128
            K+  V +KP+ +  H  P        +L  +      H  +  H  HRLD ET+G+++ 
Sbjct: 103 DKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVL 162

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLAL-AHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP 187
                    ++ LF  ++V K Y A+  H  +  +  +D PI+  +   +  H +  +SP
Sbjct: 163 AWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSP 222

Query: 188 L-----GKQ-----------SITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLS-SVD 230
                 GK            ++T  + LS    L  +L+++ P+TG  HQ+R+HLS  +D
Sbjct: 223 SYRMDDGKMVKVRRSRNAQVAVTQYQVLSST--LSSALVELQPITGIKHQLRVHLSFGLD 280

Query: 231 HRIVGEGLY 239
             I+G+  Y
Sbjct: 281 CPILGDHKY 289
>ref|NP_640600.1| (NC_003919) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
 gb|AAM35136.1| (AE011649) pseudouridylate synthase [Xanthomonas axonopodis pv.
           citri str. 306]
          Length = 244

 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 58/212 (27%), Positives = 87/212 (40%), Gaps = 28/212 (13%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHES--LLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           ++++     V DKP  +  H       E   L D ++   GK     HRLD  TSG +L 
Sbjct: 10  ILYQDDVLAVVDKPAGLMVHDSKLARGEDDFLADRLREQLGKPIFLVHRLDRATSGCLLL 69

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL 188
                S   L    M  +V+K YL +  G   +   I         +  DL       P+
Sbjct: 70  AFDRDSASALGKALMAGEVEKQYLTVCRGWPAEERFI---------VDHDLD-GGPGKPV 119

Query: 189 GKQSITLVEPLSYNPFLDI----------SLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
            K ++T  + L+    L+I          +LL+  P TGR  QIR H+  + H +VG+  
Sbjct: 120 KKPAVTHFQRLATGE-LEIPSTGFTTSRYALLRCQPQTGRFRQIRRHMKHLSHHMVGDTS 178

Query: 239 YGVADENAREYLQLKRENNAPLLMLHAASLEF 270
           +G    N R +  L        ++LHA  LEF
Sbjct: 179 HGDGRHN-RSFRML----GIHRMLLHAERLEF 205
>ref|NP_639523.1| (NC_003902) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
 gb|AAM43405.1| (AE012545) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
          Length = 298

 Score = 56.6 bits (135), Expect = 3e-07
 Identities = 47/169 (27%), Positives = 84/169 (48%), Gaps = 28/169 (16%)

Query: 83  KPHQVYTHPKGYFYHESLLDCIQSHFGK-NAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           KPH +   P G +  E+LL  +   F   +  P HR+D +T+GLVL      +    +AL
Sbjct: 101 KPHFLPVVPAGAYVRETLLARLVRRFDNPSLVPLHRIDRDTAGLVLFSANPATRGIYQAL 160

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISP----------LGK- 190
           F ++++ K YLA+A  L         P LT   +      RS++ P          +G+ 
Sbjct: 161 FRERRIHKHYLAVAPPL---------PALTFPYVH-----RSRLEPGEPFFRMREGVGEP 206

Query: 191 QSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
            S T+++ ++     D+   ++ P+TGR HQ+R+H++++   I+ +  Y
Sbjct: 207 NSETVIDVVARG--ADMWTYRLEPVTGRKHQLRVHMAALGVPILHDRFY 253
>ref|NP_325948.1| (NC_002771) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE C
           (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
           [Mycoplasma pulmonis]
 emb|CAC13290.1| (AL445563) RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE C
           (PSEUDOURIDYLATE SYNTHASE) (URACIL HYDROLYASE)
           [Mycoplasma pulmonis]
          Length = 282

 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 63/249 (25%), Positives = 113/249 (45%), Gaps = 31/249 (12%)

Query: 32  QRHLDKQRLKQNQQAVRKSQIIQ-----GVVRLIHFKPNEKTQALVFETKDFGVFDKPHQ 86
           +R++DK  +      V K  +IQ      V + + FK  E+   ++FE ++  V +K   
Sbjct: 45  KRNIDKNFI------VSKDDLIQIYGLTNVKQKLVFKKIEQKFNVIFEDQNILVINKQAG 98

Query: 87  VYTHPKGYFYHESLLDCIQSHFGKNAHPAH--RLDYETSGLVLAGKTLQSVKDLKALFMQ 144
           V  H       + +L  +      +  P+   RLD  TSG+V+  K    +K LK+    
Sbjct: 99  VSMHSDENSLDKQVLSYLNFKQVDSFVPSSIGRLDKVTSGVVVYAKNYSILKTLKS---N 155

Query: 145 KKVKKTYLALAHGLVEKSMKIDKPILTPQN-IQKDLHIRSKISPLGKQSITLVEPLSYNP 203
           + ++KTY+ +++  +E + KI+       N I+K   +  +     K + TL+  +  N 
Sbjct: 156 EHLRKTYVFMSNITLEPNQKIEHVFYHKYNPIKKKAELFKENVEESKITKTLLYKVKNNN 215

Query: 204 FLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLML 263
           + ++       +TGR HQIR  LS +   I G+  YG   ++ R YL   +      +  
Sbjct: 216 YAEL-------ITGRKHQIRATLSKLGFPIFGDVKYG-GKKDKRVYLHSYK------IKF 261

Query: 264 HAASLEFEF 272
           H+   EFE+
Sbjct: 262 HSLKGEFEY 270
>gb|AAD12509.1| (U02214) Homology to M62747 [Mycoplasma genitalium]
          Length = 119

 Score = 55.5 bits (132), Expect = 7e-07
 Identities = 37/119 (31%), Positives = 62/119 (52%), Gaps = 5/119 (4%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAH-GLVEKSMKIDKPILTPQN 174
           HRLD +TSG ++  K   S+ +L+     + +K+ Y+AL H      +  I+ P+    N
Sbjct: 4   HRLDRDTSGAIVVCKNQASLLNLQNQLQNRTLKRYYVALVHFPFNALTGSINAPLARVNN 63

Query: 175 IQKDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRI 233
            +    I    +   KQ+IT  + ++ N     +L+ +  LTGRTHQIR+HL  + H +
Sbjct: 64  NKVMFKIAQ--TAKAKQAITKFKVINQNE--KAALISLELLTGRTHQIRVHLKFIQHPV 118
>ref|NP_635620.1| (NC_003902) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
 gb|AAM39544.1| (AE012118) pseudouridylate synthase [Xanthomonas campestris pv.
           campestris str. ATCC 33913]
          Length = 245

 Score = 54.3 bits (129), Expect = 2e-06
 Identities = 59/231 (25%), Positives = 93/231 (39%), Gaps = 30/231 (12%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHES--LLDCIQSHFGKNAHPAHRLDYETSGLVLA 128
           ++++     V DKP  +  H       E   L D ++   G+     HRLD  TSG +L 
Sbjct: 10  ILYQDAVLAVVDKPAGLMVHDSKLARGEDDFLADRLRVQLGRPIFLVHRLDRATSGCLLL 69

Query: 129 GKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPL 188
                +   L    M  +V+K YLA+  G   +   I         +  DL       P+
Sbjct: 70  AFDRDTASALGKALMAGEVEKDYLAICRGWPAEERFI---------VDHDLD-GGPGKPI 119

Query: 189 GKQSITLVEPLSYNPFLDI----------SLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
            K ++T  + L+    L+I          +LL+  P TGR  QIR HL  + H ++G+  
Sbjct: 120 KKPAVTHFQRLATGE-LEIPSTGFATSRYALLRCQPQTGRFRQIRRHLKHLSHHMIGDTS 178

Query: 239 YGVADENAREYLQLKRENNAPLLMLHAASLEFEF--KGAIYKIASPMPERF 287
           +G    N R +  L        ++LHA  L F     G    + +P+   F
Sbjct: 179 HGDGRHN-RSFRML----GIHRMLLHAERLGFPHPADGRRISVVAPLDVEF 224
>ref|XP_134644.1| (XM_134644) RIKEN cDNA 2410001E19 [Mus musculus]
 dbj|BAB26852.1| (AK010322) data source:SPTR, source key:Q9HZM9,
           evidence:ISS~putative~related to RIBOSOMAL LARGE SUBUNIT
           PSEUDOURIDINE SYNTHASE C [Mus musculus]
          Length = 377

 Score = 53.1 bits (126), Expect = 4e-06
 Identities = 61/259 (23%), Positives = 111/259 (42%), Gaps = 46/259 (17%)

Query: 26  CSLKEAQRHLDKQRL-------KQNQQAV-----------RKSQIIQGVVRLIHFKPN-- 65
           CS   + R L+ QRL       KQ Q+A            R  ++++   +L    PN  
Sbjct: 32  CSSATSSRPLNAQRLAEKLRAQKQEQKAKEVRVPTNPVQRRVQELVRFTQQLQRVHPNVL 91

Query: 66  --EKTQALVFETKDFGVFDKPHQVYTH--PKGYFYHESLLDCI----QSHFGKNAHPAHR 117
             E ++ ++ +  D  V +KP+ +  H  P        +L  +      H  +  H  HR
Sbjct: 92  AKELSRRILHQDNDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHR 151

Query: 118 LDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLAL-------AHGLVEKSMKIDKPIL 170
           LD ET+G+++          ++ LF  ++V+K Y A+       + G+V+  +K +K + 
Sbjct: 152 LDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIK-EKEVQ 210

Query: 171 TPQNIQK---------DLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQ 221
            PQ   K         D     K+       + + +    +     +L+++ P+TG  HQ
Sbjct: 211 GPQQHHKMTLSPSYRLDNGKMVKVRASRDAHVAVTQYQVLSSASSSALVELQPVTGIKHQ 270

Query: 222 IRLHLS-SVDHRIVGEGLY 239
           +R+HLS  +D  I+G+  Y
Sbjct: 271 LRVHLSFGLDCPILGDHKY 289
>ref|NP_439586.1| (NC_000907) conserved hypothetical protein [Haemophilus influenzae
           Rd]
 pir||I64029 hypothetical protein HI1435 - Haemophilus influenzae (strain Rd
           KW20)
 gb|AAC23084.1| (U32822) conserved hypothetical protein [Haemophilus influenzae Rd]
          Length = 182

 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 40/144 (27%), Positives = 67/144 (45%), Gaps = 16/144 (11%)

Query: 91  PKGYFYHESLLDCIQSHF---------GKNAHPAHRLDYETSGLVLAGKTLQSVKDLKAL 141
           P G   H S LD  ++ F         G++  P HRLD  TSG++L   + +    +   
Sbjct: 17  PAGMLVHRSWLDPHETQFVMQTLRDQIGQHVFPIHRLDRPTSGVLLFALSSEIANLMCEQ 76

Query: 142 FMQKKVKKTYLALAHGLVEKSMKIDKPI------LTPQNIQKDLHIRSKISPL-GKQSIT 194
           F QK V+K+YLA+  G ++   +ID P+      +  +  Q+D   +  I+   G + + 
Sbjct: 77  FEQKYVQKSYLAVVRGYLQGKERIDYPLKIQLDKIADKFSQEDKEPQEAITDYEGLKIVE 136

Query: 195 LVEPLSYNPFLDISLLKITPLTGR 218
           +  P         SL+K+ P TG+
Sbjct: 137 MPYPAGRYQTARYSLVKLIPHTGQ 160
>ref|NP_212949.1| (NC_001318) conserved hypothetical protein [Borrelia burgdorferi]
 pir||F70201 conserved hypothetical protein BB0815 - Lyme disease spirochete
 gb|AAC67167.1| (AE001180) conserved hypothetical protein [Borrelia burgdorferi]
          Length = 297

 Score = 51.6 bits (122), Expect = 1e-05
 Identities = 40/176 (22%), Positives = 73/176 (40%), Gaps = 15/176 (8%)

Query: 71  LVFETKDFGVFDKPHQVYTH----PKGYFYHESLLDCIQSHFGKNAHPAHRLDYETSGLV 126
           +++E  D  V DK   +  H       +  +  LL              HRLD  TSG++
Sbjct: 94  IIYEDSDLLVLDKQKGILVHGGKNSLDFLVNSYLLSQNLRSLSFKPSAVHRLDRNTSGII 153

Query: 127 LAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKIS 186
           +  K + + + L   F    + K Y A+  G      ++  P++   ++ ++  +R    
Sbjct: 154 IFAKNINTARKLSEAFSGGSIIKKYFAILLG------EVKSPVVYKNHLFRNKRLRKTFV 207

Query: 187 PLGKQSITLVEPLSYNPFLD---ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
              K  +  +  +  NP L     +L++I   TG THQIR   S  +H ++ +  Y
Sbjct: 208 LEDKNFVNAITKV--NPILSCKRATLVEIVIETGFTHQIRSQCSFNNHPLINDKKY 261
>ref|NP_266520.1| (NC_002662) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
 gb|AAK04462.1|AE006273_8 (AE006273) pseudouridine synthase [Lactococcus lactis subsp.
           lactis]
          Length = 293

 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 49/184 (26%), Positives = 84/184 (45%), Gaps = 11/184 (5%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYT-----HPKGYFYHESLLDCIQSHFG-KNAHPAHR 117
           P++    ++FE   + V +KP    +     HP G   +       Q ++  +  H   R
Sbjct: 72  PDDFPLNVLFEDDHYLVVEKPAGKPSITGSLHPTGAMSNAVKGYISQKNYANQTVHIITR 131

Query: 118 LDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGL-VEKSMKIDKPILTPQNIQ 176
           LD +TSGL+   K   +   +     +  ++K Y A+ +   +  S +ID PI      +
Sbjct: 132 LDRDTSGLMFLAKHRYAHALMNQHKFRDTMEKRYFAIVNDQDLPDSGRIDLPI----GRR 187

Query: 177 KDLHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGE 236
            D  I+ ++    K    L   +      D++LL I   TGRTHQIR+H S + + ++G+
Sbjct: 188 DDSIIQRQVRFDEKAKDALTSYVVAERKNDLALLDIILHTGRTHQIRVHFSHLGYPLIGD 247

Query: 237 GLYG 240
            LYG
Sbjct: 248 DLYG 251
>dbj|BAB26589.1| (AK009926) data source:SPTR, source key:Q9UJJ7,
           evidence:ISS~homolog to C321D2.1 (RIBOSOMAL LARGE
           SUBUNIT PSEUDOURIDINE SYNTHASE (EC 4.2.1.70,
           PSEUDOURIDYLATE SYNTHASE, URACIL HYDROLASE) LIKE
           PROTEIN)~putative [Mus musculus]
          Length = 177

 Score = 50.1 bits (118), Expect = 3e-05
 Identities = 29/85 (34%), Positives = 48/85 (56%), Gaps = 11/85 (12%)

Query: 207 ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAA 266
           +S + + PLTGRTHQ+R+H S++ H IVG+  YG A++         +E+    +MLHA 
Sbjct: 32  VSKVLLKPLTGRTHQLRVHCSALGHPIVGDLTYGQAED---------QEDQPFRMMLHAF 82

Query: 267 SLEFEFKGAIYKIASPMPERFMPFL 291
            L    +    ++ +  P+ F+P L
Sbjct: 83  YLRIPTQAE--RVEACTPDPFLPAL 105
>ref|NP_218593.1| (NC_000919) conserved hypothetical protein [Treponema pallidum]
 pir||H71358 conserved hypothetical protein TP0154 - syphilis spirochete
 gb|AAC65144.1| (AE001200) conserved hypothetical protein [Treponema pallidum]
          Length = 345

 Score = 48.9 bits (115), Expect = 7e-05
 Identities = 51/191 (26%), Positives = 83/191 (42%), Gaps = 40/191 (20%)

Query: 70  ALVFETKDFGVFDKPHQVYTH-PKGYFYHESLLDCIQSHFGKNAH----------PAHRL 118
           ++VF+T+D   F KP  +  H P+        LD      G+ AH          P HRL
Sbjct: 106 SVVFKTQDLLFFHKPAGLCVHGPRS-------LDAWVRGQGR-AHVPPALSFRPGPLHRL 157

Query: 119 DYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTPQNIQKD 178
           D  T GL+   ++L+  +   A   Q  ++K YLA                +T    +  
Sbjct: 158 DRGTEGLIAFSRSLRGAQWFSAALQQHTLRKFYLA----------------ITAAPARTA 201

Query: 179 LHIRSKISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGL 238
              R+ + P     +T V+ + ++    + L  I P+TG+ HQIR + ++    +VG+  
Sbjct: 202 AAARTLVRP---GEVTHVQTVLHSCDSALVLRVIVPVTGKKHQIRRYCAAQGFPLVGDRT 258

Query: 239 YGVADE--NAR 247
           YG A +  NAR
Sbjct: 259 YGGASQHGNAR 269
>pir||S26602 hypothetical protein 185 - Pseudomonas aeruginosa
 emb|CAA78140.1| (Z12154) putative protein  of unknown function [Pseudomonas
           aeruginosa]
          Length = 185

 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 30/101 (29%), Positives = 49/101 (47%), Gaps = 5/101 (4%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGKNAHP-----AHRLDYETSGL 125
           +V+E +   V DKP  +  HP       +LL+ +  H    A+       HRLD +T+GL
Sbjct: 85  IVYEDEHILVIDKPAGLVVHPAAGHQDGTLLNALLYHVPDIANVPRAGIVHRLDKDTTGL 144

Query: 126 VLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKID 166
           ++  KTL++   L A    + V + Y A+  G++     ID
Sbjct: 145 MVVAKTLEAHTKLVAQLQARSVSRIYEAIVIGVITSGGTID 185
>gb|AAB07777.1| (U67934) 44.9 kDa protein C18B11 homolog [Homo sapiens]
          Length = 189

 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 24/55 (43%), Positives = 35/55 (63%), Gaps = 2/55 (3%)

Query: 185 ISPLGKQSITLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLY 239
           + P GK   T+ + LSYN     S+++  PLTGRTHQIR+HL  + H I+ + +Y
Sbjct: 4   VDPRGKPCETVFQRLSYNG--QSSVVRCRPLTGRTHQIRVHLQFLGHPILNDPIY 56
>gb|AAH12951.1|AAH12951 (BC012951) Unknown (protein for IMAGE:3853655) [Homo sapiens]
          Length = 194

 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 29/85 (34%), Positives = 44/85 (51%), Gaps = 11/85 (12%)

Query: 207 ISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNAPLLMLHAA 266
           +S + + PLTGRTHQ+R+H S++ H +VG+  YG             RE+    +MLHA 
Sbjct: 43  VSKVLLKPLTGRTHQLRVHCSALGHPVVGDLTYGEVS---------GREDRPFRMMLHAF 93

Query: 267 SLEFEFKGAIYKIASPMPERFMPFL 291
            L         ++ +P P  F+P L
Sbjct: 94  YLRIPTDTECVEVCTPDP--FLPSL 116
>ref|NP_188575.1| (NM_112831) unknown protein [Arabidopsis thaliana]
 dbj|BAB02469.1| (AB025624) contains similarity to unknown
           protein~gb|AAC83020.1~gene_id:MLD14.18 [Arabidopsis
           thaliana]
          Length = 477

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 46/180 (25%), Positives = 77/180 (42%), Gaps = 22/180 (12%)

Query: 98  ESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGKTLQSVKDLKALFMQK------------ 145
           E    C++    ++    HRLD + SGL++  +T  +   L ++F +K            
Sbjct: 215 ELAASCLKFDKSESPRLVHRLDRDCSGLLVLARTQTAATVLHSIFREKTTGASAYGVKKN 274

Query: 146 --KVKKTYLALAHGLVEKSMKIDKPILTPQNIQKDLHIRSKISPLGK-----QSITLVEP 198
              +K+ Y+AL  G   +        L    +      R  ++  G+      +IT    
Sbjct: 275 VKSLKRKYMALVIGCPPRQRGQISAPLRKVVVDDGKSERITVNDNGELVSTQHAITEYRV 334

Query: 199 LSYNPFLDISLLKITPLTGRTHQIRLHLSSV-DHRIVGEGLYGVADENAREYLQLKRENN 257
           +  +P    + L++ PLTGR HQ+R+H + V    IVG+  YG     ARE   +  ENN
Sbjct: 335 IESSPH-GYTWLELRPLTGRKHQLRVHCAEVLGTPIVGDYKYGWQAHKAREPF-VSSENN 392
>gb|AAM33173.1| (AC117072) hypothetical protein [Dictyostelium discoideum]
          Length = 316

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 34/111 (30%), Positives = 55/111 (48%), Gaps = 6/111 (5%)

Query: 64  PNEKTQALVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQS----HFGKNAHPAHRLD 119
           P +     ++  K++ V +KP  V    +      +++  I++    HFG N    +R+D
Sbjct: 16  PTDPKYETIYLDKEYIVVNKPFDVNIDDETGERLTTVVKYIETEYPEHFG-NVRFVNRID 74

Query: 120 YETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVE-KSMKIDKPI 169
           Y TSGLV+     +S      LF  ++  +TYLA+ HG +E     IDKPI
Sbjct: 75  YATSGLVVVSFNKKSTTVAMELFQCRETSETYLAIVHGHMEFDESIIDKPI 125
 Score = 44.3 bits (103), Expect = 0.002
 Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 12/75 (16%)

Query: 199 LSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRENNA 258
           ++ + ++ I+ + + P TGR HQ+R+HL S+ H IVG+  YG  D               
Sbjct: 227 INNDEYIPITKVMLFPKTGRRHQLRVHLLSIGHVIVGDETYGPKDSTIHR---------- 276

Query: 259 PLLMLHAASLEFEFK 273
             +MLH+  L   FK
Sbjct: 277 --MMLHSWKLILPFK 289
>gb|AAB09035.1| (U68242) orfEU5; uncharacterized orf upstream of txpA similar to H.
           influenzae HI0412 [Bartonella bacilliformis]
          Length = 221

 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 18/144 (12%)

Query: 28  LKEAQRHLDKQRLKQNQQAVRKSQIIQGVVRLIHFKPNEKTQALVFETKDFGVFDKPHQV 87
           L+  Q  +D  R+K N + V   Q I+     I  K N    + V   +D G   K   +
Sbjct: 70  LRSGQVRVDGGRVKANMRLVT-GQSIRVPSFFIESKRNISITSKVISQQDDGDLLKKMLL 128

Query: 88  YTHPKGYFYH-----------------ESLLDCIQSHFGKNAHPAHRLDYETSGLVLAGK 130
           Y  PK + ++                 + +L+  ++  G+     HRLD ETSGL++  +
Sbjct: 129 YEDPKIFVFNKPAGLAVQGGSGLTRHVDGMLEAWRNKKGEKPRLVHRLDRETSGLLVVAR 188

Query: 131 TLQSVKDLKALFMQKKVKKTYLAL 154
           +  + + L A F  +++KK Y AL
Sbjct: 189 SXXAAQALTAAFRTREMKKIYWAL 212
>gb|AAA03374.1| (U02220) unknown [Mycoplasma genitalium]
          Length = 119

 Score = 45.8 bits (107), Expect = 6e-04
 Identities = 29/97 (29%), Positives = 47/97 (47%), Gaps = 10/97 (10%)

Query: 71  LVFETKDFGVFDKPHQVYTHPKGYFYHESLLDCIQSHFGK--------NAHP--AHRLDY 120
           ++FE ++  V DKP  +   P       +L + +  H G         N +P  AHR+D 
Sbjct: 10  IIFEDENIIVVDKPTGIVCQPDKKHSIINLSNMLLKHCGYRQFDSNKLNFYPQFAHRIDR 69

Query: 121 ETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHG 157
            TSG+V+  KT +++K+L  +F    + K Y  L  G
Sbjct: 70  NTSGIVIGAKTNKALKELNKVFKNNHLTKRYKGLVFG 106
>ref|NP_224603.1| (NC_000922) predicted pseudouridine synthetase family
           [Chlamydophila pneumoniae CWL029]
 ref|NP_300460.1| (NC_002491) pseudouridine synthetase family [Chlamydophila
           pneumoniae J138]
 pir||B72082 probable pseudouridine synthetase family - Chlamydophila pneumoniae
           (strain CWL029)
 gb|AAD18547.1| (AE001624) predicted pseudouridine synthetase family [Chlamydophila
           pneumoniae CWL029]
 dbj|BAA98611.1| (AP002546) pseudouridine synthetase family [Chlamydophila
           pneumoniae J138]
          Length = 232

 Score = 45.1 bits (105), Expect = 0.001
 Identities = 23/57 (40%), Positives = 31/57 (54%)

Query: 116 HRLDYETSGLVLAGKTLQSVKDLKALFMQKKVKKTYLALAHGLVEKSMKIDKPILTP 172
           HRLD  TSG +L GK+ Q+  +L  LF Q+K+ K Y+A   G  +K     K    P
Sbjct: 118 HRLDKGTSGCLLMGKSKQAATELMKLFKQRKIHKQYIAFVFGHPKKKFGTVKSYTAP 174
>gb|AAG24942.1|AF128845_1 (AF128845) RluD [Sinorhizobium meliloti]
          Length = 163

 Score = 43.9 bits (102), Expect = 0.002
 Identities = 26/74 (35%), Positives = 36/74 (48%), Gaps = 5/74 (6%)

Query: 216 TGRTHQIRLHLSSVDHRIVGEGLYGVADENAREYLQLKRE---NNAPLLMLHAASLEFEF 272
           TGRTHQIR+H++ + H ++G+  YG A       L        N  P   LHA  L+FE 
Sbjct: 75  TGRTHQIRVHMAHIGHPLIGDPDYGAAFRTKANLLPEPARAAVNRFPRQALHAFMLQFEH 134

Query: 273 --KGAIYKIASPMP 284
              G      +P+P
Sbjct: 135 PATGETMHFETPVP 148
>emb|CAC00347.2| (AL160371) possible hypothetical 46.8 Kd protein in clc1-pds2
           intergenic region [Leishmania major]
          Length = 1067

 Score = 42.0 bits (97), Expect = 0.008
 Identities = 20/54 (37%), Positives = 34/54 (62%)

Query: 194 TLVEPLSYNPFLDISLLKITPLTGRTHQIRLHLSSVDHRIVGEGLYGVADENAR 247
           T ++ + Y+   D +++K T  TGRTHQ+R+HL+S+ H IV +  Y   + + R
Sbjct: 903 TALQVMHYDAATDQTVVKCTLGTGRTHQLRVHLASLGHPIVHDSKYIALEAHMR 956
  Database: /home/scwang/download_20020708_db/nr
    Posted date:  Aug 7, 2002 12:55 PM
  Number of letters in database: 324,149,939
  Number of sequences in database:  1,026,957
  
Lambda     K      H
   0.322    0.139    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 184,957,637
Number of Sequences: 1026957
Number of extensions: 7562663
Number of successful extensions: 17257
Number of sequences better than 1.0e-02: 225
Number of HSP's better than  0.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 16844
Number of HSP's gapped (non-prelim): 231
length of query: 298
length of database: 324,149,939
effective HSP length: 120
effective length of query: 178
effective length of database: 200,915,099
effective search space: 35762887622
effective search space used: 35762887622
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 97 (42.0 bits)