BLASTP 2.2.1 [Apr-13-2001]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15645361|ref|NP_207535.1| conserved hypothetical
protein [Helicobacter pylori 26695]
(161 letters)
Database: /home/scwang/download_20020708_db/nr
1,026,957 sequences; 324,149,939 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
ref|NP_207535.1| (NC_000915) conserved hypothetical protein... 335 1e-91
ref|NP_223396.1| (NC_000921) HIT FAMILY PROTEIN [Helicobact... 322 1e-87
ref|NP_281686.1| (NC_002163) HIT-like protein [Campylobacte... 139 1e-32
ref|NP_376157.1| (NC_003106) 171aa long hypothetical bis(5'... 139 1e-32
ref|NP_577737.1| (NC_003413) hit family protein (hit) [Pyro... 137 3e-32
ref|NP_142074.1| (NC_000961) hypothetical protein [Pyrococc... 137 3e-32
ref|NP_125757.1| (NC_000868) HIT FAMILY PROTEIN (HIT) [Pyro... 137 4e-32
ref|NP_214481.1| (NC_000918) putative protein [Aquifex aeol... 137 4e-32
ref|NP_146980.1| (NC_000854) hit-like protein [Aeropyrum pe... 128 2e-29
ref|NP_341798.1| (NC_002754) HIT-like protein, hypothetical... 128 2e-29
ref|NP_661655.1| (NC_002932) Hit family protein [Chlorobium... 122 2e-27
ref|NP_071036.1| (NC_000917) HIT family protein (hit) [Arch... 118 2e-26
ref|NP_625809.1| (NC_003888) conserved hypothetical protein... 113 9e-25
ref|NP_280585.1| (NC_002607) histidine triad protein; Hit2 ... 103 7e-22
ref|NP_560819.1| (NC_003364) HIT family protein [Pyrobaculu... 102 2e-21
gb|AAG17335.1|AF265558_2 (AF265558) unknown [Mycobacterium ... 99 2e-20
ref|NP_217129.1| (NC_000962) hypothetical protein Rv2613c [... 95 3e-19
dbj|BAB99063.1| (AP005279) Diadenosine tetraphosphate (Ap4A... 92 2e-18
emb|CAB09619.1| (Z96801) hypothetical protein MLCL581.17c [... 91 6e-18
ref|NP_301409.1| (NC_002677) conserved hypothetical protein... 91 6e-18
ref|NP_600882.1| (NC_003450) COG0537:Diadenosine tetraphosp... 85 3e-16
ref|NP_142915.1| (NC_000961) hypothetical protein [Pyrococc... 68 3e-11
ref|NP_578836.1| (NC_003413) hit family protein (hit) [Pyro... 68 3e-11
ref|NP_126658.1| (NC_000868) HIT-LIKE PROTEIN [Pyrococcus a... 66 2e-10
ref|NP_280841.1| (NC_002607) histidine triad protein; Hit1 ... 61 5e-09
ref|NP_486506.1| (NC_003272) hypothetical protein [Nostoc s... 61 5e-09
ref|NP_394598.1| (NC_002578) histidine triad (HIT) related ... 60 7e-09
pir||B64408 histidine triad (HIT) protein MJ0866 - Methanoc... 60 9e-09
ref|NP_247861.1| (NC_000909) HIT family protein (hit) [Meth... 59 1e-08
ref|NP_615770.1| (NC_003552) histidine triad protein [Metha... 59 3e-08
ref|NP_377432.1| (NC_003106) 141aa long hypothetical histid... 58 3e-08
ref|NP_633982.1| (NC_003901) Hit-like protein [Methanosarci... 57 6e-08
ref|NP_560536.1| (NC_003364) HIT family protein [Pyrobaculu... 57 6e-08
ref|NP_249997.1| (NC_002516) probable HIT family protein [P... 57 1e-07
ref|NP_148648.1| (NC_000854) histidine triad (HIT) protein ... 55 4e-07
ref|NP_109961.1| (NC_000912) nucleotidyl hydrolases/transfe... 54 8e-07
ref|NP_111736.1| (NC_002689) HIT (histidine triad) family p... 53 1e-06
dbj|BAB60383.1| (AP000995) histidine triad protein [HIT] [T... 53 1e-06
ref|NP_378146.1| (NC_003106) 150aa long hypothetical histid... 52 2e-06
ref|NP_269754.1| (NC_002737) putative cell-cycle regulation... 52 3e-06
ref|NP_242055.1| (NC_002570) Hit-like protein involved in c... 51 4e-06
gb|AAK96091.1|AF393466_28 (AF393466) HIT superfamily hydrol... 50 9e-06
ref|NP_345039.1| (NC_003028) HIT family protein [Streptococ... 50 1e-05
ref|NP_471651.1| (NC_003212) similar to histidine triad (HI... 49 2e-05
ref|NP_072794.1| (NC_000908) hit protein, putative [Mycopla... 49 2e-05
ref|NP_212513.1| (NC_001318) protein kinase C1 inhibitor (p... 49 2e-05
sp|P94252|YHIT_BORBU Hypothetical HIT-like protein BB0379 >... 49 2e-05
ref|NP_465740.1| (NC_003210) similar to histidine triad (HI... 49 2e-05
ref|NP_343549.1| (NC_002754) Histidine triad (Hit) family p... 49 3e-05
ref|NP_348235.1| (NC_003030) HIT family hydrolase [Clostrid... 48 3e-05
ref|NP_325839.1| (NC_002771) HIT-LIKE PROTEIN (CELL CYCLE R... 47 6e-05
ref|NP_010591.1| (NC_001136) Fhit homolog, member of the hi... 45 2e-04
ref|NP_078106.1| (NC_002162) probable HIT protein [Ureaplas... 45 3e-04
ref|NP_268155.1| (NC_002662) HYPOTHETICAL PROTEIN [Lactococ... 45 4e-04
ref|NP_372362.1| (NC_002758) Hit-like protein involved in c... 44 5e-04
ref|NP_273646.1| (NC_003112) hitA protein [Neisseria mening... 44 5e-04
ref|NP_597168.1| (NC_003235) HIT FAMILY PROTEIN [Encephalit... 44 6e-04
ref|NP_102422.1| (NC_002678) probable Hit-like protein invo... 44 6e-04
ref|NP_388884.1| (NC_000964) Hit-like protein [Bacillus sub... 44 8e-04
ref|NP_213096.1| (NC_000918) protein kinase C inhibitor (HI... 43 0.001
ref|NP_588328.1| (NC_003421) hypothetical HIT-family protei... 42 0.002
ref|NP_283602.1| (NC_003116) putative nucleotide-binding pr... 42 0.002
ref|NP_394795.1| (NC_002578) cell-cycle regulation histidin... 42 0.002
ref|NP_654589.1| (NC_003995) HIT, HIT family [Bacillus anth... 42 0.002
ref|NP_587836.1| (NC_003421) diadenosine tetraphosphatase [... 42 0.003
emb|CAB95210.1| (AL359773) probable hypothetical hit-family... 41 0.005
sp|O07817|HITA_NEIGO HITA PROTEIN >gi|2197079|gb|AAB61288.1... 41 0.005
gb|AAL92398.1| (AC115611) FRAGILE HISTIDINE TRIAD PROTEIN [... 40 0.007
>ref|NP_207535.1| (NC_000915) conserved hypothetical protein [Helicobacter pylori
26695]
pir||E64612 conserved hypothetical protein HP0741 - Helicobacter pylori
(strain 26695)
gb|AAD07787.1| (AE000586) conserved hypothetical protein [Helicobacter pylori
26695]
Length = 161
Score = 335 bits (858), Expect = 1e-91
Identities = 161/161 (100%), Positives = 161/161 (100%)
Query: 1 MQHLYAPWRESYLKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLI 60
MQHLYAPWRESYLKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLI
Sbjct: 1 MQHLYAPWRESYLKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLI 60
Query: 61 IPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH 120
IPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
Sbjct: 61 IPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH 120
Query: 121 LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG 161
LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG
Sbjct: 121 LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG 161
>ref|NP_223396.1| (NC_000921) HIT FAMILY PROTEIN [Helicobacter pylori J99]
pir||D71903 hit family protein - Helicobacter pylori (strain J99)
gb|AAD06245.1| (AE001499) HIT FAMILY PROTEIN [Helicobacter pylori J99]
Length = 161
Score = 322 bits (824), Expect = 1e-87
Identities = 153/161 (95%), Positives = 156/161 (96%)
Query: 1 MQHLYAPWRESYLKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLI 60
MQHLYAPWRESYLK KNKSCVFC ISQNP KDSENRVLYRNSDLFVVMNAYPYNPGHLLI
Sbjct: 1 MQHLYAPWRESYLKEKNKSCVFCGISQNPTKDSENRVLYRNSDLFVVMNAYPYNPGHLLI 60
Query: 61 IPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH 120
+PH HQASVELLDLNTWLNMNALAPK+LKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH
Sbjct: 61 VPHAHQASVELLDLNTWLNMNALAPKILKALYAYGAQGINLGLNLHRNAGAGIPEHLHMH 120
Query: 121 LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKELG 161
LVPRFLGDSNF+SVIAQTRVCGMDLNETYL LKNLLEKELG
Sbjct: 121 LVPRFLGDSNFISVIAQTRVCGMDLNETYLALKNLLEKELG 161
>ref|NP_281686.1| (NC_002163) HIT-like protein [Campylobacter jejuni]
pir||F81395 HIT-like protein Cj0499 [imported] - Campylobacter jejuni (strain
NCTC 11168)
emb|CAB75137.1| (AL139075) HIT-like protein [Campylobacter jejuni]
Length = 161
Score = 139 bits (350), Expect = 1e-32
Identities = 66/155 (42%), Positives = 94/155 (60%), Gaps = 5/155 (3%)
Query: 1 MQHLYAPWRESYLKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLI 60
MQ+LYAPWR Y + C FC+ + D E V++R F VMN YPY+ GH ++
Sbjct: 1 MQYLYAPWRSEYFEKVKSICPFCDCANKIKSDEELGVIFRAKHCFGVMNRYPYSAGHFMV 60
Query: 61 IPHVHQASVELLDLNTWLNMN---ALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHL 117
IP++H+ +E L W M+ L K+LK A G+N+G+NL ++AGAGI H
Sbjct: 61 IPYIHEEHIENLSDEIWQEMSYFVRLGVKILKE--QIHANGVNIGMNLSKDAGAGIAFHC 118
Query: 118 HMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTL 152
H HLVPR+ GD+NF++ I +TRVCG ++ + Y L
Sbjct: 119 HYHLVPRWSGDTNFITTIGETRVCGTNIEQVYQKL 153
>ref|NP_376157.1| (NC_003106) 171aa long hypothetical bis(5'-adenosyl)-triphosphatase
[Sulfolobus tokodaii]
dbj|BAB65266.1| (AP000982) 171aa long hypothetical bis(5'-adenosyl)-triphosphatase
[Sulfolobus tokodaii]
Length = 171
Score = 139 bits (349), Expect = 1e-32
Identities = 70/163 (42%), Positives = 103/163 (62%), Gaps = 6/163 (3%)
Query: 1 MQHLYAPWRESYL----KGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPG 56
M L+APWR Y+ K K+ SC+FC++ + +D N ++YR F+++NA+PYNPG
Sbjct: 1 MDILWAPWRSKYVSEASKNKSSSCLFCDVIEKK-EDKNNWIVYRGKFSFIILNAFPYNPG 59
Query: 57 HLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPE 115
HL+I+P+ H +S+E L+ L M +KA+ Y G N+G+N+ R AGAGI +
Sbjct: 60 HLMIVPYKHVSSIEGLEEKEILEMMYFLKVSMKAIRKVYSPDGFNIGINIGRVAGAGIDQ 119
Query: 116 HLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEK 158
H+H+HLVPR+ GD+NFM VI +V L +TY LK +EK
Sbjct: 120 HVHIHLVPRWNGDANFMPVIGGVKVLPEILEDTYNKLKPEIEK 162
>ref|NP_577737.1| (NC_003413) hit family protein (hit) [Pyrococcus furiosus DSM 3638]
gb|AAL80132.1| (AE010126) hit family protein (hit) [Pyrococcus furiosus DSM 3638]
Length = 164
Score = 137 bits (346), Expect = 3e-32
Identities = 69/160 (43%), Positives = 101/160 (63%), Gaps = 3/160 (1%)
Query: 1 MQHLYAPWRESYLKG-KNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLL 59
M+ L+APWR Y++ K++ C+FC+ + +D E +LYR F++MN YPYNPGH++
Sbjct: 1 MKILWAPWRIEYIRAPKHEGCIFCDFPREN-RDRERLILYRGKHAFIIMNNYPYNPGHVM 59
Query: 60 IIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLH 118
+ P+ H ASVE L L + LA ++KA+ G NLG N+ + AGAG+ H+H
Sbjct: 60 VAPYRHVASVEDLTDEEMLEIMKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVH 119
Query: 119 MHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEK 158
+H+VPR+ GD+NFM VIA T+V L + Y LK LE+
Sbjct: 120 LHIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEE 159
>ref|NP_142074.1| (NC_000961) hypothetical protein [Pyrococcus horikoshii]
pir||F71224 hypothetical protein PH0057 - Pyrococcus horikoshii
dbj|BAA29125.1| (AP000001) 168aa long hypothetical protein [Pyrococcus horikoshii]
Length = 168
Score = 137 bits (346), Expect = 3e-32
Identities = 68/160 (42%), Positives = 101/160 (62%), Gaps = 3/160 (1%)
Query: 1 MQHLYAPWRESYLKG-KNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLL 59
M+ L+APWR Y++ K++ C+FC+ + +D E +LYR F++MN YPYNPGH++
Sbjct: 1 MKVLWAPWRIEYIRSPKHEGCIFCDFPKEN-RDKERLILYRGKHAFIIMNNYPYNPGHVM 59
Query: 60 IIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLH 118
+ P+ H AS+E L L + LA ++KA+ G NLG N+ + AGAG+ H+H
Sbjct: 60 VAPYRHVASIEDLTDEEMLEIMKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVH 119
Query: 119 MHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEK 158
+H+VPR+ GD+NFM VIA T+V L + Y LK LE+
Sbjct: 120 LHIVPRWNGDTNFMPVIADTKVIPESLEQAYEELKKALEE 159
>ref|NP_125757.1| (NC_000868) HIT FAMILY PROTEIN (HIT) [Pyrococcus abyssi]
pir||E75192 hit family protein (hit). PAB2301 - Pyrococcus abyssi (strain
Orsay)
emb|CAB48988.1| (AJ248283) HIT FAMILY PROTEIN (HIT). [Pyrococcus abyssi]
Length = 185
Score = 137 bits (345), Expect = 4e-32
Identities = 68/160 (42%), Positives = 101/160 (62%), Gaps = 3/160 (1%)
Query: 1 MQHLYAPWRESYLKG-KNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLL 59
M+ L+APWR Y++ K++ C+FC+ + +D E +LYR F++MN YPYNPGH++
Sbjct: 18 MKILWAPWRIEYIRAPKHEGCIFCDFPKEN-RDRERLILYRGKHAFIIMNNYPYNPGHVM 76
Query: 60 IIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLH 118
+ P+ H AS+E L L + LA ++KA+ G NLG N+ + AGAG+ H+H
Sbjct: 77 VAPYRHVASIEDLTEEEMLEIMKLAALIMKAIRKVMKPDGFNLGFNIGKVAGAGVDGHVH 136
Query: 119 MHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEK 158
+H+VPR+ GD+NFM VIA T+V L + Y LK LE+
Sbjct: 137 LHIVPRWNGDTNFMPVIADTKVIPESLEQAYDELKKALEE 176
>ref|NP_214481.1| (NC_000918) putative protein [Aquifex aeolicus]
pir||D70485 hypothetical protein aq_2159 - Aquifex aeolicus
gb|AAC07886.1| (AE000776) putative protein [Aquifex aeolicus]
Length = 191
Score = 137 bits (345), Expect = 4e-32
Identities = 72/164 (43%), Positives = 103/164 (61%), Gaps = 4/164 (2%)
Query: 1 MQHLYAPWRESYLKGKNK--SCVFCE-ISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGH 57
M+ L+APWR +Y++ +K C C +SQ P K E ++Y+ + F+++N YPYN GH
Sbjct: 24 MKILWAPWRRAYVENVDKIEGCFLCHALSQPPEKWKEVLLVYKGKNAFIILNKYPYNTGH 83
Query: 58 LLIIPHVHQASVELLDLNTWLNMNALAPKVLKALYA-YGAQGINLGLNLHRNAGAGIPEH 116
L+I+P H + E +D T L M+ L LKAL Y G N+G N R AGAG+ EH
Sbjct: 84 LMIVPVKHIGNYEEVDEETALEMHKLLQVSLKALKKEYKPHGFNVGYNFGRPAGAGLEEH 143
Query: 117 LHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKEL 160
+H+H+VPR+ GD+NFM V+AQT+V DL TY +K +E+ L
Sbjct: 144 IHLHVVPRWNGDTNFMPVLAQTKVISEDLYSTYDRVKKAIEEVL 187
>ref|NP_146980.1| (NC_000854) hit-like protein [Aeropyrum pernix]
pir||G72766 probable hit-like protein APE0122 - Aeropyrum pernix (strain K1)
dbj|BAA79033.1| (AP000058) 184aa long hypothetical hit-like protein [Aeropyrum
pernix]
Length = 184
Score = 128 bits (322), Expect = 2e-29
Identities = 65/159 (40%), Positives = 98/159 (60%), Gaps = 4/159 (2%)
Query: 4 LYAPWRESYLK--GKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLII 61
L+APWR Y+K G + CVFCE + + D++ ++YR S +V++N YPYN GH+++
Sbjct: 21 LWAPWRMKYIKQAGSREGCVFCE-APSMGDDAKALIVYRGSLSYVILNKYPYNSGHIMVT 79
Query: 62 PHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLHMH 120
P+ H A +E L ++ + M L +KAL Y G N+G+N+ AGAGI H H+H
Sbjct: 80 PYRHVAELEDLTMDEIVEMAKLVRASVKALKRVYAPHGFNIGVNIGEAAGAGIAGHFHIH 139
Query: 121 LVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEKE 159
+VPR+ GDSNFM + T+V L +T+ LK +E+E
Sbjct: 140 IVPRWRGDSNFMLTVGGTKVIPESLEDTFKKLKPAVEEE 178
>ref|NP_341798.1| (NC_002754) HIT-like protein, hypothetical (hit) [Sulfolobus
solfataricus]
gb|AAK40588.1| (AE006661) HIT-like protein, hypothetical (hit) [Sulfolobus
solfataricus]
Length = 171
Score = 128 bits (322), Expect = 2e-29
Identities = 63/157 (40%), Positives = 98/157 (62%), Gaps = 6/157 (3%)
Query: 1 MQHLYAPWRESYL----KGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPG 56
M L+APWR Y+ K K C+FC + + D +N ++YR F+++NA+PYN
Sbjct: 1 MDILWAPWRAKYISETSKVKQDECLFCRVIKEE-NDEQNYIVYRGKHAFIILNAFPYNTA 59
Query: 57 HLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPE 115
H++++P+ H SVELL + L++ L+ ++A+ Y G N+G+N+ R AGAGI
Sbjct: 60 HVMVVPYRHVPSVELLSNDEALDIFTLSTIAIRAIRDIYAPDGFNIGVNIGRVAGAGIES 119
Query: 116 HLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTL 152
H+H+H+VPR+ GDSNFM VI T+V L++T+ L
Sbjct: 120 HIHVHIVPRWNGDSNFMPVIFNTKVMPETLSDTFKKL 156
>ref|NP_661655.1| (NC_002932) Hit family protein [Chlorobium tepidum TLS]
gb|AAM71997.1| (AE012845) Hit family protein [Chlorobium tepidum TLS]
Length = 174
Score = 122 bits (305), Expect = 2e-27
Identities = 67/170 (39%), Positives = 95/170 (55%), Gaps = 16/170 (9%)
Query: 1 MQHLYAPWRESYLKG---------KNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAY 51
MQ +Y+PWR+ Y++ + VF +I P +D E VL R F ++N Y
Sbjct: 1 MQRMYSPWRDVYMQTFKEEKPFTPEEGKSVFADIP--PEQDEERYVLCRGEFCFAILNLY 58
Query: 52 PYNPGHLLIIPHVHQASVELLDLNTWL---NMNALAPKVLKALYAYGAQGINLGLNLHRN 108
PYN GHL++IP++ LD T + NM+ L K LK QG N G NL R
Sbjct: 59 PYNCGHLMVIPYLQTPDFGDLDAQTMVEIFNMSNLCMKALKMTIK--PQGFNFGANLGRV 116
Query: 109 AGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETYLTLKNLLEK 158
AG I EH+H H+VPR+ GD+NFM V+ +T+V DL +TY+ L+ ++K
Sbjct: 117 AGGSIDEHIHFHIVPRWEGDTNFMPVLGETKVLSNDLRQTYIQLREAIKK 166
>ref|NP_071036.1| (NC_000917) HIT family protein (hit) [Archaeoglobus fulgidus]
pir||C69526 histidine triad protein AF2211 - Archaeoglobus fulgidus
gb|AAB89043.1| (AE000953) HIT family protein (hit) [Archaeoglobus fulgidus]
Length = 160
Score = 118 bits (296), Expect = 2e-26
Identities = 63/151 (41%), Positives = 90/151 (58%), Gaps = 3/151 (1%)
Query: 1 MQHLYAPWRESY-LKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLL 59
M+ ++APWR Y L K K CVFC + +D EN +LYR +V+MN PYNPGH++
Sbjct: 1 MERIFAPWRIRYVLAPKPKECVFCTAPKEN-RDRENLILYRGKTCYVIMNRNPYNPGHVM 59
Query: 60 IIPHVHQASVELLDLNTWLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLH 118
+ P+ H S+E + + L LKA+ G N+G+N+ + AGAGI HLH
Sbjct: 60 VNPYRHIPSIEDMTEEEIVEAMKLVRLSLKAIREVMNPDGFNVGVNIGKVAGAGIAAHLH 119
Query: 119 MHLVPRFLGDSNFMSVIAQTRVCGMDLNETY 149
+H+VPR+ GD++FM V+A +V L ETY
Sbjct: 120 IHVVPRWNGDTSFMPVLADVQVIPEALEETY 150
>ref|NP_625809.1| (NC_003888) conserved hypothetical protein SCL2.20c [Streptomyces
coelicolor A3(2)]
emb|CAB70932.1| (AL137778) conserved hypothetical protein SCL2.20c [Streptomyces
coelicolor A3(2)]
Length = 186
Score = 113 bits (282), Expect = 9e-25
Identities = 65/157 (41%), Positives = 90/157 (56%), Gaps = 13/157 (8%)
Query: 2 QHLYAPWRESYLKGKNK--------SCVFCEISQNPAKDSENRVLYRNSD-LFVVMNAYP 52
Q L+ P R +Y++G+NK C FC I PAK E+ ++ R + ++ V+N YP
Sbjct: 18 QRLWTPHRMAYIQGENKPSGPGADDGCPFCSI---PAKSDEDGLIVRRGEHVYAVLNLYP 74
Query: 53 YNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALYAY-GAQGINLGLNLHRNAGA 111
YN GHL+I+P+ H A L+ + L + + AL A GAQG NLG+N AGA
Sbjct: 75 YNGGHLMIVPYRHVADYTELNAVETAELAELTKQAMTALRAASGAQGFNLGMNQGAVAGA 134
Query: 112 GIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
GI HLH H+VPR+ GD+NFM I T+V L +T
Sbjct: 135 GIAAHLHQHVVPRWGGDTNFMPAIGHTKVLPQLLGDT 171
>ref|NP_280585.1| (NC_002607) histidine triad protein; Hit2 [Halobacterium sp. NRC-1]
gb|AAG20065.1| (AE005086) histidine triad protein; Hit2 [Halobacterium sp. NRC-1]
Length = 181
Score = 103 bits (257), Expect = 7e-22
Identities = 62/158 (39%), Positives = 89/158 (56%), Gaps = 12/158 (7%)
Query: 1 MQHLYAPWRESYLKGKNKS-----CVFCEISQNPAKDS--ENRVLYRNSDLFVVMNAYPY 53
M+ ++APWR +++ + + CVFC P ++ ++ V+ R V++N YPY
Sbjct: 1 MEQVFAPWRIEWVERDDTTDDDVDCVFCAF---PGREHARQHLVVARTDHAAVMLNNYPY 57
Query: 54 NPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAG 112
NPGH ++IP VH LD +T L+ L L AL A G N GLNL A G
Sbjct: 58 NPGHCMVIPDVHTGDYGDLDADTLLDHARLKQATLDALDAALGPDAFNTGLNLGGGAAGG 117
Query: 113 -IPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNETY 149
I +HLH H+VPR+ GD+NFM VI+ T+V L++TY
Sbjct: 118 SIGDHLHTHVVPRWNGDTNFMPVISDTKVIVEALDDTY 155
>ref|NP_560819.1| (NC_003364) HIT family protein [Pyrobaculum aerophilum]
gb|AAL65001.1| (AE009937) HIT family protein [Pyrobaculum aerophilum]
Length = 150
Score = 102 bits (253), Expect = 2e-21
Identities = 47/126 (37%), Positives = 74/126 (58%), Gaps = 2/126 (1%)
Query: 1 MQHLYAPWRESYLKGKNKS-CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLL 59
M+ +YAPWR Y+K K C C + +D EN V YR +F ++N YPY GH++
Sbjct: 1 MRVVYAPWRYRYIKSVGKGGCFLCSAAGEAGRDDENLVPYRGRHVFAILNKYPYTWGHVM 60
Query: 60 IIPHVHQASVELLDLNTWLNMNALAPKVLKALYAY-GAQGINLGLNLHRNAGAGIPEHLH 118
+ P+ H + E + W M ALA K+ +A+ G++ +GLN+ R AGAG+ H+H
Sbjct: 61 VAPYRHISQFEEMTAEEWAEMIALAKKLAEAVSKLTGSRDFVIGLNIGRAAGAGLESHIH 120
Query: 119 MHLVPR 124
+H++P+
Sbjct: 121 LHIIPK 126
>gb|AAG17335.1|AF265558_2 (AF265558) unknown [Mycobacterium smegmatis]
Length = 205
Score = 99.0 bits (245), Expect = 2e-20
Identities = 56/160 (35%), Positives = 90/160 (56%), Gaps = 14/160 (8%)
Query: 1 MQHLYAPWRESYL-------KGKNKSC----VFCEISQNPAKDSENRVLYRNSDLFVVMN 49
+Q L+ P R SY+ +G+ S F +I + P D E ++ R ++ V+N
Sbjct: 20 LQRLWTPHRMSYIAEAPMKKRGEGGSAGSAEPFTDIPEMP--DEEGLMVARGKRVYAVLN 77
Query: 50 AYPYNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGA-QGINLGLNLHRN 108
YPYNPGHL+++P+ + +E L + + A K ++ + A G N+GLNL +
Sbjct: 78 LYPYNPGHLMVVPYRRVSELEDLTEDESSELMAFTQKAIRVIKAVSRPHGFNVGLNLGSS 137
Query: 109 AGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
AG + EHLHMH+VPR+ GD+NF+++I ++V L ET
Sbjct: 138 AGGSLAEHLHMHVVPRWGGDANFITIIGGSKVIPQLLKET 177
>ref|NP_217129.1| (NC_000962) hypothetical protein Rv2613c [Mycobacterium
tuberculosis H37Rv]
ref|NP_337190.1| (NC_002755) HIT family protein [Mycobacterium tuberculosis CDC1551]
pir||D70571 hypothetical protein Rv2613c - Mycobacterium tuberculosis (strain
H37RV)
emb|CAB08629.1| (Z95387) hypothetical protein Rv2613c [Mycobacterium tuberculosis
H37Rv]
gb|AAK47004.1| (AE007101) HIT family protein [Mycobacterium tuberculosis CDC1551]
Length = 195
Score = 94.7 bits (234), Expect = 3e-19
Identities = 57/160 (35%), Positives = 90/160 (55%), Gaps = 15/160 (9%)
Query: 1 MQHLYAPWRESYL------KGKNKSCV----FCEISQNPAKDSENRVLYRNSDLFVVMNA 50
+Q L+ P+R +YL + N S F EI Q D E V+ R ++ V+N
Sbjct: 27 LQRLWTPYRMNYLAEAPVKRDPNSSASPAQPFTEIPQ--LSDEEGLVVARGKLVYAVLNL 84
Query: 51 YPYNPGHLLIIPHVHQASVE-LLDLNTWLNMNALAPKVLKALYAYGA-QGINLGLNLHRN 108
YPYNPGHL+++P+ + +E L DL + + A K ++ + G N+GLNL +
Sbjct: 85 YPYNPGHLMVVPYRRVSELEDLTDLES-AELMAFTQKAIRVIKNVSRPHGFNVGLNLGTS 143
Query: 109 AGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
AG + EHLH+H+VPR+ GD+NF+++I ++V L +T
Sbjct: 144 AGGSLAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDT 183
>dbj|BAB99063.1| (AP005279) Diadenosine tetraphosphate (Ap4A) hydrolase and other
HIT family hydrolases [Corynebacterium glutamicum ATCC
13032]
Length = 220
Score = 92.0 bits (227), Expect = 2e-18
Identities = 48/155 (30%), Positives = 84/155 (53%), Gaps = 7/155 (4%)
Query: 1 MQHLYAPWRESYLKGKNKSCVFCEISQNP------AKDSENRVLYRNSDLFVVMNAYPYN 54
++ L+AP+R SY+ ++ ++P D + ++ R ++ V+N YPYN
Sbjct: 32 LERLWAPYRMSYINTRSGGKQSTTAKRDPFIEVPKMSDEDGLIVARGELVYCVLNLYPYN 91
Query: 55 PGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGI 113
GH+++IP + ++E L L + +KAL +N+GLNL + +G +
Sbjct: 92 AGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKALKQVSNPDAVNVGLNLGKASGGSV 151
Query: 114 PEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
+HLH+H+VPR+ GD+NFM+VI +V L +T
Sbjct: 152 GDHLHVHVVPRWSGDANFMTVIDGVKVLPQTLRQT 186
>emb|CAB09619.1| (Z96801) hypothetical protein MLCL581.17c [Mycobacterium leprae]
Length = 186
Score = 90.5 bits (223), Expect = 6e-18
Identities = 50/156 (32%), Positives = 84/156 (53%), Gaps = 10/156 (6%)
Query: 1 MQHLYAPWRESYLK-------GKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPY 53
+Q L+ P+R +YL + F +I Q D + V+ R ++ V+N YPY
Sbjct: 9 LQRLWTPYRMTYLAEAPVNHDNSTPAQPFTDIPQ--LSDEDGLVVARGELVYAVLNLYPY 66
Query: 54 NPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGA-QGINLGLNLHRNAGAG 112
NPGHL+++P+ + +E L + K ++ + G N+GLNL +AG
Sbjct: 67 NPGHLMVVPYRQVSELEDLTDAESAELMTFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGS 126
Query: 113 IPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
+ EHLH+H+VPR+ GD+NF+++I ++V L +T
Sbjct: 127 LAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDT 162
>ref|NP_301409.1| (NC_002677) conserved hypothetical protein [Mycobacterium leprae]
emb|CAC29963.1| (AL583918) conserved hypothetical protein [Mycobacterium leprae]
Length = 206
Score = 90.5 bits (223), Expect = 6e-18
Identities = 50/156 (32%), Positives = 84/156 (53%), Gaps = 10/156 (6%)
Query: 1 MQHLYAPWRESYLK-------GKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPY 53
+Q L+ P+R +YL + F +I Q D + V+ R ++ V+N YPY
Sbjct: 29 LQRLWTPYRMTYLAEAPVNHDNSTPAQPFTDIPQ--LSDEDGLVVARGELVYAVLNLYPY 86
Query: 54 NPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKALYAYGA-QGINLGLNLHRNAGAG 112
NPGHL+++P+ + +E L + K ++ + G N+GLNL +AG
Sbjct: 87 NPGHLMVVPYRQVSELEDLTDAESAELMTFTQKAIRVIKNVSRPHGFNVGLNLGTSAGGS 146
Query: 113 IPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
+ EHLH+H+VPR+ GD+NF+++I ++V L +T
Sbjct: 147 LAEHLHVHVVPRWGGDANFITIIGGSKVIPQLLRDT 182
>ref|NP_600882.1| (NC_003450) COG0537:Diadenosine tetraphosphate (Ap4A) hydrolase and
other HIT family hydrolases [Corynebacterium glutamicum]
Length = 180
Score = 84.7 bits (208), Expect = 3e-16
Identities = 41/118 (34%), Positives = 68/118 (56%), Gaps = 1/118 (0%)
Query: 32 DSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKAL 91
D + ++ R ++ V+N YPYN GH+++IP + ++E L L + +KAL
Sbjct: 29 DEDGLIVARGELVYCVLNLYPYNAGHMMVIPFRKEKNLEDLSLAESAELMLFTQTAIKAL 88
Query: 92 -YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQTRVCGMDLNET 148
+N+GLNL + +G + +HLH+H+VPR+ GD+NFM+VI +V L +T
Sbjct: 89 KQVSNPDAVNVGLNLGKASGGSVGDHLHVHVVPRWSGDANFMTVIDGVKVLPQTLRQT 146
>ref|NP_142915.1| (NC_000961) hypothetical protein [Pyrococcus horikoshii]
pir||D71092 hypothetical protein PH1001 - Pyrococcus horikoshii
dbj|BAA30098.1| (AP000004) 150aa long hypothetical protein [Pyrococcus horikoshii]
Length = 150
Score = 68.2 bits (165), Expect = 3e-11
Identities = 38/113 (33%), Positives = 62/113 (54%), Gaps = 9/113 (7%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C FC NP K++ +LY + + ++++ YP NPGHLLI+P H +E L +
Sbjct: 3 CPFC----NPIKEN---ILYEDDTIRILLDNYPANPGHLLIVPRRHVTKLEELSEGEKAS 55
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNF 131
+ ++AL G N+G+N+ + AG + EHLH+H++PRF D +
Sbjct: 56 LLRGIEIAIEALKKTLNPDGFNVGINIGKAAGQTV-EHLHIHVIPRFNNDCKY 107
>ref|NP_578836.1| (NC_003413) hit family protein (hit) [Pyrococcus furiosus DSM 3638]
gb|AAL81231.1| (AE010221) hit family protein (hit) [Pyrococcus furiosus DSM 3638]
Length = 146
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/110 (32%), Positives = 64/110 (57%), Gaps = 9/110 (8%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C FC NP ++ ++Y + + ++++++P NPGHLL++P H ++E L+ +
Sbjct: 3 CPFC----NPPAEN---IVYEDDKIRILLDSFPANPGHLLVVPKRHITNIEGLNEEEKVM 55
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ +KAL A G N+G+NL + AG + HLH+H++PR+ GD
Sbjct: 56 LMKGVEMAIKALKEALNPDGFNVGINLGKAAGQTV-SHLHVHVIPRYKGD 104
>ref|NP_126658.1| (NC_000868) HIT-LIKE PROTEIN [Pyrococcus abyssi]
pir||D75073 hit-like protein PAB0657 - Pyrococcus abyssi (strain Orsay)
emb|CAB49889.1| (AJ248286) HIT-LIKE PROTEIN [Pyrococcus abyssi]
Length = 147
Score = 65.9 bits (159), Expect = 2e-10
Identities = 36/113 (31%), Positives = 62/113 (54%), Gaps = 9/113 (7%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C FC V+Y + + ++++ YP NPGHLL++P H S+ L + L
Sbjct: 3 CPFCH-------PKPENVVYEDKFIRILLDNYPANPGHLLVVPKRHVTSIGNLTEDEKLA 55
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNF 131
+ +KAL A A G N+G+N+ + AG + +H+H+H++PR+ GD ++
Sbjct: 56 LLKGIELAVKALKRALKADGFNVGINIGKAAGQTV-DHIHIHVIPRYEGDCDY 107
>ref|NP_280841.1| (NC_002607) histidine triad protein; Hit1 [Halobacterium sp. NRC-1]
gb|AAG20321.1| (AE005106) histidine triad protein; Hit1 [Halobacterium sp. NRC-1]
Length = 142
Score = 60.8 bits (146), Expect = 5e-09
Identities = 48/138 (34%), Positives = 69/138 (49%), Gaps = 18/138 (13%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLD------ 73
CVFC+I A + RV++ ++D ++A P PGH L+IP H A+ L D
Sbjct: 5 CVFCQII---ADEIPARVVHEDADTLAFLDATPMAPGHTLVIPKTHAAT--LADTPGDDA 59
Query: 74 LNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNF-M 132
+ ++ALAP V A+ A +G N AG +P H+H H++PRF D +
Sbjct: 60 TAVFETLHALAPTVEAAV---DADATTIGFNNGTAAGQEVP-HVHGHIIPRFADDDGGPL 115
Query: 133 SVIAQTR--VCGMDLNET 148
V A TR V DL+ T
Sbjct: 116 HVAAGTRPDVSDADLDAT 133
>ref|NP_486506.1| (NC_003272) hypothetical protein [Nostoc sp. PCC 7120]
dbj|BAB74165.1| (AP003589) ORF_ID:all2466~hypothetical protein [Nostoc sp. PCC
7120]
Length = 284
Score = 60.8 bits (146), Expect = 5e-09
Identities = 38/114 (33%), Positives = 63/114 (54%), Gaps = 14/114 (12%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLN---- 75
C+FC NP K+ ++L ++ + + + YP + GH+L+IP H + L
Sbjct: 166 CIFC----NPHKNL--KLLTESATAYAIFDGYPISKGHILVIPKRHVSDYFELPQKEQSA 219
Query: 76 TWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDS 129
WL +N A + LKA +A G N+G+N++R AG I H +H++PR+ GD+
Sbjct: 220 CWLMVNK-AQEFLKAEFA--PDGFNIGMNINRAAGQNI-MHASIHIIPRYQGDA 269
>ref|NP_394598.1| (NC_002578) histidine triad (HIT) related protein [Thermoplasma
acidophilum]
emb|CAC12267.1| (AL445066) histidine triad (HIT) related protein [Thermoplasma
acidophilum]
Length = 147
Score = 60.5 bits (145), Expect = 7e-09
Identities = 36/111 (32%), Positives = 59/111 (52%), Gaps = 7/111 (6%)
Query: 17 NKSCVFCEISQNPAKDSENRVLYRNSDLFV-VMNAYPYNPGHLLIIPHVHQASVELLDLN 75
+ SCVFC N N + +D+ + M+ P PGH+L+IP H ++ +D
Sbjct: 4 DSSCVFC----NEIITKRNAAIVAENDMVISFMDNAPVEPGHILVIPKEHFENIFDIDSR 59
Query: 76 TWLNMNALAPKVLKA-LYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
++ + +A +V KA + A GA GIN+G N A + H H+H++PR+
Sbjct: 60 YYIEVQLMAKRVAKAVMKAMGADGINIGQNNGWCANQRV-MHFHVHVIPRW 109
>pir||B64408 histidine triad (HIT) protein MJ0866 - Methanococcus jannaschii
Length = 129
Score = 60.1 bits (144), Expect = 9e-09
Identities = 39/136 (28%), Positives = 64/136 (46%), Gaps = 11/136 (8%)
Query: 20 CVFCEI--SQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
C+FC+I + PAK V+Y + + ++ P N GH L++P H + + +
Sbjct: 2 CIFCKIINGEIPAK-----VVYEDEHVLAFLDINPRNKGHTLVVPKKHYERFDEMPDDEL 56
Query: 78 LNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQ 137
N K ++ L G G N+ N R AG + H+H H++PR+ GD V+
Sbjct: 57 CNFIKGVKKTVEVLKKLGFDGYNIVNNNGRVAGQEV-NHVHFHIIPRYXGDG---EVVKF 112
Query: 138 TRVCGMDLNETYLTLK 153
V +DL+E +K
Sbjct: 113 GEVKNVDLDEVLKEIK 128
>ref|NP_247861.1| (NC_000909) HIT family protein (hit) [Methanococcus jannaschii]
[Methanocaldococcus jannaschii]
sp|Q58276|Y866_METJA Hypothetical HIT-like protein MJ0866
gb|AAB98871.1| (U67530) HIT family protein (hit) [Methanococcus jannaschii]
[Methanocaldococcus jannaschii]
Length = 129
Score = 59.3 bits (142), Expect = 1e-08
Identities = 39/136 (28%), Positives = 64/136 (46%), Gaps = 11/136 (8%)
Query: 20 CVFCEI--SQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
C+FC+I + PAK V+Y + + ++ P N GH L++P H + + +
Sbjct: 2 CIFCKIINGEIPAK-----VVYEDEHVLAFLDINPRNKGHTLVVPKKHYERFDEMPDDEL 56
Query: 78 LNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVIAQ 137
N K ++ L G G N+ N R AG + H+H H++PR+ GD V+
Sbjct: 57 CNFIKGVKKTVEVLKKLGFDGYNIVNNNGRVAGQEV-NHVHFHIIPRYEGDG---EVVKF 112
Query: 138 TRVCGMDLNETYLTLK 153
V +DL+E +K
Sbjct: 113 GEVKNVDLDEVLKEIK 128
>ref|NP_615770.1| (NC_003552) histidine triad protein [Methanosarcina acetivorans
str. C2A] [Methanosarcina acetivorans C2A]
gb|AAM04250.1| (AE010743) histidine triad protein [Methanosarcina acetivorans str.
C2A] [Methanosarcina acetivorans C2A]
Length = 150
Score = 58.5 bits (140), Expect = 3e-08
Identities = 33/112 (29%), Positives = 61/112 (54%), Gaps = 5/112 (4%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
++C+FC+I + + +Y + ++ ++ YP + GH LI P H ++ ++
Sbjct: 14 ENCLFCKIITG---EIPSHRIYEDDAIYAFLDIYPASEGHTLIAPKKHLSNFTDMNAEDV 70
Query: 78 LNMNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ A KV A+ A+ A+G N+G+N AG +P H+H+H++PR GD
Sbjct: 71 ALLFEAARKVTAAVEKAFSAEGSNIGINNGEVAGQEVP-HVHVHVIPRKKGD 121
>ref|NP_377432.1| (NC_003106) 141aa long hypothetical histidine triad
nucleotide-binding protein [Sulfolobus tokodaii]
dbj|BAB66541.1| (AP000986) 141aa long hypothetical histidine triad
nucleotide-binding protein [Sulfolobus tokodaii]
Length = 141
Score = 58.2 bits (139), Expect = 3e-08
Identities = 32/110 (29%), Positives = 57/110 (51%), Gaps = 4/110 (3%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I + K + +Y + ++ ++ P N GH+L+IP H ++ +
Sbjct: 5 NCIFCKIVKGEIKSQK---VYEDQEIMAFLDINPVNKGHVLVIPKDHYENIFDVPKEKLG 61
Query: 79 NMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ + KV AL GA G+N+ N + A I HLH+H++PR+ D
Sbjct: 62 KVIEVVQKVAIALRKMGADGVNIVSNNGKAAEQHI-FHLHIHVIPRYFND 110
>ref|NP_633982.1| (NC_003901) Hit-like protein [Methanosarcina mazei Goe1]
gb|AAM31654.1| (AE013433) Hit-like protein [Methanosarcina mazei Goe1]
Length = 155
Score = 57.4 bits (137), Expect = 6e-08
Identities = 33/112 (29%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
++C+FC+I + ++ +Y + + ++ YP + GH LI P H S +
Sbjct: 7 ENCLFCKIISG---EIPSKKVYEDDAVCAFLDIYPASEGHTLIAPKKHFNSFTDMGAEDT 63
Query: 78 LNMNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ A K+ A+ A+ A+G N+G+N AG +P H+H+H++PR GD
Sbjct: 64 ARLFEAARKITAAVEKAFSAEGSNIGINNGEVAGQEVP-HVHVHVIPRKKGD 114
>ref|NP_560536.1| (NC_003364) HIT family protein [Pyrobaculum aerophilum]
gb|AAL64718.1| (AE009914) HIT family protein [Pyrobaculum aerophilum]
Length = 137
Score = 57.4 bits (137), Expect = 6e-08
Identities = 30/106 (28%), Positives = 58/106 (54%), Gaps = 4/106 (3%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I + A + +Y + + V+++ YP + GH+L++ H ++ +
Sbjct: 3 CIFCKIIRGEAPAWK---VYEDEEFVVILDKYPASYGHVLVVSKKHFTNIVDAPVELSAR 59
Query: 80 MNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
+A ++ KA GA G+N+ N R+AG + HLH+H++PR+
Sbjct: 60 GFEIAIRLAKAWAKLGAPGVNIVTNAGRSAGQAV-FHLHIHVIPRW 104
>ref|NP_249997.1| (NC_002516) probable HIT family protein [Pseudomonas aeruginosa]
pir||F83481 probable HIT family protein PA1306 [imported] - Pseudomonas
aeruginosa (strain PAO1)
gb|AAG04695.1|AE004560_3 (AE004560) probable HIT family protein [Pseudomonas aeruginosa]
Length = 153
Score = 56.6 bits (135), Expect = 1e-07
Identities = 38/118 (32%), Positives = 61/118 (51%), Gaps = 6/118 (5%)
Query: 13 LKGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELL 72
+ G CVFC I+ ++ +R L+ + V+++ +P P H+LI+ H + L
Sbjct: 1 MSGFPMDCVFCAIAGG--REPAHR-LFEDEHFIVLLDIFPLRPAHVLIVAREHALHLSDL 57
Query: 73 DLNTWLNMNALAPKVLKAL--YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ ALA ++ +AL +G +GINL LN A + HLH+HL+PR GD
Sbjct: 58 SAAARDALLALAERIGRALRRAGFGVEGINLLLNDGVAANQHV-AHLHLHLIPRRRGD 114
>ref|NP_148648.1| (NC_000854) histidine triad (HIT) protein [Aeropyrum pernix]
pir||G72481 probable histidine triad (HIT) protein APE2495 - Aeropyrum pernix
(strain K1)
dbj|BAA81511.1| (AP000064) 153aa long hypothetical histidine triad (HIT) protein
[Aeropyrum pernix]
Length = 153
Score = 54.7 bits (130), Expect = 4e-07
Identities = 34/110 (30%), Positives = 56/110 (50%), Gaps = 11/110 (10%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVEL----LDLN 75
C+FC I + A E +Y+ + + V ++ YP + GHLL++P H S+ +
Sbjct: 7 CIFCRIVKGEA---EAYTVYKGNGVTVFLDRYPASKGHLLVVPDEHYESIHTAPPRVAAK 63
Query: 76 TWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
WL +A+A + GA +N+ N R AG I H H+H++PR+
Sbjct: 64 VWLAASAIARYYREKA---GAPAVNVLTNSGRYAGQ-IIFHFHVHVIPRW 109
>ref|NP_109961.1| (NC_000912) nucleotidyl hydrolases/transferase [Mycoplasma
pneumoniae]
sp|P75504|YHIT_MYCPN Hypothetical 16.1 kDa HIT-like protein (A65_orf144)
pir||S73888 histidine triad protein A65_orf144 - Mycoplasma pneumoniae (strain
ATCC 29342)
gb|AAB96210.1| (AE000055) nucleotidyl hydrolases/transferase [Mycoplasma
pneumoniae]
Length = 144
Score = 53.5 bits (127), Expect = 8e-07
Identities = 37/136 (27%), Positives = 62/136 (45%), Gaps = 5/136 (3%)
Query: 17 NKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNT 76
N +C+FC I + K + + N F ++A+P GH L+IP H + D +
Sbjct: 9 NNNCIFCGIVEGNVKSFK---VGENEHAFAFLDAFPVADGHTLVIPKKHAVNYSSTDDES 65
Query: 77 WLNMNALAPKV-LKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSVI 135
++ LA ++ LK G+N +N AG + H HMH+VP++ F +
Sbjct: 66 LKAVSLLAKEMALKLQQRLQPAGLNYVVNEGAKAGQEV-FHYHMHVVPKYETGLGFCYNV 124
Query: 136 AQTRVCGMDLNETYLT 151
+T ++ N LT
Sbjct: 125 RKTNNRSIEANWELLT 140
>ref|NP_111736.1| (NC_002689) HIT (histidine triad) family protein [Thermoplasma
volcanium]
Length = 151
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/109 (33%), Positives = 55/109 (49%), Gaps = 7/109 (6%)
Query: 19 SCVFC-EISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
SCVFC EI Q V+ N M+ P PGH+L+IP H ++ +D +
Sbjct: 5 SCVFCTEIIQK----RNAAVVAENEYTIAFMDKAPVEPGHVLVIPKRHFINIFDIDDFYY 60
Query: 78 LNMNALAPKVLKA-LYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
+ + + +V KA L A A +N+G N R A I H H+H++PR+
Sbjct: 61 IEVQKMVKRVSKAVLEALSADALNVGQNNGRCANQ-IVMHYHVHVIPRW 108
>dbj|BAB60383.1| (AP000995) histidine triad protein [HIT] [Thermoplasma volcanium]
Length = 157
Score = 52.8 bits (125), Expect = 1e-06
Identities = 37/109 (33%), Positives = 55/109 (49%), Gaps = 7/109 (6%)
Query: 19 SCVFC-EISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
SCVFC EI Q V+ N M+ P PGH+L+IP H ++ +D +
Sbjct: 11 SCVFCTEIIQK----RNAAVVAENEYTIAFMDKAPVEPGHVLVIPKRHFINIFDIDDFYY 66
Query: 78 LNMNALAPKVLKA-LYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
+ + + +V KA L A A +N+G N R A I H H+H++PR+
Sbjct: 67 IEVQKMVKRVSKAVLEALSADALNVGQNNGRCANQ-IVMHYHVHVIPRW 114
>ref|NP_378146.1| (NC_003106) 150aa long hypothetical histidine triad
nucleotide-binding protein [Sulfolobus tokodaii]
dbj|BAB67255.1| (AP000989) 150aa long hypothetical histidine triad
nucleotide-binding protein [Sulfolobus tokodaii]
Length = 150
Score = 52.0 bits (123), Expect = 2e-06
Identities = 34/110 (30%), Positives = 54/110 (48%), Gaps = 5/110 (4%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C FC I ++ E +Y + +++ YP + GH L+IP H + D +T
Sbjct: 2 CTFCSIIN---RELEGYFVYEDEKFAAILDKYPVSLGHTLVIPKKHFENYLEADEDTLAE 58
Query: 80 MNALAPKV-LKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ + V L A A G+ L N+ R+AG I HLH+H++P + GD
Sbjct: 59 LAKVVKLVSLGIKDAVKADGLRLLTNIGRSAGQVI-FHLHVHIIPTWEGD 107
>ref|NP_269754.1| (NC_002737) putative cell-cycle regulation histidine triad (HIT)
protein [Streptococcus pyogenes] [Streptococcus pyogenes
M1 GAS]
ref|NP_607768.1| (NC_003485) putative cell-cycle regulation histidine triad (HIT)
protein [Streptococcus pyogenes MGAS8232]
gb|AAK34475.1| (AE006602) putative cell-cycle regulation histidine triad (HIT)
protein [Streptococcus pyogenes M1 GAS]
gb|AAL98267.1| (AE010084) putative cell-cycle regulation histidine triad (HIT)
protein [Streptococcus pyogenes MGAS8232]
Length = 139
Score = 51.6 bits (122), Expect = 3e-06
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 5/109 (4%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
++C+FC I Q S+ +Y + + ++ GH L+IP H ++ + T
Sbjct: 2 ENCIFCSIIQGDIPSSK---VYEDEQVLAFLDISQTTKGHTLVIPKQHVRNLLEMTAETA 58
Query: 78 LNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
++ A PK+ +A+ A GA +N+ N AG + H H+HLVPR+
Sbjct: 59 SHLFARIPKIARAIQSATGATAMNIINNNEALAGQTV-FHAHVHLVPRY 106
>ref|NP_242055.1| (NC_002570) Hit-like protein involved in cell-cycle regulation
[Bacillus halodurans]
dbj|BAB04908.1| (AP001511) Hit-like protein involved in cell-cycle regulation
[Bacillus halodurans]
Length = 142
Score = 51.2 bits (121), Expect = 4e-06
Identities = 31/108 (28%), Positives = 57/108 (52%), Gaps = 5/108 (4%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I A + + +Y + ++ ++ GH L+IP VH+ +V L
Sbjct: 6 NCIFCKII---AGEIPSATVYEDDHVYAFLDISQVTKGHTLVIPKVHKRNVFELSEEIAS 62
Query: 79 NMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
++ A PK+ +A+ A+ G+N+ N AG + H H+HL+PR+
Sbjct: 63 SLFAAVPKISRAINDAFQPIGMNIVNNNGEAAGQTV-FHYHLHLLPRY 109
>gb|AAK96091.1|AF393466_28 (AF393466) HIT superfamily hydrolase [uncultured crenarchaeote
74A4]
Length = 135
Score = 50.1 bits (118), Expect = 9e-06
Identities = 32/112 (28%), Positives = 58/112 (51%), Gaps = 9/112 (8%)
Query: 20 CVFCEI--SQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
C+FC+I Q PAK +L+ S ++A+P GH+L+IP H ++ + +
Sbjct: 3 CIFCKIISRQIPAK-----ILHETSHSICFLDAFPLTKGHVLVIPKNHHKKIQDMSSSEN 57
Query: 78 LNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDS 129
++ +L ++ + + + + ++ AG IP H+H+HLVPR DS
Sbjct: 58 SDLFSLVHVMMSKVDSITGSTL-IAIHNGETAGQEIP-HVHVHLVPRSESDS 107
>ref|NP_345039.1| (NC_003028) HIT family protein [Streptococcus pneumoniae TIGR4]
ref|NP_358052.1| (NC_003098) Conserved hypothetical protein [Streptococcus
pneumoniae R6]
gb|AAK74679.1| (AE007363) HIT family protein [Streptococcus pneumoniae TIGR4]
gb|AAK99262.1| (AE008426) Conserved hypothetical protein [Streptococcus pneumoniae
R6]
Length = 136
Score = 49.7 bits (117), Expect = 1e-05
Identities = 31/112 (27%), Positives = 53/112 (46%), Gaps = 5/112 (4%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I S+ +Y + + ++ GH L++P H ++ +D +
Sbjct: 4 CIFCKIIAGEIPASK---VYEDEQVLAFLDISQVTLGHTLVVPKEHYRNLLEMDATSASQ 60
Query: 80 MNALAPKVL-KALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSN 130
+ A PKV K + A G+N+ N AG + H H+HLVPR+ D +
Sbjct: 61 LFAQVPKVAQKVMKVTKAAGMNIISNCEEVAGQTV-FHTHVHLVPRYSADDD 111
>ref|NP_471651.1| (NC_003212) similar to histidine triad (HIT) protein [Listeria
innocua]
emb|CAC97547.1| (AL596171) similar to histidine triad (HIT) protein [Listeria
innocua]
Length = 140
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 5/113 (4%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I + ++ +Y + +++ ++ GH L+IP H + L T
Sbjct: 4 CIFCKIVRGEIPSAK---VYEDDEVYAFLDLGQVTEGHTLVIPKKHARNTFDLPEETAAE 60
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNF 131
+ PK+ +AL A QG+N+ LN + H H+HL+PR+ +F
Sbjct: 61 LFRRVPKIARALKEALPLQGLNI-LNNNEEVAYQSVFHCHIHLIPRYSKSDDF 112
>ref|NP_072794.1| (NC_000908) hit protein, putative [Mycoplasma genitalium]
sp|P47378|YHIT_MYCGE Hypothetical HIT-like protein MG132
pir||F64214 histidine triad protein MG132 - Mycoplasma genitalium
gb|AAC71349.1| (U39693) hit protein, putative [Mycoplasma genitalium]
Length = 141
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/134 (25%), Positives = 56/134 (41%), Gaps = 5/134 (3%)
Query: 14 KGKNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLD 73
K SC+FC+I Q + + N ++A+P GH L+IP H D
Sbjct: 3 KNTTSSCIFCDIVQGSITSYK---IGENEHAIAFLDAFPVADGHTLVIPKKHAVDFSSTD 59
Query: 74 LNTWLNMNALAPKV-LKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFM 132
++ LA ++ LK G+N N AG + H H+H+VP++ F
Sbjct: 60 QKELQAVSLLAKQIALKLKMTLKPSGLNYVSNEGAIAGQ-VVFHFHLHIVPKYETGKGFG 118
Query: 133 SVIAQTRVCGMDLN 146
+ +T ++ N
Sbjct: 119 YNVNKTNKRSLEEN 132
>ref|NP_212513.1| (NC_001318) protein kinase C1 inhibitor (pkcI) [Borrelia
burgdorferi]
pir||B70147 protein kinase C inhibitor homolog - Lyme disease spirochete
gb|AAC66761.1| (AE001143) protein kinase C1 inhibitor (pkcI) [Borrelia
burgdorferi]
Length = 149
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/114 (29%), Positives = 55/114 (47%), Gaps = 11/114 (9%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I K+ + +Y + + ++ P GH L+IP H S LL+++ N
Sbjct: 14 CIFCKIIN---KELPSYKVYEDDLVLAFLDINPLTVGHTLVIPKEHSES--LLNMDDKFN 68
Query: 80 MNAL--APKVLKALYAYGAQGINLGLNLHRNAGAGIPE---HLHMHLVPRFLGD 128
L K+ AL + I G+N++ GAG + H H H++PRF D
Sbjct: 69 ERVLKVCKKISNALKRINS-SIYGGINIYSALGAGAGQEVFHTHFHVIPRFKND 121
>sp|P94252|YHIT_BORBU Hypothetical HIT-like protein BB0379
gb|AAC44716.1|AAC44716 (U49938) protein kinase C1 inhibitor Pkci [Borrelia burgdorferi]
Length = 139
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/114 (29%), Positives = 55/114 (47%), Gaps = 11/114 (9%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I K+ + +Y + + ++ P GH L+IP H S LL+++ N
Sbjct: 4 CIFCKIIN---KELPSYKVYEDDLVLAFLDINPLTVGHTLVIPKEHSES--LLNMDDKFN 58
Query: 80 MNAL--APKVLKALYAYGAQGINLGLNLHRNAGAGIPE---HLHMHLVPRFLGD 128
L K+ AL + I G+N++ GAG + H H H++PRF D
Sbjct: 59 ERVLKVCKKISNALKRINS-SIYGGINIYSALGAGAGQEVFHTHFHVIPRFKND 111
>ref|NP_465740.1| (NC_003210) similar to histidine triad (HIT) protein [Listeria
monocytogenes EGD-e]
emb|CAD00294.1| (AL591982) similar to histidine triad (HIT) protein [Listeria
monocytogenes]
Length = 140
Score = 48.9 bits (115), Expect = 2e-05
Identities = 30/113 (26%), Positives = 54/113 (47%), Gaps = 5/113 (4%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC+I + ++ +Y + +++ ++ GH L+IP H + L T
Sbjct: 4 CIFCKIVRGEIPSAK---VYEDDEVYAFLDLGQVTEGHTLVIPKKHARNTFDLPDETAAE 60
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNF 131
+ PK+ +AL A QG+N+ LN + H H+HL+PR+ +F
Sbjct: 61 LFRRVPKIARALKEALPIQGLNI-LNNNEEVAFQSVFHCHIHLIPRYSKSDDF 112
>ref|NP_343549.1| (NC_002754) Histidine triad (Hit) family protein, putative
[Sulfolobus solfataricus]
sp|P95937|YHIT_SULSO Hypothetical hit-like protein SSO2163
pir||S74070 histidine triad (HIT) protein c0139 - Sulfolobus solfataricus
emb|CAA69441.1| (Y08256) HIT protein [Sulfolobus solfataricus]
gb|AAK42339.1| (AE006822) Histidine triad (Hit) family protein, putative
[Sulfolobus solfataricus]
Length = 139
Score = 48.5 bits (114), Expect = 3e-05
Identities = 29/114 (25%), Positives = 53/114 (46%), Gaps = 5/114 (4%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C+FC I + ++Y N + ++ +P PGH L++P H + + +
Sbjct: 2 CIFCNIVEGR---DHGYIVYSNDRVVAFLDKFPITPGHTLVVPRTHYENFLEISEDVIPY 58
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFM 132
+ K+ A+ A A GI + N+ ++AG + H H H+VP + D + M
Sbjct: 59 LCTAVRKISIAVKKALKADGIRILTNIGKSAGQ-VVFHSHFHIVPTWSQDPDIM 111
>ref|NP_348235.1| (NC_003030) HIT family hydrolase [Clostridium acetobutylicum]
gb|AAK79575.1|AE007670_7 (AE007670) HIT family hydrolase [Clostridium acetobutylicum]
Length = 122
Score = 48.1 bits (113), Expect = 3e-05
Identities = 35/119 (29%), Positives = 57/119 (47%), Gaps = 19/119 (15%)
Query: 16 KNKSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLII-----PHVHQASVE 70
+N +C FC + ++ N F +++ P N GH LII P +AS E
Sbjct: 2 ENNNCPFCS-------SNNFDIICENKLAFAILDKNPVNEGHTLIITKRHFPFFFEASGE 54
Query: 71 LLDLNTWLNMNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ + M +L + L Y G N+G+N+ AG + +H+H+HL+PR+ GD
Sbjct: 55 EV-----MAMYSLLHEAKGILDIQYEPSGYNIGVNVGYYAGQTV-KHMHIHLIPRYKGD 107
>ref|NP_325839.1| (NC_002771) HIT-LIKE PROTEIN (CELL CYCLE REGULATION) [Mycoplasma
pulmonis]
emb|CAC13181.1| (AL445563) HIT-LIKE PROTEIN (CELL CYCLE REGULATION) [Mycoplasma
pulmonis]
Length = 116
Score = 47.4 bits (111), Expect = 6e-05
Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 2/89 (2%)
Query: 36 RVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLK-ALYAY 94
+++Y + +M+ +PYNPGH L+IP H +++ ++ + ++ +A K+ K +
Sbjct: 20 QIIYEDDQAIAIMDKFPYNPGHFLVIPKKHSTNLKDIEEQSINHLMKIAIKLAKEKIENK 79
Query: 95 GAQGINLGLNLHRNAGAGIPEHLHMHLVP 123
+ L +N AG + H H+H++P
Sbjct: 80 EFEDFKLIINNGEKAGQ-VVYHTHIHIIP 107
>ref|NP_010591.1| (NC_001136) Fhit homolog, member of the histidine triad superfamily
of nucleotide binding-proteins; Hnt2p [Saccharomyces
cerevisiae]
sp|P49775|HNT2_YEAST HIT FAMILY PROTEIN 2
pir||S61191 asymmetrical hydrolase homolog YDR305c - yeast (Saccharomyces
cerevisiae)
gb|AAB64741.1| (U28374) Hnt2p: yeast homolog of histidine triad nucleotide-binding
protein (HINT) [Saccharomyces cerevisiae]
Length = 217
Score = 45.4 bits (106), Expect = 2e-04
Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 9/95 (9%)
Query: 36 RVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDL-----NTWLNMNALAPKVLKA 90
+V Y++ + ++N P PGH+LI+P + + L DL + L + +K
Sbjct: 26 QVFYKSKYTYALVNLKPIVPGHVLIVP-LRTTVLNLSDLTMPESQDYFKTLQLIHRFIK- 83
Query: 91 LYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRF 125
+ Y A IN+ + AG +P HLH H++PR+
Sbjct: 84 -WQYKADSINVAIQDGPEAGQSVP-HLHTHIIPRY 116
>ref|NP_078106.1| (NC_002162) probable HIT protein [Ureaplasma urealyticum]
pir||D82911 probable HIT protein UU272 [imported] - Ureaplasma urealyticum
gb|AAF30681.1|AE002124_3 (AE002124) probable HIT protein [Ureaplasma urealyticum]
Length = 152
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/108 (24%), Positives = 51/108 (47%), Gaps = 4/108 (3%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
+ C+FC+I + + ++++ N +++ P + GH+LIIP H + L D
Sbjct: 2 QDCIFCKILKG---EIISKIIDENEFAIAILDIQPASDGHMLIIPKKHYRNFSLTDPIYL 58
Query: 78 LNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAG-IPEHLHMHLVPR 124
M LA + L + ++ N+ AG + H H+H++P+
Sbjct: 59 DGMMRLAKNMTFVLEEVFPNVLGFNYLMNSNSSAGQVIMHTHLHIIPK 106
>ref|NP_268155.1| (NC_002662) HYPOTHETICAL PROTEIN [Lactococcus lactis subsp. lactis]
gb|AAK06096.1|AE006430_1 (AE006430) HYPOTHETICAL PROTEIN [Lactococcus lactis subsp. lactis]
Length = 133
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/119 (24%), Positives = 58/119 (48%), Gaps = 11/119 (9%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELL----D 73
+ C+FC+I A + + +Y + D+ ++ GH L++P H ++ +
Sbjct: 2 EDCIFCKII---AGEIPSTKIYEDDDVLAFLDITQTTKGHTLVVPKKHYRNILSMTGEQS 58
Query: 74 LNTWLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFM 132
+ + +A K++ L+A +G+N+ N AG + H H+HL+PRF + F+
Sbjct: 59 AELFSKVPFIANKIVNNLHA---KGMNILQNNEEIAGQTV-FHTHIHLIPRFDENDGFV 113
>ref|NP_372362.1| (NC_002758) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus Mu50]
ref|NP_374945.1| (NC_002745) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus N315]
ref|NP_646595.1| (NC_003923) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus MW2]
dbj|BAB42924.1| (AP003135) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus N315]
dbj|BAB58000.1| (AP003363) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus Mu50]
dbj|BAB95643.1| (AP004828) Hit-like protein involved in cell-cycle regulation
[Staphylococcus aureus subsp. aureus MW2]
Length = 140
Score = 44.3 bits (103), Expect = 5e-04
Identities = 26/92 (28%), Positives = 45/92 (48%), Gaps = 2/92 (2%)
Query: 38 LYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKAL-YAYGA 96
+Y + ++ ++ GH L+IP A++ D T ++ A PKV A+ A+
Sbjct: 19 VYEDDYVYAFLDISQVTKGHTLLIPKKASANIFETDEETMKHIGAALPKVANAIKRAFNP 78
Query: 97 QGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
G+N+ N A + H+H HL+PR+ D
Sbjct: 79 DGLNIIQNNGEFADQSV-FHIHFHLIPRYEND 109
>ref|NP_273646.1| (NC_003112) hitA protein [Neisseria meningitidis MC58]
pir||F81181 hitA protein NMB0602 [imported] - Neisseria meningitidis (group B
strain MD58)
gb|AAF41029.1| (AE002415) hitA protein [Neisseria meningitidis MC58]
Length = 107
Score = 44.3 bits (103), Expect = 5e-04
Identities = 30/105 (28%), Positives = 52/105 (48%), Gaps = 5/105 (4%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I+ AKD + +Y + ++ + P P HLL+IP VH S+ +
Sbjct: 3 NCIFCKIA---AKDIPAQTVYEDGEMVCFKDINPAAPVHLLLIPKVHFDSLAHAAPEHQM 59
Query: 79 NMNALAPKVLKALYAYG-AQGINLGLNLHRNAGAGIPEHLHMHLV 122
+ + KV + A G A G +N + G + HLH+H++
Sbjct: 60 LLGKMMLKVPEIAKAAGLADGFKTLINTGKGGGQEV-FHLHIHIM 103
>ref|NP_597168.1| (NC_003235) HIT FAMILY PROTEIN [Encephalitozoon cuniculi]
emb|CAD26344.1| (AL590448) HIT FAMILY PROTEIN [Encephalitozoon cuniculi]
Length = 131
Score = 43.9 bits (102), Expect = 6e-04
Identities = 25/115 (21%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTW 77
+ C+FC + + A ++Y LF +++ YP + GH L+IP H +
Sbjct: 2 EGCIFCTLYRKGAN-----IIYETDRLFALIDRYPLSKGHFLVIPKAHHPYLHNYKPE-- 54
Query: 78 LNMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFM 132
++ + + + +G + N+ L N H+H H++P D M
Sbjct: 55 -ELSGVLDTIRHLVQKFGFERYNI---LQNNGNHQEVFHVHFHVIPFVSADERLM 105
>ref|NP_102422.1| (NC_002678) probable Hit-like protein involved in cell-cycle
regulation [Mesorhizobium loti]
dbj|BAB48208.1| (AP002995) probable Hit-like protein involved in cell-cycle
regulation [Mesorhizobium loti]
Length = 143
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 6/93 (6%)
Query: 38 LYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLN--TWLNMNALAPKVLKAL-YAY 94
+Y + + M+ P PGH L++P S LLD N T+ + + KV +A+ A
Sbjct: 25 VYEDDAVVAFMDVMPQGPGHTLVVPKA--PSRNLLDANPSTFGPLFNVVQKVAQAVKKAL 82
Query: 95 GAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLG 127
A G+ + L + A HLH+H++PRF G
Sbjct: 83 NADGVTI-LQFNEPASGQTVYHLHVHVIPRFDG 114
>ref|NP_388884.1| (NC_000964) Hit-like protein [Bacillus subtilis]
sp|O07513|HIT_BACSU Hit protein
pir||A69642 cell-cycle regulation histidine triad (HIT) protein - Bacillus
subtilis
emb|CAA74410.1| (Y14077) Hypothetical protein [Bacillus subtilis]
emb|CAB12843.1| (Z99109) Hit-like protein [Bacillus subtilis]
Length = 145
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/119 (27%), Positives = 57/119 (47%), Gaps = 7/119 (5%)
Query: 18 KSCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASV-ELLDLNT 76
++C+FC+I A D + +Y + + ++ GH L+IP H +V E D
Sbjct: 5 ENCIFCKII---AGDIPSAKVYEDEHVLAFLDISQVTKGHTLVIPKTHIENVYEFTDELA 61
Query: 77 WLNMNALAPKVLKALY-AYGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGDSNFMSV 134
+A+ PK+ +A+ + G+N N AG + H HMH++PR+ F +V
Sbjct: 62 KQYFHAV-PKIARAIRDEFEPIGLNTLNNNGEKAGQSV-FHYHMHIIPRYGKGDGFGAV 118
>ref|NP_213096.1| (NC_000918) protein kinase C inhibitor (HIT family) [Aquifex
aeolicus]
sp|O66536|YHIT_AQUAE Hypothetical HIT-like protein AQ_141
pir||E70313 histidine triad-like protein pkcI - Aquifex aeolicus
gb|AAC06496.1| (AE000675) protein kinase C inhibitor (HIT family) [Aquifex
aeolicus]
Length = 121
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/115 (27%), Positives = 53/115 (45%), Gaps = 13/115 (11%)
Query: 16 KNKSCVFCEISQN--PAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLD 73
+ K C+FC+I + PAK +Y + + + P P H+LIIP H ++ L+
Sbjct: 2 QEKDCIFCKIVRGEVPAKK-----VYEDDKVLAFHDINPVAPVHILIIPKKHIMGIQTLE 56
Query: 74 LNTWL---NMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPE---HLHMHLV 122
+M +A K+ + L + +N G L N G + HLH+HL+
Sbjct: 57 PEDECLVGHMFYVARKIAEDLGIAPDENLNKGYRLVFNVGKDAGQSVFHLHLHLI 111
>ref|NP_588328.1| (NC_003421) hypothetical HIT-family protein [Schizosaccharomyces
pombe]
pir||T40979 hypothetical HIT-family protein - fission yeast
(Schizosaccharomyces pombe)
emb|CAA21448.1| (AL031966) hypothetical HIT-family protein [Schizosaccharomyces
pombe]
Length = 133
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/106 (28%), Positives = 51/106 (47%), Gaps = 7/106 (6%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
SC+FC+I + D L + ++ P + GH L+IP H A + L +
Sbjct: 2 SCIFCKIVKG---DIPCVKLAETALSLAFLDIAPTSKGHALVIPKEHAAKMHELSDESCA 58
Query: 79 NMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPR 124
++ L KV KA+ G + N+ N R A + +H+H H++P+
Sbjct: 59 DILPLVKKVTKAI---GPENYNVLQNNGRIAHQFV-DHVHFHIIPK 100
>ref|NP_283602.1| (NC_003116) putative nucleotide-binding protein [Neisseria
meningitidis Z2491]
pir||F81925 probable nucleotide-binding protein NMA0806 [imported] - Neisseria
meningitidis (group A strain Z2491)
emb|CAB84089.1| (AL162754) putative nucleotide-binding protein [Neisseria
meningitidis Z2491]
Length = 107
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 5/105 (4%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I+ AKD + +Y + ++ + P P HLL+IP VH S+
Sbjct: 3 NCIFCKIA---AKDIPAQTVYEDGEMVCFKDINPAAPVHLLLIPKVHFDSLAHAAPEHQP 59
Query: 79 NMNALAPKVLKALYAYG-AQGINLGLNLHRNAGAGIPEHLHMHLV 122
+ + KV + A G A G +N + G + HLH+H++
Sbjct: 60 LLGKMMLKVPEIAKAAGLADGFKTLINTGKGGGQEV-FHLHIHIM 103
>ref|NP_394795.1| (NC_002578) cell-cycle regulation histidine triad (HIT) related
protein [Thermoplasma acidophilum]
emb|CAC12460.1| (AL445067) cell-cycle regulation histidine triad (HIT) related
protein [Thermoplasma acidophilum]
Length = 160
Score = 42.4 bits (98), Expect = 0.002
Identities = 27/106 (25%), Positives = 49/106 (45%), Gaps = 7/106 (6%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLN 79
C FC+I + + ++Y + + ++ P GH L++P H A + +D T
Sbjct: 20 CKFCDIISGK---TASEIVYSDENFVAFLDYKPLFKGHTLLVPRKHFADIYAMDDLTLSK 76
Query: 80 MNALAPKVLKAL-YAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPR 124
M + A+ A G+ G + +N +P H+H+H+VPR
Sbjct: 77 MMKTVTIISMAVERATGSDGTFIAIN--NKVSQSVP-HVHVHIVPR 119
>ref|NP_654589.1| (NC_003995) HIT, HIT family [Bacillus anthracis A2012] [Bacillus
anthracis str. A2012]
Length = 144
Score = 42.0 bits (97), Expect = 0.002
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 16/145 (11%)
Query: 20 CVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLD---LNT 76
C+ C ++ K + +Y + + ++ P+ GH LI+P H V+ LD +
Sbjct: 3 CLGCRLAGGEEKIYK---VYEDDYVTCFLDHEPFYTGHTLIVPKQHVVEVDELDDVVAKS 59
Query: 77 WLNMNALAPKVLKALYAYGAQGINLGLNLHRNAGA-GIPEHLHMHLVPRFLGDSNFMSVI 135
++ + L K +K LY G+ + +N G H HMH+VPR+ S +
Sbjct: 60 IMDASKLITKAIKLLYKPD------GVTVCQNGGIFNELTHYHMHVVPRYKERSFAEFYM 113
Query: 136 AQTRVCGMDLNETYLTLKNLLEKEL 160
Q G + N + KNLL++ +
Sbjct: 114 VQQ---GENKNYNFEETKNLLKEAI 135
>ref|NP_587836.1| (NC_003421) diadenosine tetraphosphatase [Schizosaccharomyces
pombe]
sp|P49776|APH1_SCHPO Bis(5'-nucleosyl)-tetraphosphatase (Asymmetrical) (Diadenosine
5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase)
(Diadenosine tetraphosphatase) (AP4A hydrolase)
(AP4AASE)
pir||S64700 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (EC 3.6.1.17) -
fission yeast (Schizosaccharomyces pombe)
pir||T41374 diadenosine tetraphosphatase - fission yeast (Schizosaccharomyces
pombe)
gb|AAC49143.1| (U32615) diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical
hydrolase [Schizosaccharomyces pombe]
emb|CAB09779.1| (Z97052) diadenosine tetraphosphatase [Schizosaccharomyces pombe]
Length = 182
Score = 41.6 bits (96), Expect = 0.003
Identities = 26/95 (27%), Positives = 47/95 (49%), Gaps = 2/95 (2%)
Query: 35 NRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWLNMNALAPKVLKAL-YA 93
++V YR +N P PGH+L+IP ++ L + ++ KV + +
Sbjct: 14 SQVFYRTKLSAAFVNLKPILPGHVLVIPQRAVPRLKDLTPSELTDLFTSVRKVQQVIEKV 73
Query: 94 YGAQGINLGLNLHRNAGAGIPEHLHMHLVPRFLGD 128
+ A N+G+ +AG +P H+H+H++PR D
Sbjct: 74 FSASASNIGIQDGVDAGQTVP-HVHVHIIPRKKAD 107
>emb|CAB95210.1| (AL359773) probable hypothetical hit-family protein [Leishmania
major]
Length = 142
Score = 40.8 bits (94), Expect = 0.005
Identities = 27/107 (25%), Positives = 50/107 (46%), Gaps = 5/107 (4%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I + D + S M+ P + GH+L+IP H + + L +
Sbjct: 4 NCIFCKIIKG---DIPCAKVAETSKALAFMDINPLSRGHMLVIPKEHASCLHELGMEDAA 60
Query: 79 NMNALAPKVLKALYA-YGAQGINLGLNLHRNAGAGIPEHLHMHLVPR 124
++ L K +A+ G+ N+ N A +P H+H H++P+
Sbjct: 61 DVGVLLAKASRAVAGPDGSMQYNVLQNNGSLAHQEVP-HVHFHIIPK 106
>sp|O07817|HITA_NEIGO HITA PROTEIN
gb|AAB61288.1| (AF003550) HitA [Neisseria gonorrhoeae]
Length = 107
Score = 40.8 bits (94), Expect = 0.005
Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 9/107 (8%)
Query: 19 SCVFCEISQNPAKDSENRVLYRNSDLFVVMNAYPYNPGHLLIIPHVHQASVELLDLNTWL 78
+C+FC+I+ AK+ + +Y + ++ + P P HLL+IP VH S+
Sbjct: 3 NCIFCKIA---AKEIPAQTVYEDGEMVCFKDINPAAPLHLLLIPKVHFDSLAHAAPE--- 56
Query: 79 NMNALAPKVLKALYAYGAQGINLGLNLHRNAGAGIPE---HLHMHLV 122
+ L +LK A G+ G N G G + HLH+H++
Sbjct: 57 HQPLLGKMMLKVPEIAKASGLTDGFKTLINTGKGGGQEVFHLHIHIM 103
>gb|AAL92398.1| (AC115611) FRAGILE HISTIDINE TRIAD PROTEIN [Dictyostelium
discoideum]
Length = 149
Score = 40.4 bits (93), Expect = 0.007
Identities = 25/96 (26%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 34 ENRVLYRNSDLFVVMNAYPYNPGHLL-----IIPHVHQASVELLDLNTWLNMNALAPKVL 88
++ + + F ++N P PGH+L I+P V + E + WL+ ++ V
Sbjct: 13 QSEIFFTTELSFALVNLKPVLPGHVLVCPKRIVPRVKDLTKEEFT-DLWLSAQRISSVVE 71
Query: 89 KALYAYGAQGINLGLNLHRNAGAGIPEHLHMHLVPR 124
+ + GI + +NAG + EH+H+H++PR
Sbjct: 72 EH---FNGDGITFAIQDGKNAGQTV-EHVHIHIIPR 103
Database: /home/scwang/download_20020708_db/nr
Posted date: Aug 7, 2002 12:55 PM
Number of letters in database: 324,149,939
Number of sequences in database: 1,026,957
Lambda K H
0.321 0.138 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 107,101,858
Number of Sequences: 1026957
Number of extensions: 4126273
Number of successful extensions: 10317
Number of sequences better than 1.0e-02: 68
Number of HSP's better than 0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 10217
Number of HSP's gapped (non-prelim): 68
length of query: 161
length of database: 324,149,939
effective HSP length: 111
effective length of query: 50
effective length of database: 210,157,712
effective search space: 10507885600
effective search space used: 10507885600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 92 (40.0 bits)